Journal
ANALYTICA CHIMICA ACTA
Volume 1038, Issue -, Pages 191-197Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.aca.2018.07.001
Keywords
Supercritical fluid chromatography; Enantioseparation; Liquid crystalline materials; Chiral fluorinated liquid crystals; Amylose
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Funding
- Czech Science Foundation [16-05942S]
- Charles University [SVV260440]
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A fast and simple supercritical fluid chromatography method for the enantioseparation of twenty newly synthesized orthoconic antiferroelectric liquid crystals is reported for the first time. The effects of alkoxy spacer length and fluorine atom presence and position in the phenyl ring on chromatographic behavior were investigated. Baseline enantioseparation of all compounds was achieved using simple mobile phases consisting of carbon dioxide and alcohol as cosolvent on (3,5-dimethylphenylcarbamate) derivative of amylose as chiral stationary phase. The analysis times ranged from 2 to 4 and from 4 to 7 min for most samples when using methanol and propane-2-ol, respectively. The significant effect of cosolvent type on the enantioseparation of these compounds was assessed and partial complementarity of methanol and propane-2-ol was observed. (C) 2018 Elsevier B.V. All rights reserved.
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