Article
Surgery
A. K. Israni, D. Zaun, J. D. Rosendale, C. Schaffhausen, W. McKinney, J. J. Snyder
Summary: In 2019, there was an increase in both the number of deceased organ donors and organ transplants, which may be linked to the rising death rates of young people due to the opioid epidemic. The data indicates an opportunity to increase transplant numbers by reducing organ discards.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Caroline Liu, Sami Alasfar, Peter P. Reese, Sumit Mohan, Mona D. Doshi, Isaac E. Hall, Heather Thiessen Philbrook, Yaqi Jia, Darren Stewart, Chirag R. Parikh
Summary: Kidney procurement and discard rates from deceased donors with AKI have increased from 2010 to 2020, especially for stage 3 AKI donors. Despite the increase in procurement of stage 3 AKI kidneys, high discard rates suggest room for improvement in utilization.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Kristen L. King, S. Ali Husain, Adler Perotte, Joel T. Adler, Jesse D. Schold, Sumit Mohan
Summary: Deceased donor kidney allocation allows exceptions in special circumstances, but these exceptions are often concentrated in a few outlier centers. The kidneys involved in the exceptions are usually transplanted to larger centers with higher acceptance rates.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Matthew P. Sypek, Martin Howell, Kirsten Howard, Germaine Wong, Emily Duncanson, Philip D. Clayton, Peter Hughes, Stephen McDonald
Summary: The study found that community members prioritize equity in kidney allocation, while healthcare professionals focus on maximizing utility. There are discordant views between community members and healthcare professionals, which should be taken into consideration in the design, evaluation, and implementation of deceased donor kidney allocation protocols.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Syed A. Husain, Kristen L. King, David C. Cron, Nikole A. Neidlinger, Han Ng, Sumit Mohan, Joel T. Adler
Summary: This study investigated the impact of local market competition and/or organ availability on kidney procurement and utilization. The results showed that lower competition was associated with higher export, while market monopoly was weakly associated with lower discard. Higher organ availability was associated with both export and discard.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Kristen L. King, S. Ali Husain, David J. Cohen, Jesse D. Schold, Sumit Mohan
Summary: This study examined the filter settings of 175 kidney transplant centers in 2007 and 2019, and found that centers became more open to receiving offers over time. Centers with more open filter settings had higher transplant volume and offer acceptance ratios, but there was geographic heterogeneity in the distribution of these centers.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Raymond J. Lynch, Brianna L. Doby, David S. Goldberg, Kevin J. Lee, Arielle Cimeno, Seth J. Karp
Summary: Research indicates that understanding performance across decedents and hospital types can help organ procurement organizations meet new Centers for Medicare and Medicaid Services metrics. Differences in recovery of organ donors exist between different OPOs, but are not apparent in SDRR rankings. Real-time recognition of underperformance across hospitals may provide important data for regulators and OPOs.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Xingxing S. Cheng, Philip J. Held, Avi Dor, Jennifer L. Bragg-Gresham, Jane C. Tan, John D. Scandling, Glenn M. Chertow, John P. Roberts
Summary: Expanding donor acceptability criteria to include nonstandard donors could be a potential solution to the organ shortage issue. Despite higher costs per organ, kidney transplantation from nonstandard donors remained cost-effective based on contemporary US data, with economies of scale observed in high OPO volume leading to lower costs.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Kathleen Yu, Syed A. Husain, Kristen King, Jacob S. Stevens, Chirag R. Parikh, Sumit Mohan
Summary: Acute kidney injury (AKI) severity is a strong risk factor for kidney nonprocurement in deceased organ donors. Efforts to address the organ shortage should focus on encouraging the procurement and utilization of kidneys from deceased donors with severe AKI, given the large prevalence of donor AKI and successful transplant outcomes with these kidneys.
CLINICAL TRANSPLANTATION
(2022)
Article
Surgery
Peter P. Reese, Sumit Mohan, Kristen L. King, Winfred W. Williams, Vishnu S. Potluri, Meera N. Harhay, Nwamaka D. Eneanya
Summary: The article points out the issues of fairness in kidney transplantation, focusing on the healthcare system features that disadvantage Black patients and inadequate medical standards. It proposes several initiatives to improve equity, including standardized wait-listing eligibility criteria, increased education for clinicians, innovations in electronic medical record capabilities, and advocating for rapid listing of patients. If these initiatives fail, consideration should be given to eliminating preemptive wait-listing and transplantation with deceased donor kidneys.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Emmanouil Giorgakis, Shirin E. Khorsandi, Amit K. Mathur, Lyle Burdine, Wayel Jassem, Nigel Heaton
Summary: The study findings suggest that using older grafts from donors aged 70 years and above can lead to acceptable outcomes in a highly selected cohort at experienced transplant centers. Advanced age should not be considered an absolute contraindication for utilizing DCD grafts from donors aged 70 years and older.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Vikrant Reddy, Briget da Graca, Eric Martinez, Richard Ruiz, Sumeet K. Asrani, Giuliano Testa, Anji Wall
Summary: The volume of abdominal organ offers received by the Baylor Simmons Transplant Institute has increased over time, resulting in a higher workload for the donor call team. The study collected data on organ offers and analyzed the increase in workload for the transplant center. The results showed an increase in organ offers but stable transplant numbers, indicating an inefficiency in organ allocation and increased workload for the center.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Transplantation
George H. B. Greenhall, Matthew Robb, Rachel J. Johnson, Maria Ibrahim, Rachel Hilton, Laurie A. Tomlinson, Chris J. Callaghan, Christopher J. E. Watson
Summary: This study examined the relationship between deceased donor albuminuria and kidney utilization, survival, and function. The findings suggest that kidneys from donors with albuminuria are less likely to be accepted for transplantation, but there is no evidence of an association between albuminuria and graft survival or function.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Review
Immunology
Mohamed Eftal Bin Mohamed Ebrahim, Zafar Mohamed Rizvi, Ahmer Hameed, Jerome Laurence, Angela Webster, Elena Cavazzoni, Taina Lee, Lawrence Yuen, Henry Pleass
Summary: It has been found that burn victims may be an additional source of organ donors, but the number of related studies is limited, and information on organ function and complications post-transplantation is scarce, thus caution is advised.
TRANSPLANTATION PROCEEDINGS
(2022)
Article
Surgery
K. A. Chotkan, J. W. Mensink, R. A. Pol, N. P. van der Kaaij, L. F. M. Beenen, W. N. Nijboer, B. Schaefer, I. P. J. Alwayn, A. E. Braat
Summary: Policies regarding imaging in deceased organ donation vary greatly between countries, and there is a lack of consensus on which imaging method should be applied. A uniform approach would contribute to quality and safety, justifying international exchange of organs.
TRANSPLANT INTERNATIONAL
(2022)
Article
Immunology
Amanda R. Vest, Wida S. Cherikh, Samantha M. Noreen, Josef Stehlik, Kiran K. Khush
Summary: This study analyzed the incidence and risk factors of post-heart transplantation diabetes and evaluated its impact on major outcomes. The results showed a high prevalence of post-heart transplantation diabetes and its association with increased risk of severe renal dysfunction and death or retransplantation.
Article
Gastroenterology & Hepatology
Andrew Wey, Samantha Noreen, Sommer Gentry, Matt Cafarella, James Trotter, Nicholas Salkowski, Dorry Segev, Ajay Israni, Bertram Kasiske, Ryutaro Hirose, Jon Snyder
Summary: The new liver allocation system, Acuity circles (AC), has a positive impact on the transplant rates of candidates with higher PELD/MELD scores, while exceptions can affect offer rates. The quality of liver donors may see minor changes with the use of donation after circulatory death (DCD) donors.
LIVER TRANSPLANTATION
(2022)
Article
Surgery
Caroline Liu, Sami Alasfar, Peter P. Reese, Sumit Mohan, Mona D. Doshi, Isaac E. Hall, Heather Thiessen Philbrook, Yaqi Jia, Darren Stewart, Chirag R. Parikh
Summary: Kidney procurement and discard rates from deceased donors with AKI have increased from 2010 to 2020, especially for stage 3 AKI donors. Despite the increase in procurement of stage 3 AKI kidneys, high discard rates suggest room for improvement in utilization.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Samantha M. Noreen, David Klassen, Roger Brown, Yolanda Becker, Kevin O'Connor, Jennifer Prinz, Matthew Cooper
Summary: The study found that there was no significant change in the percentage of eligible donors accepted during the accelerated placement project, but the conversion rate from acceptance to transplant slightly increased. Waiting to accelerate placement after kidneys have been declined by multiple transplant programs may be too late to effectively increase utilization. Future research should continue to investigate how to improve transplant rates of nationally shared and marginal kidneys.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Urology & Nephrology
Kaicheng Wang, Yanhong Deng, Darren Stewart, Richard N. Formica
Summary: This study explores the improvement of evaluating kidney transplant programs by incorporating allograft function into the endpoint. The results suggest that the composite endpoint performs better in differentiating long-term graft outcomes between transplant programs.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Urology & Nephrology
Darren E. Stewart, Julia Foutz, Layla Kamal, Samantha Weiss, Harrison S. McGehee, Matthew Cooper, Gaurav Gupta
Summary: The role of procurement biopsies in deceased donor kidney evaluation is still debated, and existing literature is filled with conflicting and ambiguous findings, which are often derived from small studies focused on short-term outcomes or reliant on biopsies prepared by methods impractical in the time-sensitive context of organ procurement.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Surgery
Darren Stewart, Tatenda Mupfudze, David Klassen
Summary: We estimated the median waiting time for kidney transplant in the United States using different methods and timeframes. The overall median waiting time decreased to 5.19 years between 2015 and 2018 and further declined to 4.05 years from April 2021 to March 2022. There were significant differences in median waiting times based on blood type, donor service area, and pediatric vs adult status, but less variation by race/ethnicity. We recommend using the period-prevalent Kaplan-Meier approach in addition to the competing risks approach to address the lack of information on kidney transplant waiting times.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Surgery
Siobhan Sutcliffe, Mengmeng Ji, Su-Hsin Chang, Darren Stewart, David A. Axelrod, Krista L. Lentine, Jason Wellen, Louai Alrata, Gaurav Gupta, Tarek Alhamad
Summary: In this study, we found that receiving a kidney transplant from a hepatitis C virus (HCV) positive donor did not increase the risk of transplant failure in recipients who were HCV-negative and treated with direct-acting antiviral medications. Kidneys from HCV-positive donors were associated with higher estimated glomerular filtration and a lower risk of delayed graft function compared to HCV-negative kidneys. These findings suggest that including donor HCV status in the Kidney Donor Risk Index may no longer be necessary in current practice.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Surgery
Deirdre Sawinski, Jennifer C. Lai, Sean Pinney, Alice L. Gray, Annette M. Jackson, Darren Stewart, Deborah Jo Levine, Jayme E. Locke, James J. Pomposelli, Matthew G. Hartwig, Shelley A. Hall, Darshana M. Dadhania, Rebecca Cogswell, V. Richard Perez, Jesse D. Schold, Nicole A. Turgeon, Jon Kobashigawa, Jasleen Kukreja, John C. Magee, John Friedewald, John S. Gill, Gabriel Loor, Julie K. Heimbach, Elizabeth C. Verna, Mary Norine Walsh, Norah Terrault, Guiliano Testa, Joshua M. Diamond, Peter P. Reese, Kimberly Brown, Susan Orloff, Maryjane A. Farr, Kim M. Olthoff, Mark Siegler, Nancy Ascher, Sandy Feng, Bruce Kaplan, Elizabeth Pomfret
Summary: Solid organ transplantation is the best treatment for end-stage organ failure, but there are significant sex-based disparities in access to transplantation. A multidisciplinary conference held on June 25, 2021, addressed these disparities and identified common themes contributing to them across various types of transplantations. Barriers to referral and wait listing for women, issues with serum creatinine, size mismatch between donors and recipients, frailty, and higher prevalence of allosensitization among women were noted. Actionable solutions to improve access to transplantation were discussed, as well as key knowledge gaps and high-priority areas for future investigation.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Letter
Surgery
Darren Stewart
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Surgery
Ian McCulloh, Darren Stewart, Kevin Kiernan, Ferben Yazicioglu, Heather Patsolic, Christopher Zinner, Sumit Mohan, Laura Cartwright
Summary: The heterogeneity in decision making among transplant surgeons and hospitals due to various factors necessitates the use of predictive analytics for improving the quality and confidence of decision making in kidney transplantation. Providing predictions for better quality organs and patient mortality can enhance decision consensus and decision-maker confidence.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Management
Theodore Papalexopoulos, James Alcorn, Dimitris Bertsimas, Rebecca Goff, Darren Stewart, Nikolaos Trichakis
Summary: In 2019, the United Network for Sharing (UNOS) sought to design a new national lung transplant allocation policy that would prioritize candidates on the waiting list in a more efficient and equitable manner. The Massachusetts Institute of Technology (MIT)/UNOS team utilized a novel analytical framework developed at MIT to consider trade-offs among outcomes and guide the choice of attribute weights in the allocation formula. The team's proposal was implemented as the national lung allocation policy in the United States on March 9, 2023.
INFORMS JOURNAL ON APPLIED ANALYTICS
(2023)
Article
Management
Theodore Papalexopoulos, James Alcorn, Dimitris Bertsimas, Rebecca Goff, Darren Stewart, Nikolaos Trichakis
Summary: This study introduces a novel analytical framework that uses machine learning, simulation, and optimization to explore the tradeoffs in organ allocation policies. The researchers have successfully designed a new national policy for lung allocation, which is projected to significantly reduce waitlist mortality. The framework can also be applied to other policy domains.
OPERATIONS RESEARCH
(2023)
Article
Urology & Nephrology
Darren Stewart, Bekir Tanriover, Gaurav Gupta
Article
Ethics
Theodore P. Papalexopoulos, Dimitris Bertsimas, I. Glenn Cohen, Rebecca R. Goff, Darren E. Stewart, Nikolaos Trichakis
Summary: The distribution of crucial medical goods and services in conditions of scarcity is a crucial and contested area of public policy development. Policymakers must balance efficiency and fairness objectives while considering different value judgments from stakeholders. This study presents a framework that combines ethical theory, data modeling, and stakeholder input to design organ transplant allocation policies. The development of an analytical tool based on machine learning and optimization allows stakeholders to engage in evidence-based value judgments.
JOURNAL OF LAW AND THE BIOSCIENCES
(2022)