Article
Chemistry, Multidisciplinary
Viktor Merz, Julia Merz, Maximilian Kirchner, Julian Lenhart, Todd B. Marder, Anke Krueger
Summary: A chemosensor based on pyrene monomer fluorescence with triazole groups demonstrates high selectivity in detecting Cu2+, Pb2+, and Hg2+ in organic solvents over a wide range of concentrations, even in the presence of common ions. The sensor's strongly emissive fluorescence is quenched by metal ion complex formation, leading to the formation of agglomerates. Conventional linear correlations are not observed for all concentrations, leading to the need for non-linear fits in analysis.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Analytical
Chenglong Liao, Miao Zhang, Qingyun Tian, Xiaomei Yang, Jiangfan Shi, Shuai Chen, Yanke Che, Chuanyi Wang, Ling Zang
Summary: In this study, a simple and unique sensor composite was created for efficient detection of gaseous formaldehyde with low limit of detection and high selectivity. The sensor composite consists of a hydroxylamine sulfuric acid salt and a fluorescence turn-on probe coated within a porous cellulose plate. By measuring the fluorescence increase, formaldehyde can be detected quantitatively and specifically. This work not only provides a new sensor for formaldehyde, but also opens up a new design pathway for sensor composites to detect other air pollutants and toxic chemicals.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Min Wang, Xiao Zhang, Le Wang, Jingyi Zhang, Na Liu, Di Zhang
Summary: A novel fluorescent probe (FAP1) with lysosomal localization group was designed and synthesized for the detection of formaldehyde. The probe showed good fluorescence recognition performances for formaldehyde, including large Stokes shift (130 nm), specific selectivity, good anti-interference ability, and low minimum detection limit (16 nM). It is notable that the probe exhibited good biocompatibility and could be applied to the imaging detection of formaldehyde in lysosome.
MICROCHEMICAL JOURNAL
(2023)
Article
Multidisciplinary Sciences
Masaharu Hazawa, Shogo Amemori, Yoshio Nishiyama, Yoshihiro Iga, Yuki Iwashima, Akiko Kobayashi, Hirohisa Nagatani, Motohiro Mizuno, Kenji Takahashi, Richard W. Wong
Summary: The study introduced a novel dipyrene probe Pyr-A to characterize liquid-liquid phase separation (LLPS) of biomolecules, shedding light on the physicochemical properties of phase-separated condensates. Using fluorescent microscopic imaging, the research investigated protein droplets and centrosomes, showing that their hydrophobic and viscous properties increased with size and maturation, respectively. Overall, Pyr-A proved to be a valuable tool for studying LLPS and enhancing understanding of biological functions underlying phase separation.
Article
Spectroscopy
Zongcheng Wang, Weikang Su, Huihuang Zheng, Shun Yang, Tingting Yang, Ting Han, Wubliker Dessie, Xingrui He, Yuren Jiang, Yuanqiang Hao
Summary: Fluorescence probe detection of selenocysteine (Sec) content in cells is important for identifying human related diseases. Two turn-on fluorescent probes, A4 and B4, were designed and synthesized for fast and sensitive detection of Sec. Both A4 and B4 show rapid turn-on response, high selectivity, and sensitivity towards Sec, making them applicable for fluorescence imaging of Sec in living cells. A4 has a larger Stokes shift, wider pH range, and lower detection limit compared to B4, due to its excited state intramolecular proton transfer (ESIPT) effect. These two probes can serve as effective tools for detecting Sec in biological systems.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Physical
Lijuan Liang, Yimeng Sun, Chang Liu, Xiaojie Jiao, Ye Shang, Xianshun Zeng, Liancheng Zhao, Jianlong Zhao
Summary: Water-soluble and fast-responsive fluorescent probes PTZ-TPP and PTZ-MP based on phenothiazine moiety were developed for accurate analysis and detection of changes in HOCl and viscosity, with low detection limits. Furthermore, PTZ-MP probe can also be used for viscosity detection, and is expected to be utilized for simultaneous determination of intracellular HOCl and viscosity.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Physical
Yulong Liu, Lu Li, Yeqi Zhang, Ming Sheng, Yuanzhen Wang, Zhiyong Xing, Liu Yang, Mingli Yue, Ying Fu, Fei Ye
Summary: A novel multifunctional fluorescent probe based on a pyrene derivative, 4[(pyren-1-ylimino)methyl]benzene-1,3-diol (PBD), is reported for the recognition and quantification of Al3+, Cr3+, Fe3+, mesotrione, and Hg2+.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Spectroscopy
Maria A. Ustimova, Yuri V. Fedorov, Nelly S. Chmelyuk, Maxim A. Abakumov, Olga A. Fedorova
Summary: The study found that two bis(styryl) dyes have strong affinity for DNA and RNA, with their binding mode shifting between DNA groove binding and RNA intercalation. The fluorescence enhancement effect is more pronounced on DNA than on RNA, and the presence of energy transfer in the bis(styryl) system increases the Stokes shift of the dye.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Analytical
Biru Chen, Lei Li, Yue Hu, Bolin Liu, Ming Guo, Qi Zhang, Qianqian Yang, Mingcui Zhang
Summary: A sensitive and eco-friendly fluorescence immunoassay technique using red carbon dots as an immunoprobe was developed for the detection of DEP in daily supplies. This method provides an accurate and simple strategy for detecting the content of environmental endocrine DEP.
MICROCHEMICAL JOURNAL
(2022)
Article
Spectroscopy
Yu Liu, Yue Zhang, Changyao Liu, Ce Wang, Baocai Xu, Li Zhao
Summary: A highly sensitive detection platform for heparin was developed using a cationic fluorescent dye (cresyl violet acetate) as a fluorescence probe. The platform demonstrated high selectivity towards heparin and achieved detection in both HEPES solution and serum.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2024)
Article
Chemistry, Analytical
Yan Huang, Lei Yu, Pengpeng Lu, Yinghui Wei, Xiaoyan Wang, Lingxin Chen
Summary: Breast cancer has the highest incidence rate among malignant tumors in women worldwide, and early diagnosis and therapy are crucial. CYP1A1, commonly expressed in breast cancer, plays a vital role and may serve as a new biomarker for early diagnosis of breast cancer.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Ying Hu, Shiman Guo, Junqian Peng, Yao Fan, Fang Wang, Lingmin Lu, Haiyan Fu, Xiaoqiang Chen, Yuanbin She
Summary: A ratiometric pyrene-based fluorescence sensor PN was developed for visual detection of formaldehyde (FA) by featuring homoallylamino group as specific recognition site. Sensor PN has high selectivity, fast response (< 100 s), low detection limit (18 mu M), wide quantitative detection range (0.018-4 mM) and large ratio enhancement (up to 10-fold), making it suitable for detecting FA in diverse food samples. It can also be used for fluorescence imaging of FA in living cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Physical
Yongfeng Liu, Xiaosheng Tang, Ming Deng, Tao Zhu, Ludvig Edman, Jia Wang
Summary: This study reports a one-step aqueous synthesis of more benign and hydrophilic AgInZnS quantum dots as a fluorescent probe for the detection of Cd2+ in aqueous solutions, with a detection range of 0.1-290 mu M and a lower limit of detection of 37.8 nM. The excellent turn-on detection of Cd2+ is attributed to the passivation of surface defects on the AgInZnS quantum dots by Cd2+, resulting in a prolonged fluorescent lifetime and increased photoluminescence quantum yield. Additionally, the AgInZnS quantum dot probe is capable of detecting Cd2+ in lake water samples and meets the WHO standard.
JOURNAL OF ALLOYS AND COMPOUNDS
(2021)
Article
Spectroscopy
Songtao Cai, Chang Liu, Jin Gong, Song He, Liancheng Zhao, Xianshun Zeng
Summary: The article introduces a novel fluorescence probe NP-Lyso for detecting and imaging formic acid (FA) in lysosomes, which shows promising features after rational design and synthesis, providing a potential approach for investigating the biofunctions of FA in living systems.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Chemistry, Analytical
Chunwei Yu, Mei Yang, Shuhua Cui, Yuxiang Ji, Jun Zhang
Summary: A novel ratiometric Cu2+-selective probe was constructed based on pyrene derivative, which showed selective recognition and detection of Cu2+ through a turn-on fluorescent response. The formation of a 1:1 metal-ligand complex and the binding mode were confirmed by MS spectra, Job's plot experiment, and H-1 NMR experiment. Satisfactory results were obtained from fluorescence imaging in living cells for Cu2+ detection.
Article
Chemistry, Analytical
Yujia Ying, Huilin Li
Summary: Enzymes play a crucial role as biological catalysts in accelerating biochemical reactions in living organisms. This study proposes a convenient method for monitoring enzymatic catalytic processes using native top-down mass spectrometry. By exploring the heterogeneity of the chymotrypsin sample and using tandem mass spectrometry, the researchers were able to monitor covalent and noncovalent enzymatic complexes, substrates, and products during catalysis. The results demonstrate that this method has the potential to be a promising tool for characterizing biocatalysts.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Kang Yang, Shuaibo Shi, Jinyu Wu, Shaolong Han, Shengdi Tai, Shishen Zhang, Kun Zhang
Summary: H2O and D2O are important analogues closely related to various industries and monitoring fields. This study successfully distinguishes and detects H2O and D2O by designing a novel eu(III)-macrocycle with dual emitters, Eu-2a, and conducting fluorescence titration experiments.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Julia Kuligowski, Alvaro Perez-Rubio, Marta Moreno-Torres, Polina Soluyanova, Judith Perez-Rojas, Ivan Rienda, David Perez-Guaita, Eugenia Pareja, Ramon Trullenque-Juan, Jose Castell, Marcha Verheijen, Florian Caiment, Ramiro Jover, Guillermo Quintas
Summary: This study introduces a novel variable selection approach called cluster PLS (c-PLS) to assess the joint impact of variable groups selected based on biological characteristics on the predictive performance of a multivariate model. The usefulness of c-PLS is shown using miRNomic and metabolomic datasets obtained from the analysis of liver tissue biopsies.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Meixue Lai, Lijie Zhong, Siyi Liu, Yitian Tang, Tingting Han, Huali Deng, Yu Bao, Yingming Ma, Wei Wang, Li Niu, Shiyu Gan
Summary: This study presents a method for constructing wearable sweat electrolyte sensors using carbon fiber-based solid-contact ion-selective electrodes (SC-ISEs). By using carbon fibers extracted from commercial cloth as electrode material, the cost and reproducibility issues of flexible SC-ISEs were addressed. The results showed that the carbon fiber-based SC-ISEs exhibited reversible voltammetric and stable impedance performances, and had high reproducibility of standard potentials between normal and bending states.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Yang, Ying Liu, Min Deng, Peipei Wang, Dan Cheng, Songjiao Li, Longwei He
Summary: A near-infrared fluorescent probe has been developed to accurately measure the levels of peroxynitrite (ONOO-) in the endoplasmic reticulum (ER) in acute lung injury (ALI). The probe demonstrated rapid response, high selectivity, good sensitivity, and enhanced fluorescence intensity in response to ONOO-. It was successfully used to detect changes in ONOO- levels and showed significant increases in an ALI cell model and an ALI mouse model.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yanping Wang, Yuemei Chen, Kejun Li, Jinrong Zhou, Xin Yuan, Mei Zhang, Ke Huang
Summary: In this work, a portable analytical system based on point discharge chemical vapor generation atomic emission spectrometry (PD-CVG-AES) coupling with gold filament enrichment was designed. The highly sensitive analysis of Hg2+ indirectly realized the detection of ascorbic acid (AA). The measurement is based on the fact that Ag+ can decrease the concentration of Hg2+ by forming Ag-Hg amalgam in the presence of the reductant SnCl2, while AA can pre-reduce Ag+ to Ag0, leading to the generation of silver nanoparticles (Ag NPs). The developed novel analytical strategy broadens the application of microplasma-based AES and offers a higher level of sensitivity compared to current AA detection techniques.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yundi Huang, Bo Song, Kaiwen Chen, Deshu Kong, Jingli Yuan
Summary: This study developed two lysosome-targetable background-free TGL probes for efficient and accurate detection of 1O2, which can be used for monitoring endogenous 1O2 concentrations in lysosomes and discriminating variability induced by different photosensitizers. Furthermore, a smart luminescent sensor film was successfully prepared for on-site 1O2 production detection during PDT processes, offering a promising clinical monitoring tool for skin diseases.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Wei Lang, Jia-Mei Qin, Qian-Yong Cao
Summary: A novel polymer-based probe P1 was successfully synthesized for fluorescently ratiometric sensing of H2S with high selectivity and sensitivity. A smartphone sensing platform was constructed to conduct visual quantitative detection of H2S. P1 can be employed in evaluating the level fluctuations of H2S in living cells, testing water samples/wine samples, and monitoring food freshness.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yuanyuan Qin, Shuda Liu, Shuyun Meng, Dong Liu, Tianyan You
Summary: The study developed a split aptamer-based sandwich-type ratiometric biosensor for the detection of 17 beta-estradiol (E2) using photoelectrochemical and electrochemical assays. The biosensor utilized split aptamer fragments to recognize E2 and trigger a hybridization chain reaction, resulting in the production of double-stranded DNA labeled with CdTe quantum dots. This DNA complex was able to sensitize CdTe quantum dots and generate response signals for E2 detection. The developed biosensor demonstrated high sensitivity and accuracy with two linear ranges and low detection limits.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Siriwan Teepoo, Jongjit Jantra, Khaunnapa Panapong, David Taiwo Ajayi
Summary: A novel immunochromatographic assay based on hyperbranched Au plasmonic blackbodies with a smartphone readout was developed for rapid and sensitive detection of leucomalachite green residues in fish and shrimp products.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Andrea L. Larraga-Urdaz, Borja Moreira-Alvarez, Jorge Ruiz Encinar, Jose M. Costa-Fernandez, Maria Luisa Fernandez-Sanchez
Summary: A major challenge in the 21st century is the development of point-of-care diagnostic tools. In this study, a highly sensitive and simple bioassay using AuNPs and MNAzymes was developed for rapid detection and quantification of miRNA-4739. The proposed strategy shows potential for breast cancer diagnosis.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Xiaohan Zhao, Anyu Wang, Lingzi Zhai, Jiuhe Gao, Sizhe Lyu, Yingshan Jiang, Tian Zhong, Ying Xiao, Xi Yu
Summary: A novel method using polystyrene-coated magnetic nanoparticles for extracting monohydroxy polycyclic aromatic hydrocarbons from urine samples was investigated. The proposed method is simple, sensitive, and efficient, with desirable sensitivity for analyzing low-abundance metabolites in large volumes of complex urine samples.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Quan, Yuqing Zeng, Wenke Zhang, Fengfeng Li, Mengjiao Li, Zhihe Qing, Linlin Wu
Summary: In this study, a visual and reusable biosensor was developed for detecting substrates that are closely associated with human physiological health. The immobilized oxidase showed higher stability and sensitivity under harsh conditions, enabling reliable detection of substrates in complex fluids.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Dongjuan Wang, Xiuqian Ding, Jinling Xie, Juan Wang, Guanhao Li, Xin Zhou
Summary: In this study, a three-in-one sensor was developed for real-time detection of biogenic amines (BAs) with high sensitivity and selectivity. The sensor showed multimodal responses and could be used to fabricate portable devices for on-site non-destructive assessment of food spoilage indicators.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Jinting Meng, Zihao Xu, Shasha Zheng, Hongqun Yang, Tianfu Wang, Hong Wang, Yingwei Zhang
Summary: This study demonstrates the development of a cascade signal amplification system using a multi-pedal DNA walker and strand displacement reactions for the electrochemical detection of miRNA-155. The biosensor exhibited high sensitivity, selectivity, and the potential for clinical applications.
ANALYTICA CHIMICA ACTA
(2024)