Platelet procoagulant phenotype is modulated by a p38-MK2 axis that regulates RTN4/Nogo proximal to the endoplasmic reticulum: utility of pathway analysis

Temporal contribution of the platelet body and balloon to thrombin generation

(2017) Ejaife O. Agbani et al.   HAEMATOLOGICA

New Concepts and Mechanisms of Platelet Activation Signaling

(2017) Brian Estevez et al.   PHYSIOLOGY

Potentiation of TRAP-6-induced platelet dense granule release by blockade of P2Y12 signaling with MRS2395

(2017) Annachiara Mitrugno et al.   PLATELETS

p38 mitogen-activated protein kinase regulates mitochondrial function and microvesicle release in riboflavin- and ultraviolet light-treated apheresis platelet concentrates

(2017) Zhongming Chen et al.   TRANSFUSION

Temporal contribution of the platelet body and balloon to thrombin generation

(2017) Ejaife O. Agbani et al.   HAEMATOLOGICA

Heat shock protein 70 regulates platelet integrin activation, granule secretion and aggregation

(2016) Rachel A. Rigg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Ask1 regulates murine platelet granule secretion, thromboxane A2generation, and thrombus formation

(2016) Meghna U. Naik et al.   BLOOD

Temporal quantitative phosphoproteomics of ADP stimulation reveals novel central nodes in platelet activation and inhibition

(2016) Florian Beck et al.   BLOOD

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics

(2016) Najoua Lalaoui et al.   CANCER CELL

Dynamics of calcium spiking, mitochondrial collapse and phosphatidylserine exposure in platelet subpopulations during activation

(2016) S. I. Obydennyy et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Platelet Physiology

(2016) Andrew Frelinger et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Lysine acetyltransfer supports platelet function

(2015) J. E. Aslan et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

p38- and MK2-dependent signalling promotes stress-induced centriolar satellite remodelling via 14-3-3-dependent sequestration of CEP131/AZI1

(2015) Maxim A. X. Tollenaere et al.   Nature Communications

A systems approach to hemostasis: 3. Thrombus consolidation regulates intrathrombus solute transport and local thrombin activity

(2014) T. J. Stalker et al.   BLOOD

Integrating biological pathways and genomic profiles with ChiBE 2

(2014) Özgün Babur et al.   BMC GENOMICS

What Can Proteomics Tell Us About Platelets?

(2014) Julia M. Burkhart et al.   CIRCULATION RESEARCH

Reticulon 4 Is Necessary for Endoplasmic Reticulum Tubulation, STIM1-Orai1 Coupling, and Store-operated Calcium Entry

(2014) Levente Jozsef et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PhosphoSitePlus, 2014: mutations, PTMs and recalibrations

(2014) Peter V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

STRING v10: protein–protein interaction networks, integrated over the tree of life

(2014) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

p21 Activated Kinase Signaling Coordinates Glycoprotein Receptor VI–Mediated Platelet Aggregation, Lamellipodia Formation, and Aggregate Stability Under Shear

(2013) Joseph E. Aslan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Pattern search in BioPAX models

(2013) Özgün Babur et al.   BIOINFORMATICS

Dual role of the p38 MAPK/cPLA 2 pathway in the regulation of platelet apoptosis induced by ABT-737 and strong platelet agonists

(2013) N Rukoyatkina et al.   Cell Death & Disease

Using Biological Pathway Data with Paxtools

(2013) Emek Demir et al.   PLoS Computational Biology

The first comprehensive and quantitative analysis of human platelet protein composition allows the comparative analysis of structural and functional pathways

(2012) J. M. Burkhart et al.   BLOOD

Phospho-Bcl-xL(Ser62) plays a key role at DNA damage-induced G2checkpoint

(2012) Jianfang Wang et al.   CELL CYCLE

Reactome - a curated knowledgebase of biological pathways: megakaryocytes and platelets

(2012) S. JUPE et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The integration of proteomics and systems approaches to map regulatory mechanisms underpinning platelet function

(2012) Bernice Wright et al.   Proteomics Clinical Applications

S6K1 and mTOR regulate Rac1-driven platelet activation and aggregation

(2011) J. E. Aslan et al.   BLOOD

Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets

(2011) S. M. Schoenwaelder et al.   BLOOD

PlateletWeb: a systems biologic analysis of signaling networks in human platelets

(2011) D. Boyanova et al.   BLOOD

The Role of Nogo and the Mitochondria-Endoplasmic Reticulum Unit in Pulmonary Hypertension

(2011) G. Sutendra et al.   Science Translational Medicine

Signaling During Platelet Adhesion and Activation

(2010) Zhenyu Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mechanisms and functions of p38 MAPK signalling

(2010) Ana Cuadrado et al.   BIOCHEMICAL JOURNAL

Pathway Commons, a web resource for biological pathway data

(2010) E. G. Cerami et al.   NUCLEIC ACIDS RESEARCH

ChiBE: interactive visualization and manipulation of BioPAX pathway models

(2009) Ozgun Babur et al.   BIOINFORMATICS

p38 mitogen-activated protein kinase activation during platelet storage: consequences for platelet recovery and hemostatic function in vivo

(2009) M. Canault et al.   BLOOD

Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function

(2009) S. M. Schoenwaelder et al.   BLOOD

Oxidative stress activates ADAM17/TACE and induces its target receptor shedding in platelets in a p38-dependent fashion

(2009) A. Brill et al.   CARDIOVASCULAR RESEARCH

Calcium signaling in platelets

(2009) D. VARGA-SZABO et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Death by Committee: Organellar Trafficking and Communication in Apoptosis

(2009) Joseph E. Aslan et al.   TRAFFIC

HSP27 phosphorylation is correlated with ADP-induced platelet granule secretion

(2008) Hisaaki Kato et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Cell autonomous function of nogo and reticulons: The emerging story at the endoplasmic reticulum

(2008) Felicia Yu Hsuan Teng et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mitogen-activated protein kinases in hemostasis and thrombosis

(2008) F. ADAM et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Mitofusin 2 tethers endoplasmic reticulum to mitochondria

(2008) Olga Martins de Brito et al.   NATURE

Omics meets hypothesis-driven research

(2008) Jean-Daniel Tissot et al.   THROMBOSIS AND HAEMOSTASIS