Article
Biochemistry & Molecular Biology
Hye Jin Jee, Dajung Ryu, Suyeon Kim, Sung Hum Yeon, Rak Ho Son, Seung Hwan Hwang, Yi-Sook Jung
Summary: Excessive stress is involved in the development of mood disorders, and fermented natural products like fermented Perilla frutescens (FPF) have shown potential health benefits. This study found that FPF improved depression-like behaviors in sleep-deprived mice, reduced stress hormone levels, increased levels of serotonin and dopamine, and reversed abnormal expression of proinflammatory cytokines and brain-derived neurotrophic factor. FPF also activated phosphorlation of TrkB, ERK, and CREB, suggesting its therapeutic potential through regulating the hypothalamic-pituitary-adrenal axis and the BDNF/TrkB/ERK/CREB signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Psychiatry
Ayyub Babaei, Maryam Nourshahi, Maryam Fani, Zahra Entezari, Seyed Behnamedin Jameie, Abbas Haghparast
Summary: Both continuous and interval exercise were found to effectively prevent depression induced by chronic unpredictable stress by increasing hippocampal PGC-1?, FNDC5, and BDNF proteins levels, leading to improvements in anxiety- and depression-like behaviors.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Zhi-ying Gao, Tian-yu Chen, Ting-ting Yu, Li-ping Zhang, Si-jie Zhao, Xiao-yang Gu, Ying Pan, Ling-dong Kong
Summary: Paternal stress exposure may contribute to depression in offspring, and cinnamaldehyde could be a potential intervention for intergenerational inheritance of depression.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Medicine, Research & Experimental
Kuo Zhang, Fan Wang, Mengying Zhai, Meiyao He, Yuxuan Hu, Lijin Feng, Yuting Li, Jingyu Yang, Chunfu Wu
Summary: Chronic stress can induce depressive-like behavior and inhibit adult hippocampal neurogenesis. Chronic corticosterone treatment decreases the proliferation and survival of neural stem cells, impairs the migration of newborn neurons, and increases neuronal autophagy. Inhibiting hyperactive neuronal autophagy can reverse the decrease in neuronal brain-derived neurotrophic factor levels, rescue neurogenesis, and exert antidepressant effects.
Review
Biochemistry & Molecular Biology
Shima Mohammadi, Milad Zandi, Parviz Dousti Kataj, Leila Karimi Zandi
Summary: Stress plays a crucial role in the development and progression of diseases, particularly in neurodegenerative conditions. Effective stress management can help maintain quality of life and improve capacity. Neurodegenerative diseases, such as Alzheimer's, cause motor and cognitive dysfunctions which themselves are stressful and can disrupt neural circuits related to stress responses. Stress also contributes to illness and can exacerbate symptoms in such conditions.
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2022)
Article
Cell Biology
Hailah M. ALmohaimeed, Zuhair M. Mohammedsaleh, Ashwaq H. Batawi, Maha Jameal Balgoon, Osama Ibrahim Ramadan, Hasan Ahmed Baz, Soad Al Jaouni, Nasra Naeim Ayuob
Summary: Cinnamomum cassia and Zingiber officinale in combination exhibit synergistic effects in improving blood glucose levels, reducing neuroinflammation, enhancing antioxidant capacity, and alleviating depressive-like behaviors in diabetic rats. This combination therapy shows superior efficacy compared to single administration of either ginger or cinnamon, providing a promising alternative or complementary supplement for managing diabetes and its neurological and psychiatric complications.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Neurosciences
Zhen Yao, Bei-Xuan Zhang, Hui Chen, Xiao-Wei Jiang, Wei-Min Qu, Zhi-Li Huang
Summary: Elevated glucocorticoid levels triggered by stress potentially contribute to sleep disturbances in stress-induced depression. However, the effects of the major glucocorticoid corticosterone (CORT) on sleep in rodents remain unclear. In this study, acute or chronic administration of CORT in mice resulted in rapid promotion of wakefulness, suppression of REM and NREM sleep, and altered EEG activity. Prolonged CORT exposure led to excessive wakefulness and REM sleep, decreased NREM sleep, and persistent sleep changes even after drug withdrawal. The observed sleep alterations were associated with elevated plasma CORT levels and depressive phenotypes. These findings provide insight into the neural link between insomnia and depression.
Article
Biology
Shihui Guo, Zijin Chen, Yingying Dong, Yingdong Ni, Ruqian Zhao, Wenqiang Ma
Summary: Copper is essential for human health, but chronic stress can lead to disorders in copper metabolism. In this study, it was found that corticosterone impairs copper transport by down-regulating intestinal CTR1 expression via GR-mediated transcriptional inhibition. This study provides a theoretical basis for regulating copper homeostasis under chronic stress.
Article
Medicine, General & Internal
Eva Ma Arroyo-Anllo, Corinne Souchaud, Pierre Ingrand, Jorge Chamorro Sanchez, Alejandra Melero Ventola, Roger Gil
Summary: Alexithymia, defined as the inability to identify and express emotions, has been linked to cognitive functioning, but studies have shown that Alzheimer's disease patients do not exhibit significantly higher levels of alexithymia compared to healthy individuals.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Inhye Park, Jiwoo Kim, Minji Kim, Dong Wook Lim, Jonghoon Jung, Min Jung Kim, Junho Song, Suengmok Cho, Min Young Um
Summary: This study found that the ethanol extract of Sargassum horneri has antidepressant effects by regulating the hypothalamic-pituitary-adrenal axis and monoaminergic pathway, as well as activating the ERK-CREB-BDNF signaling pathway in the prefrontal cortex and hippocampus.
Article
Biochemistry & Molecular Biology
Owen Davis Sanders, Lekshmy Rajagopal, Jayalekshmi Archa Rajagopal
Summary: The amyloid-beta oligomer hypothesis of Alzheimer's disease remains dominant in the field, but clinical trial evidence does not strongly support it. To rescue the hypothesis, researchers propose a new ad-hoc hypothesis suggesting that the vulnerable hippocampus may produce A beta peptides even in healthy aging individuals, and DNA damage, pathogens, and metal ions may drive A beta peptide aggregation and contribute to neurodegeneration in AD.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Immunology
Joao Paulo Bras, Isabelle Guillot de Suduiraut, Olivia Zanoletti, Silvia Monari, Mandy Meijer, Jocelyn Grosse, Mario Adolfo Barbosa, Susana Gomes Santos, Carmen Sandi, Maria Ines Almeida
Summary: This study suggests that male rats with high-CORT stress responsiveness exhibit increased anhedonia and passive coping responses in adulthood following peripubertal stress exposure. Additionally, exposure to peripubertal stress leads to increased hippocampal TNF-alpha expression, which correlates with passive coping responses. Furthermore, peripubertal stress has long-term effects on hippocampal microglia, particularly in high-CORT stress-responsive rats.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Biochemistry & Molecular Biology
Dong Wook Lim, Daeseok Han, Changho Lee
Summary: The antidepressant-like effects of Pedicularis resupinata extract (PRE) were evaluated in mice with CORT-induced depression. The study found that high dose PRE significantly alleviated the depressive-like behaviors induced by CORT and improved the effects on brain-derived neurotrophic factor.
Article
Geriatrics & Gerontology
Catarina Alexandra de Melo Rondao, Maria Paula Mota, Maria Manuel Oliveira, Francisco Peixoto, Dulce Esteves
Summary: Regular exercise is crucial in improving functional performance and reducing morbidity and mortality among older people. However, there is limited information on the effects of multicomponent exercise and cognitive stimulation on oxidative stress. This study aimed to investigate the impact of a multicomponent exercise program on physical fitness and cognitive function in older adults with mild cognitive impairment, and to determine the role of oxidative stress and BDNF. The results showed significant improvements in physical and functional performance, as well as a decrease in oxidative damage. These findings suggest that multicomponent exercise training can enhance functional capacity and reduce oxidative stress-related damage.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
Xiao-Ling Li, Hua Liu, Shu-Han Liu, Yong Cheng, Guo-Jun Xie
Summary: This study demonstrates that intranasal administration of BDNF can reduce depressive-like behaviors induced by chronic unpredictable mild stress, decrease the expression of inflammatory cytokines, and attenuate oxidative stress. Additionally, BDNF treatment increases neurogenesis in the hippocampus. These findings suggest that BDNF may represent a new therapeutic strategy for major depressive disorder.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2022)
Article
Andrology
Mona Ramadan Al-Shathly, Soad Shaker Ali, Nasra Naeim Ayuob
Article
Cell Biology
Nasra Ayuob, Maha Jameal Balgoon, Ahmed A. El-Mansy, Wafaa A. Mubarak, Alaa El-Din L. Firgany
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Article
Psychiatry
Nasra N. Ayuob, Maha J. Balgoon, Soad Ali, Ibrahim S. Alnoury, Hailah M. ALmohaimeed, Amany A. AbdElfattah
FRONTIERS IN PSYCHIATRY
(2020)
Article
Pharmacology & Pharmacy
Maha Jameal Balgoon, Maryam H. Al-Zahrani, Soad Al Jaouni, Nasra Ayuob
Summary: The combined topical and oral application of pumpkin extract (PE) significantly reduced inflammatory and oxidative changes induced by contact dermatitis and depression compared to standard treatment, mainly through downregulation of pro-inflammatory cytokines and upregulation of antioxidants.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Nasra Ayuob, Mona Ramadan Al-Shathly, Abdulaziz Bakhshwin, Nouf Saeed Al-Abbas, Nehad A. Shaer, Soad Al Jaouni, Walaa H. E. Hamed
Summary: The combined administration of ginger and cinnamon significantly lowers blood glucose levels, increases serum insulin levels, and exerts antioxidant effects by enhancing repair of pancreatic islet cells. This suggests a therapeutic potential for diabetes treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Nasra Ayuob, Soad Ali Shaker, Etedal Hawuit, Nouf Saeed Al-Abbas, Nehad A. Shaer, Soad Al Jaouni, Mohamed R. Mahdi
Summary: The study found that pumpkin extract exhibited significant antidepressant effects in a rat model of depression, improving behavioral, biochemical, and hippocampal pathological alterations. Compared to fluoxetine, pumpkin extract showed similar effects in reducing stress hormones, inflammatory mediators, oxidative stress levels, and improving tissue changes in the hippocampal region.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Behavioral Sciences
Hailah M. M. Almohaimeed, Ashwaq H. H. Batawi, Zuhair M. M. Mohammedsaleh, Soad Al Jaouni, Samiah A. A. Mutlq Alsawat, Manal G. G. Abd El Wahab, Amany A. A. AbdElfattah, Nasra N. N. Ayuob
Summary: Musk inhalation significantly reduced corticosterone level, inflammatory cytokines, and oxidative stress markers in CUMS-exposed mice. Musk ameliorated neuronal alterations in the MOB and enhanced neural cell proliferation, mainly through its antioxidant and anti-inflammatory effects.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Endocrinology & Metabolism
Khadija Faddladdeen, Soad Shaker, Safia Bahshwan, Nasra Ayuob
Summary: This study evaluated the impact of PTU-induced hypothyroidism on pancreatic islet cells and found that TQ could alleviate these effects by its antioxidant properties and promotion of pancreatic beta-catenin expression, thereby improving insulin homeostasis and beta-cell function in rats.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Cell Biology
Hailah M. ALmohaimeed, Zuhair M. Mohammedsaleh, Ashwaq H. Batawi, Maha Jameal Balgoon, Osama Ibrahim Ramadan, Hasan Ahmed Baz, Soad Al Jaouni, Nasra Naeim Ayuob
Summary: Cinnamomum cassia and Zingiber officinale in combination exhibit synergistic effects in improving blood glucose levels, reducing neuroinflammation, enhancing antioxidant capacity, and alleviating depressive-like behaviors in diabetic rats. This combination therapy shows superior efficacy compared to single administration of either ginger or cinnamon, providing a promising alternative or complementary supplement for managing diabetes and its neurological and psychiatric complications.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Duaa Bakhshwin, Khadija Abdul Jalil Faddladdeen, Soad Shaker Ali, Samar Mohammed Alsaggaf, Nasra Naeim Ayuob
Summary: This study aimed to assess the efficacy of nanoparticles of Costus speciosus in preserving the prostatic structure of diabetic rats and explore the mechanism behind this effect. The results showed that nanoparticles of Costus speciosus could effectively protect the prostatic structure of diabetic rats through the down-regulation of inflammatory cytokines and the up-regulation of antioxidant activity, as well as the anti-hyperglycemic effect by enhancing insulin secretion.
Article
Pharmacology & Pharmacy
Hailah M. Almohaimeed, Shereen Hamed, Hanan S. Seleem, Ashwaq H. Batawi, Zuhair M. Mohammedsaleh, Maha Jameal Balgoon, Soad S. Ali, Soad Al Jaouni, Nasra Ayuob
Summary: The study investigated the efficacy of Cucurbita pepo L. extract in alleviating behavioral, biochemical, and structural changes in the adrenal gland induced by chronic unpredictable mild stress (CUMS). The results showed that the extract reduced corticosterone levels, immobility time, and inflammatory and oxidative changes, suggesting its antioxidant and anti-inflammatory effects in mitigating stress-induced effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Correction
Psychiatry
Nasra N. Ayuob, Maha J. Balgoon, Soad Ali, Ibrahim S. Alnoury, Hailah M. ALmohaimeed, Amany A. AbdElfattah
FRONTIERS IN PSYCHIATRY
(2021)
Article
Allergy
Nasra Ayuob, Etedal Hawuit, Zuhair M. Mohammedsaleh, Dalia Shaalan, Maryam Mousa Hassn Hawasah, Khadija Abdulrhman Ahmed Basheikh, Soad Ali Shaker
Summary: This study assessed the efficacy of pumpkin fruit extract in relieving contact dermatitis in depressed rats and explored the mechanism behind this effect. The results showed that pumpkin extract significantly reduced inflammation and oxidative changes, down-regulated the expression of proinflammatory cytokines, and up-regulated antioxidants. This suggests that pumpkin extract could be a potential alternative treatment for contact dermatitis.
POSTEPY DERMATOLOGII I ALERGOLOGII
(2022)
Article
Dentistry, Oral Surgery & Medicine
Hailah M. Almohaimeed, Emad A. Albadawi, Zuhair M. Mohammedsaleh, Hadel M. Alghabban, Hanan S. Seleem, Osama Ramadan, Nasra N. Ayuob
Summary: The study found that exposure to chronic unpredictable mild stress induced changes in the structure and biochemical effects of the salivary glands in albino rats, which were ameliorated by pumpkin extract. Pumpkin extract significantly increased BDNF expression in the salivary glands and mitigated the histopathological and biochemical alterations induced by chronic stress.
JOURNAL OF APPLIED ORAL SCIENCE
(2021)
Article
Developmental Biology
Nasra Naeim Ayuob, Ahmed Abdel-Hamid Mohamed Abdel-Hamid, Ghada Mohamed Moneir Helal, Wafaa Alaa Mubarak
ROMANIAN JOURNAL OF MORPHOLOGY AND EMBRYOLOGY
(2019)
