Journal
ALZHEIMERS & DEMENTIA
Volume 14, Issue 3, Pages 271-279Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jalz.2017.08.015
Keywords
Neuropsychiatric symptoms; Risk factors; Dementia; Aged; Population-based study
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Funding
- US Alzheimer's Association [IIRG-04-1286]
- Wellcome Trust Health Consequences of Population Change Programme [GR08002]
- Gilberto Isaac Acosta Castillo of CONACyT [344748]
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Introduction: Cognitive and/or memory impairment are the main clinical markers currently used to identify subjects at risk of developing dementia. This study aimed to explore the relationship between the presence of neuropsychiatric symptoms and dementia incidence. Methods: We analyzed the association between neuropsychiatric symptoms and incident dementia in a cohort of 1355 Mexican older adults from the general population over 3 years of follow-up, modeling cumulative incidence ratios using Poisson models. Results: Five neuropsychiatric symptoms were associated with incident dementia: delusions, hallucinations, anxiety, aberrant motor behavior, and depression. The simultaneous presence of two symptoms had a relative risk, adjusted for mild cognitive impairment, diabetes, indicators of cognitive function, and sociodemographic factors, of 1.9 (95% confidence interval, 1.2-2.9), whereas the presence of three to five, similarly adjusted, had a relative risk of 3.0 (95% confidence interval, 1.9-4.8). Discussion: Neuropsychiatric symptoms are common in predementia states and may independently contribute as risk factors for developing dementia. (C) 2017 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer's Association.
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