Review
Ophthalmology
Gurkaran S. Sarohia, Keean Nanji, Mohammad Khan, Muhammad F. Khalid, Daniel Rosenberg, Deven M. Deonarain, Mark R. Phillips, Lehana Thabane, Peter K. Kaiser, Sunir J. Garg, Sobha Sivaprasad, Charles C. Wykoff, Varun Chaudhary
Summary: This study compared different treatment protocols for anti-vascular endothelial growth factor (Anti-VEGF) agents in diabetic macular edema. The results showed that visual acuity and anatomic outcomes at 12 and 24 months were similar between treat-and-extend (T&E) with fixed or pro re nata (PRN) regimens.
SURVEY OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Yuyako Nakano, Jun Takeuchi, Etsuyo Horiguchi, Hikaru Ota, Yosuke Taki, Yasuki Ito, Hiroko Terasaki, Koji M. Nishiguchi, Keiko Kataoka
Summary: This study aimed to examine the morphologic changes in macular neovascularization (MNV) secondary to age-related macular degeneration after 2 years of aflibercept treatment under a treat-and-extend (T&E) regimen. The medical records of 26 eyes of 25 patients with treatment-naive neovascular age-related macular degeneration were analyzed retrospectively, and these patients were treated with aflibercept under a treat-and-extend regimen for 2 years. Swept-source optical coherence tomography angiography was used to assess the areas of the MNV and vascular structures at baseline and after 2 years of treatment. The results showed that the MNV area increased significantly after 2 years of treatment, and the baseline MNV area was negatively correlated with the change ratio of the MNV areas at 2 years and baseline.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2023)
Review
Ophthalmology
Sheng Yang Lim, Wendy Meihua Wong, Ivan Seah, Hwei Wuen Chan, Xinyi Su, Gopal Lingam, Yew Sen Yuen
Summary: This meta-analysis evaluated the outcomes of treat and extend (T&E) regimen in the treatment of CI-DMO. The results showed that T&E did not reduce the number of injections compared to landmark clinical trials, and the visual and anatomical outcomes in the first year were limited. However, T&E approach could reduce patient visits and treatment burden.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Medicine, General & Internal
Huixun Jia, Bing Lu, Yuanzhi Yuan, Fei Yuan, Lei Li, Yanping Song, Ao Rong, Minwen Zhou, Fenghua Wang, Xiaodong Sun
Summary: This study compared the efficacy and safety of conbercept using a T&E regimen vs. a PRN regimen in Chinese patients with nAMD. The results showed that the T&E regimen was not non-inferior to the PRN regimen in terms of BCVA outcomes, and the rates of adverse events were comparable in both treatment groups.
FRONTIERS IN MEDICINE
(2022)
Article
Chemistry, Medicinal
Wataru Kikushima, Yoichi Sakurada, Yoshiko Fukuda, Mio Matsubara, Yumi Kotoda, Atsushi Sugiyama, Kenji Kashiwagi
Summary: This study aimed to investigate the effectiveness of a treat-and-extend regimen of intravitreal brolucizumab for eyes with exudative AMD refractory to aflibercept. The study found that after switching to brolucizumab, the follow-up interval significantly extended and 43% of the eyes achieved the desired treatment outcome at 12 months, but the best-corrected visual acuity did not improve.
Article
Ophthalmology
S. W. Quist, L. A. de Jong, F. van Asten, P. Knoester, M. J. Postma, R. D. Freriks
Summary: Although intraocular anti-vascular endothelial growth factors (anti-VEGFs) are effective in treating neovascular age-related macular degeneration (nAMD), the burden on the healthcare system is considerable. A treat-and-extend (T&E) regimen can help optimise nAMD treatment by reducing the number of injections. Bevacizumab is the cheapest treatment option, with aflibercept and ranibizumab following as the second and third choices.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Multidisciplinary Sciences
Takao Hirano, Yuichi Toriyama, Yoshihiro Takamura, Masahiko Sugimoto, Taiji Nagaoka, Yoshimi Sugiura, Fumiki Okamoto, Michiyuki Saito, Kousuke Noda, Shigeo Yoshida, Akihiro Ishibazawa, Osamu Sawada, Toshinori Murata
Summary: This study demonstrated that a 2-year treat-and-extend aflibercept regimen, combined with adjunct focal/grid laser, could effectively improve BCVA and CST in patients with diabetic macula edema.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Aki Kato, Tsutomu Yasukawa, Iichiro Sugita, Munenori Yoshida, Miho Nozaki, Yoshio Hirano, Junko Kondo, Tomohiro Abe, Kimiko Sugita, Takahide Okita, Hiroshi Morita, Noriaki Takase, Yuichiro Ogura
Summary: The study found that the TAE regimen of intravitreal ranibizumab injections can reduce the mental burden associated with disease relapse in nvAMD patients. Most patients were able to adhere to the TAE regimen for one year, with improvements in visual acuity and significantly decreased anxiety and depression scores.
ADVANCES IN THERAPY
(2022)
Article
Ophthalmology
Emilien Faudi, Anne-Sophie Gauthier, Bernard Delbosc, Maher Saleh
Summary: The study compared the outcomes of pro re nata (PRN) and treat and extend (T&E) regimens in patients previously treated for neovascular age-related macular degeneration (nAMD). The results showed that both regimens were non-inferior in terms of visual and anatomical outcomes at 24 months, but the T&E regimen required significantly more injections.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Multidisciplinary Sciences
Hidetaka Matsumoto, Junki Hoshino, Kosuke Nakamura, Hideo Akiyama
Summary: This study evaluated the second-year results of a treat-and-extend regimen with intravitreal brolucizumab for type 1 macular neovascularization associated with treatment-naive neovascular age-related macular degeneration. The results showed that the TAE therapy effectively maintained the improved visual acuity and the diminished exudative changes in the second year, as well as reduced the treatment burden for patients. The risk of developing brolucizumab-related intraocular inflammation appeared to be very low during the second year of this regimen.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Hidetaka Matsumoto, Junki Hoshino, Ryo Mukai, Kosuke Nakamura, Hideo Akiyama
Summary: The use of brolucizumab in the treatment of nAMD shows significant improvements in visual acuity and reductions in retinal thickness and choroidal thickness. It also has the potential to reduce the treatment burden and regress polypoidal lesions.
SCIENTIFIC REPORTS
(2022)
Review
Ophthalmology
Matteo Fallico, Andrew J. Lotery, Antonio Longo, Teresio Avitabile, Vincenza Bonfiglio, Andrea Russo, Nicolo Castellino, Guglielmo Parisi, Alfredo Pulvirenti, Chiara Eandi, Gilda Cennamo, Claudio Furino, Maria Vittoria Cicinelli, Camilla Alovisi, Michele Reibaldi
Summary: In the treatment of neovascular age-related macular degeneration, T&E and fixed dosage protocols showed no difference in visual improvement and retinal thickness change, however, the T&E regimen required a lower number of injections.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2021)
Review
Ophthalmology
Cheng-Kuo Cheng, Shih-Jen Chen, Jiann-Torng Chen, Lee-Jen Chen, San-Ni Chen, Wen-Lu Chen, Sheng-Min Hsu, Chien-Hsiung Lai, Shwu-Jiuan Sheu, Pei-Chang Wu, Wei-Chi Wu, Wen-Chuan Wu, Chung-May Yang, Ling Yeung, Ta-Ching Chen, Chang-Hao Yang
Summary: The treat-and-extend approach with anti-VEGF agents is an effective strategy to manage neovascular age-related macular degeneration (nAMD), aiming to maximize visual acuity benefits while minimizing treatment burden. Treatment intervals can be extended or shortened based on patient response, and discontinuation of treatment with regular monitoring may be considered for stable disease.
Article
Ophthalmology
Chu-Hsuan Huang, Tso-Ting Lai, Chang-Hao Yang, Yi-Ting Hsieh
Summary: This study evaluated the efficacy of aflibercept combined with a treat-and-extend (TnE) regimen in treating neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV) in a real-world setting. The treatment interval could be extended to >= 16 weeks after a 2-year treatment regimen. Optical coherence tomography (OCT) can be used to predict the treatment course and visual outcomes.
OPHTHALMOLOGY AND THERAPY
(2023)
Article
Ophthalmology
Paul Mitchell, Frank G. Holz, Philip Hykin, Edoardo Midena, Eric Souied, Helmut Allmeier, George Lambrou, Thomas Schmelter, Sebastian Wolf
Summary: The study compared the efficacy of early-start vs. late-start intravitreal aflibercept treat-and-extend (T&E) regimens in patients with neovascular age-related macular degeneration. The outcomes showed similar visual and anatomical results between the two groups over a two-year period, with only one injection difference.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Article
Ophthalmology
Josephine R. Gunawan, Sarah H. Thiele, Ben Isselmann, Emily Caruso, Robyn H. Guymer, Chi D. Luu
Summary: A single treatment with 100 SNL spots causes a short-term change in retinal structure and improvement in retinal function that are apparent at 3 months post treatment.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Jeremy P. M. Flanagan, Roderick F. O'Day, Kelsey A. Roelofs, Myra B. McGuinness, Peter van Wijngaarden, Bertil E. Damato
Summary: The MOLES scoring system can be safely applied by community optometrists to manage patients with melanocytic choroidal tumors. Additional measures are needed to reduce over-referral of choroidal nevi and evaluate the usage of the MOLES system in clinical optometric practice, where certain imaging modalities may not be readily available.
CLINICAL AND EXPERIMENTAL OPTOMETRY
(2023)
Article
Medicine, Research & Experimental
Jiang-Hui Wang, Ching-Li Tseng, Fan-Li Lin, Jinying Chen, Erh-Hsuan Hsieh, Suraj Lama, Yu-Fan Chuang, Satheesh Kumar, Linxin Zhu, Myra B. McGuinness, Jessika Hernandez, Leilei Tu, Peng-Yuan Wang, Guei-Sheung Liu
Summary: This study demonstrates the important role of TAK1 in the pathogenesis of CoNV and the potential of TAK1 inhibitor, 5Z-7-oxozeaenol, in reducing angiogenesis and promoting pro-angiogenic activity. The gelatin nanoparticle coupled with 5Z-7-oxozeaenol shows promise as a new eyedrop administration model for the treatment of CoNV.
Article
Ophthalmology
Brandon Thia, Myra B. McGuinness, Peter R. Ebeling, Jwu Jin Khong
Summary: This study recruited 140 patients diagnosed with GH within the previous 12 months, with 53.6% of them having TAO. The TSI levels were higher in individuals with TAO but showed poor diagnostic accuracy and no correlation with clinical markers of TAO severity or activity.
INTERNATIONAL OPHTHALMOLOGY
(2022)
Article
Ophthalmology
William Yan, Myra McGuinness, Rahul Chakrabarti, Kathy Fotis, Robert P. Finger
Summary: This study aimed to evaluate and compare the sensitivity and specificity of mydriatic and non-mydriatic photographic screening methods for diabetic retinopathy. The results showed that the number of photographic fields is positively associated with the sensitivity and specificity of DR screening.
OPHTHALMIC EPIDEMIOLOGY
(2023)
Article
Medicine, General & Internal
Anthea M. Burnett, Ling Lee, Myra McGuinness, Beatrice Varga, Yadira Perez Hazel, Suit May Ho
Summary: This study aims to evaluate the quality of refractive error care in Cambodia, Malaysia, and Pakistan by using unannounced standardised patients to identify the proportion of prescribed and dispensed spectacles appropriate for people's refractive error needs, and to pinpoint opportunities for quality improvement.
Article
Biochemistry & Molecular Biology
Heather G. Mack, Alexis Ceecee Britten-Jones, Myra B. McGuinness, Fred K. Chen, John R. Grigg, Robyn V. Jamieson, Thomas L. Edwards, John De Roach, Fleur O'Hare, Keith R. Martin, Lauren N. Ayton
Summary: This study assessed the knowledge, attitudes, and perceptions of genetic therapies among potential recipients with inherited retinal diseases (IRD). The results showed a high level of interest in gene therapies within the IRD community, but also revealed knowledge gaps and identified areas for improved clinician and patient education.
Article
Ophthalmology
Myra B. McGuinness, Liubov D. Robman, John J. McNeil, Cammie Tran, Robyn L. Woods, Alice J. Owen, Thao Pham, Robyn H. Guymer
Summary: Based on the Australian ASPREE study, we found that most relatively healthy older adults self-reported good eyesight, but a significant minority reported poor eyesight, which was associated with poorer health measures. These findings highlight the need for additional resources to prevent vision loss and its associated consequences.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Editorial Material
Ophthalmology
Andrea Darzi, Jason Busse, Mark Phillips, Charles J. Wykoff, Robyn J. Guymer, Lehana P. Thabane, Mohit G. Bhandari, Varun Y. Chaudhary
Review
Ophthalmology
Anat Loewenstein, Alan Berger, Avril Daly, Catherine Creuzot-Garcher, Richard Gale, Federico Ricci, Javier Zarranz-Ventura, Robyn Guymer
Summary: With the aging population increasing, there is a higher prevalence of age-related eye disease and associated eye care. The demand for eye care is expected to grow, especially for retinal diseases such as nAMD and diabetic eye disease. To manage this expected burden, collective action is needed to address capacity limitations and implement sustainable strategies. Sufficient capacity will result in streamlined and personalized patient care, reduced treatment burden, equitable access, and optimal health outcomes. A multi-modal approach involving clinical experts, patient advocates, and evidence-based perspectives has identified capacity challenges and proposed strategies for better management of retinal diseases.
Article
Ophthalmology
Meri Vukicevic, Myra B. McGuinness, Nandor Jaross
Summary: This retrospective clinical audit aimed to investigate whether the presence and location of subretinal fluid affect the visual outcomes of treatment naive patients with nARMD treated with VEGF inhibitors in the real-world setting. The findings suggest that allowing some subretinal fluid to remain will not affect treatment outcomes.
SEMINARS IN OPHTHALMOLOGY
(2023)
Article
Ophthalmology
William R. Freeman, Francesco Bandello, Eric Souied, Robyn H. Guymer, Sunir J. Garg, Fred K. Chen, Ryan Rich, Frank G. Holz, Sunil S. Patel, Kimmie Kim, Francisco J. Lopez, BEACON Study Grp
Summary: The study evaluated the safety and efficacy of repeat injections of Brimo DDS (Gen 2) containing 400μg brimonidine in patients with geographic atrophy (GA) secondary to age-related macular degeneration (AMD). The results showed that Brimo DDS can slow down the progression of GA compared to sham treatment.
OPHTHALMOLOGY RETINA
(2023)
Article
Medicine, General & Internal
Alexis Ceecee Britten-Jones, Demi Markakis, Robyn H. Guymer, Ming-Lee Lin, Simon Skalicky, Lauren N. Ayton, Heather G. Mack
Summary: This article aims to investigate the potential misdiagnosis of inherited macular dystrophy as age-related macular degeneration (AMD) in real-world ophthalmic practice. A retrospective review of medical records will be conducted, followed by a consensus review by an expert panel. The outcomes include determining the misdiagnosis rate, identifying useful clinical imaging modalities, and establishing preliminary guidance for clinicians to improve diagnosis.
ANNALS OF MEDICINE
(2023)
Correction
Ophthalmology
Anat Loewenstein, Alan Berger, Avril Daly, Catherine Creuzot-Garcher, Richard Gale, Federico Ricci, Javier Zarranz-Ventura, Robyn Guymer
Article
Ophthalmology
Kylie E. J. Gran, Meri Vukicevic, Myra B. McGuinness, Catherine Lewis, Konstandina Koklanis
Summary: Understanding the impact of vision and binocular vision on learning, as well as how to assess these aspects, is crucial for eye health care professionals evaluating children with learning difficulties. This study aimed to investigate the similarities and differences in knowledge, attitudes, and practice patterns among eye care professionals when evaluating such children. The results indicated variations in testing the vision and binocular functions of children with learning difficulties across different professions.
CLINICAL AND EXPERIMENTAL OPTOMETRY
(2023)
Editorial Material
Ophthalmology
David Cui, Ian J. Saldanha, Gavin Li, Priya M. Mathews, Michael X. Lin, Esen K. Akpek
Summary: This article reports on the heterogeneity in methodology of clinical trials submitted to the US Food and Drug Administration for approval of topical dry eye treatments. Multiple outcome measures were used in these trials, highlighting the need for standardized assessment tools to optimize the evaluation and comparison of therapeutic benefits.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Adanna Udeh, Dana Huh, Terri Young, O'rese Knight, Fasika Woreta
Summary: This study examines the rates and trends of faculty promotions within the field of ophthalmology, with a focus on the rates of promotion among underrepresented in medicine (URiM) faculty. The results show that Black faculty had lower promotion rates and were more likely to leave academic medicine, highlighting the need for strategies and policies to address equity in promotion rates and retention of URiM faculty in academic ophthalmology.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Ursula Greferath, Erica Fletcher, Judy Savige, Heather G. Mack
Summary: Retinal drusen are uncommon in IgA nephropathy, but they resemble drusen found in age-related macular degeneration. The IgA-staining deposits in the drusen are likely related to systemic deposition of IgA. The nature of cystic spaces in the drusen is still unknown. Further research on the retinas of people with glomerulonephritis is recommended.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Andrew Mihalache, Ryan S. Huang, Nikhil S. Patil, Marko M. Popovic, Ashwin Mallipatna, Peter J. Kertes, Rajeev H. Muni, Radha P. Kohly
Summary: This study examines sociodemographic predictors of poor vision in children and adolescents in the US. The findings suggest that factors such as affordability of medical care, public health insurance, age, and parental education level are associated with vision difficulty. Addressing these disparities through public health policies is crucial for achieving equity in vision health.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Johannes Birtel, Richard Caswell, Samantha R. De Silva, Philipp Herrmann, Salwah Rehman, Andrew J. Lotery, Omar A. Mahroo, Michel Michaelides, Andrew R. Webster, Robert E. Maclaren, Peter Charbel Issa
Summary: The study investigated the phenotype, variability, and penetrance of IMPG2-related maculopathy. The results showed that mono-allelic IMPG2 variants could result in haploinsufficiency manifesting as a maculopathy with variable penetrance and expressivity. Family members of patients with IMPG2-related retinitis pigmentosa may also present with vitelliform lesions. The maculopathy is usually limited to the fovea and is associated with moderate visual impairment.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Colas Nils Authie, Mylene Poujade, Alireza Talebi, Alexis Defer, Ariel Zenouda, Cecilia Coen, Saddek Mohand-Said, Philippe Chaumet-Riffaud, Isabelle Audo, Jose-Alain Sahel
Summary: MOST has been validated as a reliable mobility test for measuring the movement ability of patients with vision impairments in both real and virtual environments.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Maria Krisch, Jordan Ueberroth, Neha Gupta, Stephen Merriam, Mark p. Breazzano
Summary: Orbeez-related ocular trauma can lead to severe visual morbidity and various intraocular sequelae. Adolescents may be at higher risk for posterior segment complications. Elevated IOP and hyphema at initial presentation may indicate a need for more aggressive interventions.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Jaron Pruett, Kelly Ruland, Sean Donahue
Summary: The study aimed to validate or refute the hypothesis that infants with birthweight over 750 g and gestational age over 27 weeks, who did not have retinopathy of prematurity (ROP) at 37 weeks, would not develop treatable ROP. The findings of the study supported the termination of examination at 37 weeks in infants meeting these criteria, as the value of continued screening was minimal.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Emily Sun, Jing Tian, Loaah Eltemsah, Divya Srikumaran, Grace Sun, Jessica Chow, Fasika Woreta
Summary: This study aims to evaluate the research productivity of ophthalmology residency applicants and identify differences in productivity based on gender and race. The findings reveal that women have similar or higher research outputs compared to men, while self-identified underrepresented in medicine (URiM) students have lower research outputs in ophthalmology. Therefore, greater mentorship and support for URiM students are needed to promote the recruitment of diverse trainees in ophthalmology programs.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Isaac A. Bernstein, Ann Caroline Fisher, Kuldev Singh, Sophia Y. Wang
Summary: This study aims to investigate the association between visual field loss and frailty in a nationally representative cohort of US adults.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)