Article
Pharmacology & Pharmacy
Alexander Vugler, James O'Connell, Mai Anh Nguyen, Dietmar Weitz, Thomas Leeuw, Elizabeth Hickford, Alexander Verbitsky, Xiaoyou Ying, Markus Rehberg, Bruce Carrington, Mark Merriman, Andrew Moss, Jean-Marie Nicholas, Phil Stanley, Sara Wright, Tim Bourne, Yann Foricher, Daniel Brookings, Helen Horsley, Matthias Herrmann, Srinivas Rao, Markus Kohlmann, Peter Florian
Summary: This article reports the discovery and development of a potent small molecule inhibitor of TNF, SAR441566, which has shown potential as a treatment option for chronic autoimmune diseases. By stabilizing an asymmetrical form of TNF and compromising its functions, SAR441566 offers a promising alternative to established biologic drugs targeting TNF.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Allergy
Ming-Li Chen, Tanawin Nopsopon, Ayobami Akenroye
Summary: This study aimed to determine the incidence of antidrug antibodies (ADAs) and their impact on clinical outcomes in patients with asthma receiving biologics. The results showed that the overall ADA incidence was 2.91%, with benralizumab having the highest incidence (8.35%) and omalizumab having the lowest incidence (0.00%). The subcutaneous route and longer dosing intervals were associated with higher ADA development.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Rheumatology
Sorwe Mojtahed Poor, Marina Henke, Thomas Ulshoefer, Michaela Koehm, Frank Behrens, Harald Burkhardt, Susanne Schiffmann
Summary: This study aimed to investigate the impact of concomitant MTX on ustekinumab (UST) levels and antidrug antibody (ADA) formation in PsA patients, as well as to evaluate the consequences in pharmacodynamics and pharmacokinetics. The results showed that concomitant MTX did not significantly affect the immunogenicity of UST, and ADA formation was not associated with UST safety, efficacy, or trough levels.
Review
Chemistry, Analytical
Kyungah Suh, Isaac Kyei, David S. Hage
Summary: Antibody-based therapeutic agents and other biopharmaceuticals are widely used in the treatment of various diseases. However, they may cause immune reactions that reduce the drug's efficacy and lead to side effects. The immunogenicity of biopharmaceuticals can be evaluated by detecting and measuring antidrug antibodies. This review discusses various methods for antidrug antibody detection and analysis, including immunoassays and antigen binding tests.
JOURNAL OF SEPARATION SCIENCE
(2022)
Review
Biotechnology & Applied Microbiology
Muhammad Safwan Akram, Neelam Pery, Lucy Butler, Muhammad Imtiaz Shafiq, Nayab Batool, Muhammad Fayyaz Ur Rehman, Luke G. Grahame-Dunn, Ali K. Yetisen
Summary: Global healthcare systems are facing challenges in funding innovative treatment costs, particularly in the biosimilars market as patent expirations approach for well-known monoclonal antibodies. The development costs of biosimilars are significantly higher than generic equivalents due to therapeutic trials and manufacturing expenses, impacting efforts to lower prices for cancer and autoimmune disorder treatments. Academic and industry understanding of the complex costs and stages of biologics processing is crucial for navigating the evolving landscape of healthcare.
CRITICAL REVIEWS IN BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tomasz Wysocki, Agnieszka Paradowska-Gorycka
Summary: Rheumatoid arthritis is a common inflammatory arthritis in which tumor necrosis factor plays a key role. However, there is variation in response to TNF-targeting drugs, which may be influenced by genetic factors. The field of pharmacogenomics offers potential for developing novel prognostic tools.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Chao-Yi Wu, Huang-Yu Yang, Shue-Fen Luo, Jenn-Haung Lai
Summary: RA is a chronic inflammatory disease involving synovial inflammation and articular destruction. RFs, ACPAs, and anti-CarP Abs have been identified as important autoantibodies in predicting and diagnosing RA, with potential implications for treatment response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Scott P. Henry, Cecilia Arfvidsson, Josh Arrington, Jasna Canadi, Dave Crowe, Shalini Gupta, Sabine Lohmann, Benoit Massonnet, Daniel Mytych, Tina Rogers, Hobart Rogers, Chris Stebbins, Craig Stovold, Daniela Verthelyi, Adam Vigil, Chi Xuan, Yuanxin Xu, Rosie Yu, Thomas Klem
Summary: This study summarizes the experience of the Oligonucleotide Safety Working Group in designing the immunogenicity assessment for therapeutic oligonucleotides, providing advice on assay development, clinical monitoring, and evaluation of the impact of immunogenicity on exposure, efficacy, and safety.
NUCLEIC ACID THERAPEUTICS
(2022)
Article
Dermatology
Tasnim Abdalla, Mark Mansour, Dorra Bouazzi, Michelle A. Lowes, Gregor B. E. Jemec, Afsaneh Alavi
Summary: This study examined serum adalimumab concentrations and anti-adalimumab antibody status in 38 patients with moderate-to-severe hidradenitis suppurativa who had suboptimal response to adalimumab therapy. The results showed that patients with anti-adalimumab antibodies had significantly lower adalimumab levels, suggesting that therapeutic drug monitoring may help identify reasons for suboptimal response and guide dose optimization strategies.
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
(2021)
Review
Immunology
Liana Barenbrug, Maarten te Groen, Frank Hoentjen, Joris van Drongelen, Juul M. P. A. van den Reek, Irma Joosten, Elke M. G. J. de Jong, Renate G. van der Molen
Summary: The use of anti-TNF alpha agents during pregnancy in women with immune mediated inflammatory diseases, such as IBD, RA, and PS, is associated with an increased risk of preterm birth and infections in newborns, particularly for women with IBD. However, there was no increased risk for adverse pregnancy outcomes in women with RA and PS. Vaccination in children exposed to anti-TNF alpha seems to be safe and important in reducing the risk of infections.
JOURNAL OF AUTOIMMUNITY
(2021)
Article
Immunology
Jose Manuel Sanchez-Maldonado, Rafael Caliz, Miguel Angel Lopez-Nevot, Antonio Jose Cabrera-Serrano, Ana Moniz-Diez, Helena Canhao, Rob Ter Horst, Luca Quartuccio, Signe B. Sorensen, Bente Glintborg, Merete L. Hetland, Ileana Filipescu, Eva Perez-Pampin, Pablo Conesa-Zamora, Jerzy Swierkot, Alfons A. den Broeder, Salvatore De Vita, Eva Rabing Brix Petersen, Yang Li, Miguel A. Ferrer, Alejandro Escudero, Mihai G. Netea, Marieke J. H. Coenen, Vibeke Andersen, Joao E. Fonseca, Manuel Jurado, Katarzyna Bogunia-Kubik, Eduardo Collantes, Juan Sainz
Summary: This study confirmed the influence of the LINC02549 and LRRC55 loci on determining the response to TNFi in RA patients, while suggesting a weak effect of the MAFB and CNTN5 loci that require further investigation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Lieve Van Hoovels, Bert Vander Cruyssen, Daniela Sieghart, Carolien Bonroy, Eszter Nagy, Rille Pullerits, Sasa Cucnik, Charlotte Dahle, Ingmar Heijnen, Luca Bernasconi, Farid Benkhadra, Laura Bogaert, Stefanie Van den Bremt, Ann Van Liedekerke, Geert Vanheule, Johan Robbrecht, Lucy Studholme, Claudine Wirth, Ruediger Mueller, Diego Kyburz, Christopher Sjowall, Alf Kastbom, Rok Jese, Boja Jovancevic, Emese Kiss, Peggy Jacques, Daniel Aletaha, Guenter Steiner, Patrick Verschueren, Xavier Bossuyt
Summary: This study aimed to refine the interpretation of RF and ACPA across commercial assays. By determining thresholds for antibody levels and assigning test result interval-specific LRs, clinical interpretation can be aligned for all RF and ACPA assays.
Article
Public, Environmental & Occupational Health
Ting Zhao, Jiayan Shen, Youyang Zhu, Xiaofang Tian, Guangfen Wen, Yuanyuan Wei, Bonan Xu, Chenyang Fu, Zhaohu Xie, Yujiang Xi, Zhenmin Li, Jiangyun Peng, Yang Wu, Xiaohu Tang, Chunping Wan, Lei Pan, Zhaofu Li, Dongdong Qin
Summary: This study analyzed the safety and immunogenicity of inactivated SARS-CoV-2 vaccines in rheumatoid arthritis (RA) patients. The results showed that RA patients had lower inhibition rates after vaccination, highlighting the importance of a third or fourth vaccination in this population.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Tatyana P. Makalish, Ilya O. Golovkin, Volodymyr V. Oberemok, Kateryna V. Laikova, Zenure Z. Temirova, Olesya A. Serdyukova, Ilya A. Novikov, Roman A. Rosovskyi, Andrey I. Gordienko, Evgeniya Yu. Zyablitskaya, Elvina A. Gafarova, Kseniya A. Yurchenko, Iryna I. Fomochkina, Anatoly V. Kubyshkin
Summary: The study demonstrates the potential of Cytos-11 antisense oligonucleotide in treating rheumatoid arthritis by effectively suppressing TNF-alpha gene expression, reducing joint inflammation, and inhibiting pannus development, showing comparable results to adalimumab.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Andrea Picchianti-Diamanti, Assunta Navarra, Alessandra Aiello, Bruno Lagana, Gilda Cuzzi, Andrea Salmi, Valentina Vanini, Fabrizio Maggi, Silvia Meschi, Giulia Matusali, Stefania Notari, Chiara Agrati, Simonetta Salemi, Roberta Di Rosa, Damiano Passarini, Valeria Di Gioia, Giorgio Sesti, Fabrizio Conti, Francesca Romana Spinelli, Angela Corpolongo, Maria Sole Chimenti, Mario Ferraioli, Gian Domenico Sebastiani, Maurizio Benucci, Francesca Li Gobbi, Anna Paola Santoro, Andrea Capri, Vincenzo Puro, Emanuele Nicastri, Delia Goletti
Summary: Breakthrough infections (BIs) in rheumatoid arthritis (RA) patients after a COVID-19 vaccination booster dose were analyzed. Older age, receiving conventional synthetic disease modifying antirheumatic drugs (csDMARDs), and higher neutralising antibody titres were identified as protective factors, while anti-IL6R treatment and anti-CD20 therapy increased the risk. The incidence of hospitalization for BIs was significantly higher in RA patients compared to healthcare workers.
Letter
Psychology, Clinical
Hui-Yuan Chen, Renin Chang, James Cheng-Chung Wei
PSYCHOLOGICAL MEDICINE
(2023)
Letter
Medicine, General & Internal
W. -H Hung, Y-M Hung, H-T Yip, J. C-C Wei, R. Chang
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2023)
Letter
Medicine, General & Internal
P. F. Liao, Y. T. Wang, Y. H. Wang, J. Y. Chiou, J. C. C. Wei
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2023)
Letter
Immunology
Wei Min Chu, Yung Heng Lee, James Cheng Chung Wei
JOURNAL OF INFECTIOUS DISEASES
(2023)
Review
Rheumatology
Man Li, Jhe-Yuan Hsu, Yong-Xin Xie, Yong-Lan Wu, James Cheng-Chung Wei
Summary: This article presents a case of a patient diagnosed with ankylosing spondylitis (AS) along with Kikuchi-Fujimoto disease (KFD), possibly triggered by infection or autoimmunity. Both AS and KFD involve a similar immune pathway, hence, the possibility of KFD should be considered when lymphadenopathy is observed, especially in patients with infection or underlying autoimmune diseases.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Virology
Fu-Shun Yen, James Cheng-Chung Wei, Hei-Tung Yip, Chih-Cheng Hsu, Chii-Min Hwu
Summary: Metformin use is associated with a lower risk of herpes zoster and postherpetic neuralgia in patients with type 2 diabetes, and a higher cumulative dose of metformin further reduces the risks of these conditions.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Rheumatology
Filip Van den Bosch, James Cheng-Chung Wei, Peter Nash, Francisco J. Blanco, Daniela Graham, Chuanbo Zang, Edmund Arthur, Cecilia Borlenghi, Vassilis Tsekouras, Bonnie Vlahos, Atul Deodhar
Summary: This study investigated the withdrawal and retreatment of etanercept in patients with nr-axSpA achieving inactive disease. The results showed that approximately 25% of patients maintained inactive disease for 40 weeks after discontinuing etanercept. Baseline absence of MRI sacroiliitis and high hs-CRP predicted response maintenance after etanercept withdrawal.
JOURNAL OF RHEUMATOLOGY
(2023)
Review
Immunology
Jin-Xian Huang, Yung-Heng Lee, James Cheng-Chung Wei
Summary: Tumor necrosis factor inhibitors are widely used for axial spondyloarthritis, and current guidelines recommend dose reduction instead of withdrawal. This study reviewed and updated the evidence on dose reduction strategies based on prospective and retrospective studies. The core issues and solutions concerning timing, intensity, maintenance, and monitoring of dose reduction were discussed. Remission/relapse and extra-articular manifestations should be considered in individualized dose reduction plans.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Rheumatology
Yi-Chiao Bai, Yi-Ling Chen, Wuu-Tsun Perng, Yao-Min Hung, Yu-Hsun Wang, James Cheng-Chung Wei
Summary: This study found that patients with SLE have a higher risk of developing glaucoma, especially in males.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Editorial Material
Rheumatology
Kuan-Kai Tung, Chih-Chin Yeh, Yung-Chun Lei, Pui-Ying Leong, James Cheng-Chung Wei
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Letter
Rheumatology
Kevin Sheng-Kai Ma, Chien-Han Tsao, James Cheng-Chung Wei, Li-Tzu Wang
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Virology
Kevin Sheng-Kai Ma, Ning-Chien Chin, Ting-Yu Tu, Yao-Cheng Wu, Hei-Tung Yip, James Cheng-Chung Wei, Ren-in Chang
Summary: This cohort study investigated the correlation between HPV infections and the risk of osteoporosis. It found that patients with HPV infections had a significantly higher risk of osteoporosis. Subgroup analysis revealed that females, those aged between 60 and 80 years, and patients with long-term use of glucocorticoids were at greater risk. Furthermore, treatments for HPV infections attenuated the risk of HPV-associated osteoporosis.
Article
Multidisciplinary Sciences
Tzu-Hsuan Lee, Meng-Che Wu, Ming-Hung Lee, Pei-Lun Liao, Chieh-Chung Lin, James Cheng-Chung Wei
Summary: This 17-year retrospective cohort study found an association between Helicobacter pylori infection and rheumatoid arthritis, with higher susceptibility in women under 30 years old. Longer follow-up duration was associated with a higher risk of developing rheumatoid arthritis.
SCIENTIFIC REPORTS
(2023)
Letter
Rheumatology
Han-You Mo, James Cheng Chung Wei, Xiao-Huan Chen, Hsin-Hua Chen
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Letter
Medicine, General & Internal
Kuan-Jung Chen, Jing-Yang Huang, James Cheng-Chung Wei
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)