Polypeptides with High Zwitterion Density for Safe and Effective Therapeutics

Substituted Polyesters by Thiol–Ene Modification: Rapid Diversification for Therapeutic Protein Stabilization

(2017) Emma M. Pelegri-O’Day et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Analysis of Pre-existing IgG and IgM Antibodies against Polyethylene Glycol (PEG) in the General Population

(2016) Qi Yang et al.   ANALYTICAL CHEMISTRY

Measurement of Pre-Existing IgG and IgM Antibodies against Polyethylene Glycol in Healthy Individuals

(2016) Bing-Mae Chen et al.   ANALYTICAL CHEMISTRY

Pre-existing anti-PEG antibodies are associated with severe immediate allergic reactions to pegnivacogin, a PEGylated aptamer

(2016) Thomas J. Povsic et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Pre-existing anti–polyethylene glycol antibody linked to first-exposure allergic reactions to pegnivacogin, a PEGylated RNA aptamer

(2016) Nancy J. Ganson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Anti-PEG antibodies in the clinic: Current issues and beyond PEGylation

(2016) Peng Zhang et al.   JOURNAL OF CONTROLLED RELEASE

PEGylation of Biopharmaceuticals: A Review of Chemistry and Nonclinical Safety Information of Approved Drugs

(2016) Peter L. Turecek et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Zwitterionic polymer-protein conjugates reduce polymer-specific antibody response

(2016) Sijun Liu et al.   Nano Today

A brush-polymer/exendin-4 conjugate reduces blood glucose levels for up to five days and eliminates poly(ethylene glycol) antigenicity

(2016) Yizhi Qi et al.   Nature Biomedical Engineering

Zwitterionic gel encapsulation promotes protein stability, enhances pharmacokinetics, and reduces immunogenicity

(2015) Peng Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PEGylated Biopharmaceuticals

(2015) Inge A. Ivens et al.   TOXICOLOGIC PATHOLOGY

Anti-PEG immunity: emergence, characteristics, and unaddressed questions

(2015) Qi Yang et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Molecular Understanding and Design of Zwitterionic Materials

(2014) Qing Shao et al.   ADVANCED MATERIALS

PEG — A versatile conjugating ligand for drugs and drug delivery systems

(2014) Atul Kolate et al.   JOURNAL OF CONTROLLED RELEASE

Therapeutic Protein–Polymer Conjugates: Advancing Beyond PEGylation

(2014) Emma M. Pelegri-O’Day et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Single-dose, subcutaneous recombinant phenylalanine ammonia lyase conjugated with polyethylene glycol in adult patients with phenylketonuria: an open-label, multicentre, phase 1 dose-escalation trial

(2014) Nicola Longo et al.   LANCET

Zwitterionic-Coated “Stealth” Nanoparticles for Biomedical Applications: Recent Advances in Countering Biomolecular Corona Formation and Uptake by the Mononuclear Phagocyte System

(2014) Karina Pombo García et al.   Small

Induced and pre-existing anti-polyethylene glycol antibody in a trial of every 3-week dosing of pegloticase for refractory gout, including in organ transplant recipients

(2014) Michael S Hershfield et al.   ARTHRITIS RESEARCH & THERAPY

Pegloticase immunogenicity: the relationship between efficacy and antibody development in patients treated for refractory chronic gout

(2014) Peter E Lipsky et al.   ARTHRITIS RESEARCH & THERAPY

Semi-permeable coatings fabricated from comb-polymers efficiently protect proteins in vivo

(2014) Mi Liu et al.   Nature Communications

Binding characteristics between polyethylene glycol (PEG) and proteins in aqueous solution

(2014) Jiang Wu et al.   Journal of Materials Chemistry B

Polyethylene Glycol Modified FGF21 Engineered to Maximize Potency and Minimize Vacuole Formation

(2013) Jing Xu et al.   BIOCONJUGATE CHEMISTRY

High Molecular Weight Polyethylene Glycol Cellular Distribution and PEG-associated Cytoplasmic Vacuolation Is Molecular Weight Dependent and Does Not Require Conjugation to Proteins

(2013) Daniel G. Rudmann et al.   TOXICOLOGIC PATHOLOGY

Softer Zwitterionic Nanogels for Longer Circulation and Lower Splenic Accumulation

(2012) Lei Zhang et al.   ACS Nano

Role of the Methoxy Group in Immune Responses to mPEG-Protein Conjugates

(2012) Merry R. Sherman et al.   BIOCONJUGATE CHEMISTRY

Antibodies against polyethylene glycol in healthy subjects and in patients treated with PEG-conjugated agents

(2012) Ricardo P Garay et al.   Expert Opinion on Drug Delivery

Different effects of zwitterion and ethylene glycol on proteins

(2012) Qing Shao et al.   JOURNAL OF CHEMICAL PHYSICS

Rapid and Versatile Construction of Diverse and Functional Nanostructures Derived from a Polyphosphoester-Based Biomimetic Block Copolymer System

(2012) Shiyi Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Poly(zwitterionic)protein conjugates offer increased stability without sacrificing binding affinity or bioactivity

(2011) Andrew J. Keefe et al.   Nature Chemistry

FDA-approved poly(ethylene glycol)–protein conjugate drugs

(2011) Steevens N. S. Alconcel et al.   Polymer Chemistry

Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives

(2010) Katrin Knop et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ultralow-Fouling, Functionalizable, and Hydrolyzable Zwitterionic Materials and Their Derivatives for Biological Applications

(2009) Shaoyi Jiang et al.   ADVANCED MATERIALS

Highly Efficient “Grafting onto” a Polypeptide Backbone Using Click Chemistry

(2009) Amanda C. Engler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Zwitterionic Polymers Exhibiting High Resistance to Nonspecific Protein Adsorption from Human Serum and Plasma

(2008) Jon Ladd et al.   BIOMACROMOLECULES