Article
Public, Environmental & Occupational Health
Junquan Chen, Yunpeng Bai, Hong Liu, Mingzhen Qin, Zhigang Guo
Summary: The study aimed to create a prediction model for in-hospital death in Chinese patients with acute type A aortic dissection (ATAAD). A retrospective derivation cohort of 340 patients from Tianjin and a retrospective validation cohort of 153 patients from Nanjing were used. Variable selection was done using least absolute shrinkage and selection operator analysis, and risk scoring was done using logistic regression coefficients. A risk classifier was established based on independent baseline data using a multivariable logistic model. The prediction performance was evaluated using the receiver operating characteristic curve (ROC). Individualized clinical decision-making was conducted using decision curve analysis (DCA). The risk prediction model showed good performance in predicting in-hospital death in ATAAD patients.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Multidisciplinary Sciences
Guifang Yang, Xiangping Chai, Ning Ding, Donghua Yang, Qiong Ding
Summary: The study found a positive and non-linear correlation between admission serum uric acid and in-hospital mortality of patients with acute type A aortic dissection.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Yue Yuan, Zhiyu Xia, Lei Wang, Qi Sun, Wendan Wang, Chen Chai, Tiantian Wang, Xiaowei Zhang, Long Wu, Zehai Tang
Summary: This study aims to investigate the risk factors for in-hospital death in patients with acute aortic dissection (AAD) and provide a simple prediction model to assist clinicians in determining the prognosis of AAD patients. It was found that hypotension and liver dysfunction were independent risk factors for in-hospital death in type A AAD patients, while tachycardia and liver dysfunction were independent risk factors for type B AAD patients. Based on these results, a predictive model was developed to help clinicians determine the prognosis of type A AAD patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Yue Chen, Yi He, Xiang Wei, Ding-Sheng Jiang
Summary: This review focuses on the role of regulated cell death in the development of aortic aneurysm and dissection (AAD). Studies have shown that the death of smooth muscle cells, endothelial cells, and inflammatory cells is involved in the progression of AAD, and interventions targeting cell death can alleviate the disease.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Medicine, General & Internal
Thierry Carrel, Thoralf M. Sundt, Yskert von Kodolitsch, Martin Czerny
Summary: Despite advancements in the prevention, diagnosis, and treatment of acute aortic dissection, it remains a complex cardiovascular event with high mortality and morbidity rates. Recent research has improved our understanding of the disease's pathophysiology and led to reevaluations of existing classifications. There is a shift towards a unified naming system based on morphology and function. The location and extent of the initial tear, as well as the affected aortic segments, determine the appropriate management approach - emergency surgery, endovascular intervention, or medical treatment. Ongoing scientific evidence continues to shape the management and follow-up of acute aortic dissection, the most severe form of acute aortic syndrome.
Article
Medicine, General & Internal
Yaqin Chen, Yanchun Peng, Xuecui Zhang, Liangwan Chen, Yanjuan Lin
Summary: In this study, the relationship between impaired hydration status and postoperative hospitalization death in patients with A-type Aortic Dissection (AAD) was investigated. The results showed that the imminent and current dehydration groups had a significantly higher rate of postoperative in-hospital death and longer ICU stay. Multivariate logistic regression analysis revealed that imminent and current dehydration groups, continuous renal replacement therapy (CRRT), lactic acidosis, and coronary artery disease (CAD) were independent risk factors for in-hospital death in AAD patients, while albumin was a protective factor.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2023)
Article
Surgery
Yixiao Zhang, Yulin Wang, Jinmiao Chen, Jun Li, Yongxin Sun, Hao Lai, Chunsheng Wang, Qiang Ji
Summary: An extended arch repair for elderly patients with acute type A aortic dissection (ATAAD) remains challenging. However, this study found that extended arch repair in septuagenarians with ATAAD is safe and effective, with in-hospital and midterm outcomes comparable to those in patients aged less than 70 years.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Tuo Guo, Zhuo Fang, Guifang Yang, Yang Zhou, Ning Ding, Wen Peng, Xun Gong, Huaping He, Xiaogao Pan, Xiangping Chai
Summary: Acute aortic dissection is a potentially fatal cardiovascular disorder with high mortality rates. This study utilized machine learning algorithms to predict in-hospital mortality, finding that the extreme gradient boost model was the most effective and identified treatment, type of acute aortic dissection, and ischemia-modified albumin levels as significant predictors of mortality.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Chen Ke, Hao Wu, Min Xi, Wei Shi, Qihong Huang, Guirong Lu
Summary: This study retrospectively analyzed the clinical features and risk factors of patients with Stanford type A acute aortic dissection, finding that age, renal insufficiency, cardiopulmonary bypass time, and postoperative hemostasis are independent risk factors for postoperative mortality.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Cardiac & Cardiovascular Systems
Qianhao Zhao, Kun Yin, Nan Zhou, Qiuping Wu, Yuxi Xiao, Jinxiang Zheng, Da Zheng, Qiming Bi, Li Quan, Bingjie Hu, Jianding Cheng
Summary: Thoracic aortic dissection (TAD) is the leading cause of sudden cardiac death associated with aortic diseases. Autopsy-diagnosed TAD victims exhibit earlier onset, lower incidence of hypertension, and higher risk of misdiagnosis, especially in cases presenting with abdominal pain or no accompanying pain. Women and younger patients show more atypical clinical presentations.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Pengfei Huang, Hongyan Wang, Dong Ma, Yongbo Zhao, Xiao Liu, Peng Su, Jinjin Zhang, Shuo Ma, Zhe Pan, Juexin Shi, Fangfang Hou, Nana Zhang, Xiaohui Zheng, Nan Liu, Ling Zhang
Summary: This study found that the admission serum sodium level of AAD patients has a significant impact on postoperative in-hospital mortality, with higher sodium levels associated with increased risk of death.
Editorial Material
Medicine, General & Internal
Jayson R. Baman, S. Chris Malaisrie
Summary: This article describes aortic dissection, a condition characterized by a tear in the aorta, and discusses its diagnosis and treatment.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Dadi Helgason, Solveig Helgadottir, Anders Ahlsson, Jarmo Gunn, Vibeke Hjortdal, Emma C. Hansson, Anders Jeppsson, Ari Mennander, Shahab Nozohoor, Igor Zindovic, Christian Olsson, Stefan Orri Ragnarsson, Martin Sigurdsson, Arnar Geirsson, Tomas Gudbjartsson
Summary: This study examined the occurrence of AKI in patients undergoing surgery for ATAAD in 8 Nordic centers from 2005 to 2014. AKI was found to be a common complication after ATAAD surgery and independently predicted adverse long-term outcomes, emphasizing the importance of close clinical follow-up for these patients.
ANNALS OF THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Abhijit Chakraborty, Yang Li, Chen Zhang, Yanming Li, Scott A. LeMaire, Ying H. Shen
Summary: Rupture of aortic aneurysm and dissection remains a leading cause of death, with progressive smooth muscle cell loss being a crucial feature. Understanding programmed cell death pathways is critical for preventing aortic destruction and disease progression in AAD.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Kensuke Hori, Nagisa Morikawa, Eiki Tayama, Yoshihiro Fukumoto
Summary: A study found that the use of anti-thrombotic drugs during the acute phase of aortic dissection does not increase in-hospital mortality. In patients with type A dissection, those who received anti-thrombotic treatment during hospitalization had significantly lower mortality compared to those who did not receive treatment.
Letter
Emergency Medicine
Zhao-Yu Hsieh, Chen-Xiong Hsu
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Editorial Material
Emergency Medicine
Laura E. Walker, Jessica A. Stanich, Fernanda Bellolio
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Letter
Emergency Medicine
E. Tekin
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Amanda S. Dupont, Patrick S. Walsh
Summary: Recent research indicates that children who unintentionally ingest cannabis often undergo extensive additional testing, such as head imaging or lumbar puncture. However, the yield of these tests is limited. While head imaging and lumbar puncture are frequently performed, diagnoses such as skull fracture, intracranial hemorrhage, intracranial neoplasm, meningitis, or intracranial abscess are rare. Additionally, discharge diagnoses related to other drugs are infrequent. The most common co-diagnoses are cocaine and opioids. Therefore, prompt consideration of cannabis ingestion and quick identification through testing may result in more effective neuroimaging outcomes.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Letter
Emergency Medicine
Mio Nagata, Shunsuke Kudo, Motoyasu Nakamura
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Andy Hung-Yi Lee, Katherine Dickerson Mayes, Regan Marsh, Christina Toledo-Cornell, Eric Goralnick, Michael Wilson, Leon D. Sanchez, Alice Bukhman, Damarcus Baymon, Dana Im, Paul C. Chen
Summary: This study assessed the disparities in transferring patients from an academic medical center emergency department to a community hospital general medical service, revealing healthcare disparities among different patient populations.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Annabelle Croskey, William Trautman, David Barton, Mary Kathleen Ratay, Joshua Shulman
Summary: This case report describes a successful management of ocular palytoxin exposure in a young male, highlighting the importance of prompt recognition and treatment of ocular PTX toxicity.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Matthew K. Kolbeck, Rachel F. Schult, Nicholas Nacca
Summary: This article presents four cases of adolescents who experienced seizures after acute fluoxetine overdose. Although seizures are an uncommon complication after fluoxetine overdose, they occurred in some patients at doses lower than those reported in the literature.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Editorial Material
Emergency Medicine
Daven Patel, John Bailitz, Simone Ymson, Jonas Neichin, Gary D. Peksa, Michael Gottlieb
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Amichai Gutgold, Shaden Salameh, Jeries Nashashibi, Yonatan Gershinsky
Summary: This study aimed to test the prognosis of patients with a pH lower than 6.9 on emergency department admission. The findings showed that a small but significant portion of these patients survived at least 24 hours and until hospital discharge.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Na-Yeon Emily Song, Ki Hong Kim, Ki Jeong Hong
Summary: This study aimed to evaluate the effect of the duration of no-flow (NF) interval on the vaso-pressor effect of initial epinephrine administration in a porcine model of cardiac arrest. The results showed that a shorter NF interval can enhance the vasopressor effect of epinephrine.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Kenneth A. Scheppke, Paul E. Pepe, Jonathan Jui, Remle P. Crowe, Eric K. Scheppke, Nancy G. Klimas, Aileen M. Marty
Summary: This study reported cases of rapid and complete remission of severe long COVID after receiving monoclonal antibody treatment. The findings suggest that monoclonal antibody infusions may be effective in treating severe debilitation caused by long COVID.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Suhrith Bhattaram, Varsha S. Shinde
Summary: Nerve blocks have emerged as promising options for targeted pain relief in the Emergency Department, providing effective analgesia without compromising motor function. The successful use of ultrasound-guided genicular nerve blocks (GNBs) in this case series demonstrates their potential as an alternative to traditional nerve blocks and opioid-based pain control strategies in the ED.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Rick Kye Gan, Jude Chukwuebuka Ogbodo, Yong Zheng Wee, Ann Zee Gan, Pedro Arcos Gonzalez
Summary: The aim of this study was to evaluate and compare the performance of ChatGPT, Google Bard, and medical students in performing START triage during mass casualty situations. The results showed that Google Bard had significantly higher accuracy compared to ChatGPT, while there was no significant difference between Google Bard and medical students.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Emergency Medicine
Nancy Clemens, Paria M. Wilson, Matthew J. Lipshaw, Holly Depinet, Yin Zhang, Michelle Eckerle
Summary: This study compared clinical features and outcomes between pediatric sepsis patients with blood cultures positive versus negative for bacterial pathogens. The results showed that children with blood culture positive sepsis had higher rates of organ dysfunction, a larger base deficit, and higher procalcitonin levels.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)