Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 57, Issue 37, Pages 12116-12120Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201806937
Keywords
aldehyde addition; asymmetric catalysis; enantioselective synthesis; homogeneous catalysis; vinylboronate
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Funding
- National Research Foundation of Korea (NRF) - Korean government (MEST) [NRF-2016R1A2B4011719, NRF-2016R1A4A1011451]
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We report the copper-catalyzed stereoselective addition of in situ generated chiral boron-alpha-alkyl intermediates to various aldehydes including alpha,beta-unsaturated aldehydes under mild conditions. This tandem and multicomponent method facilitated the synthesis of enantiomerically enriched 1,2-hydroxyboronates bearing contiguous stereocenters in good yield with high diastereo- and enantioselectivity up to a ratio greater than 98:2. In particular, alpha,beta-unsaturated aldehydes were successfully used as electrophiles in Cu-H catalysis through 1,2-addition without significant reduction. The resulting 1,2-hydroxyboronates were used in various transformations.
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