Article
Radiology, Nuclear Medicine & Medical Imaging
Soleen Ghafoor, Manon Germann, Christoph Juengst, Beat Muellhaupt, Cacilia S. Reiner, Daniel Stocker
Summary: COVID-19-associated secondary sclerosing cholangitis presents with intrahepatic bile duct strictures, upstream dilatation, and bile duct beading on MRI/MRCP, with the extrahepatic biliary tree and periportal lymph nodes being typically spared.
INSIGHTS INTO IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Marwa F. Ismail, Gideon M. Hirschfield, Bettina Hansen, Monica Tafur, Khaled Y. Elbanna, Marc H. Goldfinger, Gerard R. Ridgway, Kartik S. Jhaveri
Summary: MRCP+ showed significant associations with biochemical scores and MRE, with its association with biochemical scores comparable to ANALI scores. MRCP+ enhanced the associations of ANALI2 and MRE with the Mayo Risk Score.
EUROPEAN RADIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Aristeidis Grigoriadis, Kristina Imeen Ringe, Johan Bengtsson, Erik Baubeta, Cecilia Forsman, Nafsika Korsavidou-Hult, Fredrik Rorsman, Emma Nilsson, Nikolaos Kartalis, Annika Bergquist
Summary: Magnetic resonance cholangiopancreatography (MRCP) plays an important role in the prognosis assessment of primary sclerosing cholangitis (PSC). A novel, simple, and reproducible risk-score (DiStrict score) based on MRCP findings was developed and showed a strong association with prognosis in individuals with PSC. This score can be easily used in clinical practice and has the potential to be useful in clinical trials and patient counseling and management.
Article
Gastroenterology & Hepatology
European Assoc Study Liver
Summary: This article presents guidelines for the management of primary or secondary sclerosing cholangitis, covering topics such as diagnostic methods, prognostic assessment, early detection of complications, optimal care pathways, and therapeutic options for both adults and children.
JOURNAL OF HEPATOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sarah Poetter-Lang, Alina Messner, Nina Bastati, Kristina I. Ringe, Maxime Ronot, Sudhakar K. Venkatesh, Raphael Ambros, Antonia Kristic, Aida Korajac, Gregor Dovjak, Martin Zalaudek, Jacqueline. C. Hodge, Christoph Schramm, Emina Halilbasic, Michael Trauner, Ahmed Ba-Ssalamah
Summary: T1-MRC was found to be superior to T2-MRCP in diagnosing and locating strictures, as well as predicting prognosis in patients with primary sclerosing cholangitis.
EUROPEAN RADIOLOGY
(2023)
Article
Gastroenterology & Hepatology
John E. Eaton, Christopher L. Welle, Zeinab Bakhshi, Shannon P. Sheedy, Ilkay S. Idilman, Gregory J. Gores, Charles B. Rosen, Julie K. Heimbach, Timucin Taner, Denise M. Harnois, Keith D. Lindor, Nicholas F. LaRusso, Andrea A. Gossard, Konstantinos N. Lazaridis, Sudhakar K. Venkatesh
Summary: This study aimed to evaluate the diagnostic performances and prognostic implications of ultrasound and MRI-based perihilar cholangiocarcinoma (CCA) detection among patients with primary sclerosing cholangitis (PSC). Results showed that MRI was superior to ultrasound for the detection of early-stage CCA in PSC patients, and identifying CCA before symptom onset with MRI was associated with improved outcomes.
Article
Gastroenterology & Hepatology
Satoru Hagiwara, Takeshi Yoshida, Naoshi Nishida, Hiroshi Ida, Kazuomi Ueshima, Yasunori Minami, Masahiro Takita, Tomoko Aoki, Masahiro Morita, Hirokazu Cishina, Yoriaki Komeda, Akihiro Yoshida, Hidetoshi Hayashi, Kazuhiko Nakagawa, Masatoshi Kudo
Summary: This case report describes a rare case of immune-related cholangitis in a patient with squamous cell lung cancer. The patient did not respond to conventional treatment for liver dysfunction but showed improvement with the introduction of immunotherapy.
HEPATOLOGY RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Christina Villard, Ingalill Friis-Liby, Fredrik Rorsman, Karouk Said, Anna Warnqvist, Martin Cornillet, Stergios Kechagias, Nils Nyhlin, Marten Werner, Izabella Janczewska, Therese Hagstrom, Emma Nilsson, Annika Bergquist
Summary: This study prospectively evaluated the effectiveness of yearly MRI/MRCP surveillance in detecting cholangiocarcinoma (CCA) in patients with primary sclerosing cholangitis (PSC) and found it to be ineffective in detecting cancer early enough to support long-term survival. Personalized follow-up strategies and improved diagnostic methods for PSC-related CCA are needed.
JOURNAL OF HEPATOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yun Zhang, Xiaoli Fan, Bin Song, Yifeng Liu, Yidi Chen, Tianying Zheng, Yuxin Guo, Ting Duan, Zixing Huang, Li Yang
Summary: This study explored the feasibility of using nonenhanced magnetic resonance imaging (MRI) to predict insufficient biochemical response to ursodeoxycholic acid (UDCA) in patients with primary biliary cholangitis (PBC). The results showed that a predictive model based on three pretreatment MRI features could accurately predict insufficient biochemical response to UDCA treatment in PBC patients within 12 months. Early identification of high-risk patients can facilitate the timely initiation of additional treatment.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Erick Cruz Grave, Thomas Loehfelm, Michael T. Corwin, Joseph Zepeda, Harjot K. Bath, Sandeep Dhaliwal, Maryam Yazdanfar, Christopher L. Bowlus
Summary: This study found that the Anali score provides additional predictive value for hepatic decompensation in patients with PSC. The Anali score has good discriminative ability with the Mayo risk score and can serve as an independent predictor.
ABDOMINAL RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yu Zhang, Wanlin Peng, Yi Xiao, Yue Ming, Kehang Ma, Sixian Hu, Wen Zeng, Lingming Zeng, Zejun Liang, Xiaoyong Zhang, Chunchao Xia, Zhenlin Li
Summary: A study compared the image quality of different magnetic resonance cholangiopancreatography (MRCP) techniques and found that three-dimensional breath-hold MRCP with deep learning-based compressed sensing reconstruction (3D DL-CS-MRCP) demonstrated superior performance compared to other methods.
EUROPEAN RADIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Nora Cazzagon, Ester Gonzalez-Sanchez, Haquima El-Mourabit, Dominique Wendum, Dominique Rainteau, Lydie Humbert, Christophe Corpechot, Olivier Chazouilleres, Lionel Arrive, Chantal Housset, Sara Lemoinne
Summary: In patients with primary sclerosing cholangitis (PSC), the gallbladder status affects bile acid homeostasis and disease features. Evidence suggests less bile acid toxicity in patients with enlarged gallbladders and increased disease severity in those who had undergone cholecystectomy. In a mouse model of PSC, cholecystectomy worsened cholangitis and liver fibrosis. Overall, the gallbladder plays a protective role in PSC.
Article
Radiology, Nuclear Medicine & Medical Imaging
Aristeidis Grigoriadis, Kristina I. Ringe, Mats Andersson, Nikolaos Kartalis, Annika Bergquist
Summary: The study evaluated the interreader agreement and prognostic performance of two ANALI-scores for patients with PSC, finding poor to moderate agreement and better outcome-free survival rates for patients with low ANALI-scores.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Annika Bergquist, Tobias J. Weismueller, Cynthia Levy, Christian Rupp, Deepak Joshi, Jeremy Shanika Nayagam, Aldo J. Montano-Loza, Ellina Lytvyak, Ewa Wunsch, Piotr Milkiewicz, Roman Zenouzi, Christoph Schramm, Nora Cazzagon, Annarosa Floreani, Ingalill Friis Liby, Miriam Wiestler, Heiner Wedemeyer, Taotao Zhou, Christian P. Strassburg, Eirini Rigopoulou, George Dalekos, Manasa Narasimman, Xavier Verhelst, Helena Degroote, Mette Vesterhus, Andreas E. Kremer, Bennet Buendgens, Fredrik Rorsman, Emma Nilsson, Kristin Kaasen Jorgensen, Erik von Seth, Martin Cornillet Jeannin, Nils Nyhlin, Harry Martin, Stergios Kechagias, Kristine Wiencke, Marten Werner, Benedetta Terziroli Beretta-Piccoli, Marco Marzioni, Helena Isoniemi, Johanna Arola, Agnes Wefer, Jonas Soderling, Martti Farkkila, Henrike Lenzen
Summary: This study compares different follow-up strategies in patients with PSC and finds that scheduled imaging can improve survival. There are considerable variations in follow-up strategies across centers, but multiple factors may contribute to this result.
LIVER INTERNATIONAL
(2023)
Article
Multidisciplinary Sciences
Rolf Reiter, Mehrgan Shahryari, Heiko Tzschatzsch, Dieter Klatt, Britta Siegmund, Bernd Hamm, Jurgen Braun, Ingolf Sack, Patrick Asbach
Summary: The study assessed spatial heterogeneity of hepatic fibrosis in PSC and viral hepatitis using MR elastography, finding significantly increased fibrosis heterogeneity in PSC compared to viral hepatitis. There was no significant difference in shear-wave speed between PSC and viral hepatitis, indicating potential for enhanced diagnosis based on spatial heterogeneity patterns revealed by MRI.
SCIENTIFIC REPORTS
(2021)
Article
Gastroenterology & Hepatology
Michael Trauner, Christopher L. Bowlus, Aliya Gulamhusein, Bilal Hameed, Stephen H. Caldwell, Mitchell L. Shiffman, Charles Landis, Andrew J. Muir, Andrew Billin, Jun Xu, Xiangyu Liu, Xiaomin Lu, Chuhan Chung, Robert P. Myers, Kris V. Kowdley
Summary: In this 96-week open-label extension study, Cilofexor was found to be safe and effective in improving liver function and biomarkers of cholestasis and cellular injury in patients with PSC.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Jun Xu, Ya Wang, Mina Khoshdeli, Matt Peach, Jen-Chieh Chuang, Julie Lin, Wen-Wei Tsai, Sangeetha Mahadevan, Wesley Minto, Lauri Diehl, Ruchi Gupta, Michael Trauner, Keyur Patel, Mazen Noureddin, Kris Kowdley, Aliya Gulamhusein, Christopher L. Bowlus, Ryan S. Huss, Robert P. Myers, Chuhan Chung, Andrew N. Billin
Summary: This study evaluated IL-31 as a potential biomarker for pruritus in clinical trials of cilofexor, an FXR agonist, in patients with cholestatic liver diseases. IL-31 levels were found to be elevated in patients with PSC and PBC and correlated with serum bile acids. The study also showed that cilofexor therapy increased IL-31 levels in patients with NASH.
Article
Surgery
Melisa Dirchwolf, Chiara Becchetti, Susanne Stampf, Christa Haldimann, Franz Immer, Franziska Beyeler, Christian Toso, Philipp Dutkowski, Daniel Candinas, Jean-Francois Dufour, Vanessa Banz
Summary: This study analyzed the impact of perceived liver donor quality on transplant recipient outcomes. It included all deceased liver donors during 2008-2018 in the Swiss Transplant Cohort Study. The results showed that perceived poor-quality liver donors accounted for 19.2% of the total, but this did not significantly affect re-listing or death within the first week and first year post-transplant.
ANZ JOURNAL OF SURGERY
(2023)
Article
Gastroenterology & Hepatology
Jasmin Zessner-Spitzenberg, Lena Jiricka, Elisabeth Waldmann, Lisa -Maria Rockenbauer, Jeremy Cook, Anna Hinterberger, Barbara Majcher, Aleksandra Szymanska, Arno Asaturi, Michael Trauner, Monika Ferlitsch
Summary: A retrospective study with 316,001 individuals revealed that polyps sized 10-20mm and high-grade dysplasia are significantly associated with post-colonoscopy colorectal cancer (PCCRC) mortality. Patients with polyps <10mm and without high-grade dysplasia have significantly lower PCCRC mortality compared to the general population, while those with polyps >10mm or with high-grade dysplasia do not have this advantage.
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Infectious Diseases
David Chromy, David Bauer, Benedikt Simbrunner, Mathias Jachs, Lukas Hartl, Philipp Schwabl, Teresa Binter, Lisa Steininger, Caroline Schwarz, Armin Rieger, Katharina Grabmeier-Pfistershammer, Michael Trauner, Peter Ferenci, Markus Peck-Radosavljevic, Mattias Mandorfer, Thomas Reiberger
Summary: HCV cure rates in Viennese HIV patients increased significantly from 49% in the IFN era to 88-95% in the DAA era. However, MSM-related risk behavior and reinfections have become the key challenges towards HCV elimination in HIV/HCV-coinfected patients.
INFECTIOUS DISEASES
(2023)
Article
Oncology
K. Pomej, L. Balcar, K. Shmanko, S. Welland, V. Himmelsbach, B. Scheiner, A. Mahyera, B. Mozayani, M. Trauner, F. Finkelmeier, A. Weinmann, A. Vogel, M. Pinter
Summary: There is no consensus on the optimal systemic treatment regimen for combined hepatocellular-cholangiocarcinoma (cHCC-CCA) patients. This European multicenter study analyzed the clinical characteristics and outcomes of cHCC-CCA patients, focusing on those receiving palliative systemic therapy, including immune checkpoint inhibitors (ICIs). The study found no significant difference in overall survival, progression-free survival, overall response rate, and disease control rate between patients receiving cytotoxic chemotherapy (CHT) and non-cytotoxic chemotherapy (nCHT).
Article
Gastroenterology & Hepatology
Gideon M. Hirschfield, Mitchell L. Shiffman, Aliya Gulamhusein, Kris Kowdley, John M. Vierling, Cynthia Levy, Andreas E. Kremer, Ehud Zigmond, Pietro Andreone, Stuart C. Gordon, Christopher L. Bowlus, Eric J. Lawitz, Richard J. Aspinall, Daniel S. Pratt, Karina Raikhelson, Maria S. Gonzalez-Huezo, Michael A. Heneghan, Sook-Hyang Jeong, Alma L. Ladron de Guevara, Marlyn J. Mayo, George N. Dalekos, Joost P. H. Drenth, Ewa Janczewska, Barbara A. Leggett, Frederik Nevens, Victor Vargas, Eli Zuckerman, Christophe Corpechot, Eduardo Fassio, Holger Hinrichsen, Pietro Invernizzi, Palak J. Trivedi, Lisa Forman, David E. J. Jones, Stephen D. Ryder, Mark G. Swain, Alexandra Steinberg, Pol F. Boudes, Yun-Jung Choi, Charles A. McWherter
Summary: This study evaluated the efficacy and safety of seladelpar in patients with primary biliary cholangitis who had inadequate response or intolerance to ursodeoxycholic acid. The results showed that seladelpar significantly improved liver biochemistry and pruritus in these patients, and it was well tolerated.
Article
Gastroenterology & Hepatology
Grazia Pennisi, Marco Enea, Vincenzo Falco, Guruprasad P. Aithal, Naaventhan Palaniyappan, Yusuf Yilmaz, Jerome Boursier, Christophe Cassinotto, Victor de Ledinghen, Wah Kheong Chan, Sanjiv Mahadeva, Peter Eddowes, Philip Newsome, Thomas Karlas, Johannes Wiegand, Vincent Wai-Sun Wong, Joern M. Schattenberg, Christian Labenz, Won Kim, Myoung Seok Lee, Monica Lupsor-Platon, Jeremy F. L. Cobbold, Jian-Gao Fan, Feng Shen, Katharina Staufer, Michael Trauner, Rudolf Stauber, Atsushi Nakajima, Masato Yoneda, Elisabetta Bugianesi, Ramy Younes, Silvia Gaia, Ming-Hua Zheng, Calogero Camma, Quentin M. Anstee, Ferenc E. Mozes, Michael Pavlides, Salvatore Petta
Summary: This study evaluated the diagnostic accuracy of simple, noninvasive tests (NITs) in patients with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D). The results showed that liver stiffness measurement (LSM) and AGILE 3+ were better at determining advanced fibrosis compared to serum tests. The evaluation of diagnostic methods for NAFLD with T2D is clinically significant.
Article
Gastroenterology & Hepatology
Mary E. Rinella, Jeffrey V. Lazarus, Vlad Ratziu, Sven M. Francque, Arun J. Sanyal, Fasiha Kanwal, Diana Romero, Manal F. Abdelmalek, Quentin M. Anstee, Juan Pablo Arab, Marco Arrese, Ramon Bataller, Ulrich Beuers, Jerome Boursier, Elisabetta Bugianesi, Christopher D. Byrne, Graciela E. Castro Narro, Abhijit Chowdhury, Helena Cortez-Pinto, Donna R. Cryer, Kenneth Cusi, Mohamed El-Kassas, Samuel Klein, Wayne Eskridge, Jiangao Fan, Samer Gawrieh, Cynthia D. Guy, Stephen A. Harrison, Seung Up Kim, Bart G. Koot, Marko Korenjak, Kris V. Kowdley, Florence Lacaille, Rohit Loomba, Robert Mitchell-Thain, Timothy R. Morgan, Elisabeth E. Powell, Michael Roden, Manuel Romero-Gomez, Marcelo Silva, Shivaram Prasad Singh, Silvia C. Sookoian, C. Wendy Spearman, Dina Tiniakos, Luca Valenti, Miriam B. Vos, Vincent Wai-Sun Wong, Stavra Xanthakos, Yusuf Yilmaz, Zobair Younossi, Ansley Hobbs, Marcela Villota-Rivas, Philip N. Newsome
Summary: This study aimed to determine if there was a need to change the nomenclature and definition of NAFLD and NASH. Through a Delphi process involving content experts and patient advocates, a consensus was reached to replace NAFLD with metabolic dysfunction-associated steatotic liver disease (MetALD) and modify the diagnostic criteria. The new nomenclature and criteria are widely supported, nonstigmatizing, and can improve awareness and patient identification.
Review
Gastroenterology & Hepatology
Iulia Minciuna, Suchira Gallage, Mathias Heikenwalder, Shira Zelber-Sagi, Jean-Francois Dufour
Summary: NASH, a chronic liver disease that can progress to end-stage liver disease and HCC, can be effectively treated with intermittent fasting, which not only induces weight loss but also reduces inflammation and oxidative stress.
Article
Multidisciplinary Sciences
Lorenz Balcar, David Bauer, Katharina Pomej, Tobias Meischl, Mattias Mandorfer, Thomas Reiberger, Michael Trauner, Bernhard Scheiner, Matthias Pinter
Summary: Immunotherapy is the new standard of care for hepatocellular carcinoma, but there is a need for biomarkers that predict treatment response and survival. This study suggests that the relative change in IgG after ICI treatment can serve as a negative prognostic marker in patients with HCC.
Article
Oncology
Al B. Benson, Michael I. D'Angelica, Thomas Abrams, Daniel E. Abbott, Aijaz Ahmed, Daniel A. Anaya, Robert Anders, Chandrakanth Are, Melinda Bachini, David Binder, Mitesh Borad, Christopher Bowlus, Daniel Brown, Adam Burgoyne, Jason Castellanos, Prabhleen Chahal, Jordan Cloyd, Anne M. Covey, Evan S. Glazer, William G. Hawkins, Renuka Iyer, Rojymon Jacob, Lawrence Jennings, R. Kate Kelley, Robin Kim, Matthew Levine, Manisha Palta, James O. Park, Steven Raman, Sanjay Reddy, Sean Ronnekleiv-Kelly, Vaibhav Sahai, Gagandeep Singh, Stacey Stein, Anita Turk, Jean-Nicolas Vauthey, Alan P. Venook, Adam Yopp, Nicole McMillian, Ryan Schonfeld, Cindy Hochstetler
Summary: In 2023, the NCCN Guidelines for Hepatobiliary Cancers were divided into two separate guidelines: Hepatocellular Carcinoma and Biliary Tract Cancers. The Biliary Tract Cancers guidelines provide recommendations for the evaluation and comprehensive care of patients with gallbladder cancer, intrahepatic cholangiocarcinoma, and extrahepatic cholangiocarcinoma. A multidisciplinary panel of experts meets regularly to review new data and therapies.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2023)
Article
Gastroenterology & Hepatology
Anne-Sofie H. Jensen, Marie Winther-Sorensen, Johan Burisch, Annika Bergquist, Henriette Ytting, Lise L. Gluud, Nicolai J. Wewer Albrechtsen
Summary: Patients with autoimmune liver diseases have a significantly increased risk of diabetes. Increased awareness of diabetes risk in patients with autoimmune liver diseases is warranted.
LIVER INTERNATIONAL
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Matthew A. Morgan, Rachita Khot, Karthik M. Sundaram, Daniel R. Ludwig, Rashmi T. Nair, Pardeep K. Mittal, Dhakshina M. Ganeshan, Sudhakar K. Venkatesh
Summary: Primary sclerosing cholangitis is a chronic disease that affects the bile ducts, leading to various complications. Imaging plays a crucial role in diagnosis and treatment.
ABDOMINAL RADIOLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Christopher L. Welle, Patrick J. Navin, Michael C. Olson, Safa Hoodeshenas, Michael S. Torbenson, Sudhakar K. Venkatesh
Summary: Primary sclerosing cholangitis is a chronic liver disease without effective medical treatment, and liver fibrosis is a crucial factor in patient outcome. Magnetic resonance elastography is an accurate non-invasive method for assessing liver fibrosis and is particularly important in evaluating PSC patients.
ABDOMINAL RADIOLOGY
(2023)