Journal
ANALYTICAL BIOCHEMISTRY
Volume 546, Issue -, Pages 5-9Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ab.2018.01.017
Keywords
Biosensor; HIV-1 DNA; Zinc-methylimidazolate framework-8
Funding
- National Basic Research Program of China (973 Program) [2015CB932600, 2013CB933000, 2016YFF0100800]
- National Natural Science Foundation of China [21375042, 21405054, 21525523, 21574048]
- National Key RAMP
- D Program of China [2016YFF0100800, 2017YFA0208000]
- Fok Ying-Tong Education Foundation, China [151011]
- China Postdoctoral Science Foundation [2017M622402]
- 1000 Young Talent
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ZIF-8(zinc-methylimidazolate framework-8), one of the zeolitic imidazolate frameworks (ZIFs), as quenching platforms for detection of HIV-1 DNA, which was identified to be effective for highly sensitive detection of HIV-1 DNA. The enhanced fluorescence signal has a relationship with the ssDNA concentration, the detection limit is as low as 1.2 nmol L-1 with good selectivity. This study is an important step toward rational design of materials to achieve specific interactions between biomolecules and synthetic particle surfaces.
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