Review
Rheumatology
Nanette L. A. Vincken, Deepak M. W. Balak, Andre C. Knulst, Paco M. J. Welsing, Jacob M. van Laar
Summary: While systemic glucocorticoids (SGC) are traditionally discouraged in the treatment of psoriatic arthritis (PsA) and psoriasis, they are frequently prescribed for these patients. However, studies show that the occurrence of psoriatic flares appears to be low upon SGC exposure. In patients with a clear indication for SGC, consideration should be given to the low risk of skin flaring, while also weighing the risks of short- and long-term SGC-related side effects.
Review
Medicine, General & Internal
Kamran Ghoreschi, Anna Balato, Charlotta Enerback, Robert Sabat
Summary: Psoriasis is a chronic inflammatory disease affecting 2-3% of the global population, characterized by sharply demarcated erythematous and scaly skin lesions. The disease results from hyperproliferation and disturbed differentiation of epidermal keratinocytes provoked by immune mediators of the IL-23 and IL-17 pathway. Therapeutics targeting IL-23, IL-17, and IL-17RA have shown excellent efficacy in treating psoriasis.
Article
Rheumatology
Raisa Lomanto Silva, Gretchen M. Swabe, Sebastian Eduardo Sattui, Jared W. Magnani
Summary: This study investigated the association between medication copayment and treatment adherence to hydroxychloroquine and immunosuppressants for systemic lupus erythematosus (SLE). The results showed that higher copayment was associated with reduced adherence to prescribed medications for SLE.
LUPUS SCIENCE & MEDICINE
(2023)
Review
Dentistry, Oral Surgery & Medicine
Erick Souza Pedraca, Eduardo Liberato da Silva, Taiane Berguemaier de Lima, Pantelis Varvaki Rados, Fernanda Visioli
Summary: This scoping review evaluated the efficacy and safety of systemic nonsteroidal immunomodulators (SNSI) for oral lichen planus (OLP) treatment. The review found that methotrexate and dapsone were the best options, providing significant improvement in the clinical condition.
CLINICAL ORAL INVESTIGATIONS
(2023)
Review
Biochemistry & Molecular Biology
Tomoko Tashiro, Yu Sawada
Summary: Psoriasis is not only a skin disease but can also cause systemic inflammatory diseases. Clinical and experimental studies have shown that there is an important interaction between psoriasis and systemic inflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Emilio Berna-Rico, Javier Perez-Bootello, Carlota Abbad-Jaime de Arago, Alvaro Gonzalez-Cantero
Summary: Psoriasis is a chronic inflammatory disease with a genetic background. Genetic variations in HLA-Cw*06 allele and genes related to inflammation and keratinocyte proliferation have been associated with disease development. This review assessed the evidence on how these genetic variations may affect the response to psoriasis treatment. Variations in VDR gene may influence topical vitamin D and phototherapy response, while variations in ABC transporter genes are associated with methotrexate and cyclosporine outcomes. Multiple single-nucleotide polymorphisms related to anti-TNF-α response modulation show conflicting results. HLA-Cw*06 has been extensively studied and related to ustekinumab response. Further research is needed to establish the usefulness of these genetic biomarkers in clinical practice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
James B. Brock, Peyton Herrington, Melissa Hickman, Aubri Hickman
Summary: This study reports the successful viral suppression in 12 patients with persistent viremia who were unable to maintain suppression on oral antiretroviral therapy, through the use of injectable cabotegravir/rilpivirine (iCAB/RPV). No virologic rebound was observed in any of the patients. iCAB/RPV can be considered as an alternative option for patients unable to maintain suppression on oral antiretroviral therapy.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Ian Maidment, Geoff Wong, Claire Duddy, Rachel Upthegrove, Sherifat Oduola, Katherine Allen, Simon Jacklin, Jo Howe, Maura MacPhee
Summary: Severe mental illness (SMI) is associated with high morbidity and mortality. This study aims to optimize medication regimens and address non-adherence in SMI patients using a realist approach.
Article
Rheumatology
Kristina Elizabeth Neergaard Clark, Corrado Campochiaro, Eszter Csomor, Adam Taylor, Katherine Nevin, Nicholas Galwey, Mary A. Morse, Jennifer Singh, Yee Voan Teo, Voon H. Ong, Emma Derrett-Smith, Nicolas Wisniacki, Shaun M. Flint, Christopher P. Denton
Summary: Clinical heterogeneity is a key feature of systemic sclerosis (SSc), with hallmark SSc autoantibodies playing a central role in diagnosis and associating with distinct patterns of complications. This study used high-dimensional transcriptional and proteomic analysis to reveal a molecular spectrum of SSc based on skin gene expression and serum protein analysis, showing differences in fibrosis markers and gene expression profiles between different autoantibody specificities. Individual patient pathway analysis identified overlapping and distinct disease processes within SSc subgroups.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Chemistry, Multidisciplinary
Wang Hee Lee, Jun Gi Rho, Yeyoung Yang, Seulbi Lee, Sohui Kweon, Hyung-Mo Kim, Juhwan Yoon, Hongseo Choi, Eunyoung Lee, Su Ha Kim, Sohee You, Yujin Song, Young Soo Oh, Hwan Kim, Hwa Seung Han, Ji Hye Han, Myeongwoo Jung, Young Hwan Park, Yang Seon Choi, Sukyoung Han, Junho Lee, Sangdun Choi, Jung-Woong Kim, Jae Hyung Park, Eun Kyung Lee, Woo Keun Song, Eunha Kim, Wook Kim
Summary: Hyaluronic acid nanoparticles (HA-NPs) have been identified as a potential topical nanomedicine for effectively and safely treating psoriasis by suppressing immune responses and restoring skin barrier function without causing overt toxicity.
Review
Dermatology
Shekhar Neema, Sunmeet Sandhu, Ankan Gupta, Soumya Jagadeesan, Biju Vasudevan
Summary: Psoriasis is a common skin disease that can be treated with various options, including topical therapy, phototherapy, conventional systemic therapy, biologics, and oral small molecules. However, due to the chronic nature of the disease, toxicity of conventional drugs, or high cost of newer drugs, there is often a lack of treatment options. Therefore, it is important to explore unconventional treatment methods.
INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY
(2022)
Article
Multidisciplinary Sciences
Nicholas G. Lamson, Katherine C. Fein, John P. Gleeson, Alexandra N. Newby, Sijie Xian, Kyle Cochran, Namit Chaudhary, Jilian R. Melamed, Rebecca L. Ball, Kanika Suri, Vishal Ahuja, Anna Zhang, Adrian Berger, Dmytro Kolodieznyi, Brigitte F. Schmidt, Gloria L. Silva, Kathryn A. Whitehead
Summary: The study found that strawberry and its red pigment pelargonidin can serve as effective enhancers for oral absorption of macromolecules, with minimal adverse effects and significant bioactivity in mouse models.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Microbiology
Brandon Khor, Michael Snow, Elisa Herrman, Nicholas Ray, Kunal Mansukhani, Karan A. Patel, Nasser Said-Al-Naief, Tom Maier, Curtis A. Machida
Summary: The human microbiota plays a pivotal role in maintaining health balance and preventing diseases, with dysbiosis contributing to various oral and systemic conditions. Current treatment modalities include fecal microbiota transplantation and precision medicine targeting immune response. Continued research and collaboration are needed to uncover the complex interplay between the microbiome, immune system, and disease.
Review
Nutrition & Dietetics
Ana Maria Alexandra Stanescu, Anca Angela Simionescu, Camelia Cristina Diaconu
Summary: Oral vitamin D may be effective as an adjuvant treatment option in psoriasis, but more large-scale studies are needed to determine its efficacy, optimal dose, and adverse effects for patients with psoriasis.
Review
Urology & Nephrology
Sidar Copur, Ibrahim B. Peltek, Ali Mutlu, Cem Tanriover, Mehmet Kanbay
Summary: Systemic hypertension is a common medical comorbidity worldwide, with various associated outcomes. Despite advancements in therapy, a considerable number of patients still have treatment-resistant hypertension. Recent pre-clinical studies have shown the involvement of the immune system in hypertension, with potential benefits from immunosuppressant medications. However, further research is needed to determine the applicability of these findings to human subjects. This is a rapidly growing field of study.
CLINICAL KIDNEY JOURNAL
(2023)