Article
Immunology
Julio Cesar Garcia de Alencar, Claudia de Lucena Moreira, Alicia Dudy Muller, Cleuber Esteves Chaves, Marina Akemi Fukuhara, Elizabeth Aparecida da Silva, Maria de Fatima Silva Miyamoto, Vanusa Barbosa Pinto, Caue Gasparotto Bueno, Felippe Lazar Neto, Luz Marina Gomez Gomez, Maria Clara Saad Menezes, Julio Flavio Meirelles Marchini, Lucas Oliveira Marino, Rodrigo Antonio Brandao Neto, Heraldo Possolo Souza
Summary: The study found that high-dose NAC did not affect the progression of severe COVID-19 in patients. There were no significant differences observed between the group receiving NAC and the placebo group.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Critical Care Medicine
Bruno da Silva Guimaraes, Leonardo Cordeiro de Souza, Hebe Faria Cordeiro, Thiago Loureiro Regis, Cristiane Almeida Leite, Fernanda Patricio Puga, Sergio Hernando Alvim, Jocemir Ronaldo Lugon
Summary: The study showed that inspiratory muscle training program with an electronic resistive loading device led to significant improvements in muscle strength and positive impacts on ICU survival and successful weaning rates.
CRITICAL CARE MEDICINE
(2021)
Article
Critical Care Medicine
Jose Dianti, Samira Fard, Jenna Wong, Timothy C. Y. Chan, Lorenzo Del Sorbo, Eddy Fan, Marcelo B. Passos Amato, John Granton, Lisa Burry, W. Darlene Reid, Binghao Zhang, Damian Ratano, Shaf Keshavjee, Arthur S. Slutsky, Laurent J. Brochard, Niall D. Ferguson, Ewan C. Goligher
Summary: This study aimed to optimize respiratory effort in patients with acute hypoxemic respiratory failure (AHRF) to achieve lung- and diaphragm-protective (LDP) targets. Titrating ventilation and sedation could optimize respiratory effort for lung and diaphragm protection in most patients, and the use of veno-venous extracorporeal membrane oxygenation (VV-ECMO) facilitated the delivery of a LDP strategy. Partial neuromuscular blockade (pNMBA) treatment was effective for patients with excessive respiratory effort.
Article
Nutrition & Dietetics
Josipa Domazet Bugarin, Svjetlana Dosenovic, Darko Ilic, Nikola Delic, Ivana Saric, Ivo Ugrina, Sanda Stojanovic Stipic, Bozidar Duplancic, Lenko Saric
Summary: COVID-19 symptoms range from asymptomatic cases to severe illness requiring hospitalization and intensive care. Low vitamin D levels have been associated with increased severity and mortality of COVID-19. However, this study found no significant benefit of vitamin D supplementation in patients with severe COVID-19 disease admitted to the ICU and in need of respiratory support.
Article
Anesthesiology
Domenico Luca Grieco, Andrea Russo, Gian Marco Anzellotti, Bruno Romano, Filippo Bongiovanni, Antonio M. Dell'Anna, Luigi Mauti, Laura Cascarano, Valerio Gallotta, Tommaso Rosa, Francesco Varone, Luca S. Menga, Lorenzo Polidori, Marco D'Indinosante, Serena Cappuccio, Claudia Galletta, Lucia Tortorella, Barbara Costantini, Salvatore Gueli Alletti, Liliana Sollazzi, Giovanni Scambia, Massimo Antonelli
Summary: The study aimed to assess the effects of a protective ventilation strategy during Trendelenburg pneumoperitoneum surgery on postoperative oxygenation. A randomized trial was conducted with patients randomized into standard ventilation group and protective ventilation group during anesthesia. The results showed that there was no significant difference in PaO2/FiO2 one hour after extubation between the protective ventilation group and the standard ventilation group, but the protective ventilation group exhibited less injurious ventilation during the surgery.
JOURNAL OF CLINICAL ANESTHESIA
(2023)
Article
Critical Care Medicine
Ana Carolina Costa Monteiro, Heidi Flori, Mary K. Dahmer, Myung Shin Sim, Michael W. Quasney, Martha A. Q. Curley, Michael A. Matthay, Anil Sapru
Summary: In children with ARF, plasma sTM levels are associated with mortality and other clinical markers of poor outcomes.
Article
Multidisciplinary Sciences
Wei Zhang, Feifei Liu, Zhanqi Zhao, Chunqing Shao, Xin Xu, Jiajia Ma, Ruquan Han
Summary: This study found that driving pressure-guided positive end expiratory pressure (PEEP) can improve ventilation homogeneity, gas exchange, and respiratory compliance in patients undergoing gynecological laparoscopy.
SCIENTIFIC REPORTS
(2022)
Article
Critical Care Medicine
Raquel F. de Magalhaes, Daniela G. Cruz, Mariana A. Antunes, Marcos V. de S. Fernandes, Milena V. Oliveira, Cassia L. Braga, Joshua Satalin, Penny Andrews, Nader Habashi, Gary Nieman, Cassiano F. Goncalves de-Albuquerque, Adriana R. Silva, Roseli V. Ribeiro, Vera L. Capelozzi, Fernanda F. Cruz, Cynthia dos S. Samary, Patricia R. M. Rocco, Pedro L. Silva
Summary: In an animal study comparing time-controlled adaptive ventilation with volume-controlled ventilation in a Pseudomonas aeruginosa-induced pneumonia model, time-controlled adaptive ventilation showed lower lung damage, bacteremia, and reduced gene expression of inflammatory mediators compared to volume-controlled ventilation with similar mean airway pressure.
CRITICAL CARE MEDICINE
(2021)
Article
Anesthesiology
Almos Schranc, John Diaper, Roberta Suedy, Gergely H. Fodor, Walid Habre, Gergely Albu
Summary: Compared with pressure-regulated volume control (PRVC) ventilation, flow-controlled ventilation (FCV) can significantly improve oxygenation and decrease carbon dioxide levels during one-lung ventilation (OLV), with lower respiratory elastance and peak inspiratory pressure.
ANESTHESIA AND ANALGESIA
(2023)
Article
Biology
M. D. P. Godoy, L. C. de Souza, A. E. da Silva Neto, J. R. Lugon
Summary: The study aimed to determine whether the TIE index predicts successful extubation at a similar rate as the T-piece trial with less time required. A non-inferiority randomized controlled trial was conducted with ICU subjects, with 80 participants allocated to the TIE group and the T-piece group. The results showed that the TIE group had significantly lower time required for successful extubation compared to the T-piece group, and there were no significant differences in successful weaning and survival rate between the two groups.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2023)
Article
Critical Care Medicine
Jonathan D. Casey, Erin M. Vaughan, Bradley D. Lloyd, Peter A. Billas, Karen E. Jackson, Eric J. Hall, Alexandra H. Toporek, Kevin G. Buell, Ryan M. Brown, Roger K. Richardson, J. Craig Rooks, Reagan B. Buie, Li Wang, Christopher J. Lindsell, E. Wesley Ely, Wesley H. Self, Gordon R. Bernard, Todd W. Rice, Matthew W. Semler
Summary: A study conducted at an academic medical center found that providing protocolized postextubation respiratory support to all critically ill patients undergoing extubation did not reduce the rate of reintubation compared to usual care. The primary feature of protocolized support was an increased use of high-flow nasal cannula.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Medicine, General & Internal
Blanca Ayuso Garcia, Alvaro Marchan, Estibaliz Arrieta Ortubay, Cristina Castillo Maza, Eva Romay Lema, Antonio Lalueza, Carlos Lumbreras
Summary: Respiratory failure is a common complication in hospitalized influenza patients, particularly in those with pneumonia and since the 2009 pandemic. However, there is significant heterogeneity in the definition and reporting of respiratory failure, making it difficult to characterize and compare across cohorts and other respiratory viruses.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Immunology
Zachary M. Holliday, Alexander P. Earhart, Mohammed M. Alnijoumi, Armin Krvavac, Lee-Ann H. Allen, Adam G. Schrum
Summary: The study found that dornase alfa can improve oxygenation and decrease lung DNA : MPO complexes in patients with ARDS secondary to COVID-19, showing potential benefits. However, these effects were only effective during the period of drug delivery.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Critical Care Medicine
Bharath A. Chhabria, Kuruswamy Thurai Prasad, Sahajal Dhooria, Valliappan Muthu, Ashutosh Nath Aggarwal, Ritesh Agarwal, Raghava Rao Gandra, Inderpaul Singh Sehgal
Summary: This study compared the efficacy of neurally adjusted ventilator assist (NAVA-NIV) with adaptive support ventilation (ASV-NIV) in non-invasive ventilation (NIV) for patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). The results showed no significant difference between the two methods in reducing NIV failure rates, number of physician manipulations, asynchrony index, and 90-day mortality.
JOURNAL OF CRITICAL CARE
(2023)
Article
Infectious Diseases
Maria Tsilika, Giannoula Thoma, Zoi Aidoni, Georgia Tsaousi, Kyriakos Fotiadis, George Stavrou, Petra Malliou, Angeliki Chorti, Helen Massa, Elli Antypa, Georgia Vasiliadou, Kyriaki Pagdatoglou, Antonios Voudouris, Spyridoula Vasiliagou, Giakoumis Mitos, Ntina Kontopoulou, Niki Paraforou, Eleni Antoniadou, Helen Mouloudi, Eleni Gkeka, Vasilis Grosomanidis, Evangelos J. Giamarellos-Bourboulis, Katerina Kotzampassi
Summary: Probiotic prophylaxis can reduce the incidence of ventilator-associated pneumonia and sepsis in mechanically ventilated multi-trauma patients, as well as shorten hospital stay.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Pediatrics
Manjinder Singh Randhawa, Suresh Kumar Angurana, Karthi Nallasamy, Mahendra Kumar, Namita Ravikumar, Puspraj Awasthi, Arnab Ghosh, R. K. Ratho, Ranjana W. Minz, Rohit Manoj Kumar, Arun Bansal, Muralidharan Jayashree
Summary: This study compared the clinical and laboratory features of children with MIS-C and dengue, and found that MIS-C children were more likely to have rash, conjunctival injection, and oral mucocutaneous changes, while dengue children were more likely to have petechiae, myalgia, and hepatomegaly. Additionally, the levels of CRP and interleukin 6 were also different.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Article
Pediatrics
Suresh Kumar Angurana, Puspraj Awasthi, K. C. Sudeep, Karthi Nallasamy, Arun Bansal, Muralidharan Jayashree
Summary: This study described the clinical and laboratory profile, management, intensive care needs, and outcome of children with toxic shock syndrome (TSS) admitted to a pediatric intensive care unit (PICU) in a tertiary care center in North India. The study found that TSS is not uncommon in children in India, and the management includes early recognition, intensive care, antibiotics, source control, and adjunctive therapy. Multiorgan dysfunction and the need for organ supportive therapies predicted mortality.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Article
Pediatrics
C. R. Vishwa, Raman Sharma, Muralidharan Jayashree, Karthi Nallasamy, Arun Bansal, Suresh Kumar Angurana, Joseph L. Mathew, Naveen Sankhyan, Sourabh Dutta, Sanjay Verma, Rakesh Kumar, Mahesh Devnanai, Pankaj C. Vaidya, Ram Samujh, Mini P. Singh, Kapil Goyal, P. V. M. Lakshmi, Akshay K. Saxena
Summary: This study compared the epidemiological, clinical profile, intensive care needs, and outcomes of children hospitalized with SARS-CoV-2 infection during the first and second waves of the pandemic. The results showed that disease severity, comorbidities, ICU needs, and mortality were similar during both waves. However, children admitted during the second wave were younger, had a higher proportion of NIV use, and shorter length of hospital stay.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Review
Pediatrics
R. Muthuvel, Arun Bansal
Summary: Children with neurological illness in the critical care unit are at higher risk of developing secondary brain injury. Assessment and monitoring of cerebral functional parameters can help improve patient care and neurological outcomes.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Review
Anesthesiology
Saptharishi Lalgudi Ganesan, Laura Hornby, Matthew Weiss, Kirk Dawe, Chelsea Lanos, Krista Wollny, Sonny Dhanani, Teneille Gofton
Summary: This systematic review evaluated the evidence for using different arterial pulse pressure thresholds to confirm permanent cessation of circulation for death determination. The study found that applying any arterial pulse pressure threshold higher than 5 mm Hg may lead to incorrect diagnosis of circulatory death, and there is insufficient evidence to determine a safe pulse pressure threshold between 0 and 5 mm Hg for circulatory death determination.
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
(2023)
Article
Anesthesiology
Nicholas B. Murphy, Charles Weijer, Saptharishi Lalgudi Ganesan, Sonny Dhanani, Teneille Gofton, Marat Slessarev
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
(2023)
Article
Pediatrics
Ashish Agarwal, G. Sathwik, Shankar Prasad, Jerin C. Sekhar, Raman Sharma, Muralidharan Jayashree
Summary: Diabetic ketoacidosis in children can cause various complications, including cerebral edema, acute kidney injury, hypokalemia, and hypoglycemia. Severe symptomatic hypophosphatemia, although rare, can lead to life-threatening complications. The authors present a case of a newly diagnosed T1DM patient who developed severe hypophosphatemia during management, resulting in arrhythmias and cardiac dysfunction, which improved with prompt recognition and correction.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Letter
Pediatrics
Veena Raghunathan, Maninder Dhaliwal, Sunit Singhi
INDIAN JOURNAL OF PEDIATRICS
(2023)
Article
Pediatrics
Surjeet Kumar, Arun Bansal, Lalit Takia, Shankar Prasad, Manpreet Saini, Pooja Chetal, Karthi Nallasamy, Suresh K. Angurana, Prabhjot Malhi, Muralidharan Jayashree
Summary: This study aimed to understand the moral distress experienced by HCWs in the COVID PICU and assess their psychological well-being and coping mechanisms. The most common causes of moral distress were compromised patient care due to lack of resources and caring for too many patients. Psychological stress was found in 23.3% of HCWs, higher in younger HCWs without children. The typical coping mechanisms used by HCWs were seeking help and support, reframing situations, and meditation.
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2023)
Article
Clinical Neurology
Giulia M. Benedetti, Lindsey A. Morgan, Arnold J. Sansevere, Dana B. Harrar, Rejean M. Guerriero, Mark S. Wainwright, Kerri L. LaRovere, Agnieszka Kielian, Saptharishi Lalgudi Ganesan, Craig A. Press
Summary: Continuous electroencephalography (cEEG) is commonly used for neuromonitoring in pediatric intensive care units (PICU). A survey found that over half of the institutions in the survey utilize quantitative EEG (qEEG) in their ICUs. However, the review, reporting, and application of qEEG remain highly variable.
PEDIATRIC NEUROLOGY
(2023)
Article
Clinical Neurology
Angom Kiran Devi, Manjinder Singh Randhawa, Arun Bansal, Suresh Kumar Angurana, Prahbhjot Malhi, Karthi Nallasamy, Muralidharan Jayashree
Summary: This study assessed the long-term outcomes of children with Guillain-Barre syndrome (GBS) in terms of neurological, behavioral, functional, quality of life, and school performance. The majority of children showed favorable outcomes in these areas, but severe clinical presentation and prolonged hospital stay predicted poor long-term outcomes.
PEDIATRIC NEUROLOGY
(2023)
Article
Pediatrics
Ashish Agarwal, Muralidharan Jayashree, Suresh Kumar Angurana, Raman Sharma, Arnab Ghosh, Mini P. Singh, Karthi Nallasamy, Arun Bansal
Summary: This study aimed to investigate the epidemiology of non-COVID-19 respiratory viral infections and their clinical outcomes after the relaxation of non-pharmacological interventions during the COVID-19 pandemic. The results showed a surge in severe acute respiratory illness cases once lockdown measures were relaxed, with nearly 1/3 of patients progressing to multi-organ failure and death. Elevated liver enzymes, hypoxemic respiratory failure at admission, hypotensive shock, and multi-organ dysfunction syndrome predicted mortality.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Letter
Pediatrics
Pooja Khanna, Arjun Parihar, Aditi Gupta, Saurav Yadav, Sunit Chandra Singhi
INDIAN JOURNAL OF PEDIATRICS
(2023)