Review
Cell Biology
Shaobin Yang, Yaqin Du, Xiaoqian Zhao, Chendong Wu, Peng Yu
Summary: The study provides an overview of the neuropathology of Alzheimer's disease (AD) and the role of the PDK1/Akt signaling pathway in its pathophysiology. It discusses the modulation of AD by the PDK1/Akt/TACE signaling axis and its potential for therapeutic targeting.
Article
Biochemistry & Molecular Biology
Dong Han, Wei Wang, Julie Heejin Jeon, Tao Shen, Xiangsheng Huang, Ping Yi, Bingning Dong, Feng Yang
Summary: Phosphoinositide-dependent kinase-1 (PDK1) is a master kinase that regulates cancer cell proliferation, survival, and metabolism. It phosphorylates/activates AKT and other AGC kinases, including MAPK4, promoting tumor growth. MAPK4 can independently promote AKT activation and tumor growth, and also enhance PDK1 protein synthesis, leading to the activation of PDK1 substrates beyond AKT. Co-targeting AKT and PDK1 effectively represses MAPK4-induced cancer cell growth, providing a potential therapeutic strategy for MAPK4-high cancers.
Article
Chemistry, Physical
Lin Yang, Xueying An, Wang Gong, Wenshu Wu, Bin Liu, Xiaoyan Shao, Yansi Xian, Rui Peng, Baosheng Guo, Qing Jiang
Summary: This study investigates the potential of alpha-cyperone (alpha-CYP) as a therapeutic agent for osteoporosis and develops a liposome-based nano-drug delivery system that specifically targets bone resorption. The results demonstrate that alpha-CYP inhibits osteoclast differentiation and the progression of osteoporosis by silencing the PI3K/Akt pathway. The liposome targeting delivery system loaded with alpha-CYP shows enhanced efficacy in inhibiting osteoclasts and may provide a novel strategy for treating osteoporosis.
Article
Pharmacology & Pharmacy
Fang Zhu, Jujia Zheng, Fang Xu, Yiyuan Xi, Jun Chen, Xiangwei Xu
Summary: The study found that RSV can alleviate UC symptoms by mediating intestinal microflora homeostasis, suppressing the activation of the PI3K/Akt pathway, and reducing the expression of the VEGFA gene.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yan He, Miao Miao Sun, Guo Geng Zhang, Jing Yang, Kui Sheng Chen, Wen Wen Xu, Bin Li
Summary: The PI3K/Akt signaling pathway plays a crucial role in cancer, and targeting inhibitors against it may aid in drug discovery. Additionally, combining pathway inhibitors with other cancer treatment strategies could be an effective approach to solving therapeutic dilemmas.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Integrative & Complementary Medicine
Huiping Huang, Lingjin Kong, Shaohua Luan, Chuanzong Qi, Fanrong Wu
Summary: Ligustrazine has a protective effect on PAH by alleviating symptoms induced by MCT in rats, inhibiting proliferation and inflammation of PASMCs through regulating the PI3K/AKT signaling pathway, making it a promising therapeutic for PAH.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Endocrinology & Metabolism
Xi-juan Zhao, Kui Wang, Rong Li, Yang Lu, Pan Lu, Pei Fan, Yu-ying Lv, Xin-lin Chen, Hao-zheng Yuan
Summary: This study aimed to investigate the action of simvastatin on cortical neurons exposed to isoflurane and establish the mechanism of this action. It was found that simvastatin pretreatment protected neurons from isoflurane-induced neurotoxicity in vitro, and the phosphoinositide 3-kinase (PI3K)/Akt pathway mediated this effect.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Gastroenterology & Hepatology
Ting Liu, Xiao-Li Xie, Xue Zhou, Sheng-Xiong Chen, Yi-Jun Wang, Lin-Ping Shi, Shu-Jia Chen, Yong-Juan Wang, Shu-Ling Wang, Jiu-Na Zhang, Shi-Ying Dou, Xiao-Yu Jiang, Ruo-Lin Cui, Hui-Qing Jiang
Summary: YB-1, overexpressed in HCC tissues, enhances sorafenib resistance through the PI3K/Akt pathway. Knockdown of YB-1 can improve the efficacy of sorafenib in vivo. The interaction between YB-1 and key proteins of the PI3K/Akt pathway contributes to sorafenib resistance in HCC.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Multidisciplinary Sciences
Qiwei Jiang, Xiaomei Zhang, Xiaoming Dai, Shiyao Han, Xueji Wu, Lei Wang, Wenyi Wei, Ning Zhang, Wei Xie, Jianping Guo
Summary: The study demonstrates that S6K1 can directly phosphorylate PDK1, inhibiting the activity of AKT kinase and its role in tumorigenesis. This feedback regulation of AKT signaling through S6K1-mediated PDK1 phosphorylation provides insight into the regulation of the AKT pathway and potential strategies for combating mutant PDK1-driven cancers.
NATURE COMMUNICATIONS
(2022)
Article
Plant Sciences
Meizhu Zheng, Minghui Chen, Wenli Wang, Mi Zhou, Chunming Liu, Yajun Fan, Dongfang Shi
Summary: Rhy has been shown to have a neuroprotective effect by activating the PI3K/Akt signaling pathway, improving cell viability, inhibiting apoptosis, and reducing levels of LDH, [Ca2+]i, and ROS in models of Parkinson's disease.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Oncology
Fei Li, Weiwei Xie, Yunze Fang, Kunfeng Xie, Wendong Liu, Lina Hou, Wanlong Tan
Summary: HnRNP-F promotes the proliferation of BC cells through the PI3K/AKT pathway and is regulated by phosphorylation of FOXO1.
Review
Immunology
Ebru Aydin, Sebastian Faehling, Mariam Saleh, Laura Llao Cid, Martina Seiffert, Philipp M. Roessner
Summary: PI3K pathway plays a crucial role in cell growth and malignant transformation, with its hyperactivation being a hallmark of cancer. Inhibiting PI3K not only affects cancer cells but also impacts the tumor microenvironment and immune cell function. Understanding the effects of PI3K inhibition on the tumor microenvironment in CLL can lead to improved drug development and novel combinatory treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Genetics & Heredity
Payel W. Ganguly, Landiso Madonsela, Jesse t J. Chao, Christopher J. R. Loewen, Timothy P. J. O'Connor, Esther M. Verheyen, Douglas W. J. Allan
Summary: DNA sequencing is widely used in clinical practice, and the fruit fly Drosophila melanogaster has been proven to be a valuable tool for testing the function of hundreds of human gene variants. Experimental assessments of variant function are becoming more common, and Drosophila offers a powerful platform for clinical variant interpretation.
Article
Respiratory System
Huiyuan Wang, Bo Zhong, Yan Geng, Juanjuan Hao, Qiaoyan Jin, Yang Zhang, Lijuan Dong, Dan Gao, Jing Li, Wei Hou
Summary: The study found that TIPE2 inhibits PDGF-BB-induced ASMC proliferation, migration, and phenotype switching through the PI3K/Akt signaling pathway. TIPE2 may be a potential therapeutic target for the treatment of asthma.
RESPIRATORY RESEARCH
(2021)
Article
Multidisciplinary Sciences
Qian Wang, Chenqi Tao, Abdul Hannan, Sungtae Yoon, Xuanyu Min, John Peregrin, Xiuxia Qu, Hongge Li, Honglian Yu, Jean Zhao, Xin Zhang
Summary: The patterning of epithelial buds in lacrimal gland development is determined by the interplay between PI3K, Ras, and ERK signaling pathways. PI3K is activated by both IGF and FGF signaling, and also promotes ERK signaling through direct interaction with Ras. Inhibition of EGF signaling is essential for induction of lacrimal gland buds, and the cross-talk among FGF, IGF, and EGF signaling is mediated by PI3K, MAPK, and mTOR.