Review
Cardiac & Cardiovascular Systems
Fiona Thoi, Daniel J. Scherer, David M. Kaye, Prashanthan Sanders, Michael B. Stokes
Summary: The increasing usage of methamphetamine worldwide has led to the emergence of methamphetamine-associated cardiomyopathy (MA-CMP), which is becoming a significant cause of heart failure burden. MA-CMP presents unique challenges, including its recognition, severity, complications, and management options. With high levels of methamphetamine use in Australia, it is crucial for clinicians responsible for heart failure management to be aware of this disease entity and its specific clinical challenges.
HEART LUNG AND CIRCULATION
(2022)
Article
Environmental Sciences
Agnieszka Chlopas-Konowalek, Kaja Tusiewicz, Olga Wachelko, Pawel Szpot, Marcin Zawadzki
Summary: This study presents the first reported case of a simultaneous amphetamine and methamphetamine intoxication of a cat. The toxicological study analyzed the concentrations of these substances in various biological materials. Intentional or accidental poisoning of pets with psychoactive substances is a serious problem that poses a risk to the health and life of animals. Thus, it is important to increase awareness of the high risk of poisoning in domestic animals and to research the pharmacokinetic mechanisms of drugs in animals.
Article
Medicine, Legal
Ahmed Al-Asmari
Summary: The study revealed a more than 500% increase in deaths involving methamphetamine in Jeddah, Saudi Arabia, between 2016 and 2018. The majority of the deceased were males, and most deaths were due to the combined toxicity of methamphetamine and other drugs.
FORENSIC SCIENCE INTERNATIONAL
(2021)
Article
Cardiac & Cardiovascular Systems
Michael B. B. Stokes, Fiona Thoi, Daniel J. J. Scherer, Kyi T. H. Win, David M. M. Kaye, Karen S. S. Teo, Prashanthan Sanders
Summary: CMR findings in patients with methamphetamine-associated cardiomyopathy (MA-CMP) reveal severe biventricular dilatation and dysfunction, with a high prevalence of intraventricular thrombus.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2022)
Article
Cardiac & Cardiovascular Systems
Harpreet Singh Bhatia, Marin Nishimura, Stephen Dickson, Eric Adler, Barry Greenberg, Isac C. Thomas
Summary: Methamphetamine cessation improves left ventricular systolic function and reduces heart failure admissions in METHrEF patients, suggesting potential reversibility. However, cessation did not lead to significant improvements in echocardiographic parameters or clinical outcomes in METHpEF patients.
Article
Cardiac & Cardiovascular Systems
Marco Merlo, Marco Mase, Andrew Perry, Eluisa La Franca, Elena Deych, Laura Ajello, Diego Bellavia, Andrea Boscutti, Marco Gobbo, Giuseppe Romano, Davide Stolfo, John Gorcsan, Francesco Clemenza, Gianfranco Sinagra, Luigi Adamo
Summary: In patients with non-ischaemic dilated cardiomyopathy (NICM) and normalised left ventricular ejection fraction (LVEF), an impaired absolute global longitudinal strain (aGLS) at the time of LVEF recovery is common and associated with worse outcomes.
Article
Cardiac & Cardiovascular Systems
Amam C. Mbakwem, Johann Bauersachs, Charle Viljoen, Julian Hoevelmann, Peter van der Meer, Mark C. Petrie, Alexandre Mebazaa, Sorel Goland, Kamilu Karaye, Cecile Laroche, Karen Sliwa
Summary: In peripartum cardiomyopathy (PPCM) patients, ECG abnormalities are common, with sinus tachycardia predicting poor systolic function and wide QRS, left bundle branch block (LBBB), and left ventricular hypertrophy (LVH) associated with left ventricular dilatation.
Article
Medicine, General & Internal
Mon Myat Oo, Isaiah Tan Chung Zhen, Kee Seong Ng, Kok Leng Tan, Alexander T. B. Tan, Shireene Ratna Vethakkan, R. Jeyakantha A L Ratnasingam, Kok Han Chee
Summary: The study identified a high prevalence of stage B heart failure in patients with type 2 diabetes without a history of cardiovascular disease in Malaysia. Most participants were female, with a mean body mass index of 27.5 kg/m(2). A large proportion of patients had a history of hypertension and had been living with type 2 diabetes for more than 10 years. Diastolic dysfunction, increased left ventricular mass index, and increased left atrial volume index were common among the study population. Newer anti-diabetes agents were also frequently used in this group.
Article
Cardiac & Cardiovascular Systems
Pascal Amedro, Marie Vincenti, Hamouda Abassi, Nicolas Lanot, Gregoire De La Villeon, Sophie Guillaumont, Lucie Gamon, Thibault Mura, Karine Lopez-Perrin, Stephany Haouy, Anne Sirvent, Olivier Cazorla, Laurence Vergely, Alain Lacampagne, Martina Avesani, Nicolas Sirvent, Laure Saumet
Summary: In childhood cancer survivors, speckle tracking echocardiography (STE) detects altered myocardial strain despite normal left ventricular (LV) function, highlighting the importance of monitoring cardiomyopathy.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Veena Manja, Ananya Nrusimha, Ya Gao, Aleesha Sheikh, Mark McGovern, Paul A. Heidenreich, Alex Tarlochan Singh Sandhu, Steven Asch
Summary: This systematic review found that the prevalence of Methamphetamine-associated heart failure (MethHF) is increasing, affecting various racial/ethnic/sociodemographic groups with a male predominance. The study highlights the importance of methamphetamine abstinence, female sex, and guideline-directed heart failure therapy in improving outcomes. However, there is heterogeneity in study design, population, comparator, and outcome assessment, preventing the combination of results and resulting in low certainty in the evidence. Prospective studies are urgently needed to accurately assess the epidemiology, clinical features, disease trajectory, and outcomes of MethHF.
Article
Medicine, General & Internal
Vincenzo Somma, Michael Osekowski, Elizabeth Paratz, Yvonne Bonomo
Summary: Methamphetamine-associated cardiomyopathy (MaCM) is a serious complication from methamphetamine (MA) use that leads to unexplained heart failure. It primarily affects young individuals and is a major cause of mortality in patients with MA use disorder. Treatment is dependent on abstinence and medical therapies may be ineffective without it. Understanding and educating patients on the risks of ongoing MA use is important, and referral to addiction medicine specialists is recommended. This review aims to explain the pathogenesis of MaCM, provide recommendations for screening and treatment, and emphasize the role of addiction medicine in managing patients with MaCM.
INTERNAL MEDICINE JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Hyun-Jung Lee, Hyung-Kwan Kim, Tae-Min Rhee, You-J Ung Choi, In-Chang Hwang, Yeonyee E. Yoon, Jun-Bean Park, Seung-Pyo Lee, Yong-Jin Kim, Goo-Yeong Cho
Summary: LARS can be used to categorize LV diastolic function and predict HF events in patients with hypertrophic cardiomyopathy.
CIRCULATION-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Maciej Stapor, Adam Pilat, Andrzej Gackowski, Agnieszka Misiuda, Izabela Gorkiewicz-Kot, Michal Kaleta, Pawel Kleczynski, Krzysztof Zmudka, Jacek Legutko, Boguslaw Kapelak, Karol Wierzbicki
Summary: This study evaluates the feasibility of physiological pump speed optimization based on aortic valve opening (AVO) imaging during a cardiopulmonary exercise test (CPET) in LVAD patients. The results show that dynamic echo-guided pump speed adjustment based on AVO improves exercise tolerance and augments peak oxygen consumption and maximum workload.
Article
Medicine, General & Internal
Barry J. Maron, Ethan J. Rowin, Shray P. Ambe, Martin S. Maron
Summary: This study found that patients with hypertrophic cardiomyopathy are now older and more likely to have outflow obstruction compared to previous years. However, the maximum left ventricular wall thickness has decreased. These observations may impact disease recognition and diagnostic criteria.
AMERICAN JOURNAL OF MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Teruhiko Imamura, Hiroshi Onoda, Keisuke Uchida, Koichiro Kinugawa
Summary: This study aims to investigate the role of ivabradine in up-titrating betablockers to improve clinical outcomes in patients with systolic dysfunction. The results will provide valuable information for gradually increasing the dose of beta-blockers in clinical practice.
INTERNATIONAL HEART JOURNAL
(2021)
Article
Substance Abuse
John R. Richards, J. Adam Hawkins, Eric W. Acevedo, Erik G. Laurin
Article
Emergency Medicine
John R. Richards, Gagan D. Singh, Aman K. Parikh, Sandhya Venugopal
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2019)
Article
Multidisciplinary Sciences
Naomi van der Linden, Thomas Longden, John R. Richards, Munawar Khursheed, Wilhelmina M. T. Goddijn, Michiel J. van Veelen, Uzma Rahim Khan, M. Christien van der Linden
Letter
Emergency Medicine
John R. Richards, Robert W. Derlet
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2019)
Review
Toxicology
John R. Richards, Mary L. Bing, Aimee K. Moulin, Joshua W. Elder, Robert T. Rominski, Phillip J. Summers, Erik G. Laurin
CLINICAL TOXICOLOGY
(2019)
Review
Emergency Medicine
Craig D. Nowadly, Brandon D. Trapp, Stephen K. Robinson, John R. Richards
PREHOSPITAL AND DISASTER MEDICINE
(2019)
Review
Toxicology
John R. Richards, Eike Blohm, Kara A. Toles, Angela F. Jarman, Dylan F. Ely, Joshua W. Elder
CLINICAL TOXICOLOGY
(2020)
Review
Cardiac & Cardiovascular Systems
John R. Richards
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS
(2020)
Article
Emergency Medicine
Joshua W. Elder, Evan F. Wu, James A. Chenoweth, James F. Holmes, Aman K. Parikh, Aimee K. Moulin, Tommie G. Trevino, John R. Richards
EMERGENCY MEDICINE INTERNATIONAL
(2020)
Review
Pharmacology & Pharmacy
Guillermo Burillo-Putze, John R. Richards, Consuelo Rodriguez-Jimenez, Alejandro Sanchez-Aguera
Summary: CHS is a rare but unique disorder characterized by recurrent abdominal pain, intractable nausea, and vomiting in cannabis users. It does not respond well to usual antiemetics but improves with hot water therapy. Complete resolution of CHS can only be achieved by stopping cannabis use.
EXPERT OPINION ON PHARMACOTHERAPY
(2022)
Article
Emergency Medicine
John R. Richards, Robert W. Derlet
Summary: This article discusses the reasons for emergency department crowding and hallway care, the impact of the COVID-19 pandemic, potential solutions, and the reasons why little has changed despite widespread awareness. Lack of awareness and financial/legal considerations are the main obstacles to solving this problem.
JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Substance Abuse
Aimee K. Moulin, Evan F. Wu, Tommie G. Trevino, John R. Richards
Summary: The study evaluated the impact of a new SBIRT program conducted by a dedicated CADC for ED patients, focusing on alcohol and drug abuse issues. Results indicated that the program has the potential to reduce ED utilization and visits for patients, especially those at risk of recidivism.
JOURNAL OF SUBSTANCE USE
(2021)
Article
Psychology, Clinical
John R. Richards, Colin G. Wang, Roderick W. Fontenette, Rory P. Stuart, Kerry F. McMahon, Samuel D. Turnipseed
JOURNAL OF DUAL DIAGNOSIS
(2020)
Article
Emergency Medicine
Amar Tomar, Siddhi S. Ganesh, John R. Richards
WESTERN JOURNAL OF EMERGENCY MEDICINE
(2019)
Article
Emergency Medicine
John R. Richards, Jessica B. Gould, Erik G. Laurin, Timothy E. Albertson
CLINICAL AND EXPERIMENTAL EMERGENCY MEDICINE
(2019)
Letter
Emergency Medicine
Zhao-Yu Hsieh, Chen-Xiong Hsu
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Editorial Material
Emergency Medicine
Laura E. Walker, Jessica A. Stanich, Fernanda Bellolio
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Letter
Emergency Medicine
E. Tekin
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Amanda S. Dupont, Patrick S. Walsh
Summary: Recent research indicates that children who unintentionally ingest cannabis often undergo extensive additional testing, such as head imaging or lumbar puncture. However, the yield of these tests is limited. While head imaging and lumbar puncture are frequently performed, diagnoses such as skull fracture, intracranial hemorrhage, intracranial neoplasm, meningitis, or intracranial abscess are rare. Additionally, discharge diagnoses related to other drugs are infrequent. The most common co-diagnoses are cocaine and opioids. Therefore, prompt consideration of cannabis ingestion and quick identification through testing may result in more effective neuroimaging outcomes.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Letter
Emergency Medicine
Mio Nagata, Shunsuke Kudo, Motoyasu Nakamura
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Andy Hung-Yi Lee, Katherine Dickerson Mayes, Regan Marsh, Christina Toledo-Cornell, Eric Goralnick, Michael Wilson, Leon D. Sanchez, Alice Bukhman, Damarcus Baymon, Dana Im, Paul C. Chen
Summary: This study assessed the disparities in transferring patients from an academic medical center emergency department to a community hospital general medical service, revealing healthcare disparities among different patient populations.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Annabelle Croskey, William Trautman, David Barton, Mary Kathleen Ratay, Joshua Shulman
Summary: This case report describes a successful management of ocular palytoxin exposure in a young male, highlighting the importance of prompt recognition and treatment of ocular PTX toxicity.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Matthew K. Kolbeck, Rachel F. Schult, Nicholas Nacca
Summary: This article presents four cases of adolescents who experienced seizures after acute fluoxetine overdose. Although seizures are an uncommon complication after fluoxetine overdose, they occurred in some patients at doses lower than those reported in the literature.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Editorial Material
Emergency Medicine
Daven Patel, John Bailitz, Simone Ymson, Jonas Neichin, Gary D. Peksa, Michael Gottlieb
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Amichai Gutgold, Shaden Salameh, Jeries Nashashibi, Yonatan Gershinsky
Summary: This study aimed to test the prognosis of patients with a pH lower than 6.9 on emergency department admission. The findings showed that a small but significant portion of these patients survived at least 24 hours and until hospital discharge.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Na-Yeon Emily Song, Ki Hong Kim, Ki Jeong Hong
Summary: This study aimed to evaluate the effect of the duration of no-flow (NF) interval on the vaso-pressor effect of initial epinephrine administration in a porcine model of cardiac arrest. The results showed that a shorter NF interval can enhance the vasopressor effect of epinephrine.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Kenneth A. Scheppke, Paul E. Pepe, Jonathan Jui, Remle P. Crowe, Eric K. Scheppke, Nancy G. Klimas, Aileen M. Marty
Summary: This study reported cases of rapid and complete remission of severe long COVID after receiving monoclonal antibody treatment. The findings suggest that monoclonal antibody infusions may be effective in treating severe debilitation caused by long COVID.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Suhrith Bhattaram, Varsha S. Shinde
Summary: Nerve blocks have emerged as promising options for targeted pain relief in the Emergency Department, providing effective analgesia without compromising motor function. The successful use of ultrasound-guided genicular nerve blocks (GNBs) in this case series demonstrates their potential as an alternative to traditional nerve blocks and opioid-based pain control strategies in the ED.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Rick Kye Gan, Jude Chukwuebuka Ogbodo, Yong Zheng Wee, Ann Zee Gan, Pedro Arcos Gonzalez
Summary: The aim of this study was to evaluate and compare the performance of ChatGPT, Google Bard, and medical students in performing START triage during mass casualty situations. The results showed that Google Bard had significantly higher accuracy compared to ChatGPT, while there was no significant difference between Google Bard and medical students.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Nancy Clemens, Paria M. Wilson, Matthew J. Lipshaw, Holly Depinet, Yin Zhang, Michelle Eckerle
Summary: This study compared clinical features and outcomes between pediatric sepsis patients with blood cultures positive versus negative for bacterial pathogens. The results showed that children with blood culture positive sepsis had higher rates of organ dysfunction, a larger base deficit, and higher procalcitonin levels.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)