Article
Multidisciplinary Sciences
Donghwan Ji, Jae Min Park, Myeong Seon Oh, Thanh Loc Nguyen, Hyunsu Shin, Jae Seong Kim, Dukjoon Kim, Ho Seok Park, Jaeyun Kim
Summary: In this study, the authors demonstrate the synthesis of superstrong, superstiff, and conductive alginate hydrogels with densely interconnecting networks. By using a simple reconstructing process, they achieve specific mechanical properties required for applications in artificial biological tissues, flexible electronics, and conductive membranes. The hydrogels show exceptional tensile strengths and elastic moduli, and they can also hold cations and exhibit high ionic conductivity.
NATURE COMMUNICATIONS
(2022)
Article
Engineering, Environmental
Peixuan Wu, Ziyu Qin, Rohan Dassanayake, Zhicheng Sun, Meijuan Cao, Kun Fu, Yang Zhou, Yuanyuan Liu
Summary: In this study, an antibacterial and conductive MXene-SA-TSA-AM hydrogel was developed through radical polymerization. The coupling between sodium alginate (SA) and dimethyloctadecyl-(3-trimethoxysilylpropyl) ammonium chloride (TSA) resulted in excellent antibacterial properties. The MXene-SA-TSA-AM hydrogel showed remarkable swelling ratios, mechanical properties, self-healing ability, and reproducible adhesion. It also exhibited high stability and rapid response in monitoring human physiological activities, and demonstrated efficient antibacterial properties against Staphylococcus aureus and Escherichia coli.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Polymer Science
Kyuha Park, Heewon Choi, Kyumin Kang, Mikyung Shin, Donghee Son
Summary: In this study, a soft stretchable conductive hydrogel composite with good electrical and mechanical properties was reported. This material can stably sense physiological signals and provide feedback regulation in unstable biotic-abiotic interfaces.
Article
Engineering, Environmental
Taotao Yang, Chao Xu, Changlu Liu, Yongqin Ye, Zhaowei Sun, Bin Wang, Zhiqiang Luo
Summary: The study found that crosslinking different conductive polymers with PEDOT:PSS as a conductive dopant can result in conductive hydrogels with higher conductivity and biocompatibility, suitable for bioelectronic device applications and in situ electrochemical sensing of bioactive molecules.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Materials Science, Biomaterials
Ling Fan, Lizhen Hu, Jinliang Xie, Zhongjie He, Yaping Zheng, DaiXu Wei, Dongdong Yao, Fangfang Su
Summary: The study introduces a high-performance multifunctional hydrogel PSAB, which shows excellent adhesion and mechanical properties, as well as broad-spectrum antibacterial activity and biocompatibility, making it a promising material for biomedical applications.
BIOMATERIALS SCIENCE
(2021)
Article
Engineering, Biomedical
Thomas Distler, Christian Polley, Fukun Shi, Dominik Schneidereit, Mark. D. Ashton, Oliver Friedrich, Jurgen F. Kolb, John G. Hardy, Rainer Detsch, Hermann Seitz, Aldo R. Boccaccini
Summary: Electroactive hydrogels incorporating pyrrole and high gelatin-content oxidized alginate-gelatin (ADA-GEL) have been developed, with electroactive polypyrrole synthesized inside the ADA-GEL matrix. These hydrogels exhibit 3D printability, cytocompatibility, and conductivity, making them promising for cell therapies and electrical-stimulation assisted tissue engineering.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Engineering, Biomedical
Yafeng Jing, Anhe Wang, Jieling Li, Qi Li, Qingquan Han, Xuefang Zheng, Hongyu Cao, Shuo Bai
Summary: The integration of hydrophilic conductive polydopamine-doped polypyrrole nanoparticles into dipeptide hydrogel networks creates conductive nanofibrils in situ, allowing for a good level of hydrophilic templating and maintaining transparency. This strategy not only provides the dipeptide hydrogel with good conductivity and high transparency, but also shows great potential for applications in body-adhered signal detection based on experimental data.
BIO-DESIGN AND MANUFACTURING
(2022)
Article
Engineering, Multidisciplinary
Benny Ryplida, Byung Chan Lee, Sung Young Park
Summary: A thermo-responsive conductive hydrogel membrane with volume transition is fabricated for cell filtration, water purification, and thermal sensing. The electronic performance and pore size of the hydrogel can be influenced by temperature, providing different efficiencies for cell filtration and oil-in-water purification.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Polymer Science
Sumin Kim, Heewon Choi, Donghee Son, Mikyung Shin
Summary: An intrinsically conductive and tissue-adhesive granular hydrogel was fabricated using an electrohydrodynamic spraying method. This hydrogel can be applied in soft and flexible electronics to connect humans and machines.
Article
Polymer Science
Yeonsun Choi, Kyuha Park, Heewon Choi, Donghee Son, Mikyung Shin
Summary: The article introduces a plant-inspired conductive alginate hydrogel composed of boronic acid modified alginate and oligomerized epigallocatechin gallate extracted from plant compounds. The conductive hydrogels exhibit high stretchability and self-healing properties, suitable for electrophysiological bridging to transfer electromyographic signals in an ex vivo muscle defect model.
Article
Chemistry, Applied
Kelin Peng, Weizhe Wang, Jinghua Zhang, Yan Ma, Lizhi Lin, Qiang Gan, Yu Chen, Changgen Feng
Summary: In this study, a physical conductive hydrogel (CHs) with high ionic conductivities was prepared by combining the anti-polyelectrolyte effect with the semi-dissolution acidification sol-gel transition method. The obtained hydrogels exhibit high ionic conductivities at both room temperature and low temperature, and can be used in flexible supercapacitors.
CARBOHYDRATE POLYMERS
(2022)
Article
Materials Science, Multidisciplinary
P. K. Muhammed Adnan, Lisa Sreejith
Summary: This study reports a simple, cost-effective and environmentally friendly strategy for developing a pH-sensitive complex coacervate hydrogel for sensing wound status. The hydrogel exhibits good mechanical integrity and user-friendliness. Additionally, it shows antioxidant properties and biocompatibility, which enhances its usefulness as a biosensor.
Article
Engineering, Environmental
Yan Wang, Dan Yuan, Lei Sun, Shuying Xu, Shungang Wan
Summary: A new conductive bacteria-hydrogel system is reported for the rapid and complete removal of para-xylene (PX). The system combines hydrophobically modified sodium alginate (SA) with bacteria and electron shuttles, and allows hydrogel to adsorb VOCs through the action of hydrophobicity. The system also exhibits excellent PX removal and is reusable after three cycles.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Biomedical
Ivana Perkucin, Kylie S. K. Lau, Cindi M. Morshead, Hani E. Naguib
Summary: Electrode impedance is a significant challenge in neural interfacing medical devices and neurology and regenerative medicine. Researchers have developed a hydrogel-based matrix inspired by marine mussels, which has good electrical properties and adhesion, and is non-toxic to neural cells.
BIOMEDICAL MATERIALS
(2023)
Article
Environmental Sciences
Ademola Adekunle, Abraham Gomez Vidales, Lyne Woodward, Boris Tartakovsky
Summary: The study introduces a soft sensor approach for real-time evaluation of the internal state of an MFC biosensor, based on estimating the equivalent circuit model parameters in real time. Experimental results demonstrate that this soft sensor approach can serve as a replacement for invasive EIS measurements and provides additional information for earlier detection of toxicity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Chemistry, Analytical
Josune J. Ezenarro, Tobias Nils Ackerman, Pablo Pelissier, Doriane Combot, Laurent Labbe, Xavier Munoz-Berbel, Jordi Mas, Francisco Javier del Campo, Naroa Uria
Summary: Cyanobacterial blooms can produce toxins, deplete oxygen, and affect water quality, but current technologies for detecting cyanobacteria are limited by cost and complexity. A new portable photonic system has been developed that can detect low concentrations of cyanobacteria in water samples quickly and effectively, making it a potentially powerful tool for early warning and detection of pathogens in water.
ANALYTICAL CHEMISTRY
(2021)
Article
Acoustics
Amparo Ferrer-Vilanova, Yasmine Alonso, Jiri Dietvorst, Marta Perez-Montero, Rosalia Rodriguez-Rodriguez, Kristina Ivanova, Tzanko Tzanov, Nuria Vigues, Jordi Mas, Gonzalo Guirado, Xavier Munoz-Berbel
Summary: This technology utilizes sonochemical coating to create robust blue-colored textiles with bacterial sensing capability, enabling on-site detection of live bacteria. The textiles are sensitive to both Gram-positive and Gram-negative bacteria, recover their original blue color through oxidation-reduction reactions, and can be applied to various materials for controlling and preventing microbial infections in hospitals, industries, schools, and homes.
ULTRASONICS SONOCHEMISTRY
(2021)
Article
Nanoscience & Nanotechnology
Sara Santiago, Pablo Gimenez-Gomez, Xavier Munoz-Berbel, Jordi Hernando, Gonzalo Guirado
Summary: By using ionogels as an alternative to supporting solid matrices, the challenges of fabricating multistimuli-responsive chromic materials and devices can be overcome, allowing molecular switches to retain their solution-like properties and be exposed to a variety of different stimuli for optimal photo-, halo-, thermo-, and electrochromic switching behaviors.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Chemistry, Analytical
Josune J. Ezenarro, Jordi Mas, Xavier Munoz-Berbel, Naroa Uria
Summary: This review summarizes the recent advances in bacterial concentration/detection platforms, with a focus on the concentration strategy. By introducing and comparing five concentration strategies, namely centrifugation, filtration, magnetic separation, electric separation, and acoustophoresis, the review aims to facilitate the development of future platforms for fast, sensitive, and in situ bacterial detection in real samples.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Multidisciplinary
Sharath Narayana Iyengar, Jiri Dietvorst, Amparo Ferrer-Vilanova, Gonzalo Guirado, Xavier Munoz-Berbel, Aman Russom
Summary: Sepsis is a serious bloodstream infection that compromises the host's immunity. This study introduces a rapid detection method for bacteria in blood, combining selective cell lysis and a sensitive colorimetric approach to detect as low as 10(3) CFU/mL bacteria in less than 5 hours.
Article
Biochemical Research Methods
Anahita Hosseini, Jordi Mas
Summary: This study establishes the optimal conditions for beta-galactosidase assay and highlights the importance of sample induction, permeabilization, and enzyme substrate selection in determining the sensitivity of the detection. It is crucial to ensure that the substrate concentration is high enough (around 3 to 4 times K-m) to prevent limited activity and that the pH at the time of reading is sufficiently high for maximum signal.
ANALYTICAL BIOCHEMISTRY
(2021)
Article
Chemistry, Analytical
Jiri Dietvorst, Amparo Ferrer-Vilanova, Sharath Narayana Iyengar, Aman Russom, Nuria Vigues, Jordi Mas, Lluisa Vilaplana, Maria-Pilar Marco, Gonzalo Guirado, Xavier Munoz-Berbel
Summary: This study introduces a cyanotype-based photochemical amplification reaction for detecting low bacterial concentrations efficiently and simply, which is expected to have a significant impact on clinical diagnosis of infectious diseases.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Amparo Ferrer-Vilanova, Yasmine Alonso, Josune J. Ezenarro, Sara Santiago, Xavier Munoz-Berbel, Gonzalo Guirado
Summary: Microbial detection is essential for controlling and preventing infectious diseases globally. Techniques based on metabolic indicators are gaining interest for their ability to differentiate between live and dead bacteria. This study investigates the potential use of Prussian blue as a metabolic indicator in bacterial sensing.
Article
Chemistry, Physical
Ferran Pujol-Vila, Pedro Escudero, Pau Guell-Grau, Carlos Pascual-Izarra, Rosa Villa, Mar Alvarez
Summary: This study demonstrates a mechanical imaging approach based on low-stiffness cantilevers, which can monitor and quantify molecular conformational changes with high sensitivity and spatial resolution, suitable for monitoring molecular changes.
Article
Microbiology
Teresa Lucena, Olga Sanchez, Isabel Sanz-Saez, Silvia G. Acinas, Laura Garrido, Jordi Mas, M. Carmen Macian, Maria A. Ruvira, David R. Arahal, Maria J. Pujalte
Summary: Two strains of bacteria isolated from activated sludge in a seawater-based wastewater treatment plant in Spain were found to be potentially new taxa. One strain was distantly related to Vicingus serpentipes and other members of the order Flavobacteriales, while the other strain was a putative new species of Lysobacter. Based on a comprehensive taxonomic analysis, new taxa were proposed.
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Ferran Pujol-Vila, Pau Guell-Grau, Josep Nogues, Mar Alvarez, Borja Sepulveda
Summary: Soft optomechanical systems have the ability to respond reversibly to external stimuli by changing their properties. They combine the optical properties of nanomaterials with the deformability of soft polymers, enabling the development of mechanically tunable optical systems, sensors, and actuators. This review summarizes the recent progress in soft optomechanical systems for mechanical sensing, optical modulation, and light-induced mechanical actuators, and analyzes the limitations and future prospects of these systems.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Biophysics
Joan Aymerich, Amparo Ferrer-Vilanova, Jose Cisneros-Fernandez, Roger Escude-Pujol, Gonzalo Guirado, Lluis Teres, Michele Dei, Xavier Munoz-Berbel, Francisco Serra- Graells
Summary: Early detection of low bacterial concentrations is crucial for minimizing healthcare and safety issues. In this study, a potentiostatic-amperometric Delta-Sigma modulator with the ability to cancel flicker noise and improve the limit of detection was developed. The integrated circuit, with an area of 2.3 mm2, was attached to an inkjet-printed electrochemical sensor. The disposable device was capable of detecting live bacterial concentrations as low as 102 CFU/mL within an hour.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Analytical
Antonio Velarte, Aranzazu Otin, Pablo Gimenez-Gomez, Xavier Munoz-Berbel, Esther Pueyo
Summary: This study developed a sensor to measure tissue stretch in excised tissues, aiming to better understand cardiovascular diseases. The sensor, based on a simple topology and technology, achieved high precision in measuring.
Article
Biochemical Research Methods
Augusto Marquez, Moliria V. Santos, Gonzalo Guirado, Alex Moreno, Salvador D. Aznar-Cervantes, Jose Luis Cenis, Silvia H. Santagneli, Carlos Dominguez, Fiorenzo G. Omenetto, Xavier Munoz-Berbel
Summary: Silk fibroin (SF) shows promise as an alternative material in optical biosensing, offering excellent optical properties, enhanced sensitivity in bioassays, and additional functions such as capillary pumping activity and blood cell filtration. Functionalized SF films enhance biosensing sensitivity and durability, making them ideal for developing microfluidic test strips for various optical bioassays.
Article
Chemistry, Analytical
Yujia Ying, Huilin Li
Summary: Enzymes play a crucial role as biological catalysts in accelerating biochemical reactions in living organisms. This study proposes a convenient method for monitoring enzymatic catalytic processes using native top-down mass spectrometry. By exploring the heterogeneity of the chymotrypsin sample and using tandem mass spectrometry, the researchers were able to monitor covalent and noncovalent enzymatic complexes, substrates, and products during catalysis. The results demonstrate that this method has the potential to be a promising tool for characterizing biocatalysts.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Kang Yang, Shuaibo Shi, Jinyu Wu, Shaolong Han, Shengdi Tai, Shishen Zhang, Kun Zhang
Summary: H2O and D2O are important analogues closely related to various industries and monitoring fields. This study successfully distinguishes and detects H2O and D2O by designing a novel eu(III)-macrocycle with dual emitters, Eu-2a, and conducting fluorescence titration experiments.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Julia Kuligowski, Alvaro Perez-Rubio, Marta Moreno-Torres, Polina Soluyanova, Judith Perez-Rojas, Ivan Rienda, David Perez-Guaita, Eugenia Pareja, Ramon Trullenque-Juan, Jose Castell, Marcha Verheijen, Florian Caiment, Ramiro Jover, Guillermo Quintas
Summary: This study introduces a novel variable selection approach called cluster PLS (c-PLS) to assess the joint impact of variable groups selected based on biological characteristics on the predictive performance of a multivariate model. The usefulness of c-PLS is shown using miRNomic and metabolomic datasets obtained from the analysis of liver tissue biopsies.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Meixue Lai, Lijie Zhong, Siyi Liu, Yitian Tang, Tingting Han, Huali Deng, Yu Bao, Yingming Ma, Wei Wang, Li Niu, Shiyu Gan
Summary: This study presents a method for constructing wearable sweat electrolyte sensors using carbon fiber-based solid-contact ion-selective electrodes (SC-ISEs). By using carbon fibers extracted from commercial cloth as electrode material, the cost and reproducibility issues of flexible SC-ISEs were addressed. The results showed that the carbon fiber-based SC-ISEs exhibited reversible voltammetric and stable impedance performances, and had high reproducibility of standard potentials between normal and bending states.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Yang, Ying Liu, Min Deng, Peipei Wang, Dan Cheng, Songjiao Li, Longwei He
Summary: A near-infrared fluorescent probe has been developed to accurately measure the levels of peroxynitrite (ONOO-) in the endoplasmic reticulum (ER) in acute lung injury (ALI). The probe demonstrated rapid response, high selectivity, good sensitivity, and enhanced fluorescence intensity in response to ONOO-. It was successfully used to detect changes in ONOO- levels and showed significant increases in an ALI cell model and an ALI mouse model.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yanping Wang, Yuemei Chen, Kejun Li, Jinrong Zhou, Xin Yuan, Mei Zhang, Ke Huang
Summary: In this work, a portable analytical system based on point discharge chemical vapor generation atomic emission spectrometry (PD-CVG-AES) coupling with gold filament enrichment was designed. The highly sensitive analysis of Hg2+ indirectly realized the detection of ascorbic acid (AA). The measurement is based on the fact that Ag+ can decrease the concentration of Hg2+ by forming Ag-Hg amalgam in the presence of the reductant SnCl2, while AA can pre-reduce Ag+ to Ag0, leading to the generation of silver nanoparticles (Ag NPs). The developed novel analytical strategy broadens the application of microplasma-based AES and offers a higher level of sensitivity compared to current AA detection techniques.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yundi Huang, Bo Song, Kaiwen Chen, Deshu Kong, Jingli Yuan
Summary: This study developed two lysosome-targetable background-free TGL probes for efficient and accurate detection of 1O2, which can be used for monitoring endogenous 1O2 concentrations in lysosomes and discriminating variability induced by different photosensitizers. Furthermore, a smart luminescent sensor film was successfully prepared for on-site 1O2 production detection during PDT processes, offering a promising clinical monitoring tool for skin diseases.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Wei Lang, Jia-Mei Qin, Qian-Yong Cao
Summary: A novel polymer-based probe P1 was successfully synthesized for fluorescently ratiometric sensing of H2S with high selectivity and sensitivity. A smartphone sensing platform was constructed to conduct visual quantitative detection of H2S. P1 can be employed in evaluating the level fluctuations of H2S in living cells, testing water samples/wine samples, and monitoring food freshness.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yuanyuan Qin, Shuda Liu, Shuyun Meng, Dong Liu, Tianyan You
Summary: The study developed a split aptamer-based sandwich-type ratiometric biosensor for the detection of 17 beta-estradiol (E2) using photoelectrochemical and electrochemical assays. The biosensor utilized split aptamer fragments to recognize E2 and trigger a hybridization chain reaction, resulting in the production of double-stranded DNA labeled with CdTe quantum dots. This DNA complex was able to sensitize CdTe quantum dots and generate response signals for E2 detection. The developed biosensor demonstrated high sensitivity and accuracy with two linear ranges and low detection limits.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Siriwan Teepoo, Jongjit Jantra, Khaunnapa Panapong, David Taiwo Ajayi
Summary: A novel immunochromatographic assay based on hyperbranched Au plasmonic blackbodies with a smartphone readout was developed for rapid and sensitive detection of leucomalachite green residues in fish and shrimp products.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Andrea L. Larraga-Urdaz, Borja Moreira-Alvarez, Jorge Ruiz Encinar, Jose M. Costa-Fernandez, Maria Luisa Fernandez-Sanchez
Summary: A major challenge in the 21st century is the development of point-of-care diagnostic tools. In this study, a highly sensitive and simple bioassay using AuNPs and MNAzymes was developed for rapid detection and quantification of miRNA-4739. The proposed strategy shows potential for breast cancer diagnosis.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Xiaohan Zhao, Anyu Wang, Lingzi Zhai, Jiuhe Gao, Sizhe Lyu, Yingshan Jiang, Tian Zhong, Ying Xiao, Xi Yu
Summary: A novel method using polystyrene-coated magnetic nanoparticles for extracting monohydroxy polycyclic aromatic hydrocarbons from urine samples was investigated. The proposed method is simple, sensitive, and efficient, with desirable sensitivity for analyzing low-abundance metabolites in large volumes of complex urine samples.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Quan, Yuqing Zeng, Wenke Zhang, Fengfeng Li, Mengjiao Li, Zhihe Qing, Linlin Wu
Summary: In this study, a visual and reusable biosensor was developed for detecting substrates that are closely associated with human physiological health. The immobilized oxidase showed higher stability and sensitivity under harsh conditions, enabling reliable detection of substrates in complex fluids.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Dongjuan Wang, Xiuqian Ding, Jinling Xie, Juan Wang, Guanhao Li, Xin Zhou
Summary: In this study, a three-in-one sensor was developed for real-time detection of biogenic amines (BAs) with high sensitivity and selectivity. The sensor showed multimodal responses and could be used to fabricate portable devices for on-site non-destructive assessment of food spoilage indicators.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Jinting Meng, Zihao Xu, Shasha Zheng, Hongqun Yang, Tianfu Wang, Hong Wang, Yingwei Zhang
Summary: This study demonstrates the development of a cascade signal amplification system using a multi-pedal DNA walker and strand displacement reactions for the electrochemical detection of miRNA-155. The biosensor exhibited high sensitivity, selectivity, and the potential for clinical applications.
ANALYTICA CHIMICA ACTA
(2024)