Fibroblast growth factor 19-targeted therapies for the treatment of metabolic disease

Incretin-Based Therapies, Glucometabolic Health and Endovascular Inflammation

(2014) Manfredi Rizzo et al.   CURRENT PHARMACEUTICAL DESIGN

Lipid, blood pressure and kidney update 2013

(2014) Maciej Banach et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

Fibroblast Growth Factor Receptor 4 (FGFR4) Deficiency Improves Insulin Resistance and Glucose Metabolism under Diet-induced Obesity Conditions

(2014) Hongfei Ge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inventing new medicines: The FGF21 story

(2014) Alexei Kharitonenkov et al.   Molecular Metabolism

Metabolic syndrome prevalence according to ATP III and IDF criteria and related factors in Turkish adults

(2013) Kursat Gundogan et al.   Archives of Medical Science

Serum Fibroblast Growth Factor 19 Levels Are Decreased in Chinese Subjects With Impaired Fasting Glucose and Inversely Associated With Fasting Plasma Glucose Levels

(2013) Qichen Fang et al.   DIABETES CARE

FGF19 action in the brain induces insulin-independent glucose lowering

(2013) Gregory J. Morton et al.   JOURNAL OF CLINICAL INVESTIGATION

Central action of FGF19 reduces hypothalamic AGRP/NPY neuron activity and improves glucose metabolism

(2013) Geneviève Marcelin et al.   Molecular Metabolism

Experimental research Expression of pulmonary aquaporin 1 is dramatically upregulated in mice with pulmonary fibrosis induced by bleomycin

(2012) Xiwen Gao et al.   Archives of Medical Science

Fibroblast growth factor 19 expression correlates with tumor progression and poorer prognosis of hepatocellular carcinoma

(2012) Seiki Miura et al.   BMC CANCER

Fibroblast Growth Factor-19 Action in the Brain Reduces Food Intake and Body Weight and Improves Glucose Tolerance in Male Rats

(2012) Karen K. Ryan et al.   ENDOCRINOLOGY

Endocrine fibroblast growth factors 15/19 and 21: from feast to famine

(2012) M. J. Potthoff et al.   GENES & DEVELOPMENT

Emerging role of fibroblast growth factors 15/19 and 21 as metabolic integrators in the liver

(2012) Claudia Cicione et al.   HEPATOLOGY

Dual actions of fibroblast growth factor 19 on lipid metabolism

(2012) Xinle Wu et al.   JOURNAL OF LIPID RESEARCH

Characterization of a FGF19 Variant with Altered Receptor Specificity Revealed a Central Role for FGFR1c in the Regulation of Glucose Metabolism

(2012) Hongfei Ge et al.   PLoS One

Fundamentals of FGF19 & FGF21 Action In Vitro and In Vivo

(2012) Andrew C. Adams et al.   PLoS One

Metabolic transceivers: in tune with the central melanocortin system

(2012) James P. Warne et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

FGF15/19 Regulates Hepatic Glucose Metabolism by Inhibiting the CREB-PGC-1α Pathway

(2011) Matthew J. Potthoff et al.   Cell Metabolism

FGF receptors control vitamin D and phosphate homeostasis by mediating renal FGF-23 signaling and regulating FGF-23 expression in bone

(2011) Simon Wöhrle et al.   JOURNAL OF BONE AND MINERAL RESEARCH

FGF19 Regulates Cell Proliferation, Glucose and Bile Acid Metabolism via FGFR4-Dependent and Independent Pathways

(2011) Ai-Luen Wu et al.   PLoS One

FGF19 as a Postprandial, Insulin-Independent Activator of Hepatic Protein and Glycogen Synthesis

(2011) S. Kir et al.   SCIENCE

The hepatic response to FGF19 is impaired in patients with nonalcoholic fatty liver disease and insulin resistance

(2010) Tim C. M. A. Schreuder et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Bile acid malabsorption in inflammatory bowel disease

(2010) Martin Lenicek et al.   INFLAMMATORY BOWEL DISEASES

The arcuate nucleus as a circumventricular organ in the mouse

(2010) Philippe Ciofi   NEUROSCIENCE LETTERS

Separating mitogenic and metabolic activities of fibroblast growth factor 19 (FGF19)

(2010) X. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A New Mechanism for Bile Acid Diarrhea: Defective Feedback Inhibition of Bile Acid Biosynthesis

(2009) Julian R.F. Walters et al.   Clinical Gastroenterology and Hepatology

FGFs and metabolism

(2009) Alexei Kharitonenkov   CURRENT OPINION IN PHARMACOLOGY

FGF15/FGFR4 Integrates Growth Factor Signaling with Hepatic Bile Acid Metabolism and Insulin Action

(2009) Dong-Ju Shin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fibroblast Growth Factor-19, a Novel Factor That Inhibits Hepatic Fatty Acid Synthesis

(2009) Sushant Bhatnagar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FGF19-induced Hepatocyte Proliferation Is Mediated through FGFR4 Activation

(2009) Xinle Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The FGF family: biology, pathophysiology and therapy

(2009) Andrew Beenken et al.   NATURE REVIEWS DRUG DISCOVERY

Selective activation of FGFR4 by an FGF19 variant does not improve glucose metabolism in ob/ob mice

(2009) X. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7α-hydroxylase gene expression

(2008) Kwang-Hoon Song et al.   HEPATOLOGY

Fibroblast growth factor‐19: Development, analytical characterization and clinical evaluation of a new ELISA test

(2008) D. Stejskal et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

FGF-21/FGF-21 receptor interaction and activation is determined by βKlotho

(2007) Alexei Kharitonenkov et al.   JOURNAL OF CELLULAR PHYSIOLOGY