The TZD insulin sensitizer clue provides a new route into diabetes drug discovery

Effect of pioglitazone medication on the incidence of dementia

(2015) Michael T. Heneka et al.   ANNALS OF NEUROLOGY

Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes

(2015) Rachel J. Perry et al.   CELL

Loss of Mitochondrial Pyruvate Carrier 2 in the Liver Leads to Defects in Gluconeogenesis and Compensation via Pyruvate-Alanine Cycling

(2015) Kyle S. McCommis et al.   Cell Metabolism

Insulin Resistance Predicts Medial Temporal Hypermetabolism in Mild Cognitive Impairment Conversion to Alzheimer Disease

(2015) Auriel A. Willette et al.   DIABETES

Initial combination therapy with metformin, pioglitazone and exenatide is more effective than sequential add-on therapy in subjects with new-onset diabetes. Results from the Efficacy and Durability of Initial Combination Therapy for Type 2 Diabetes (EDICT

(2015) M. A. Abdul-Ghani et al.   DIABETES OBESITY & METABOLISM

Regulation of mitochondrial pyruvate uptake by alternative pyruvate carrier complexes

(2015) T. Bender et al.   EMBO JOURNAL

MicroRNA-455 regulates brown adipogenesis via a novel HIF1an-AMPK-PGC1  signaling network

(2015) H. Zhang et al.   EMBO REPORTS

An Insulin-Sensitizing Thiazolidinedione, Which Minimally Activates PPARγ, Does Not Cause Bone Loss

(2015) Tomohiro Fukunaga et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Anti-Diabetes Drug Pioglitazone Ameliorates Synaptic Defects in AD Transgenic Mice by Inhibiting Cyclin-Dependent Kinase5 Activity

(2015) Jinan Chen et al.   PLoS One

Thiazolidinediones and the Promise of Insulin Sensitization in Type 2 Diabetes

(2014) Raymond E. Soccio et al.   Cell Metabolism

Epigenomic Approach in Understanding Alzheimer’s Disease and Type 2 Diabetes Mellitus

(2014) Munvar Shaik et al.   CNS & Neurological Disorders-Drug Targets

An Evaluation of MSDC-0160, A Prototype mTOT Modulating Insulin Sensitizer, in Patients with Mild Alzheimer’s Disease

(2014) Raj Shah et al.   Current Alzheimer Research

Mitochondrial target of thiazolidinediones

(2014) J. R. Colca et al.   DIABETES OBESITY & METABOLISM

Commentary: The hedgehog and the fox: Sir Harold Himsworth (1905-93)

(2014) E. A. Gale   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

A Novel Non-agonist Peroxisome Proliferator-activated Receptor γ (PPARγ) Ligand UHC1 Blocks PPARγ Phosphorylation by Cyclin-dependent Kinase 5 (CDK5) and Improves Insulin Sensitivity

(2014) Sun-Sil Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutamine Oxidation Maintains the TCA Cycle and Cell Survival during Impaired Mitochondrial Pyruvate Transport

(2014) Chendong Yang et al.   MOLECULAR CELL

Regulation of Substrate Utilization by the Mitochondrial Pyruvate Carrier

(2014) Nathaniel M. Vacanti et al.   MOLECULAR CELL

An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ

(2014) Alexander S. Banks et al.   NATURE

Mitochondrial Pyruvate Carrier 2 Hypomorphism in Mice Leads to Defects in Glucose-Stimulated Insulin Secretion

(2014) Patrick A. Vigueira et al.   Cell Reports

Clinical Proof-of-Concept Study With MSDC-0160, a Prototype mTOT-Modulating Insulin Sensitizer

(2013) J R Colca et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Stem cell metabolism in tissue development and aging

(2013) N. Shyh-Chang et al.   DEVELOPMENT

Individualized glycaemic targets and pharmacotherapy in type 2 diabetes

(2013) Clifford J Bailey et al.   Diabetes & Vascular Disease Research

Ambulatory Treatment of Type 2 Diabetes in the U.S., 1997–2012

(2013) Lydia W. Turner et al.   DIABETES CARE

Economic Costs of Diabetes in the U.S. in 2012

(2013)   DIABETES CARE

Global estimates of undiagnosed diabetes in adults

(2013) Jessica Beagley et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Insulin sensitizers in 2013: new insights for the development of novel therapeutic agents to treat metabolic diseases

(2013) Jerry R Colca et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Nutrient-sensing pathways and metabolic regulation in stem cells

(2013) Joshua D. Ochocki et al.   JOURNAL OF CELL BIOLOGY

Troglitazone, a thiazolidinedione, decreases tau phosphorylation through the inhibition of cyclin-dependent kinase 5 activity in SH-SY5Y neuroblastoma cells and primary neurons

(2013) Du-Hyong Cho et al.   JOURNAL OF NEUROCHEMISTRY

Pharmacological agents for NASH

(2013) Vlad Ratziu   Nature Reviews Gastroenterology & Hepatology

Novel Insulin Sensitizer Modulates Nutrient Sensing Pathways and Maintains β-Cell Phenotype in Human Islets

(2013) Nidhi Rohatgi et al.   PLoS One

Identification of a Mitochondrial Target of Thiazolidinedione Insulin Sensitizers (mTOT)—Relationship to Newly Identified Mitochondrial Pyruvate Carrier Proteins

(2013) Jerry R. Colca et al.   PLoS One

Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier

(2013) A. S. Divakaruni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insulin Resistance and Metabolic Derangements in Obese Mice Are Ameliorated by a Novel Peroxisome Proliferator-activated Receptor γ-sparing Thiazolidinedione

(2012) Zhouji Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatic Lipid Accumulation Alters Global Histone H3 Lysine 9 and 4 Trimethylation in the Peroxisome Proliferator-Activated Receptor Alpha Network

(2012) Hee-Jin Jun et al.   PLoS One

Type 2 Diabetes Can Be Prevented With Early Pharmacological Intervention

(2011) R. A. DeFronzo et al.   DIABETES CARE

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5

(2010) Jang Hyun Choi et al.   NATURE

From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus

(2009) R. A. DeFronzo   DIABETES

A Functional Peroxisome Proliferator-activated Receptor-γ Ligand-binding Domain Is Not Required for Adipogenesis

(2008) Christopher J. Walkey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY