Article
Multidisciplinary Sciences
Radhika Nair, Robert Sarmiento, Asif Sheriff, Ashfaq Shuaib, Brian Buck, Michel Gauthier, Vivian Mushahwar, Martin Ferguson-Pell, Mahesh Kate
Summary: Background Remote ischemic conditioning (RIC) is delivered by a blood pressure cuff over the limb, raising pressure 50 mmHg above the systolic blood pressure, to a maximum of 200 mmHg. The cuff is inflated for five minutes and then deflated for five minutes in a sequential ischemia-reperfusion cycle 4-5 times per session. The feasibility of RIC delivered together with a tissue reflectance sensor in patients with acute ischemic stroke (AIS) and small vessel disease will be tested in a prospective, single-center, randomized control trial.
Article
Immunology
Na Li, Stefanie Steiger, Lingyan Fei, Chenyu Li, Chongxu Shi, Natallia Salei, Barbara U. Schraml, Zhihua Zheng, Hans-Joachim Anders, Julia Lichtnekert
Summary: Our study found that IRF8 is essential for kidney cDC1s, which have a mild protective effect against post-ischemic AKI/AKD, possibly by suppressing tissue inflammation and damage, indicating an immunoregulatory role for cDC1s.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Clinical Neurology
Longfei Wu, Ming Wei, Bohao Zhang, Bowei Zhang, Jian Chen, Sifei Wang, Leilei Luo, Shuling Liu, Sijie Li, Changhong Ren, David C. Hess, Haiqing Song, Wenbo Zhao, Xunming Ji
Summary: This study investigated the safety and tolerability of direct ischemic postconditioning (IPostC) in both a dog model and patients with acute ischemic stroke treated with thrombectomy, and found it to be safe, feasible, and tolerable.
Article
Sport Sciences
Samuel Pietsch, Brady Green, Anthony G. Schache, Tania Pizzari
Summary: Quadriceps muscle strain injuries (QMSI) in elite Australian Football League (AFL) players primarily occur in the dominant leg and result in longer recovery time frames, especially for rectus femoris injuries.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Article
Physiology
Jeffeson Hildo Medeiros de Queiroz, Joao Paulo Frota, Filipe Abdala dos Reis, Rodrigo Ribeiro de Oliveira
Summary: The purpose of this study was to develop and validate the Brazilian Adductor Performance Test (BAPT) for predicting hip adductor muscle injuries in elite soccer athletes. A total of 108 soccer athletes were assessed, and the BAPT scores were compared between injured and uninjured athletes. The results showed that low BAPT scores increased the chance of injury, and the cutoff point for the number of repetitions in the BAPT was identified. The BAPT can be used to identify athletes at risk of hip adductor muscle injuries, potentially reducing the rate of this injury in soccer clubs.
INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE
(2023)
Article
Microbiology
Lin Zhao, Jing Han, Jiaqi Liu, Kechen Fan, Tianjie Yuan, Ju Han, Liangliang Chen, Sen Zhang, Ming Zhao, Jinao Duan
Summary: Natural flavonoids formononetin and ononin possess various health benefits, but succinylation modification provides a solution to overcome their limitations. The new compound FMP shows significant effects on myocardial ischemia, with high water solubility and low toxicity.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Sport Sciences
Naokazu Miyamoto, Kosuke Hirata
Summary: The study found that differences in muscle stiffness and proximal aponeurosis strain of the biceps femoris long head are minimal across different sites, and there is no exceptional muscle stiffness and proximal aponeurosis strain at moderate-to-high contraction intensity where sprinting-type hamstring strain typically occurs.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2021)
Article
Biochemistry & Molecular Biology
Lini Jin, Binfeng Yu, Hongju Wang, Lingling Shi, Jingjuan Yang, Longlong Wu, Cui Gao, Hong Pan, Fei Han, Weiqiang Lin, En Yin Lai, Yong-Fei Wang, Yi Yang
Summary: This study demonstrates that STING plays a critical role in ferroptosis during ischemic acute kidney injury. It facilitates NCOA4-mediated ferritinophagy, leading to iron overload and exacerbating renal dysfunction.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Multidisciplinary Sciences
Jiqing Zheng, Shuiming Luo, Yaobin Long
Summary: This study investigates the expression and effect of hsa_circ_0004099 in acute ischemic stroke (AIS). The results showed a negative correlation between hsa_circ_0004099 levels and disease severity score and infarct time, indicating its potential as a clinical diagnostic marker. Bioinformatic analysis revealed its enrichment in cancer pathways and its interaction with core proteins. This study provides new insights into the diagnosis and treatment of AIS.
Article
Biochemistry & Molecular Biology
Henning T. Langer, Agata A. Mossakowski, Alec M. Avey, Ross P. Wohlgemuth, Lucas R. Smith, Herman Zbinden-Foncea, Keith Baar
Summary: The study suggests that rats with the R349P Des mutation have a lower susceptibility to structural muscle damage of the cytoskeleton and sarcolemma with acute eccentric loading.
Article
Neurosciences
Longfei Wu, Bohao Zhang, Wenbo Zhao, Xunming Ji, Ming Wei
Summary: This study aims to determine the safety, tolerability, and maximum tolerable duration of ischemic post-conditioning in patients with acute ischemic stroke receiving mechanical thrombectomy. The study will provide valuable information for future research on the efficacy of ischemic post-conditioning.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Rashi Krishnan, William Mays, Lucas Elijovich
Summary: Multiple randomized clinical trials have supported the use of mechanical thrombectomy as standard care in the treatment of acute ischemic stroke caused by large vessel occlusion. Early recognition and active management of post-thrombectomy complications are crucial for improving neurological outcomes.
Review
Orthopedics
Samuel Pietsch, Tania Pizzari
Summary: Previous quadriceps injury, recent hamstring injury, the dominant kicking leg, and competitive match play were identified as the strongest risk factors for future quadriceps muscle injury in sport.
JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY
(2022)
Article
Medicine, Research & Experimental
Justin Davis, Ahmad Chouman, Jeffery Creech, Andre Monteiro da Rocha, Daniela Ponce-Balbuena, Eric N. Jimenez Vazquez, Ruthann Nichols, Andrey Lozhkin, Nageswara R. Madamanchi, Katherine F. Campbell, Todd J. Herron
Summary: A model of ischemic heart disease was successfully created using human induced pluripotent stem cell-derived cardiomyocytes, exhibiting many characteristics similar to ischemic cardiomyocytes. This provides a new opportunity for the study of human ischemic heart disease.
Article
Immunology
Jiefu Zhu, Yafei Zhang, Lang Shi, Yao Xia, Hongchu Zha, Huimin Li, Zhixia Song
Summary: This study reveals the protective role of RP105 in ischemic and septic acute kidney injury (AKI). Overexpression of RP105 alleviated renal structural injuries and dysfunction caused by ischemic and septic AKI. RP105 suppressed inflammatory responses mediated by the TLR4 signaling pathway. These findings suggest that RP105 could be a potential target for preventing and treating ischemic and septic AKI.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Physiology
Terence E. Ryan, Cameron A. Schmidt, Tom D. Green, David A. Brown, P. Darrell Neufer, Joseph M. McClung
FRONTIERS IN PHYSIOLOGY
(2015)
Article
Physiology
Joseph M. McClung, Jessica L. Reinardy, Sarah B. Mueller, Timothy J. McCord, Christopher D. Kontos, David A. Brown, Sabah N. A. Hussain, Cameron A. Schmidt, Terence E. Ryan, Tom D. Green
FRONTIERS IN PHYSIOLOGY
(2015)
Article
Endocrinology & Metabolism
Terence E. Ryan, Cameron A. Schmidt, Thomas D. Green, Espen E. Spangenburg, P. Darrell Neufer, Joseph M. McClung
Article
Cardiac & Cardiovascular Systems
Terence E. Ryan, Cameron A. Schmidt, Rick J. Alleman, Alvin M. Tsang, Thomas D. Green, P. Darrell Neufer, David A. Brown, Joseph M. McClung
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2016)
Article
Surgery
Joseph M. McClung, Timothy J. McCord, Kevin Southerland, Cameron A. Schmidt, Michael E. Padgett, Terence E. Ryan, Christopher D. Kontos
JOURNAL OF VASCULAR SURGERY
(2016)
Article
Surgery
Cameron A. Schmidt, Terence E. Ryan, Chien-Te Lin, Melissa M. R. Inigo, Tom D. Green, Jeffrey J. Brault, Espen E. Spangenburg, Joseph M. McClung
JOURNAL OF VASCULAR SURGERY
(2017)
Article
Cell Biology
Michael D. Tarpey, Adam J. Amorese, Nicholas P. Balestrieri, Terence E. Ryan, Cameron A. Schmidt, Joseph M. McClung, Espen E. Spangenburg
Article
Neurosciences
Brenton T. Laing, Peixin Li, Cameron A. Schmidt, Wyatt Bunner, Yuan Yuan, Taylor Landry, Amber Prete, Joseph M. McClung, Hu Huang
FRONTIERS IN CELLULAR NEUROSCIENCE
(2018)
Article
Multidisciplinary Sciences
Cameron A. Schmidt, Emma J. Goldberg, Tom D. Green, Reema R. Karnekar, Jeffrey J. Brault, Spencer G. Miller, Adam J. Amorese, Dean J. Yamaguchi, Espen E. Spangenburg, Joseph M. McClung
Article
Peripheral Vascular Disease
Zoe S. Terwilliger, Terence E. Ryan, Emma J. Goldberg, Cameron A. Schmidt, Dean J. Yamaguchi, Reema Karnekar, Patricia Brophy, Thomas D. Green, Tonya N. Zeczycki, Feilim Mac Gabhann, Brian H. Annex, Joseph M. McClung
Summary: CLI is the most severe manifestation of PAD with higher prevalence in Black patients. Differences in bioenergetic paradigm and alterations in specific pathways were observed in the limb muscles of Black individuals with CLI.
Review
Biochemistry & Molecular Biology
Cameron A. Schmidt
Summary: Mitochondria play a central role in the physiology and survival of eukaryotic cells. Small molecules that modulate mitochondrial metabolism can have complex systemic effects. This article reviews the effects of prescription drugs on mitochondrial metabolism, discusses qualitative models of drug-mitochondria interactions, and highlights specific drug classes for further discussion.
BIOSCIENCE REPORTS
(2022)
Review
Clinical Neurology
Cameron Schmidt, Arada Chaiyamoon, Juan J. Cardona, Mansour Mathkour, Tyler Scullen, Joe Iwanaga, James Kalyvas, Ana Carrera, Francisco Reina, Aaron S. Dumont, R. Shane Tubbs
Summary: This study examines the discrepancies in terminology regarding the pedicle, pars interarticularis, and isthmus of C2 vertebra and proposes new terminology based on anatomical study. The results show that C2 has no isthmus and a very short pars interarticularis. Therefore, it is suggested to use the more accurate term "pedicle" to describe the unique structure of C2 vertebra.
ACTA NEUROCHIRURGICA
(2023)
Article
Medicine, Research & Experimental
Terence E. Ryan, Dean J. Yamaguchi, Cameron A. Schmidt, Tonya N. Zeczycki, Saame Raza Shaikh, Patricia Brophy, Thomas D. Green, Michael D. Tarpey, Reema Karnekar, Emma J. Goldberg, Genevieve C. Sparagna, Maria J. Torres, Brian H. Annex, P. Darrell Neuter, Espen E. Spangenburg, Joseph M. McClung
Article
Cardiac & Cardiovascular Systems
Joseph M. McClung, Timothy J. McCord, Terence E. Ryan, Cameron A. Schmidt, Tom D. Green, Kevin W. Southerland, Jessica L. Reinardy, Sarah B. Mueller, Talaignair N. Venkatraman, Christopher D. Lascola, Sehoon Keum, Douglas A. Marchuk, Espen E. Spangenburg, Ayotunde Dokun, Brian H. Annex, Christopher D. Kontos