Review
Allergy
Heidi Makrinioti, Kohei Hasegawa, John Lakoumentas, Paraskevi Xepapadaki, Maria Tsolia, Jose A. Castro-Rodriguez, Wojciech Feleszko, Tuomas Jartti, Sebastian L. Johnston, Andrew Bush, Vasiliki Papaevangelou, Carlos A. Camargo, Nikolaos G. Papadopoulos
Summary: This study compares the associations of RSV-induced bronchiolitis and RV-induced bronchiolitis with the development of preschool wheeze and childhood asthma through a meta-analysis. The results show that the RV-bronchiolitis group is more likely to develop recurrent wheeze and asthma. This study is clinically significant for understanding the relationship between viruses and asthma.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Immunology
Pekka Hurme, Miisa Komulainen, Marleena Tulkki, Annamari Leino, Beate Ruckert, Riitta Turunen, Tytti Vuorinen, Mubeccel Akdis, Cezmi A. Akdis, Tuomas Jartti
Summary: The cytokine profiles of Rhinovirus (RV) and respiratory syncytial virus (RSV)-induced first wheezing episode differ, with higher cytokine expression and longer hospitalization time in the RSV group. In the RV group, increased expression of I-309 (CCL1) and TARC is associated with fewer relapses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Virology
Xin-hui Yuan, Li-li Pang, Jing Yang, Yu Jin
Summary: This study found that HRV-C can infect and propagate in HBE cells, and significantly increase the secretion of various cytokines. Compared with RSV, HRV-C induces weaker cytokine expression.
Review
Immunology
Heidi Makrinioti, Andrew Bush, James Gern, Sebastian Lennox Johnston, Nikolaos Papadopoulos, Wojciech Feleszko, Carlos A. Camargo, Kohei Hasegawa, Tuomas Jartti
Summary: Bronchiolitis is a common cause of hospitalization in infants and is associated with a higher risk of childhood asthma development. The mechanisms underlying asthma development following bronchiolitis hospitalization are complex and involve immune responses to respiratory viruses.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Maria Martin-Vicente, Salvador Resino, Isidoro Martinez
Summary: The human respiratory syncytial virus (HRSV) causes severe lower respiratory tract infections in infants and the elderly. The main targets of HRSV infection are the respiratory epithelial cells, where the immune response against the virus begins. The intricate signaling pathways and post-translation modifications regulate the early innate immune response to control virus replication and immunopathology.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Review
Microbiology
Federica Attaianese, Sara Guiducci, Sandra Trapani, Federica Barbati, Lorenzo Lodi, Giuseppe Indolfi, Chiara Azzari, Silvia Ricci
Summary: This review comprehensively summarizes the immune response to human respiratory syncytial virus (hRSV) infection, including innate and adaptive immune components, recognition of the virus, inflammatory response, natural killer cells, antigen presentation, T cell response, and antibody production. Understanding the complex immune response to hRSV infection is crucial for developing effective interventions against this significant respiratory pathogen.
Review
Allergy
Niek B. Achten, Annemarie M. C. van Rossum, Leonard B. Bacharier, Anne M. Fitzpatrick, Tina Hartert
Summary: This article examines the impact of early-life viral infections on the lung and immune systems and focuses on the causal relationship between early-life viral infections and asthma. The article calls for a shift in research focus towards improving patient outcomes in the spectrum of respiratory diseases.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Allergy
Orianne Dumas, Riku Erkkola, Eija Bergroth, Kohei Hasegawa, Jonathan M. Mansbach, Pedro A. Piedra, Tuomas Jartti, Carlos A. Camargo
Summary: This study aimed to investigate the association between severe bronchiolitis profiles identified by clustering and childhood asthma. The results showed that children with a history of wheezing and/or eczema and rhinovirus infection had a higher risk of developing childhood asthma.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Sergio de Jesus Romero-Tapia, Crystell Guadalupe Guzman Priego, Blanca E. Del-Rio-Navarro, Manuel Sanchez-Solis
Summary: This review summarizes the close association between viral infection and the onset, progression, and exacerbation of asthma, discussing related protective and risk factors, as well as treatment options. It also presents recent research on the innate immunological pathways and changes in the epithelial barrier. The review emphasizes the importance of genetics and epigenetics in asthma and virus susceptibility, and describes the involvement of viral etiology in bronchiolitis, childhood wheezing, and asthma. The most frequently related respiratory viruses and their mechanisms of action are mentioned.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Microbiology
Leonardo Sorrentino, Walter Toscanelli, Matteo Fracella, Marta De Angelis, Federica Frasca, Carolina Scagnolari, Laura Petrarca, Raffaella Nenna, Fabio Midulla, Anna Teresa Palamara, Lucia Nencioni, Alessandra Pierangeli
Summary: Respiratory syncytial virus (RSV) and human rhinovirus (HRV) are common causes of hospitalization in children, with RSV being more severe. The study investigated the interplay between interferon (IFN) responses and nuclear factor erythroid 2-related factor 2 (NRF2) antioxidant activity in RSV and HRV infections. The findings suggest that reduced NRF2 activation in RSV-infected infants may contribute to the severity of bronchiolitis.
Article
Immunology
Andres Pizzorno, Blandine Padey, Victoria Duliere, William Mouton, Justine Oliva, Emilie Laurent, Cedrine Milesi, Bruno Lina, Aurelien Traversier, Thomas Julien, Sophie Trouillet-Assant, Manuel Rosa-Calatrava, Olivier Terrier
Summary: This study investigates the interactions between SARS-CoV-2 and other respiratory viruses, revealing that virus type and sequence of infections play a crucial role in determining virus-virus interactions, with the primary infection having a determinant role in the immune response to the secondary infection.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Ilada Thongpan, Preeyaporn Vichaiwattana, Sompong Vongpunsawad, Yong Poovorawan
Summary: The seasonality and prevalence of HRV and RSV infections among young children in Thailand were altered by the global coronavirus pandemic in 2020. An upsurge of HRV infection began in July and was subsequently replaced by a surge of RSV infection from September onward, peaking in October. The delayed RSV season in 2020 was predominantly associated with RSV-A.
INFLUENZA AND OTHER RESPIRATORY VIRUSES
(2021)
Article
Biochemistry & Molecular Biology
Deidre Wilkins, Yuan Yuan, Yue Chang, Anastasia A. Aksyuk, Beatriz Seoane Nunez, Ulrika Wahlby-Hamren, Tianhui Zhang, Michael E. Abram, Amanda Leach, Tonya Villafana, Mark T. Esser
Summary: Nirsevimab is an extended half-life monoclonal antibody that provides sustained, high levels of neutralizing antibodies (NAbs) against the respiratory syncytial virus (RSV) while allowing the development of an immune response. It effectively protects infants from RSV disease throughout their first RSV season and has similar seroresponse rates compared with placebo recipients. It is likely due to the prolonged persistence of nirsevimab at elevated levels that leads to this observed protection.
Article
Infectious Diseases
Sheila F. Lumley, Nicholas Richens, Emily Lees, Jack Cregan, Elizabeth Kalimeris, Sarah Oakley, Marcus Morgan, Shelley Segal, Moya Dawson, A. Sarah Walker, David W. Eyre, Derrick W. Crook, Sally Beer, Alex Novak, Nicole E. Stoesser, Philippa C. Matthews
Summary: The SARS-CoV-2 pandemic had a significant impact on the incidence of paediatric viral respiratory tract infection in Oxfordshire, UK. The findings have implications for clinical service demand, testing strategies, timing of palivizumab RSV prophylaxis, and the effectiveness of public health interventions in preventing respiratory virus infections.
JOURNAL OF INFECTION
(2022)
Review
Microbiology
Yan Ouyang, Hongqun Liao, Yan Hu, Kaiyuan Luo, Shaowen Hu, Huifang Zhu
Summary: Respiratory syncytial virus (RSV) is the main cause of severe respiratory infections in young children, leading to bronchiolitis and pneumonia; despite the lack of an RSV vaccine, research is focusing on understanding the interaction between RSV infection and innate immunity to discover new drug targets and vaccines.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Kedir N. Turi, Tebeb Gebretsadik, Tan Ding, Andrew Abreo, Cosby Stone, Tina Hartert, Pingsheng Wu
Summary: This study revealed that prenatal antibiotic exposure dose-dependently affects the risk of childhood asthma, with early exposure during pregnancy and the use of broad-spectrum antibiotics associated with a higher risk.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Allergy
Meghan H. Shilts, Christian Rosas-Salazar, Kedir N. Turi, Devi Rajan, Seesandra V. Rajagopala, Megan F. Patterson, Tebeb Gebretsadik, Larry J. Anderson, R. Stokes Peebles, Tina V. Hartert, Suman R. Das
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Allergy
Kedir N. Turi, Christopher McKennan, Tebeb Gebretsadik, Brittney Snyder, Christine M. Seroogy, Robert F. Lemanske, Edward Zoratti, Suzanne Havstad, Carole Ober, Susan Lynch, Kathyrn McCauley, Chang Yu, Daniel J. Jackson, James E. Gern, Tina V. Hartert
Summary: This study identified a novel inverse, dose-dependent association between plasma levels of Z,Z unconjugated bilirubin (UCB) and related metabolites with early-life wheeze and childhood asthma, along with significant negative correlations with inflammatory lipid mediators and oxidative stress byproducts.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Virology
Samadhan J. Jadhao, Binh Ha, Courtney McCracken, Tebeb Gebretsadik, Christian Rosas-Salazar, James Chappell, Suman Das, Tina Hartert, Larry J. Anderson
Summary: RSV infection plays a major role in respiratory tract diseases in infants and throughout life. The RSV antibody enzyme-linked immunoassay is sensitive for detecting infant infection, and the two G EIAs can indicate the group of an earlier primary infection.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Review
Gastroenterology & Hepatology
Rachel Bernard, Irtiqa Fazili, Seesandra V. Rajagopala, Suman R. Das, Girish Hiremath
Summary: Further research is necessary to uncover the mechanisms by which the oral microbiome impacts the development and progression of esophageal diseases, as well as to explore if changes in the oral microbiome can influence the natural course of different esophageal conditions.
DIGESTIVE DISEASES
(2022)
Article
Allergy
Christian Rosas-Salazar, Zheng-Zheng Tang, Meghan H. Shilts, Kedir N. Turi, Qilin Hong, Derek A. Wiggins, Christian E. Lynch, Tebeb Gebretsadik, James D. Chappell, R. Stokes Peebles, Larry J. Anderson, Suman R. Das, Tina Hartert
Summary: The study found that the upper respiratory tract (URT) microbiome during RSV ARI in infancy is associated with the acute local immune response, disease severity, and number of wheezing episodes in the fourth year of life. The diversity of the URT microbiome is related to the course of RSV ARI, and there are complex interactions between the URT microbiome and the immune system.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Otorhinolaryngology
Charles R. Esther, Kyle S. Kimura, Yu Mikami, Caitlin E. Edwards, Suman R. Das, Michael H. Freeman, Britton A. Strickland, Hunter M. Brown, Bronson C. Wessinger, Veerain C. Gupta, Kate Von Wahlde, Quanhu Sheng, Li Ching Huang, Daniel R. Bacon, Adam J. Kimple, Agathe S. Ceppe, Takafumi Kato, Raymond J. Pickles, Scott H. Randell, Ralph S. Baric, Justin H. Turner, Richard C. Boucher
Summary: This study assessed the efficacy of a detergent-based virucidal agent in SARS-CoV-2-infected subjects and found that it had no impact on viral load or symptom scores in the clinical trial. Complementary in vitro studies confirmed this lack of efficacy, indicating a failure in drug absorption.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2022)
Article
Immunology
Meghan H. Shilts, Christian Rosas-Salazar, Britton A. Strickland, Kyle S. Kimura, Mohammad Asad, Esha Sehanobish, Michael H. Freeman, Bronson C. Wessinger, Veerain Gupta, Hunter M. Brown, Helen H. Boone, Viraj Patel, Mali Barbi, Danielle Bottalico, Meaghan O'Neill, Nadeem Akbar, Seesandra V. Rajagopala, Simon Mallal, Elizabeth Phillips, Justin H. Turner, Elina Jerschow, Suman R. Das
Summary: This study aims to investigate the association between COVID-19 severity and the upper respiratory tract microbiome. The study found that as the severity of COVID-19 increased, the bacterial load, bacterial richness, and within-group microbiome composition dissimilarity in the upper respiratory tract also increased, while the relative abundance of a specific amplicon sequence variant decreased.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Infectious Diseases
Jesse O. Wrenn, Suman B. Pakala, Grant Vestal, Meghan H. Shilts, Hunter M. Brown, Sara M. Bowen, Britton A. Strickland, Timothy Williams, Simon A. Mallal, Ian D. Jones, Jonathan E. Schmitz, Wesley H. Self, Suman R. Das
Summary: The clinical outcomes of infections caused by the Omicron variant were compared to those caused by the Delta variant. It was found that infections caused by the Omicron variant were less severe, with significantly lower morbidity and mortality rates, compared to those caused by the Delta variant.
INFLUENZA AND OTHER RESPIRATORY VIRUSES
(2022)
Article
Allergy
Christian Rosas-Salazar, Meghan H. Shilts, Zheng-Zheng Tang, Qilin Hong, Kedir N. Turi, Brittney M. Snyder, Derek A. Wiggins, Christian E. Lynch, Tebeb Gebretsadik, R. Stokes Peebles, Larry J. Anderson, Suman R. Das, Tina V. Hartert
Summary: Exclusive breast-feeding has a protective causal role in reducing the risk of lower respiratory tract infections, asthma, and allergic rhinitis in childhood. This association may be mediated through its impact on the early-life upper respiratory tract and gut microbiome, as well as the immune response in infancy.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Oncology
Mallory G. McKeon, Jean-Nicolas Gallant, Young J. Kim, Suman R. Das
Summary: Certain viruses, such as human papillomavirus (HPV) and Epstein-Barr virus (EBV), are associated with the development of head and neck cancer. This study reviews the mechanisms by which these viruses cause cellular transformation and chronic inflammation, and examines the interplay between viruses, cellular transformation, inflammation, and the local host microbiome in head and neck cancer.
Article
Cardiac & Cardiovascular Systems
Akihiro Nakajima, Satoru Mitomo, Haruhito Yuki, Makoto Araki, Lena Marie Seegers, Iris McNulty, Hang Lee, David Kuter, Midori Ishibashi, Kazuna Kobayashi, Jouke Dijkstra, Hirokazu Onishi, Hiroto Yabushita, Satoshi Matsuoka, Hiroyoshi Kawamoto, Yusuke Watanabe, Kentaro Tanaka, Shengpu Chou, Toru Naganuma, Masaaki Okutsu, Satoko Tahara, Naoyuki Kurita, Shotaro Nakamura, Suman Das, Sunao Nakamura, Ik-Kyung Jang
Summary: This study identified gut bacteria associated with vulnerable coronary plaque and greater plaque burden, which were also associated with elevated inflammatory or prothrombotic biomarkers.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Virology
Stephanie Goya, Maria Florencia Lucion, Meghan H. Shilts, Maria del Valle Juarez, Angela Gentile, Alicia S. Mistchenko, Mariana Viegas, Suman R. Das
Summary: Globally, the human respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infections (LRTIs) in children. This study sequenced the complete genomes of RSV from pediatric patients in Buenos Aires and found that RSV-B was dominant from 2014 to 2016 before being abruptly replaced by RSV-A in 2017. The decrease in RSV genomic diversity observed in Buenos Aires in 2016 may have allowed the RSV-A predominance switch in 2017.
Article
Biochemistry & Molecular Biology
Kedir N. Turi, Cole R. Michel, Jonathan Manke, Katrina A. Doenges, Nichole Reisdorph, Alison K. Bauer
Summary: Allergy and asthma pathogenesis are linked to dysregulation of metabolic pathways. This study used a multi-omics approach to investigate the effects of allergen sensitization on metabolic pathways in mice. The results showed that glycerophospholipid and sphingolipid metabolism were affected, with increased levels of certain oxylipins. Gene pathways related to calcium channel, G protein-signaling, and mTORC1 signaling were also upregulated. These findings suggest a role for bioactive lipids in the development of allergy and asthma.