Colorectal cancer models for novel drug discovery

Global cancer statistics, 2012

(2015) Lindsey A. Torre et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer

(2015) Lukas E. Dow et al.   CELL

Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

(2015) Marc van de Wetering et al.   CELL

Higher metastatic efficiency of KRas G12V than KRas G13D in a colorectal cancer model

(2015) Patricia Alamo et al.   FASEB JOURNAL

Sequential cancer mutations in cultured human intestinal stem cells

(2015) Jarno Drost et al.   NATURE

Comprehensive models of human primary and metastatic colorectal tumors in immunodeficient and immunocompetent mice by chemokine targeting

(2015) Huanhuan Joyce Chen et al.   NATURE BIOTECHNOLOGY

Inducible in vivo genome editing with CRISPR-Cas9

(2015) Lukas E Dow et al.   NATURE BIOTECHNOLOGY

Advances in patient-derived tumor xenografts: From target identification to predicting clinical response rates in oncology

(2014) Edward Rosfjord et al.   BIOCHEMICAL PHARMACOLOGY

Colon-specific tumorigenesis in mice driven by Cre-mediated inactivation of Apc and activation of mutant Kras

(2014) Alexander J. Byun et al.   CANCER LETTERS

Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type, KRAS mutant colorectal cancer

(2014) Jatin Roper et al.   CANCER LETTERS

Cross-species analysis of genetically engineered mouse models of MAPK-driven colorectal cancer identifies hallmarks of the human disease

(2014) P. J. Belmont et al.   Disease Models & Mechanisms

Subcutaneous preconditioning increases invasion and metastatic dissemination in mouse colorectal cancer models

(2014) P. Alamo et al.   Disease Models & Mechanisms

Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture

(2014) Xingnan Li et al.   NATURE MEDICINE

Conditional Reverse Tet-Transactivator Mouse Strains for the Efficient Induction of TRE-Regulated Transgenes in Mice

(2014) Lukas E. Dow et al.   PLoS One

A GFP-labeled Human Colon Cancer Metastasis Model Featuring Surgical Orthotopic Implantation

(2013) Hong-Jin Chen et al.   Asian Pacific Journal of Cancer Prevention

Patient-Derived Tumor Xenografts: Transforming Clinical Samples into Mouse Models

(2013) D. Siolas et al.   CANCER RESEARCH

Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients

(2013) Gerald Schwank et al.   Cell Stem Cell

Development of a Colon Cancer GEMM-Derived Orthotopic Transplant Model for Drug Discovery and Validation

(2013) E. S. Martin et al.   CLINICAL CANCER RESEARCH

Concomitant BRAF and PI3K/mTOR Blockade Is Required for Effective Treatment of BRAFV600E Colorectal Cancer

(2013) E. M. Coffee et al.   CLINICAL CANCER RESEARCH

Pathology of Rodent Models of Intestinal Cancer: Progress Report and Recommendations

(2013) Mary Kay Washington et al.   GASTROENTEROLOGY

Patient-derived xenografts, the cancer stem cell paradigm and cancer pathobiology in the 21st century

(2013) Samuel A Williams et al.   LABORATORY INVESTIGATION

In vitro expansion and genetic modification of gastrointestinal stem cells in spheroid culture

(2013) Hiroyuki Miyoshi et al.   Nature Protocols

Genetic reconstitution of tumorigenesis in primary intestinal cells

(2013) K. Onuma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Growing Self-Organizing Mini-Guts from a Single Intestinal Stem Cell: Mechanism and Applications

(2013) T. Sato et al.   SCIENCE

The Pan-ErbB Negative Regulator Lrig1 Is an Intestinal Stem Cell Marker that Functions as a Tumor Suppressor

(2012) Anne E. Powell et al.   CELL

Characterization of a Large Panel of Patient-Derived Tumor Xenografts Representing the Clinical Heterogeneity of Human Colorectal Cancer

(2012) S. Julien et al.   CLINICAL CANCER RESEARCH

Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell

(2012) Shiro Yui et al.   NATURE MEDICINE

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Histological and Molecular Evaluation of Patient-Derived Colorectal Cancer Explants

(2012) Joshua M. Uronis et al.   PLoS One

Priceless GEMMs: genetically engineered mouse models for colorectal cancer drug development

(2012) Jatin Roper et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

Prioritizing Phase I Treatment Options Through Preclinical Testing on Personalized Tumorgraft

(2011) M. Pia Morelli et al.   JOURNAL OF CLINICAL ONCOLOGY

A Pilot Clinical Study of Treatment Guided by Personalized Tumorgrafts in Patients with Advanced Cancer

(2011) M. Hidalgo et al.   MOLECULAR CANCER THERAPEUTICS

Isolation and in vitro expansion of human colonic stem cells

(2011) Peter Jung et al.   NATURE MEDICINE

Utilization of Murine Colonoscopy for Orthotopic Implantation of Colorectal Cancer

(2011) Ehud Zigmond et al.   PLoS One

A new conditional Apc-mutant mouse model for colorectal cancer

(2010) E. C. Robanus-Maandag et al.   CARCINOGENESIS

Generation of a Transgenic Mouse for Colorectal Cancer Research with Intestinal Cre Expression Limited to the Large Intestine

(2010) Y. Xue et al.   MOLECULAR CANCER RESEARCH

Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment

(2010) K. E. Hung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TGF-β Receptor Inactivation and Mutant Kras Induce Intestinal Neoplasms in Mice via a β-Catenin-Independent Pathway

(2009) Patty Trobridge et al.   GASTROENTEROLOGY

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche

(2009) Akifumi Ootani et al.   NATURE MEDICINE

Complete deletion of Apc results in severe polyposis in mice

(2009) A F Cheung et al.   ONCOGENE

A metastatic colon cancer model using nonoperative transanal rectal injection

(2009) Melissa Donigan et al.   SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES

5-aminosalicylic acid inhibits colitis-associated colorectal dysplasias in the mouse model of azoxymethane/dextran sulfate sodium-induced colitis

(2008) Margie L. Clapper et al.   INFLAMMATORY BOWEL DISEASES

Animal Models for Liver Metastases of Colorectal Cancer: Research Review of Preclinical Studies in Rodents

(2008) Gabie M. de Jong et al.   JOURNAL OF SURGICAL RESEARCH

Crypt stem cells as the cells-of-origin of intestinal cancer

(2008) Nick Barker et al.   NATURE