Thymosin β4: multiple functions in protection, repair and regeneration of the mammalian heart

Controlled Release of Thymosin Beta 4 Using a Collagen–Chitosan Sponge Scaffold Augments Cutaneous Wound Healing and Increases Angiogenesis in Diabetic Rats with Hindlimb Ischemia

(2015) Dongdong Ti et al.   TISSUE ENGINEERING PART A

A Proliferative Burst during Preadolescence Establishes the Final Cardiomyocyte Number

(2014) Nawazish Naqvi et al.   CELL

Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts

(2014) James J. H. Chong et al.   NATURE

c-kit+ cells minimally contribute cardiomyocytes to the heart

(2014) Jop H. van Berlo et al.   NATURE

An emerging consensus on cardiac regeneration

(2014) Jop H van Berlo et al.   NATURE MEDICINE

Re-Activated Adult Epicardial Progenitor Cells Are a Heterogeneous Population Molecularly Distinct from Their Embryonic Counterparts

(2014) Sveva Bollini et al.   STEM CELLS AND DEVELOPMENT

Adeno-Associated Viral Vector 2.9 Thymosin ß4 Application Attenuates Rejection After Heart Transplantation

(2014) Johannes Postrach et al.   TRANSPLANTATION

MRTF-A controls vessel growth and maturation by increasing the expression of CCN1 and CCN2

(2014) Rabea Hinkel et al.   Nature Communications

Thymosin β4 coated nanofiber scaffolds for the repair of damaged cardiac tissue

(2014) Arun Kumar et al.   JOURNAL OF NANOBIOTECHNOLOGY

Thymosin  4 Increases the Potency of Transplanted Mesenchymal Stem Cells for Myocardial Repair

(2013) L. Ye et al.   CIRCULATION

A dynamic spatiotemporal extracellular matrix facilitates epicardial-mediated vertebrate heart regeneration

(2013) Sarah E. Mercer et al.   DEVELOPMENTAL BIOLOGY

Fibronectin is deposited by injury-activated epicardial cells and is necessary for zebrafish heart regeneration

(2013) Jinhu Wang et al.   DEVELOPMENTAL BIOLOGY

Meis1 regulates postnatal cardiomyocyte cell cycle arrest

(2013) Ahmed I. Mahmoud et al.   NATURE

Characterization of Epicardial-Derived Cardiac Interstitial Cells: Differentiation and Mobilization of Heart Fibroblast Progenitors

(2013) Adrián Ruiz-Villalba et al.   PLoS One

Cardioprotection by systemic dosing of thymosin beta four following ischemic myocardial injury

(2013) Weike Bao et al.   Frontiers in Pharmacology

Essential Role for Thymosin β4 in Regulating Vascular Smooth Muscle Cell Development and Vessel Wall Stability

(2012) Alex Rossdeutsch et al.   CIRCULATION RESEARCH

Wt1 and Epicardial Fate Mapping

(2012) Carsten Rudat et al.   CIRCULATION RESEARCH

Stimulation of adult resident cardiac progenitor cells by durable myocardial expression of thymosin beta 4 with ultrasound-targeted microbubble delivery

(2012) S Chen et al.   GENE THERAPY

In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes

(2012) Li Qian et al.   NATURE

Mammalian heart renewal by pre-existing cardiomyocytes

(2012) Samuel E. Senyo et al.   NATURE

Perfusable branching microvessel bed for vascularization of engineered tissues

(2012) L. L. Y. Chiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Controlled release of thymosin β4 from injected collagen–chitosan hydrogels promotes angiogenesis and prevents tissue loss after myocardial infarction

(2012) Loraine LY Chiu et al.   Regenerative Medicine

Recapitulation of developmental cardiogenesis governs the morphological and functional regeneration of adult newt hearts following injury

(2011) Nevin Witman et al.   DEVELOPMENTAL BIOLOGY

Wnt1/βcatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair

(2011) Jinzhu Duan et al.   EMBO JOURNAL

Regeneration of the heart

(2011) Matthew L. Steinhauser et al.   EMBO Molecular Medicine

Cardiac tissue engineering: current state and perspectives

(2011) Loraine L. et al.   Frontiers in Bioscience-Landmark

Adult mouse epicardium modulates myocardial injury by secreting paracrine factors

(2011) Bin Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Controlled release of thymosin β4 using collagen–chitosan composite hydrogels promotes epicardial cell migration and angiogenesis

(2011) Loraine L.Y. Chiu et al.   JOURNAL OF CONTROLLED RELEASE

Thymosin beta 4 treatment after myocardial infarction does not reprogram epicardial cells into cardiomyocytes

(2011) Bin Zhou et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

De novo cardiomyocytes from within the activated adult heart after injury

(2011) Nicola Smart et al.   NATURE

Transient Regenerative Potential of the Neonatal Mouse Heart

(2011) E. R. Porrello et al.   SCIENCE

Thymosin β4 facilitates epicardial neovascularization of the injured adult heart

(2010) Nicola Smart et al.   Annals of the New York Academy of Sciences

Human embryonic stem cell-derived microvascular grafts for cardiac tissue preservation after myocardial infarction

(2010) Thomas P. Kraehenbuehl et al.   BIOMATERIALS

A transitional extracellular matrix instructs cell behavior during muscle regeneration

(2010) Sarah Calve et al.   DEVELOPMENTAL BIOLOGY

Elevated peripheral blood mononuclear cell count is an independent predictor of left ventricular remodeling in patients with acute myocardial infarction

(2010) Satoshi Aoki et al.   Journal of Cardiology

Epicardium-derived cells enhance proliferation, cellular maturation and alignment of cardiomyocytes

(2010) Alida Weeke-Klimp et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Primary contribution to zebrafish heart regeneration by gata4 + cardiomyocytes

(2010) Kazu Kikuchi et al.   NATURE

PDGF signaling is required for epicardial function and blood vessel formation in regenerating zebrafish hearts

(2010) J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Thymosin β4 as an effector of Hand1-mediated vascular development

(2010) Nicola Smart et al.   Nature Communications

Heart Failure Management: The Present and the Future

(2009) Mohammad N. Jameel et al.   ANTIOXIDANTS & REDOX SIGNALING

Intracoronary infusion of bone marrow-derived mononuclear cells abrogates adverse left ventricular remodelling post-acute myocardial infarction: insights from the reinfusion of enriched progenitor cells and infarct remodelling in acute myocardial infarcti

(2009) Volker Schächinger et al.   EUROPEAN JOURNAL OF HEART FAILURE

Thymosin β4 mediated PKC activation is essential to initiate the embryonic coronary developmental program and epicardial progenitor cell activation in adult mice in vivo

(2009) Ildiko Bock-Marquette et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The extracellular matrix as a modulator of the inflammatory and reparative response following myocardial infarction

(2009) Marcin Dobaczewski et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Evidence for Cardiomyocyte Renewal in Humans

(2009) Olaf Bergmann et al.   SCIENCE

Embryonic Endothelial Progenitor Cell-Mediated Cardioprotection requires Thymosin β4

(2009) Christian Kupatt et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Lives of a Heart Cell: Tracing the Origins of Cardiac Progenitors

(2008) Silvia Martin-Puig et al.   Cell Stem Cell

Thymosin β4 Is an Essential Paracrine Factor of Embryonic Endothelial Progenitor Cell–Mediated Cardioprotection

(2008) Rabea Hinkel et al.   CIRCULATION

Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart

(2008) Bin Zhou et al.   NATURE

The immune system and cardiac repair

(2008) N FRANGOGIANNIS   PHARMACOLOGICAL RESEARCH