Journal
ANALYTICAL BIOCHEMISTRY
Volume 549, Issue -, Pages 91-95Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ab.2018.03.008
Keywords
Nucleic acids; Aptamer; Tumor cell; Biomarker; SELEX; Aptasensor
Funding
- National Natural Science Foundation of China [21176272, 30870670]
- 111 Project [B06023]
- Chongqing Engineering Laboratory in Vascular Implants
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Aptamers are promising alternatives to antibodies and can be used as high affinity agents for the cancer detection and the targeted drug transportation. In this manuscript, we highlight the advantages of aptamers, such as high affinities, specificity and excellent chemical stabilities, which are likely to benefit for the diagnosis of cancer in its early stages and then achieve molecular-level treatment. Also, we discuss the challenges and problems in the current application of aptamers.
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