Article
Clinical Neurology
Xiuyun Liu, Aylin Tekes, Jamie Perin, May W. Chen, Bruno P. Soares, An N. Massaro, Rathinaswamy B. Govindan, Charlamaine Parkinson, Raul Chavez-Valdez, Frances J. Northington, Ken M. Brady, Jennifer K. Lee
Summary: This study suggests that maintaining blood pressure above the optimal mean arterial pressure (MAPopt) during therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy (HIE) may reduce the risk of brain injury. Wavelet methodology and correlation-derived indices may help identify these blood pressure values associated with brain injury, with potential for future randomized studies in neonates with HIE.
FRONTIERS IN NEUROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Gian Pietro Sechi, Flaminia Bardanzellu, Maria Cristina Pintus, Maria Margherita Sechi, Maria Antonietta Marcialis, Vassilios Fanos
Summary: This review discusses the potential therapeutic role of thiamine and its derivatives in the management of neonatal hypoxic-ischemic encephalopathy (HIE), highlighting its antioxidant properties and ability to rescue mitochondrial function. It suggests a synergistic effect between thiamine treatment and therapeutic hypothermia.
Review
Pediatrics
Suresh Victor, Eridan Rocha-Ferreira, Ahad Rahim, Henrik Hagberg, David Edwards
Summary: Around 0.75 million babies suffer from HIE each year, leading to neurodevelopmental impairment. Therapeutic hypothermia is effective but improvements are needed. Challenges for the next decade include better animal models, industry support, and well-designed clinical trials to enhance treatment outcomes.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Medicine, General & Internal
Inn-Chi Lee, Swee-Hee Wong, Xing-An Wang, Chin-Sheng Yu
Summary: The study found that the combination of lactate and LDH within 6 hours of birth can effectively diagnose HIE in neonates. Using combined biomarkers can improve the accuracy of predicting moderate or severe HIE, making it a feasible approach for early treatment.
Review
Pediatrics
Cristina Tuoni, Giulia Nuzzi, Rosa Teresa Scaramuzzo, Simona Fiori, Luca Filippi
Summary: Carbon monoxide poisoning during pregnancy can have severe adverse effects on both the mother and fetus. Recognition and timely treatment are crucial. This study reports a case of a preterm newborn exposed to CO in-utero due to a boiler explosion, resulting in neurological complications.
FRONTIERS IN PEDIATRICS
(2023)
Article
Pediatrics
Arthur Lenahan, Ulrike Mietzsch, Thomas R. Wood, Katharine Press Callahan, Elliott M. Weiss, Danny E. Miller, Kendell German, Niranjana Natarajan, Mihai Puia-Dumitrescu, Valentine Esposito, Sarah Kolnik, Janessa B. Law
Summary: This retrospective cohort study examined the presentation and evaluation of infants with non-HIE neonatal encephalopathy (NE), as well as the genetic abnormalities identified. The most common symptom of non-HIE NE was abnormal tone, and the mortality rate was 10%. Nearly half of the survivors required medical equipment at discharge. Genetic testing was performed in 40% of the patients and resulted in diagnostic rates of 10%, 41%, and 69%. The study provides valuable insights into the genetic conditions underlying non-HIE NE.
JOURNAL OF PEDIATRICS
(2023)
Article
Chemistry, Physical
Xiao Zhang, Nan Guo, Shuhong Yang, Huma Khan, Weiqiang Zhang
Summary: The poor water solubility and instability of Ru(II) carbonyl complex restrict its use as CO-releasing materials (CO-RMs) for therapeutic applications. In this study, a robust Ru(I) carbonyl sawhorse skeleton was modified with a water-soluble PEGylated sidearm to enhance the hydrophilicity and bioactivity of CO. The results showed that both the bridging carboxylate ligands and PEGylated axial ligands regulate the hydrophilicity of the CO-RMs. CO-RM 4-13 exhibited sustained release of therapeutic amounts of CO under photolysis conditions. The more hydrophilic CO-RMs released CO at a faster rate, as demonstrated by the correlation between CO release kinetics and hydrophilicity. Additionally, the low cytotoxic CO-RM 4 displayed specific anticancer activity against HT-29 tumor cells.
Article
Biochemistry & Molecular Biology
Katarina Esih, Katja Goricar, Zvonka Rener-Primec, Vita Dolzan, Aneta Soltirovska-Salamon
Summary: Genetic variability in inflammation- and antioxidant-related pathways may influence the response to hypoxic-ischemic brain injury in newborns, with certain polymorphisms being associated with specific brain injury patterns identified by MRI.
Article
Biochemistry & Molecular Biology
Katarina Esih, Katja Goricar, Aneta Soltirovska-Salamon, Vita Dolzan, Zvonka Rener-Primec
Summary: The study revealed that genetic variability in antioxidant and inflammatory pathways may be associated with epilepsy development in newborns treated with therapeutic hypothermia after HIE. Interaction between specific genetic polymorphisms could influence the risk of epilepsy in these newborns.
Article
Chemistry, Multidisciplinary
Songjiao Li, Ke Yang, Jiayu Zeng, Yiteng Ding, Dan Cheng, Longwei He
Summary: In this study, a Golgi-targetable fluorescent probe for detecting CORM-3 was proposed, and the change of CORM-3 in different cells and animal models was successfully monitored. This study provides important information for the study of CORM-3 in vivo systems.
Review
Biochemistry & Molecular Biology
Yue Zhou, Luqiang Sun, Haichuan Wang
Summary: The prevalence of neonatal hypoxic-ischemic encephalopathy (HIE) is increasing, leading to the need for effective treatments and preventions. Research has focused on understanding the underlying pathology and the potential of dietary interventions, such as a ketogenic diet (KD). The KD has shown promising effects in animal models and brain injury patients, including potential neuroprotection and improvement of mitochondrial function.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Behavioral Sciences
Tayla R. Penny, Yen Pham, Amy E. Sutherland, Madeleine J. Smith, Joohyung Lee, Graham Jenkin, Michael C. Fahey, Suzanne L. Miller, Courtney A. McDonald
Summary: This study identified specific cognitive and motor deficits tests in a neonatal hypoxic ischemic rat model. Due to high variability in the model, significant impairment is not always observed in individual tests, but by combining outcomes, long-term behavioral burden can be measured.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Cell Biology
Nurul Ajilah Mohamed Khir, Ain' Sabreena Mohd Noh, Idris Long, Rahimah Zakaria, Che Aishah Nazariah Ismail
Summary: The role of carbon monoxide (CO) in regulating neurotransmitters and neuropeptides in the nervous system is still controversial. Exogenous CO gas inhalation has shown protective effects against pathological conditions, but its therapeutic use is limited due to the generation of toxic carboxyhaemoglobin. To overcome this limitation, a controlled-release CO molecule called CORM-2 has been developed. This review focuses on the potential mechanisms of CORM-2 in reducing pain, particularly in chronic and neuropathic pain.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Pediatrics
Adrienne Bingham, Fusun Gundogan, Katherine Rand, Jessica Farrar, Richard Tucker, Abbot R. Laptook
Summary: The study found that the odds of maternal and fetal vascular malperfusion were higher in the HIE group, as well as the odds of acute chorioamnionitis. The rate of absence of placental findings was lowest in the HIE group.
JOURNAL OF PEDIATRICS
(2022)
Review
Pediatrics
Dianne G. Kleuskens, Filipe Goncalves Costa, Kim V. Annink, Agnes van den Hoogen, Thomas Alderliesten, Floris Groenendaal, Manon J. N. Benders, Jeroen Dudink
Summary: Cerebral hyperperfusion is a major complication in neonates with HIE, typically occurring within 10-30 minutes after the hypoxic-ischemic event and persisting up to 10 days and even 1 month after birth. This process is characterized by angiogenesis and cerebral vasodilation, mediated by endogenous pathways.
FRONTIERS IN PEDIATRICS
(2021)