Review
Clinical Neurology
Mark Abie Horowitz, Adele Framer, Michael P. Hengartner, Anders Sorensen, David Taylor
Summary: The brain's adaptation to drugs can predict withdrawal symptoms upon cessation. Physical dependence to antidepressants may occur in some patients, and factors such as duration of use, dosage, and specific drugs can influence the risk of withdrawal effects. Further research is needed to improve prediction tools and understand the adaptability of long-term antidepressant use.
Review
Psychology, Developmental
Jeffrey R. Strawn, Lu Lu, Tara S. Peris, Amir Levine, John T. Walkup
Summary: Anxiety disorders are common, early-onset conditions with various risk factors and are effectively treated with cognitive behavioral therapy, selective serotonin reuptake inhibitors, and serotonin-norepinephrine reuptake inhibitors. The disorders are associated with distinct neurobiological features and show consistent response to treatment, although questions remain about risk factors and neurobiology's impact on treatment outcomes.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2021)
Article
Health Care Sciences & Services
Alice Caldiroli, Lia Colzani, Enrico Capuzzi, Cecilia Quitadamo, Davide La Tegola, Teresa Surace, Stefania Russo, Mauro Capetti, Silvia Leo, Agnese Tringali, Matteo Marcatili, Francesco Zanelli Quarantini, Fabrizia Colmegna, Antonios Dakanalis, Massimiliano Buoli, Massimo Clerici
Summary: Generalized Anxiety Disorder (GAD) and Panic Disorder (PD) share similar neurobiological mechanisms and clinical features, leading to potential misdiagnosis and delayed treatment. This study aimed to assess the relationship between clinical and socio-demographic markers and GAD/PD diagnosis. Out of 290 outpatients identified with PD or GAD in mental health services in Italy, post-onset psychiatric and medical comorbidities were associated with GAD, while treatment with selective serotonin reuptake inhibitors (SSRIs) was associated with PD. GAD patients had a worse prognosis due to higher comorbidity rates, relapses, and poorer treatment compliance. The association between GAD and psychodynamic psychotherapy was a unique finding of this study.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Pediatrics
Mina Park, Gillian E. Hanley, Martin Guhn, Tim F. Oberlander
Summary: The study found that prenatal antidepressant exposure was associated with increased anxious behaviors and lower physical independence in children at kindergarten age, but had no significant effects on other developmental domains. These effects are likely attributable to the severity of underlying maternal mood disorders, emphasizing the importance of maternal mental health for developmental outcomes.
PEDIATRIC RESEARCH
(2021)
Article
Substance Abuse
Greta A. Bushnell, Moira A. Rynn, Tobias Gerhard, Katherine M. Keyes, Deborah S. Hasin, Magdalena Cerda, Abner Nyandege, Mark Olfson
Summary: Among young adults in the United States, initiating benzodiazepine treatment for anxiety and depression, alone or simultaneously with selective-serotonin reuptake inhibitors (SSRI), appears to have an increased risk of medically treated drug overdose compared with SSRI treatment alone. These associations were observed in publicly and privately insured individuals.
Article
Biochemistry & Molecular Biology
Duan Liu, Yongxian Zhuang, Lingxin Zhang, Huanyao Gao, Drew Neavin, Tania Carrillo-Roa, Yani Wang, Jia Yu, Sisi Qin, Daniel C. Kim, Erica Liu, Thanh Thanh Le Nguyen, Joanna M. Biernacka, Rima Kaddurah-Daouk, Boadie W. Dunlop, W. Edward Craighead, Helen S. Mayberg, Elisabeth B. Binder, Mark A. Frye, Liewei Wang, Richard M. Weinshilboum
Summary: ERICH3 gene may play a significant role in vesicular function in serotonergic and other neuronal cell types, which could help explain its association with plasma serotonin concentrations and SSRI clinical response.
MOLECULAR PSYCHIATRY
(2021)
Article
Psychiatry
Kirupamani Viswasam, David Berle, Denise Milicevic, Vladan Starcevic
Summary: This study investigated the prevalence of anxiety and related disorders during pregnancy, with OCD showing a steady increase in prevalence from the first to the third trimester. A significant proportion of women developed these disorders during pregnancy, indicating a potential risk factor. The findings have important implications for the recognition, prevention, and treatment of anxiety disorders during pregnancy.
PSYCHIATRY RESEARCH
(2021)
Article
Psychiatry
Zaiquan Dong, Weihong Kuang, Xiaoling Shen, Liantian Tian
Summary: This study found a correlation between plasma IL-6 levels and treatment outcomes of selective serotonin reuptake inhibitors in patients with major depressive disorder (MDD). Patients with lower baseline IL-6 levels were more likely to respond positively to treatment. A negative correlation was also found between baseline IL-6 levels and the reduction rate of HAMD-17 scores after treatment.
PSYCHIATRY RESEARCH
(2021)
Article
Psychiatry
Krzysztof Malyszczak, Anna Janocha
Summary: This study compares the nocturnal drop in blood pressure among patients with panic disorder (PD), generalized anxiety disorder (GAD), and healthy individuals. The results show that patients with GAD have a higher nocturnal drop in blood pressure compared to those with PD, while patients with PD have almost flat circadian blood pressure.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2022)
Article
Medicine, General & Internal
Jakob Christensen, Betina B. Trabjerg, Yuelian Sun, Julie Werenberg Dreier
Summary: This study examined the association between maternal antidepressant prescription during pregnancy and standardized test scores among Danish schoolchildren. Results showed that children born to mothers filling antidepressant prescriptions during pregnancy had significantly lower math test scores but no significant difference in language test scores compared to children whose mothers did not fill antidepressant prescriptions. The difference in math scores was small and of uncertain clinical importance, suggesting the need to balance the findings against the benefits of treating maternal depression during pregnancy.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Review
Cardiac & Cardiovascular Systems
Anna Calvi, Ilaria Fischetti, Ignazio Verzicco, Martino Belvederi Murri, Stamatula Zanetidou, Riccardo Volpi, Pietro Coghi, Stefano Tedeschi, Mario Amore, Aderville Cabassi
Summary: Patients with depression who take antidepressant medication may have an increased risk of developing hypertension. Different types of antidepressants have varying effects on blood pressure, with selective serotonin reuptake inhibitors being the safest class, while dopamine-norepinephrine reuptake inhibitors may lead to blood pressure increases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Psychiatry
Oday M. Abushalbaq, Hussain Y. Khdour, Eid G. Abo Hamza, Ahmed A. Moustafa, Mohammad M. Herzallah
Summary: Anxiety spectrum disorders are associated with deficits in working memory, but patients with different anxiety disorders exhibit variations in working memory function. Patients with generalized anxiety disorder and social anxiety disorder show poor performance in the maintenance component of working memory, while this is not evident in patients with panic disorder.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Clinical Neurology
Martin J. Lan, Francesca Zanderigo, Spiro P. Pantazatos, M. Elizabeth Sublette, Jeffrey Miller, R. Todd Ogden, J. John Mann
Summary: Disturbance of serotonin system function is associated with both the diagnosis of BD and its severity of depression. Pretreatment 5HT1AR binding did not predict SSRI antidepressant outcome.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Toshiya Funatsuki, Haruhiko Ogata, Hidetoshi Tahara, Akira Shimamoto, Yoshiteru Takekita, Yosuke Koshikawa, Shinpei Nonen, Koichiro Higasa, Toshihiko Kinoshita, Masaki Kato
Summary: Individual responses to antidepressant treatment varies, and understanding the factors contributing to this variability is important. This study investigated the correlation between changes in plasma miRNA levels and treatment outcomes of MIR and SSRI monotherapy in MDD patients. The results suggest that specific miRNAs may serve as potential biomarkers for predicting treatment response in depression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Psychiatry
Jeffrey R. Strawn, Jeffrey A. Mills, Vikram Suresh, Taryn Mayes, Melanie T. Gentry, Madhukar Trivedi, Paul E. Croarkin
Summary: Understanding how age affects antidepressant response is important for treatment selection. This study analyzed participant-level data from NIH-sponsored trials to identify the impact of age on antidepressant response.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)