Article
Oncology
Leah Moubadder, Lindsay J. Collin, Rebecca Nash, Jeffrey Switchenko, Jasmine Miller-Kleinhenz, Keerthi Gogineni, Kevin C. Ward, Lauren E. McCullough
Summary: The study identified tumor, treatment, and patient characteristics that may contribute to differences in breast cancer mortality by race, rurality, and area-level socioeconomic status among women diagnosed with stage IIIB-IV BC in Georgia.
Article
Oncology
Akshita Khosla, Devashish Desai, Sachi Singhal, Aanchal Sawhney, Rashmika Potdar
Summary: Breast cancer is the second most diagnosed cancer among American women, affecting 1 in 8 women. There is a lack of research on regional differences in breast cancer mortality by race in the US. It is critical to identify regions and races that need improved access to breast cancer care.
Article
Public, Environmental & Occupational Health
Shuhan Wang, Weifang Tang, Shengying Wang, Shikai Hong, Jianjun Liu
Summary: This study examines the survival disparities among breast cancer patients of different races after surgery and finds that minority groups have lower survival benefits compared to white individuals, regardless of tumor characteristics and surgery types.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Oncology
Nicole Mavingire, Petreena Campbell, Jonathan Wooten, Joyce Aja, Melissa B. Davis, Andrea Loaiza-Perez, Eileen Brantley
Summary: Breast cancer stem cells (BCSCs) play a role in promoting endocrine therapy resistance through signaling cascades such as Notch, HIF, and integrin/Akt. Understanding these mechanisms can potentially lead to targeted therapy strategies to counteract endocrine resistance in HR positive breast cancer patients. Additionally, exploring the link between BCSC-regulatory gene levels and reduced survival in African American women with basal-like breast cancer may provide insights for improving clinical outcomes in this population.
Article
Multidisciplinary Sciences
Nickolas Stabellini, Jennifer Cullen, Lifen Cao, John Shanahan, Nelson Hamerschlak, Kristin Waite, Jill S. Barnholtz-Sloan, Alberto J. Montero
Summary: The study aimed to analyze the differences in treatment patterns and treatment related adverse events in Non-Hispanic women with breast cancer based on race. The results showed that Non-Hispanic Black women were less likely to undergo surgery or receive endocrine therapy, but more likely to receive radiotherapy. They also had a higher risk of cognitive decline/dementia after treatment.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Katherine E. Reeder-Hayes, Melissa A. Troester, Stephanie B. Wheeler
Summary: There is a well-known and persistent racial disparity in breast cancer outcomes between Black and White women in the U.S., especially among those with hormone receptor-positive cancers. This gap has widened over time despite advancements in treatment, and lower adherence to endocrine therapy for Black women may be a key factor. Interventions focusing on improving communication and support for endocrine therapy use could help reduce this racial gap in breast cancer mortality.
Article
Oncology
Olga Kantor, Monica L. Wang, Kimberly Bertrand, Lori Pierce, Rachel A. Freedman, Mariana Chavez-MacGregor, Tari A. King, Elizabeth A. Mittendorf
Summary: The study found that non-Hispanic black women and those of lower socioeconomic status have inferior breast cancer outcomes, even within the pathologic prognostic staging system that takes tumor biology into account. Efforts should be made to understand the biological, behavioral, social, and environmental factors contributing to racial and socioeconomic disparities in breast cancer outcomes.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Surgery
Michael R. Poulson, Brendin R. Beaulieu-Jones, Kelly M. Kenzik, Tracey A. Dechert, Naomi Y. Ko, Teviah E. Sachs, Michael R. Cassidy
Summary: Analyzing data from 2005 to 2015, the study found that Black patients have a higher risk of presenting at advanced stage, receiving surgery for localized disease, and decreased survival rate compared to White patients as segregation increases. These results highlight the significant association between residential racial segregation and Black-White disparities in breast cancer outcomes.
Article
Public, Environmental & Occupational Health
Siobhan O. Nnorom, Lori L. Wilson
Summary: Breast cancer is the most common noncutaneous malignancy affecting women in the United States, with the highest mortality rates observed in Black women. Survival after breast cancer is influenced by factors such as early detection and effective therapy, which are affected by both biological and social factors.
JOURNAL OF WOMENS HEALTH
(2022)
Article
Medicine, General & Internal
Jacob S. Nasser, Joseph N. Fahmy, Yao Song, Lu Wang, Kevin C. Chung
Summary: This study examined whether implicit racial bias is associated with disparities in breast reconstruction and found that regional variations in utilization exist but are not associated with implicit bias. The results suggest that collaboration, data collection systems, and collaboration with high-volume breast centers can improve utilization rates and quality of care for breast cancer patients.
Article
Oncology
Kimlin Tam Ashing, Gaole Song, Veronica Jones, Charles Brenner, Raynald Samoa
Summary: Cancer inequity affects ethnic minorities and people of lower socioeconomic status, leading to poor access to care and higher prevalence of comorbid conditions like diabetes. This study found that minority cancer patients, especially non-Hispanic Blacks and Hispanic/Latino individuals, were more likely to have diabetes. Older, ethnic minority, overweight/obese, and lower educated cancer patients were also at higher risk for diabetes. Clinicians and health systems should routinely assess cancer patients for diabetes and provide coordinated care.
FRONTIERS IN ONCOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Shahnjayla K. Connors, Melody S. Goodman, Terence Myckatyn, Julie Margenthaler, Sarah Gehlert
Summary: This study identified disparities in breast reconstruction rates and types between African American and Caucasian women, possibly related to differences in sociodemographic, tumor, and treatment characteristics. Predictors of breast reconstruction varied by race, indicating that the mechanisms underlying breast reconstruction may differ in African American women. Further research is needed to understand the contributions of sociodemographic, tumor, and treatment factors to breast reconstruction disparities in African American women.
JOURNAL OF RACIAL AND ETHNIC HEALTH DISPARITIES
(2022)
Article
Oncology
Fei Wang, Wei Zheng, Christina E. Bailey, Ingrid A. Mayer, Jennifer A. Pietenpol, Xiao-Ou Shu
Summary: This study found that after considering clinical characteristics, treatment, and care-related factors, the mortality differences between white and black TNBC patients were mainly influenced by these factors. However, the mortality differences between Hispanic and Asian patients compared to white patients were largely unaffected by these factors.
Article
Surgery
Neha Goel, Sina Yadegarynia, Maya Lubarsky, Seraphina Choi, Kristin Kelly, Raymond Balise, Susan B. Kesmodel, Erin Kobetz
Summary: This comprehensive analysis of breast cancer outcomes among Hispanic patients found that Hispanic Blacks have worse overall survival compared to Hispanic Whites, indicating that race/ethnicity is a complex variable influenced by biological, social, and structural factors. Black race was identified as a marker of vulnerability, while Hispanic ethnicity was a marker of resilience, aiming to address the persistent survival gap in breast cancer.
Article
Surgery
Adeeti Aggarwal, Claire B. Rosen, Ariel Nehemiah, Ivy Maina, Rachel R. Kelz, Cary B. Aarons, Sanford E. Roberts
Summary: There is a striking lack of minority women in surgery. With increasing professional rank, the representation of Black women decreases. Minority women in the field of surgery face the unique challenge of being a minority in both race and sex.
