Article
Oncology
Xin-Wen Zhang, Alexander Wald, Martin Salzmann, Niels Halama, Jessica C. Hassel
Summary: Paraneoplastic leukemoid reaction (PLR) is a rare phenomenon associated with poor prognosis and rapid disease progression in metastasized melanoma. This study analyzed the cytokine concentrations in patients' serum samples during PLR and performed immunohistochemical staining on tumor tissue. The results showed a correlation between tumor burden and neutrophilia, as well as an increase in proinflammatory cytokines, proangiogenic cytokines, and immune stem cell growth factors during PLR. These findings provide a basis for further functional analysis and targeted therapeutic approaches against PLR.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Review
Pathology
Ibrahim Abukhiran, Sarah L. Mott, Andrew M. Bellizzi, Sarag A. Boukhar
Summary: Paraneoplastic leukemoid reaction (PLR), typically associated with carcinoma, has a poor prognosis with an inverse relationship between white blood cell count and survival. Pathologists should pay attention to white blood cell count and consider the possibility of PLR in malignant neoplasms with prominent neutrophilic stroma.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Review
Education, Scientific Disciplines
Weimin Tao, Qin Yan, Yao Zhou, Yanli Wang, Zhiqiang Liu, Zhendong Xu
Summary: Paraneoplastic syndromes are rarely seen in gynecological tumors, especially in endometrial cancer. Early identification and treatment play a significant role in improving the prognosis. This case report highlights the importance of recognizing leukemoid reaction and hypercalcemia as paraneoplastic syndromes in endometrial cancer patients.
Article
Medicine, General & Internal
Ali F. Al Sbihi, Nouraldeen Manasrah, Farah M. Al Haj, Sarah Al Qasem, Joel Appel
Summary: Pulmonary malignancies, especially pulmonary carcinomas, are associated with different paraneoplastic syndromes and have high prevalence. A case of extreme leukocytosis and lung sarcoma confirmed by CT-guided biopsy is presented.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Medicine, General & Internal
Muhammad Usman A. Khan, Abdullah Shehryar, Muhammad Imran, Ch. Muhammad Bilal, Ahmadullah Baig
Summary: This case report describes an unusual paraneoplastic leukemoid response in a rare instance of gallbladder adenosquamous carcinoma. The patient presented with abdominal pain and elevated white cell count, leading to cholecystectomy where the carcinoma was identified. The leukocytosis persisted even after surgery, but unfortunately, the patient passed away before any treatment could be initiated.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Hematology
Lucie Menier, Barbara Foucher
Summary: This case report presents a patient with squamous cell carcinoma who exhibited a significant increase in neutrophils and mild dysmyelopoeisis. After ruling out other potential causes, researchers hypothesized a paraneoplastic leukemoid reaction as the cause of this phenomenon, highlighting the substantial increase in neutrophils that can occur in such reactions.
Article
Medicine, General & Internal
Josef Heusinger, Paul Czech, Heidi Hengstler, Frank Schaumann, Anja Rueckert, Frank Schmid, Joerg Kalla, Uta Diergardt, Hinrich Bremer, Paul La Rosee
Summary: Paraneoplastic hyperleukocytosis in solid tumors is rare and associated with poor prognosis. Specific treatment options are still being investigated.
Article
Veterinary Sciences
Alba L. Gaitan-Cobo, Lynn R. Griffin, Carolynne R. Kruckman-Gatesy
Summary: A 16-year-old castrated male domestic shorthair cat presented with polyuria, polydipsia, and weight loss, which was diagnosed with a pancreatic tumor suspected to be exocrine pancreatic carcinoma. Treatment with SBRT initially showed partial response but later revealed tumor progression and metastasis, leading to a change in cytologic diagnosis and initiation of carboplatin treatment. The cat eventually had to be euthanized due to weakness. Further research is necessary to determine optimal fractionation schedules for SBRT in pancreatic tumors and its effectiveness in treating exocrine pancreatic carcinoma in cats.
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
(2021)
Article
Immunology
Reuben Beer, Cullen O. O'Gorman, Keith Horwood, Stefan Blum
Summary: This case report highlights an isolated case of anti-SOX1 antibodies associated with a rare paraneoplastic peripheral neuropathy in a male breast cancer patient. The patient responded well to treatment with IVIg, but experienced relapse of neuropathy with tumor recurrence, indicating a potential link between SOX1 antibodies and paraneoplastic syndrome in male breast carcinoma.
JOURNAL OF NEUROIMMUNOLOGY
(2021)
Article
Clinical Neurology
Meshari Alsaeed, Chloe A. R. Lim, Alyson Plecash, Tychicus Chen
Summary: Paraneoplastic neurologic syndromes (PNS) are rare but important to recognize, as they can precede the detection of an occult malignancy. It is crucial to consider PNS even in antibody negative cases, and to thoroughly investigate other possible etiologies.
Article
Clinical Neurology
Umberto Pensato, Maria Guarino, Lorenzo Muccioli
Summary: Cancer immunotherapy directly activates the immune system to fight cancer, but may lead to neurological adverse events. Neurologists play a key role in multidisciplinary oncology teams.
FRONTIERS IN NEUROLOGY
(2022)
Article
Immunology
Jingfang Lin, Tianping Yu, Minjin Wang, Jierui Wang, Jinmei Li
Summary: This article reports a case of autoimmune encephalitis caused by appendiceal goblet cell carcinoma. The patient presented with symptoms such as disturbance of consciousness, psychiatric symptoms, cognitive impairment, seizure, and hypotension. Treatment resulted in symptom resolution but recurrence occurred later. Histopathological examination revealed amphiphysin protein expression and immune cell infiltration, suggesting a possible association between amphiphysin-IgG autoimmune encephalitis and appendiceal goblet cell carcinoma.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Laura Burgess, Marissa Keenan, Alan Liang Zhou, Kiefer Lypka, Delvina Hasimja Saraqini, Jeff Yao, Samuel Martin, Christopher Morash, James Watterson, Christina Canil, Robert MacRae
Summary: Approximately 20% of renal cell carcinoma cases are diagnosed due to paraneoplastic manifestations. This case demonstrates that effective sustained treatment for PNS vasculitis caused by oligometastatic RCC is possible with SBRT.
Article
Oncology
Zeynep Ozozen Ayas, Gulgun Uncu
Summary: This article presents a rare case of a patient with paraneoplastic cerebellar degeneration (PCD) and papillary thyroid carcinoma (PTC), highlighting the importance for clinicians to be alert to this rare comorbidity.
Article
Clinical Neurology
Takeshi Imai, Kensuke Shinohara, Kenji Uchino, Hirohisa Okuma, Futaba Maki, Kiyoshi Hiruma, Yasushi Ariizumi, Yoshihisa Yamano
Summary: This case report presents a 60-year-old woman with paraneoplastic cerebellar degeneration (PCD) and anti-Yo antibodies associated with a submandibular gland tumor. Despite various treatments including methylprednisolone, plasma exchange, immunoglobulins, and cyclophosphamide therapy, the patient's symptoms did not improve.
