HDL protects against doxorubicin-induced cardiotoxicity in a scavenger receptor class B type 1-, PI3K-, and Akt-dependent manner

Diabetes Mellitus Is Associated With Reduced High-Density Lipoprotein Sphingosine-1-Phosphate Content and Impaired High-Density Lipoprotein Cardiac Cell ProtectionSignificance

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S1P in HDL promotes interaction between SR-BI and S1PR1 and activates S1PR1-mediated biological functions: calcium flux and S1PR1 internalization

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Apolipoprotein a1 increases mitochondrial biogenesis through AMP-activated protein kinase

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Regulation of High-Density Lipoprotein on Hematopoietic Stem/Progenitor Cells in Atherosclerosis Requires Scavenger Receptor Type BI Expression

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High Density Lipoprotein Stimulated Migration of Macrophages Depends on the Scavenger Receptor Class B, Type I, PDZK1 and Akt1 and Is Blocked by Sphingosine 1 Phosphate Receptor Antagonists

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Cancer Therapy–Induced Cardiotoxicity: Basic Mechanisms and Potential Cardioprotective Therapies

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Both aerobic exercise and resveratrol supplementation attenuate doxorubicin-induced cardiac injury in mice

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Beneficial effects of selective HDL-raising gene transfer on survival, cardiac remodelling and cardiac function after myocardial infarction in mice

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The Cardioprotective Protein Apolipoprotein A1 Promotes Potent Anti-tumorigenic Effects

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Delivery of hydrophilic drug doxorubicin hydrochloride-targeted liver using apoAI as carrier

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Regulation of signal transduction by HDL

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Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36

(2013) Dante Neculai et al.   NATURE

High-Density Lipoproteins Inhibit Vascular Endothelial Inflammation by Increasing 3β-Hydroxysteroid-Δ24 Reductase Expression and Inducing Heme Oxygenase-1

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An apoA-I mimetic peptide facilitates off-loading cholesterol from HDL to liver cells through scavenger receptor BI

(2012) Xuelei Song et al.   International Journal of Biological Sciences

High density lipoprotein cholesterol promotes the proliferation of bone-derived mesenchymal stem cells via binding scavenger receptor-B type I and activation of PI3K/Akt, MAPK/ERK1/2 pathways

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Crystal Structure of a Lipid G Protein-Coupled Receptor

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Thrombopoietin protects against doxorubicin-induced cardiomyopathy, improves cardiac function, and reversely alters specific signalling networks

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Adiponectin Ameliorates Doxorubicin-induced Cardiotoxicity through Akt Protein-dependent Mechanism

(2011) Sonomi Maruyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Akt1 isoform is an essential mediator of ischaemic preconditioning

(2011) Suma P. Kunuthur et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Myocardial AKT: The Omnipresent Nexus

(2011) Mark A. Sussman et al.   PHYSIOLOGICAL REVIEWS

Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M

(2011) C. Christoffersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-density lipoprotein determines adult mouse cardiomyocyte fate after hypoxia-reoxygenation through lipoprotein-associated sphingosine 1-phosphate

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A role for the scavenger receptor, class B type I in high density lipoprotein dependent activation of cellular signaling pathways

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Cardiac regulation by phosphoinositide 3-kinases and PTEN

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Native and reconstituted HDL protect cardiomyocytes from doxorubicin-induced apoptosis

(2009) Miguel A. Frias et al.   CARDIOVASCULAR RESEARCH

JAK/STAT and PI3K/AKT Pathways Form a Mutual Transactivation Loop and Afford Resistance to Oxidative Stress-Induced Apoptosis in Cardiomyocytes

(2008) Yanjie Lu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY