Cellular Immunotherapy for Septic Shock. A Phase I Clinical Trial

Cryopreserved Mesenchymal Stromal Cells Maintain Potency in a Retinal Ischemia/Reperfusion Injury Model: Toward an off-the-shelf Therapy

(2016) Oliver W. Gramlich et al.   Scientific Reports

Sepsis: pathophysiology and clinical management

(2016) Jeffrey E Gotts et al.   BMJ-British Medical Journal

Sepsis: pathophysiology and clinical management

(2016) Jeffrey E Gotts et al.   BMJ-British Medical Journal

Evaluating mesenchymal stem cell therapy for sepsis with preclinical meta-analyses prior to initiating a first-in-human trial

(2016) Manoj M Lalu et al.   eLife

Platelet-derived Wnt antagonist Dickkopf-1 is implicated in ICAM-1/VCAM-1-mediated neutrophilic acute lung inflammation

(2015) Y. Guo et al.   BLOOD

Cryopreservation does not alter main characteristics of Good Manufacturing Process–grade human multipotent mesenchymal stromal cells including immunomodulating potential and lack of malignant transformation

(2015) Jana Luetzkendorf et al.   CYTOTHERAPY

Human mesenchymal stromal cells decrease the severity of acute lung injury induced by E. coli in the rat

(2015) J. Devaney et al.   THORAX

Freshly Thawed and Continuously Cultured Human Bone Marrow-Derived Mesenchymal Stromal Cells Comparably Ameliorate Allergic Airways Inflammation in Immunocompetent Mice

(2015) Fernanda F. Cruz et al.   Stem Cells Translational Medicine

Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial

(2015) Jennifer G Wilson et al.   Lancet Respiratory Medicine

Mesenchymal stem cells as a therapeutic tool to treat sepsis

(2015) Eleuterio Lombardo   World Journal of Stem Cells

Mesenchymal stem cells decrease splenocytes apoptosis in a sepsis experimental model

(2014) Leonardo Pedrazza et al.   INFLAMMATION RESEARCH

CXCR4 Receptor Overexpression in Mesenchymal Stem Cells Facilitates Treatment of Acute Lung Injury in Rats

(2014) Jing-Xian Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mesenchymal stem cell-based developmental endothelial locus-1 gene therapy for acute lung injury induced by lipopolysaccharide in mice

(2014) YUN-FENG ZHAO et al.   Molecular Medicine Reports

Treatment of acute respiratory distress syndrome with allogeneic adipose-derived mesenchymal stem cells: a randomized, placebo-controlled pilot study

(2014) Guoping Zheng et al.   RESPIRATORY RESEARCH

Do Cryopreserved Mesenchymal Stromal Cells Display Impaired Immunomodulatory and Therapeutic Properties?

(2014) Guido Moll et al.   STEM CELLS

Why have clinical trials in sepsis failed?

(2014) John C. Marshall   TRENDS IN MOLECULAR MEDICINE

Mesenchymal stem cells: mechanisms of potential therapeutic benefit in ARDS and sepsis

(2014) James Walter et al.   Lancet Respiratory Medicine

Phase II Clinical Research Design in Cardiology

(2013) Joshua M. Hare et al.   CIRCULATION

Effects of Mesenchymal Stem Cell Therapy on the Time Course of Pulmonary Remodeling Depend on the Etiology of Lung Injury in Mice

(2013) Tatiana Maron-Gutierrez et al.   CRITICAL CARE MEDICINE

The mesenchymal stromal cells dilemma—does a negative phase III trial of random donor mesenchymal stromal cells in steroid-resistant graft-versus-host disease represent a death knell or a bump in the road?

(2013) Jacques Galipeau   CYTOTHERAPY

Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012

(2013) R. P. Dellinger et al.   INTENSIVE CARE MEDICINE

Severe Sepsis and Septic Shock

(2013) Derek C. Angus et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mesenchymal Stem Cells Ameliorate Sepsis-associated Acute Kidney Injury in Mice

(2013) Cong-juan Luo et al.   SHOCK

The Toll-like Receptor 3 Ligand, Poly(I:C), Improves Immunosuppressive Function and Therapeutic Effect of Mesenchymal Stem Cells on Sepsis via Inhibiting MiR-143

(2013) Xiaoyin Zhao et al.   STEM CELLS

Network Analysis of Transcriptional Responses Induced by Mesenchymal Stem Cell Treatment of Experimental Sepsis

(2012) Claudia C. dos Santos et al.   AMERICAN JOURNAL OF PATHOLOGY

Mesenchymal stromal cells

(2012) Manoj M. Lalu et al.   CRITICAL CARE MEDICINE

Systemic human orbital fat-derived stem/stromal cell transplantation ameliorates acute inflammation in lipopolysaccharide-induced acute lung injury

(2012) Ming-Hsien Chien et al.   CRITICAL CARE MEDICINE

Human umbilical cord mesenchymal stem cells reduce systemic inflammation and attenuate LPS-induced acute lung injury in rats

(2012) Jianjun Li et al.   Journal of Inflammation-London

Safety of Cell Therapy with Mesenchymal Stromal Cells (SafeCell): A Systematic Review and Meta-Analysis of Clinical Trials

(2012) Manoj M. Lalu et al.   PLoS One

Multipotent Mesenchymal Stromal Cell Therapy and Risk of Malignancies

(2012) Federica Casiraghi et al.   Stem Cell Reviews and Reports

Hospitalizations, costs, and outcomes of severe sepsis in the United States 2003 to 2007

(2011) Tara Lagu et al.   CRITICAL CARE MEDICINE

Cryopreserved mesenchymal stromal cells display impaired immunosuppressive properties as a result of heat-shock response and impaired interferon-γ licensing

(2011) Moïra François et al.   CYTOTHERAPY

Mesenchymal Stem Cells Reduce Inflammation while Enhancing Bacterial Clearance and Improving Survival in Sepsis

(2010) Shirley H. J. Mei et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Defining the risks of mesenchymal stromal cell therapy

(2010) Darwin J. Prockop et al.   CYTOTHERAPY

Reactive Bone Marrow Stromal Cells Attenuate Systemic Inflammation via sTNFR1

(2010) Hiroshi Yagi et al.   MOLECULAR THERAPY

Antibacterial Effect of Human Mesenchymal Stem Cells Is Mediated in Part from Secretion of the Antimicrobial Peptide LL-37

(2010) Anna Krasnodembskaya et al.   STEM CELLS

The Pathophysiology of Septic Shock

(2009) O. Okorie Nduka et al.   CRITICAL CARE CLINICS

Derivation and validation of Spo2/Fio2 ratio to impute for Pao2/Fio2 ratio in the respiratory component of the Sequential Organ Failure Assessment score*

(2009) Pratik P. Pandharipande et al.   CRITICAL CARE MEDICINE

Human adult stem cells derived from adipose tissue protect against experimental colitis and sepsis

(2009) E Gonzalez-Rey et al.   GUT

Dose Escalation Methods in Phase I Cancer Clinical Trials

(2009) Christophe Le Tourneau et al.   JNCI-Journal of the National Cancer Institute

Bone marrow stromal cells attenuate sepsis via prostaglandin E2–dependent reprogramming of host macrophages to increase their interleukin-10 production

(2008) Krisztián Németh et al.   NATURE MEDICINE