Article
Pharmacology & Pharmacy
Juan Zhang, Xiaoqin Xu, Ning Li, Li Cao, Yu Sun, Junchi Wang, Shuaibing He, Jianyong Si, Degang Qing
Summary: This study investigates the anti-inflammatory effects of licoflavone B (LB) on ulcerative colitis (UC) for the first time. The results show that LB can ameliorate UC by preserving the integrity of the colonic barrier and regulating the composition of the gut microbiota.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Ami Lee, You Chul Chung, Kwang-Youn Kim, Chan Ho Jang, Kwang Hoon Song, Youn-Hwan Hwang
Summary: This study evaluated the beneficial effects of a hydroethanolic extract of Fritillariae thunbergii Bulbus in a mouse model of DSS-induced ulcerative colitis. The extract reduced colonic inflammation and damage, improved intestinal barrier function, and decreased the expression of proinflammatory cytokines.
Article
Food Science & Technology
Weidong Dou, Hao Xu, Shuo Feng, Tao Liu, Lin Xiao, Yingchao Wu, Shanwen Chen, Yisheng Pan, Xin Wang
Summary: This study investigates the protective effects of betaine on intestinal barrier function in a mouse model of ulcerative colitis and reveals its mechanism of action. The results show that betaine protects the intestinal barrier function of mice with ulcerative colitis by inhibiting the activation of the NF-kappa B-mediated signaling pathway.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Nutrition & Dietetics
Yeon-Ji Kim, Han-Hae Kim, Chul-Soo Shin, Jong-Won Yoon, Seon-Min Jeon, Young-Ha Song, Kwang-Youn Kim, Kyungho Kim
Summary: Human milk oligosaccharides (HMOs) can prevent ulcerative colitis (UC) by enhancing intestinal barrier function and anti-inflammatory responses. In cell experiments and a mouse colitis model, HMOs reversed the damage to the intestinal barrier caused by inflammation and alleviated UC symptoms such as weight loss and shortened colon length. These findings suggest that HMOs might be a candidate treatment for UC that protects intestinal integrity.
Article
Nutrition & Dietetics
Xinge Xu, Jingwei Wu, Yuxin Jin, Kunlun Huang, Yuanyuan Zhang, Zhihong Liang
Summary: This study investigated the effect of S. boulardii and its postbiotics on DSS-induced ulcerative colitis in mice. The results showed that S. boulardii and postbiotics intervention improved colonic shortening and tissue damage, increased the expression of intestinal tight junction protein, reduced the secretion of pro-inflammatory factors, increased the secretion of anti-inflammatory factors, and maintained the homeostasis of intestinal microorganisms. Postbiotics intervention was more effective than probiotics. In conclusion, S. boulardii and its postbiotics effectively alleviate DSS-induced colitis in mice by modulating host immunity and maintaining intestinal homeostasis. Postbiotics are promising next-generation biotherapeutics for ulcerative colitis treatment.
Article
Gastroenterology & Hepatology
Jia-Li Wang, Xiao Han, Jun-Xiang Li, Rui Shi, Lei-Lei Liu, Kai Wang, Yu-Ting Liao, Hui Jiang, Yang Zhang, Jun-Cong Hu, Li-Ming Zhang, Lei Shi
Summary: The study reveals the differential intestinal microbiota and metabolites in the pathogenesis of ulcerative colitis (UC), suggesting that different microbiota and metabolites may cause varying degrees of colitis. Some microbiota and metabolites may have protective roles against colitis, influencing the composition and function of intestinal mucus barrier under colitis.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Plant Sciences
Huibiao Li, Xiaohong Chen, Jiayao Liu, Muyuan Chen, Ming Huang, Guoxin Huang, Xinlin Chen, Qin Du, Jiyan Su, Rongfeng Lin
Summary: The study found that Centella asiatica ethanol extract significantly reduced inflammation in mice with UC, alleviating symptoms of colitis and potentially serving as an effective treatment in clinical practice.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ling Chen, Xiao-lin Zhong, Wen-yu Cao, Ming-li Mao, Dan-dan Liu, Wen-jia Liu, Xu-yu Zu, Jiang-hua Liu
Summary: In this study, the role and mechanism of IGF2 in ulcerative colitis were investigated using a mouse model. The results showed that IGF2 can alleviate colon injury and inflammation caused by ulcerative colitis by downregulating the cGAS-Sting pathway, thus maintaining colonic stemness and barrier integrity.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Xiaojing Wang, Xuting Xie, Yanyang Li, Xueqian Xie, Shaowei Huang, Simin Pan, Yanling Zou, Zengfeng Pan, Qing Wang, Jinyan Chen, Lian Zhou, Xia Luo
Summary: The study discovered that quercetin has therapeutic effects on ulcerative colitis. Quercetin repairs the damaged intestinal barrier by activating AhR and enhancing the expression of tight junction proteins.
PHYTOTHERAPY RESEARCH
(2023)
Article
Food Science & Technology
Hye-Jung Moon, Youn-Soo Cha, Kyung-Ah Kim
Summary: This study investigated the protective effects of blackcurrant (BC) on ulcerative colitis (UC) in mice. BC powder relieved symptoms of colitis, reduced the production of pro-inflammatory cytokines, regulated the NF-kappa B signaling pathway and gut barrier function related genes, and modulated the gut microbiota composition.
Article
Biochemistry & Molecular Biology
Jing Wu, Junkun Niu, Maojuan Li, Yinglei Miao
Summary: KRT1 is downregulated in ulcerative colitis, but maintains intestinal barrier function by upregulating TJ proteins. In DSS-induced colitis, KRT1 transgenic group shows lower inflammation levels.
Article
Pharmacology & Pharmacy
Yongfu Wang, Jingjing Liu, Ziwei Huang, Yucui Li, Yuanyuan Liang, Chaodan Luo, Chen Ni, Jianhui Xie, Ziren Su, Jiannan Chen, Cailan Li
Summary: Coptisine has demonstrated therapeutic effects on ulcerative colitis by maintaining the integrity of the intestinal epithelial barrier, inhibiting apoptosis, and inflammatory response.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Plant Sciences
Xuan-qing Chen, Xiang-yu Lv, Shi-jia Liu
Summary: BTW significantly improved the inflammatory symptoms of mice with acute colitis, and the latent mechanism of BTW may be related to various signaling pathways, including the modulation of intestinal microflora and inflammatory signaling pathways, such as IL-6/STAT3.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Meishan Yue, Jialu Huang, Xiaolan Ma, Peng Huang, Yisong Liu, Jianguo Zeng
Summary: This study found that PRO, an anti-inflammatory ingredient in Macleaya cordata, can alleviate inflammation symptoms and restore the intestinal barrier in DSS-induced colitis mice. PRO also regulates the composition of gut microbiota.
Article
Food Science & Technology
Yukun Zhang, Feng Lu, Hang Zhang, Yuwei Ye, Penghu Liu, Dongmei Lin, Hong Zhou, Min Li, Baoxue Yang
Summary: This study investigated the therapeutic effect of Agaricus blazei Murrill polysaccharides (ABP) and selenium-enriched Agaricus blazei Murrill polysaccharides (ABP-Se) on ulcerative colitis (UC) using a mouse model. The results showed that both ABP and ABP-Se alleviated UC symptoms and improved colonic barrier functions, while reducing inflammation and oxidative stress.
JOURNAL OF FUNCTIONAL FOODS
(2022)