Journal
ANALYTICA CHIMICA ACTA
Volume 1012, Issue -, Pages 30-41Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.aca.2017.12.046
Keywords
DNA nanotechnology; DNA-Based switches; Allostery
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DNA-based switches are structure-switching biomolecules widely employed in different bioanalytical applications. Of particular interest are DNA-based switches whose activity is regulated through the use of allostery. Allostery is a naturally occurring mechanism in which ligand binding induces the modulation and fine control of a connected biomolecule function as a consequence of changes in concentration of the effector. Through this general mechanism, many different allosteric DNA-based switches able to respond in a highly controlled way at the presence of a specific molecular effector have been engineered. Here, we discuss how to design allosterically regulated DNA-based switches and their applications in the field of molecular sensing, diagnostic and drug release. (C) 2018 Published by Elsevier B.V.
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