Article
Cell Biology
Qianxia Yin, Haocai Chang, Qi Shen, Da Xing
Summary: The study found that PBMT can significantly improve atherosclerosis by reducing plaque area and promoting cholesterol efflux, potentially through activating ATP-binding cassette transporters A1 and related signaling cascades.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Liv Tybjaerg Nordestgaard, Mette Christoffersen, Shoaib Afzal, Borge Gronne Nordestgaard, Anne Tybjaerg-Hansen, Ruth Frikke-Schmidt
Summary: Genetic variants in ABCA1 associated with high HDL cholesterol concentrations are also associated with higher risk of AMD, suggesting a role for ABCA1 in AMD pathogenesis.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Leonor Jacobo-Albavera, Mayra Dominguez-Perez, Diana Jhoseline Medina-Leyte, Antonia Gonzalez-Garrido, Teresa Villarreal-Molina
Summary: ABCA1 plays a crucial role in cholesterol homeostasis, reverse cholesterol transport, lipid content in the plasma membrane, and the development of organ diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Maria Pia Adorni, Nicoletta Ronda, Franco Bernini, Francesca Zimetti
Summary: HDL cholesterol efflux capacity (CEC) has emerged as a better predictor of cardiovascular risk compared to plasma HDL-cholesterol levels, and is often impaired in various genetic and pathological conditions associated with high cardiovascular risk.
Article
Biology
Sukriti Sacher, Abhishek Mukherjee, Arjun Ray
Summary: Atherosclerosis is a major cause of cardiovascular disease, and cholesterol-loaded foam cells play a crucial role in the formation of atherosclerotic plaques. Efforts to induce cholesterol efflux and reverse cholesterol transport (RCT) as a treatment for CVD have been unsuccessful due to a lack of understanding about the relationship between HDL function and RCT. This review examines the structure-function relationships and genetic mutations that impact RCT, highlighting the need for further studies.
BIOLOGICAL REVIEWS
(2023)
Article
Cardiac & Cardiovascular Systems
Chuanfei Zeng, Caixia Yan, Shan Guo, Hengmei Zhu, Yanbing Chen, Xiaojiang Zhan
Summary: This study investigated the relationship between HAR and all-cause mortality in PD patients, finding that a high HAR was associated with an increased risk of all-cause mortality. Specifically, males, patients under 55 years old, and patients without diabetes or CVD had a higher risk of all-cause mortality with a high HAR.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Hematology
Yanni Xu, Chang Liu, Xiaowan Han, Xiaojian Jia, Yongzhen Li, Chao Liu, Ni Li, Lunming Liu, Peng Liu, Xinhai Jiang, Weizhi Wang, Xiao Wang, Yining Li, Mingzhu Chen, Jinque Luo, Xuan Zuo, Jiangxue Han, Li Wang, Yu Du, Yang Xu, Jian-Dong Jiang, Bin Hong, Shuyi Si
Summary: The study introduces a new small molecule, E17241, that may be used to treat atherosclerosis by promoting reverse cholesterol transport via upregulating ABCA1. E17241 shows promising potential as a drug candidate for atherosclerosis treatment.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Medicine, General & Internal
Hae Won Jung, Moni Ra, Han Joon Bae, Seung-Pyo Hong
Summary: The association between Apo B, Apo B/A1 ratio, lipoprotein (a), and LDL-C/Apo B ratio with coronary artery disease (CAD) in non-diabetic patients without high LDL-C levels was unclear. A study was conducted on 487 non-diabetic patients with LDL-C < 130.0 mg/dL to evaluate the most strongly associated parameter with CAD. The LDL-C/Apo B ratio was found to be the most predictive parameter for coronary atherosclerosis in non-diabetic patients without high LDL-C levels.
Article
Nanoscience & Nanotechnology
Wenmin Yuan, Kelsey Ernst, Rui Kuai, Emily E. Morin, Minzhi Yu, Denis O. Sviridov, Jie Tang, Ling Mei, Dan Li, Rose Ackermann, Alan T. Remaley, Anna Schwendeman
Summary: Synthetic high-density lipoproteins nanomedicine (sHDL) composed of ApoA-I mimetic peptides and lipids have shown promising results for the treatment of cardiovascular diseases. However, the understanding of how ApoA-I mimetic peptides affect the properties of sHDL and their relationship with potency is limited. This study evaluated different ApoA-I mimetic peptides in terms of their physical/chemical properties, cholesterol efflux, cholesterol esterification, remodeling, and pharmacokinetics/pharmacodynamics, highlighting the importance of considering overall performance for designing and optimizing ApoA-I mimetic peptides.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2023)
Article
Orthopedics
Xiaozhi Sun, Xiaotao Wu
Summary: Higher levels of apolipoprotein A1 (ApoA1) are associated with increased risk of osteoporosis, indicating the involvement of lipid metabolism in bone metabolism.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Medical Laboratory Technology
Hiromi Uekita, Hiroyasu Yamamoto, Ryu Niinaga, Noriko Yamane, Manami Yoshii, Keiko Yamauchi-Takihara, Shinji Kihara
Summary: The study found a correlation between serum Mac-2BP concentrations and clinical parameters related to metabolic syndrome, but the significance was not evident in multivariate analysis. IFN-gamma stimulation led to increased Mac-2BP and decreased ABCA1 and apo A-I mRNA concentrations in HepG2 cells.
CLINICA CHIMICA ACTA
(2021)
Article
Hematology
George E. G. Kluck, Alexander S. Qian, Emmanuel H. Sakarya, Henry Quach, Yak D. Deng, Bernardo L. Trigatti
Summary: Atherosclerosis is a chronic disease that affects the artery wall and is a major contributor to cardiovascular diseases. Necrotic cores, which contain debris from dead macrophages, increase the risk of plaque rupture and thrombus formation. HDL (high-density lipoprotein) has direct protective effects on different cells within atherosclerotic plaques, but its role in protecting against necroptosis and necrotic core formation is not fully understood.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Anouar Hafiane, Ioanna Gianopoulos, Mary G. Sorci-Thomas, Stella S. Daskalopoulou
Summary: The primary function of HDL is to remove excess cellular free cholesterol and deliver it to the liver. Recent research has focused on the interaction between apoA-I and ABCA1 in HDL formation and its relevance in atherosclerotic cardiovascular disease. Understanding the key steps in HDL formation may have potential therapeutic implications for ASCVD management.
CURRENT OPINION IN LIPIDOLOGY
(2022)
Article
Oncology
Hiroki Nishiyama, Takehiro Funamizu, Hiroshi Iwata, Hirohisa Endo, Yuichi Chikata, Shinichiro Doi, Hideki Wada, Ryo Naito, Manabu Ogita, Yoshiteru Kato, Iwao Okai, Tomotaka Dohi, Takatoshi Kasai, Kikuo Isoda, Shinya Okazaki, Katsumi Miyauchi, Tohru Minamino
Summary: This study aimed to evaluate the prognostic impact of preprocedural ApoA1 on cancer mortality in patients undergoing PCI. The results showed that patients with lower levels of ApoA1 had higher mortality rates for total, gastrointestinal, and lung cancer, while HDL-C levels had no significant impact on any type of cancer mortality. Multivariable analysis confirmed that elevated ApoA1 levels independently predicted a lower risk of total and gastrointestinal cancer. Therefore, preprocedural ApoA1 levels have prognostic implications for predicting cancer mortality in PCI patients.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Cardiac & Cardiovascular Systems
Michal Vrablik, Bohumil Seifert, Alexander Parkhomenko, Maciej Banach, Jacek J. Jozwiak, Robert Gabor Kiss, Dan Gaita, Katarina Raslova, Marie Zachlederova, Sarah Bray, Kausik K. Ray
Summary: Central and Eastern Europe has high cardiovascular disease mortality but low achievement of LDL-C goals among patients receiving lipid-lowering therapy. The 2019 guidelines are harder to achieve than the 2016 guidelines, highlighting a significant gap between practice and guidelines in lipid management in the region.
Article
Pharmacology & Pharmacy
Yu Du, Xingxing Li, Chunyan Su, Mei Xi, Xiumin Zhang, Zhibo Jiang, Li Wang, Bin Hong
BRITISH JOURNAL OF PHARMACOLOGY
(2020)
Article
Medicine, General & Internal
Xuelei Wang, Xiaofang Chen, Xiumin Zhang, Chunyan Su, Mengxia Yang, Wei He, Yu Du, Shuyi Si, Li Wang, Bin Hong
Article
Biochemical Research Methods
Xiao-Jian Jia, Yu Du, Hua-Jun Jiang, Yong-Zhen Li, Yan-Ni Xu, Shu-Yi Si, Li Wang, Bin Hong
Article
Hematology
Yanni Xu, Chang Liu, Xiaowan Han, Xiaojian Jia, Yongzhen Li, Chao Liu, Ni Li, Lunming Liu, Peng Liu, Xinhai Jiang, Weizhi Wang, Xiao Wang, Yining Li, Mingzhu Chen, Jinque Luo, Xuan Zuo, Jiangxue Han, Li Wang, Yu Du, Yang Xu, Jian-Dong Jiang, Bin Hong, Shuyi Si
Summary: The study introduces a new small molecule, E17241, that may be used to treat atherosclerosis by promoting reverse cholesterol transport via upregulating ABCA1. E17241 shows promising potential as a drug candidate for atherosclerosis treatment.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tian-Yun Fan, Yu-Xin Yang, Qing-Xuan Zeng, Xue-Lei Wang, Wei Wei, Xi-Xi Guo, Li-Ping Zhao, Dan-Qing Song, Yan-Xiang Wang, Li Wang, Bin Hong
Summary: In this study, 40 berberine derivatives were synthesized and evaluated for their potential as PCSK9 transcriptional inhibitors. Among them, compound 9k showed the strongest activity in downregulating PCSK9 protein levels and promoting LDLR expression with a mechanism targeting HNF1 alpha and/or Sp1 cluster modulation upstream of PCSK9. This compound may hold promise as a novel treatment for atherosclerosis.
BIOORGANIC CHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Xingxing Li, Chunyan Su, Zhibo Jiang, Yuxin Yang, Yue Zhang, Mengxia Yang, Xiumin Zhang, Yu Du, Jin Zhang, Li Wang, Jiandong Jiang, Bin Hong
Summary: The study found that berberine can attenuate trimethylamine-N-oxide production by modulating gut microbiota, thereby reducing atherosclerotic lesions.
NPJ BIOFILMS AND MICROBIOMES
(2021)
Article
Endocrinology & Metabolism
Chunyan Su, Xingxing Li, Yuxin Yang, Yu Du, Xiumin Zhang, Li Wang, Bin Hong
Summary: The study shows that metformin can suppress the production of TMAO from choline by regulating the structure and metabolic function of gut microbiota, thereby reducing the risk of atherosclerosis.
NUTRITION & DIABETES
(2021)
Article
Biochemistry & Molecular Biology
Xiaomin Hu, Ying Wang, Chunyan Zhao, Shufen Li, Xinxin Hu, Xuefu You, Jiajia Shen, Zhen Wang, Bin Hong, Bingya Jiang, Yu Du, Linzhuan Wu
Summary: A group of peptide metabolites called mintaimycins were isolated from Micromonospora sp. C-3509. The structures and stereochemistry of mintaimycins were determined through various methods, and the principal component, mintaimycin A(1), exhibited the biological activity of inducing pre-adipocyte differentiation.
Article
Chemistry, Medicinal
Weiwei Guo, Qianxiao Zhang, Yu Du, Junting Guo, Tingting Zhao, Liping Bai, Xiqiang An
Summary: The immunomodulatory activity of polysaccharides from Brassica rapa roots was investigated in this study. The results demonstrated that the polysaccharides exhibited a significant phagocytic capacity in macrophages, increased the production of nitric oxide and tumor necrosis factor alpha, and upregulated the mRNA levels of inducible nitric oxide synthase and tumor necrosis factor alpha. Furthermore, the modulation of macrophages by these polysaccharides was mediated through the activation of Akt and nuclear factor-kappa B. Therefore, polysaccharides from Brassica rapa roots have the potential to be used as an immunotherapeutic adjuvant for the treatment of inflammatory diseases.
CHINESE HERBAL MEDICINES
(2022)
Article
Cardiac & Cardiovascular Systems
Jin Zhang, Xuelei Wang, Huajun Jiang, Fan Yang, Yu Du, Li Wang, Bin Hong
Summary: This study demonstrates the critical role of miR-185 in regulating cholesterol and bile acid homeostasis by modulating the expression of CYP7A1 and FoxO1 at both transcriptional and translational levels. These findings suggest that miR-185 may serve as a novel therapeutic target for drug discovery in atherosclerosis.
Article
Chemistry, Medicinal
Meng-Qian Qiao, Yue Li, Yu-Xin Yang, Chen-Xu Pang, Yi-Ting Liu, Cong Bian, Li Wang, Xiao-Fang Chen, Bin Hong
Summary: Developing non-statin small molecules for hypercholesterolemia treatment is challenging. PCSK9-targeted therapies have gained attention. Through synthesis and evaluation, compounds 3s and 5r showed comparable PCSK9 inhibition activity to 7030B-C5 with lower cytotoxicity. These compounds effectively reduced PCSK9 protein levels and increased LDL receptor levels, demonstrating potential as anti-atherosclerosis drug candidates. Further investigations are needed.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Plant Sciences
Yu Du, Mei Xi, Yihua Li, Ruifang Zheng, Xiaotian Ding, Xingxing Li, Xiumin Zhang, Li Wang, Jianguo Xing, Bin Hong
Summary: This study investigates the efficiency and mechanisms of tilianin in controlling lipid profile and preventing atherosclerosis. The results show that tilianin improves lipid profiles, reduces LDL-cholesterol levels and decreases atherosclerotic lesions and hepatosteatosis. Additionally, tilianin regulates transcription and enhances the expression of LDLR to lower blood lipid levels.
Article
Engineering, Multidisciplinary
Hongmin Sun, Xingxing Li, Minghua Chen, Ming Zhong, Yihua Li, Kun Wang, Yu Du, Xin Zhen, Rongmei Gao, Yexiang Wu, Yuanyuan Shi, Liyan Yu, Yongsheng Che, Yuhuan Li, Jian-Dong Jiang, Bin Hong, Shuyi Si
Summary: This study utilized a multi-omics strategy to investigate the fermentation components of Streptomyces sp. 1647 and identified 18 novel antiviral pseudo-tetrapeptides. Some of these compounds exhibited potent activity against influenza A virus and human coronavirus, highlighting the potential of microbial secondary metabolites as valuable sources of new antivirals.