Mice with reduced expression of the telomere-associated protein Ft1 develop p53-sensitive progeroid traits

The telomeric protein AKTIP interacts with A- and B-type lamins and is involved in regulation of cellular senescence

(2016) Romina Burla et al.   Open Biology

Mammalian telomeres and their partnership with lamins

(2016) Romina Burla et al.   Nucleus

Mammalian telomeres and their partnership with lamins

(2016) Romina Burla et al.   Nucleus

DNA repair defects and genome instability in Hutchinson–Gilford Progeria Syndrome

(2015) Susana Gonzalo et al.   CURRENT OPINION IN CELL BIOLOGY

AKTIP/Ft1, a New Shelterin-Interacting Factor Required for Telomere Maintenance

(2015) Romina Burla et al.   PLoS Genetics

The Analysis of Pendolino (peo) Mutants Reveals Differences in the Fusigenic Potential among Drosophila Telomeres

(2015) Giovanni Cenci et al.   PLoS Genetics

Essential role for the TRF2 telomere protein in adult skin homeostasis

(2014) Paula Martínez et al.   AGING CELL

The evolution of thymic lymphomas in p53 knockout mice

(2014) Crissy Dudgeon et al.   GENES & DEVELOPMENT

The Role of Double-Strand Break Repair Pathways at Functional and Dysfunctional Telomeres

(2014) Y. Doksani et al.   Cold Spring Harbor Perspectives in Biology

Interaction of the oncogenic miR-21 microRNA and the p53 tumor suppressor pathway

(2013) Xiaodong Ma et al.   CARCINOGENESIS

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Robust cellular reprogramming occurs spontaneously during liver regeneration

(2013) K. Yanger et al.   GENES & DEVELOPMENT

Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span

(2013) L. Ashley Watson et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting Isoprenylcysteine Methylation Ameliorates Disease in a Mouse Model of Progeria

(2013) M. X. Ibrahim et al.   SCIENCE

Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion

(2013) Jorge de la Rosa et al.   Nature Communications

Accumulation of the Inner Nuclear Envelope Protein Sun1 Is Pathogenic in Progeric and Dystrophic Laminopathies

(2012) Chia-Yen Chen et al.   CELL

Human ZMPSTE24 disease mutations: residual proteolytic activity correlates with disease severity

(2012) Jemima Barrowman et al.   HUMAN MOLECULAR GENETICS

HIPK2 Controls Cytokinesis and Prevents Tetraploidization by Phosphorylating Histone H2B at the Midbody

(2012) Cinzia Rinaldo et al.   MOLECULAR CELL

Cell autonomous and systemic factors in progeria development: Figure 1.

(2011) Fernando G. Osorio et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Telomerase-deficient mice exhibit bone loss owing to defects in osteoblasts and increased osteoclastogenesis by inflammatory microenvironment

(2011) Hamid Saeed et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Splicing-Directed Therapy in a New Mouse Model of Human Accelerated Aging

(2011) F. G. Osorio et al.   Science Translational Medicine

Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication

(2009) Agnel Sfeir et al.   CELL

Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice

(2009) P. Martinez et al.   GENES & DEVELOPMENT

p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice

(2009) Yvonne Begus-Nahrmann et al.   NATURE GENETICS

Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing

(2008) Paola Scaffidi et al.   NATURE CELL BIOLOGY