Article
Cardiac & Cardiovascular Systems
Jarl Emanuel Strange, Daniel Molager Christensen, Caroline Sindet-Pedersen, Morten Schou, Alexander Christian Falkentoft, Lauge Ostergaard, Jawad Haider Butt, Peter Laursen Graversen, Lars Kober, Gunnar Gislason, Jonas Bjerring Olesen, Emil Loldrup Fosbol
Summary: Frailty is strongly associated with time in hospital and mortality among patients undergoing transcatheter aortic valve replacement. Higher frailty levels are linked to longer hospital stays and increased risk of death within one year. Strategies aimed at preventing hospitalization among frail patients could be beneficial in reducing the burden of care.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Public, Environmental & Occupational Health
Chun-Qing Li, Hao Kong, Zhen-Zhen Xu, Jia-Hui Ma, Xue-Ying Li
Summary: This study compared the predictive abilities of two frailty indices (mFI and RAI-rev) in predicting life-threatening morbidity and mortality in older patients undergoing high-risk abdominal surgery. The results showed that both frailty indices displayed poor discrimination for postoperative life-threatening morbidity and mortality.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Cardiac & Cardiovascular Systems
Fausto Biancari, Stefano Rosato, Giuliano Costa, Marco Barbanti, Paola D'Errigo, Corrado Tamburino, Francesco Cerza, Aldo Rosano, Fulvia Seccareccia
Summary: A novel risk assessment tool was developed and validated to predict 30-day mortality after surgical aortic valve replacement, showing high discrimination and calibration abilities. Variables including patient frailty played independent predictive roles in 30-day mortality, with the new model outperforming EuroSCORE II. The OBS AVR risk score also showed a significant association with long-term mortality.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Li-Tan Yang, Zi Ye, Muhammad Wajih Ullah, Joseph J. Maleszewski, Christopher G. Scott, Ratnasari Padang, Sorin Pislaru, Vuyisile T. Nkomo, Sunil Mankad, Patricia A. Pellikka, Jae K. Oh, Veronique L. Roger, Maurice Enriquez-Sarano, Hector Michelena
Summary: This study aimed to assess lifetime morbidity and long-term survival in patients with bicuspid aortic valve (BAV) in the community. The results showed that BAV patients have a high lifetime morbidity burden, with a high incidence of complications such as aortic stenosis or regurgitation, aortic surgery, aortic aneurysm, infective endocarditis, and aortic dissection. Compared to patients with typical valvulo-aortopathy, patients with complex valvulo-aortopathy have lower survival rates.
EUROPEAN HEART JOURNAL
(2023)
Article
Surgery
Pau Forte-Genesca, Eduard Casajuana Urgell, Carles Diaz-Duran, Lorena Romero-Montana, Ezequiel Paredes-Marinas, Albert Clara-Velasco
Summary: This study examined the relationship between multiple CT-derived measurements of sarcopenia and the 5-year survival after AAA repair. The results showed that these measurements were significantly associated with survival, but their inclusion did not improve survival prediction accuracy.
WORLD JOURNAL OF SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Annamaria Mazzone, Serena Del Turco, Giuseppe Trianni, Paola Quadrelli, Marco Marotta, Luca Bastiani, Tommaso Gasbarri, Andreina D'Agostino, Massimiliano Mariani, Giuseppina Basta, Ilenia Foffa, Silverio Sbrana, Cristina Vassalle, Marcello Ravani, Marco Solinas, Sergio Berti
Summary: This study aimed to evaluate outcomes in older severe aortic valve stenosis patients and select treatment according to frailty levels. The results showed that patients with early frailty levels were the most suitable candidates for surgical or transcatheter aortic valve replacement, while advanced frailty would make each treatment futile or palliative.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Andreas Winkler, Paul Puiu, Philipp Krombholz-Reindl, Andreas Voetsch, Johannes Steindl, Matthias Neuner, Michael Kirnbauer, Rainald Seitelberger, Roman Gottardi
Summary: The study shows that concomitant replacement of the ascending aorta prolongs operative times but does not increase morbidity and mortality. In patients undergoing aortic valve replacement, replacing a dilated ascending aorta appears to be the most durable and safest treatment option.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Geriatrics & Gerontology
Pablo Solla-Suarez, Pablo Avanzas, Marta Fernandez-Fernandez, Isaac Pascual, Carmen Moreno-Planillo, Marcel Almendarez, Eva Lopez-Alvarez, Rut Alvarez, Ana Coto-Montes, Cesar Moris, Jose Gutierrez-Rodriguez
Summary: This study aimed to analyze the distribution of functional capacity in older adults with aortic stenosis, its association with decision-making regarding valve disease, and its impact on one-year mortality rate. The results showed that increased functional capacity was associated with a tendency for more invasive treatment, and the Functional Continuum Scale (FCS) was identified as a useful predictive tool for clinical decision-making.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Kenichi Ishizu, Shinichi Shirai, Akihiro Isotani, Masaomi Hayashi, Tomohiro Kawaguchi, Tomohiko Taniguchi, Kenji Ando, Fumiaki Yashima, Norio Tada, Masahiro Yamawaki, Toru Naganuma, Futoshi Yamanaka, Hiroshi Ueno, Minoru Tabata, Kazuki Mizutani, Kensuke Takagi, Yusuke Watanabe, Masanori Yamamoto, Kentaro Hayashida
Summary: After TAVI surgery, high-risk patients had a higher long-term mortality rate compared to low and intermediate-risk patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2021)
Review
Medicine, General & Internal
Pierfranco Terrosu, Alessandro Boccanelli, Giuseppe Sabino, Paolo Alboni, Samuele Baldasseroni, Mario Bo, Giovambattista Desideri, Niccolo Marchionni, Giuseppe Palazzo, Renzo Rozzini, Andrea Ungar, Francesco Vetta, Giovanni Zito
Summary: Transcatheter aortic valve replacement (TAVR) has become the standard treatment for symptomatic severe aortic stenosis. Frailty and medical comorbidities in the elderly population are significant predictors of outcomes after TAVR.
Article
Cardiac & Cardiovascular Systems
Douglas R. Johnston, Rashed Mahboubi, Edward G. Soltesz, Amanda S. Artis, Eric E. Roselli, Eugene H. Blackstone, Lars G. Svensson
Summary: This study compared the outcomes of SAVR in low-risk patients with expected results from STS models and evaluated their intermediate-term survival. The observed mortality, stroke, and reoperation rates were lower than expected, indicating that STS models overestimate the risk of SAVR in low-risk patients. Additionally, the survival rate of low-risk patients was superior to the predicted value for the US population.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Flavien Vincent, Julien Ternacle, Tom Denimal, Mylene Shen, Bjorn Redfors, Cedric Delhaye, Matheus Simonato, Nicolas Debry, Basile Verdier, Bahira Shahim, Thibault Pamart, Hugues Spillemaeker, Guillaume Schurtz, Francois Pontana, Vinod H. Thourani, Philippe Pibarot, Eric Van Belle
Summary: TAVR is rapidly expanding its indications, but faces technical challenges and knowledge gaps when dealing with patients with bicuspid aortic valve (BAV). Physicians need to understand the BAV anatomy and TAVR procedure planning comprehensively to guide treatment decisions.
Article
Nutrition & Dietetics
Fanny Petermann-Rocha, Stuart R. Gray, Jill P. Pell, Frederick K. Ho, Carlos Celis-Morales
Summary: The study revealed the joint association of different combinations of sarcopenia and frailty with adverse health outcomes, with the combination of sarcopenic/frail showing the strongest association with incidence and mortality of cardiovascular disease, respiratory disease, and cancer.
CLINICAL NUTRITION
(2021)
Article
Medicine, General & Internal
Po-Han Lin, Hao-Ji Wei, Shih-Rong Hsieh, Hung-Wen Tsai, Chu-Leng Yu, Wen-Lieng Lee, Yung-Szu Wu
Summary: The aim of the study was to provide real-world data on outcomes for elderly Taiwanese patients who underwent transcatheter aortic valve replacement or surgical aortic valve replacement in different risk groups. The results showed that in all risk groups, patients in the TAVI group had shorter hospital stay and higher rate of paravalvular leakage compared to the SAVR group, but there were no significant differences in mortality rates between the two groups. Risk factors for higher 1-year and 5-year mortality included BMI less than 20 and acute kidney injury.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Seung-Ah Lee, Il-Young Jang, Seo-Young Park, Kyung-Won Kim, Duk-Woo Park, Ho Jin Kim, Joon Bum Kim, Sung-Ho Jung, Suk Jung Choo, Cheol-Hyun Chung, Duk-Hyun Kang, Jae-Won Lee, Dae-Hee Kim
Summary: Sarcopenia, or muscle wasting, is common in older patients and is associated with adverse outcomes after cardiac surgery. This study found that measuring muscle area using preoperative computed tomography can enhance the prediction of postoperative adverse events.
ANNALS OF THORACIC SURGERY
(2022)