Localizing Antifungal Drugs to the Correct Organelle Can Markedly Enhance their Efficacy

Shining a light

(2017) Kilian V M Huber   Nature Chemical Biology

Prediction of intracellular exposure bridges the gap between target- and cell-based drug discovery

(2017) André Mateus et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discerning the Chemistry in Individual Organelles with Small-Molecule Fluorescent Probes

(2016) Wang Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Antifungal Imidazole-Decorated Cationic Amphiphiles with Markedly Low Hemolytic Activity

(2016) Raphael I. Benhamou et al.   CHEMISTRY-A EUROPEAN JOURNAL

Global access to antifungal therapy and its variable cost

(2016) Matthew Kneale et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Emerging Frontiers in Drug Delivery

(2016) Mark W. Tibbitt et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Quantitating drug-target engagement in single cells in vitro and in vivo

(2016) J Matthew Dubach et al.   Nature Chemical Biology

Structural Insights into Binding of the Antifungal Drug Fluconazole to Saccharomyces cerevisiae Lanosterol 14α-Demethylase

(2015) Alia A. Sagatova et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

BODIPY–Coumarin Conjugate as an Endoplasmic Reticulum Membrane Fluidity Sensor and Its Application to ER Stress Models

(2015) Hoyeon Lee et al.   BIOCONJUGATE CHEMISTRY

Using Fluorescent Post-Labeling To Probe the Subcellular Localization of DNA-Targeted Platinum Anticancer Agents

(2013) Song Ding et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

LoQAtE—Localization and Quantitation ATlas of the yeast proteomE. A new tool for multiparametric dissection of single-protein behavior in response to biological perturbations in yeast

(2013) Michal Breker et al.   NUCLEIC ACIDS RESEARCH

Fitness Trade-offs Restrict the Evolution of Resistance to Amphotericin B

(2013) Benjamin Matteson Vincent et al.   PLOS BIOLOGY

Hidden Killers: Human Fungal Infections

(2012) G. D. Brown et al.   Science Translational Medicine

Biosynthesis of Cholesterol and Other Sterols

(2011) W. David Nes   CHEMICAL REVIEWS

Regulatory Circuitry Governing Fungal Development, Drug Resistance, and Disease

(2011) R. S. Shapiro et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

The Subcellular Distribution of Small Molecules: From Pharmacokinetics to Synthetic Biology

(2011) Nan Zheng et al.   MOLECULAR PHARMACEUTICS

Metabolic Response to Iron Deficiency in Saccharomyces cerevisiae

(2010) Minoo Shakoury-Elizeh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impact of Nanotechnology on Drug Delivery

(2009) Omid C. Farokhzad et al.   ACS Nano

Subcellular targeting strategies for drug design and delivery

(2009) Lawrence Rajendran et al.   NATURE REVIEWS DRUG DISCOVERY

Additional cassettes for epitope and fluorescent fusion proteins inCandida albicans

(2009) Maryam Gerami-Nejad et al.   YEAST