Article
Physiology
Kulwant S. Aulak, Sami Al Abdi, Ling Li, Jack S. Crabb, Arnab Ghosh, Belinda Willard, Dennis J. Stuehr, John W. Crabb, Raed A. Dweik, Adriano R. Tonelli
Summary: Idiopathic pulmonary arterial hypertension (IPAH) is a rapidly progressive disease with great heterogeneity in treatment response and systemic involvement, despite most of its pathology being observed in the lung. Platelets from IPAH patients exhibit characteristic metabolic shifts and activation defects, as well as abnormalities in prostacyclin and nitric oxide pathways. These findings suggest potential targets for therapy, with variations in soluble guanylate cyclase levels showing implications for personalized treatment in IPAH patients. Platelets may provide informative mechanistic insights ex vivo to guide therapeutic decisions in IPAH.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Article
Critical Care Medicine
Nicholas A. Kolaitis
Summary: Lung transplantation is a unique and effective treatment option for patients with end-stage pulmonary arterial hypertension. However, these patients face various challenges and inequities in the organ allocation process, resulting in less favorable long-term outcomes.
Article
Medicine, General & Internal
Marc Humbert, Vallerie McLaughlin, J. Simon R. Gibbs, Mardi Gomberg-Maitland, Marius M. Hoeper, Ioana R. Preston, Rogerio Souza, Aaron Waxman, Pilar Escribano Subias, Jeremy Feldman, Gisela Meyer, David Montani, Karen M. Olsson, Solaiappan Manimaran, Jennifer Barnes, Peter G. Linde, Janethe de Oliveira Pena, David B. Badesch
Summary: In this study, patients with pulmonary arterial hypertension receiving Sotatercept treatment showed a significant reduction in pulmonary vascular resistance at 24 weeks, with both Sotatercept groups performing better than the placebo group.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Review
Immunology
Shao-Fei Liu, Netra Nambiar Veetil, Qiuhua Li, Mariya M. M. Kucherenko, Christoph Knosalla, Wolfgang M. M. Kuebler
Summary: Pulmonary hypertension is a progressive disease caused by inflammation, which leads to pulmonary arterial stiffness and vascular remodeling, driving the progression of the disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Mikael Aberg, Erik Bjorklund, Gerhard Wikstrom, Christina Christersson
Summary: This study analyzed platelet activation and platelet-monocyte and granulocyte aggregates in patients with PAH and CTEPH using flow cytometry. The findings showed that circulating platelets were activated and formed aggregates with monocytes and granulocytes in these patients. Additionally, proinflammatory cytokines were found to be increased in all PH subgroups, and the platelet-leukocyte aggregates were associated with these cytokines. These results suggest that the increased concentrations of platelet-leukocyte aggregates might contribute to the inflammatory state in PH.
Article
Chemistry, Analytical
Diana Garcia-Rubio, Ivette Martinez-Vieyra, Maria Beatriz de la Mora, Marco Antonio Fuentes-Garcia, Doris Cerecedo
Summary: Arterial hypertension is a global public health concern and a significant risk factor for cardiovascular diseases and renal failure. A diagnostic assay using gold nanoparticles conjugated to ENaC antibodies showed promise for initial screening and early diagnosis of arterial hypertension.
Article
Critical Care Medicine
Bradley A. Maron, Steven H. Abman, C. Greg Elliott, Robert P. Frantz, Rachel K. Hopper, Evelyn M. Horn, Mark R. Nicolls, Oksana A. Shlobin, Sanjiv J. Shah, Gabor Kovacs, Horst Olschewski, Erika B. Rosenzweig
Summary: The diagnosis and management of pulmonary arterial hypertension have seen advances in early diagnosis, multiple pharmacotherapeutics, and new risk factors becoming focal points. Developmental biology may be useful in predicting incident PAH.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Pathology
Jan Balko, Jan Havlin, Fernando CasasMendez, Andrea Zajacova, Miroslav Koblizek, Monika Svorcova, Robert Lischke, Josef Zamecnik
Summary: This study describes the characteristics, distribution, and total count of megakaryocytes in lung transplant recipients and donors. It found that patients with idiopathic pulmonary arterial hypertension had significantly higher numbers of megakaryocytes in the lungs, which could contribute to the development of the disease.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Review
Biochemistry & Molecular Biology
Carrie L. Welch, Wendy K. Chung
Summary: Pulmonary arterial hypertension (PAH) is a rare and progressive vascular disease with no curative treatments available. Genetic variants are found in a significant portion of PAH patients, and understanding their diagnoses can inform clinical management, risk stratification, and the development of new therapies.
Article
Cardiac & Cardiovascular Systems
Andrew Constantine, Konstantinos Dimopoulos
Summary: Pulmonary artery denervation is a novel intervention aimed at reducing sympathetic activity in the pulmonary circulation for the treatment of pulmonary arterial hypertension. Despite some positive effects shown in pre-clinical studies and initial clinical trials, the technique's scope in current practice remains limited due to the lack of well-designed, large-scale, international randomized controlled clinical trials.
TRENDS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Aangi J. Shah, Mounica Vorla, Dinesh K. Kalra
Summary: Pulmonary arterial hypertension is a chronic disease characterized by abnormalities in the pulmonary vascular system and right ventricular dysfunction. Current treatments have limited effectiveness, highlighting the importance of understanding the molecular pathogenesis of this condition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
R. Mark Grady, Matthew W. Canter, Fei Wan, Anton A. Shmalts, Ryan D. Coleman, Maurice Beghetti, Rolf M. F. Berger, Maria J. del Cerro Marin, Scott E. Fletcher, Russel Hirsch, Tilman H. Umpl, D. Dunbar Ivy, Edward C. Kirkpatrick, Thomas J. Kulik, Marilyne Levy, Shahin Moledina, Delphine Yung, Pirooz Eghtesady, Damien Bonnet
Summary: Pulmonary-to-systemic arterial shunt surgery provides significant clinical improvement for children with severe PH, with high survival rates after discharge, while children at high risk in-hospital are not suitable candidates for the procedure.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Iona Cuthbertson, Nicholas W. Morrell, Paola Caruso
Summary: Pulmonary arterial hypertension (PAH) is the most severe type of pulmonary hypertension, characterized by progressive remodeling of peripheral pulmonary arteries. Endothelial cell dysfunction is a key trigger, leading to vascular remodeling, increased pressure, and right ventricular hypertrophy. Abnormal cellular molecular signatures and loss-of-function mutations in the BMPR2 gene contribute to PAH pathophysiology. Metabolic abnormalities, including glycolytic reprogramming and mitochondrial dysfunction, are observed in various tissues and may affect treatment response. This review critically discusses the mechanisms linking metabolic abnormalities with dysfunctional BMPR2 signaling and their relevance to PAH pathogenesis and potential therapies.
CIRCULATION RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Shia Vang, Phillip Cochran, Julio Sebastian Domingo, Stefanie Krick, Jarrod Wesley Barnes
Summary: Pulmonary arterial hypertension (PAH) is a complex pulmonary vascular disease with low survival rate without treatment. Idiopathic PAH (IPAH) is associated with metabolic dysregulation, including altered nitric oxide (NO) availability and dysregulated glucose metabolism. Metabolic changes may regulate multiple processes in PAH. Recent studies have highlighted similarities between PAH and cancer in terms of metabolic abnormalities.
Review
Medicine, General & Internal
Tomasz Stacel, Magdalena Latos, Maciej Urlik, Miroslaw Necki, Remigiusz Antonczyk, Tomasz Hrapkowicz, Marcin Kurzyna, Marek Ochman
Summary: Although pharmacological treatments have advanced significantly, interventional and surgical options remain viable for treating pulmonary arterial hypertension (PAH), especially in the case of idiopathic PAH. Veno-arterial extracorporeal membrane oxygenation (V-A ECMO) serves as the ultimate bridging therapy for severe PAH patients, with lung transplantation (Ltx) as the final surgical option for refractory cases. Creating artificial defects to obtain Eisenmenger physiology can improve survival, but risks associated with shunting and closure of these defects must be carefully considered.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Remigiusz Kazimierczyk, Piotr Szumowski, Stephan G. Nekolla, Piotr Blaszczak, Lukasz A. Malek, Barbara Milosz-Wieczorek, Jolanta Misko, Dorota Jurgilewicz, Marcin Hladunski, Malgorzata Knapp, Bozena Sobkowicz, Janusz Mysliwiec, Ryszard Grzywna, Wlodzimierz J. Musial, Karol A. Kaminski
Summary: The study found that RV glucose uptake in PET and decreased RVEF can identify PAH patients with worse prognosis. Combining parameters from PET and MRI may help identify higher-risk patients who could benefit from escalated therapy, but this hypothesis needs prospective validation.
Article
Medicine, Research & Experimental
Remigiusz Kazimierczyk, Lukasz A. Malek, Piotr Szumowski, Piotr Blaszczak, Dorota Jurgilewicz, Marcin Hladunski, Bozena Sobkowicz, Janusz Mysliwiec, Ryszard Grzywna, Wlodzimierz J. Musial, Karol A. Kaminski
Summary: Dysfunction of the right ventricle is crucial for survival in patients with pulmonary arterial hypertension, with late gadolinium enhancement at RV insertion points being associated with RV dysfunction. Quantification of LGE at RVIPs can provide additional prognostic information, as shown in the study where higher LGEMI correlated with worse prognosis in PAH patients. The indexed mass of LGE at RV septal insertion points may serve as a non-invasive marker of PAH prognosis.
ADVANCES IN MEDICAL SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Pawel Koziel, Piotr Jankowski, Dariusz A. Kosior, Pawel Sowa, Karolina Szostak-Janiak, Agnieszka Krzykwa, Emilia Sawicka, Maciej Haberka, Malgorzata Setny, Karol Kaminski, Zbigniew Gasior, Aldona Kubica, Dirk De Bacquer, Guy De Backer, Kornelia Kotseva, David Wood, Danuta Czarnecka, Andrzej Pajak
Summary: Smoking cessation in patients with coronary artery disease is associated with decreased risk of cardiovascular events. Factors related to persistent smoking in these patients include older age, exposure to secondhand smoke, low socioeconomic status, lack of consultation with a cardiologist, and not participating in cardiac rehabilitation.
KARDIOLOGIA POLSKA
(2021)
Article
Medicine, General & Internal
Malgorzata Chlabicz, Jacek Jamiolkowski, Wojciech Laguna, Pawel Sowa, Marlena Paniczko, Magda Lapinska, Malgorzata Szpakowicz, Natalia Drobek, Andrzej Raczkowski, Karol A. Kaminski
Summary: The study found that participants in moderate and high cardiovascular risk classes had similar unfavorable cardiometabolic profiles and lifetime cardiovascular risk, suggesting the need for more aggressive treatment management in the moderate cardiovascular risk population. Therefore, new prospective population studies are necessary to establish different cardiovascular risk profiles in a changing society.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Natalia Drobek, Pawel Sowa, Piotr Jankowski, Maciej Haberka, Zbigniew Gasior, Dariusz Kosior, Danuta Czarnecka, Andrzej Pajak, Karolina Szostak-Janiak, Agnieszka Krzykwa, Malgorzata Setny, Pawel Koziel, Marlena Paniczko, Jacek Jamiolkowski, Irina Kowalska, Karol Kaminski
Summary: This study aimed to evaluate the prevalence of undiagnosed diabetes and prediabetes in patients with chronic coronary syndromes (CCS) and identify factors associated with dysglycemia. Results showed a 5.1% newly diagnosed diabetes rate and 72.3% prediabetes rate among study participants. Body mass index and high-density lipoprotein cholesterol were identified as important factors in assessing the risk of dysglycemia development after hospital discharge.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Remigiusz Kazimierczyk, Ewelina Kazimierczyk, Malgorzata Knapp, Bozena Sobkowicz, Lukasz A. Malek, Piotr Blaszczak, Katarzyna Ptaszynska-Kopczynska, Ryszard Grzywna, Karol A. Kaminski
Summary: The study showed that the TAPSE/sPAP ratio in patients with pulmonary arterial hypertension (PAH) is a valuable prognostic parameter for assessing hemodynamic adaptation and predicting outcomes, providing an easy and reliable non-invasive tool for comprehensive evaluation of patients' condition.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medical Laboratory Technology
Mariana Ponce-de-Leon, Jakob Linseisen, Annette Peters, Birgit Linkohr, Margit Heier, Harald Grallert, Ben Schoettker, Kira Trares, Megha Bhardwaj, Xin Gao, Herman Brenner, Karol Adam Kaminski, Marlena Paniczko, Irina Kowalska, Sebastian-Edgar Baumeister, Christa Meisinger
Summary: This study investigated the association between obesity and inflammation-related proteins in European populations and identified 14 novel proteins associated with adiposity. The majority of these proteins were found to be associated with visceral fat and adipose tissue accumulation in the abdomen and trunk.
TRANSLATIONAL RESEARCH
(2022)
Article
Medicine, Research & Experimental
Remigiusz Kazimierczyk, Piotr Szumowski, Stephan Nekolla, Lukasz Malek, Piotr Blaszczak, Marcin Hladunski, Ewa Tarasiuk, Janusz Mysliwiec, Bozena Sobkowicz, Karol Kaminski
Summary: This study revealed a close relationship between platelet sTWEAK levels, plasma IL-6 levels, and RV parameters in stable PAH patients, and demonstrated their predictive value for clinical deterioration.
ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Remigiusz Kazimierczyk, Piotr Szumowski, Stephan G. G. Nekolla, Lukasz A. A. Malek, Piotr Blaszczak, Marcin Hladunski, Bozena Sobkowicz, Janusz Mysliwiec, Karol A. A. Kaminski
Summary: PET/MRI hybrid imaging in PAH is important for prognosis and predicting the effectiveness of therapy. Adequate therapy can reverse unfavorable metabolic alterations in the right ventricle and improve prognosis.
Article
Medicine, General & Internal
Maciej Haberka, Piotr Jankowski, Dariusz A. Kosior, Malgorzata Szpakowicz, Karolina Szostak-Janiak, Pawel Koziel, Agnieszka Krzykwa, Magda Lapinska, Malgorzata Setny, Karol Kaminski, Aldona Kubica, Dirk de Bacquer, Guy de Backer, Kornelia Kotseva, David Wood, Andrzej Pajak, Danuta Czarnecka, Zbigniew Gasior
Summary: This study aimed to assess the achievement of main treatment goals in secondary cardiovascular prevention in Polish coronary patients. The results showed that the majority of patients did not reach the treatment goals, highlighting the need for improved management of all risk factors.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Public, Environmental & Occupational Health
Ludmila Marcinowicz, Ewa Taranta, Jacek Jamiolkowski, Karol Kaminski, Slawomir Jerzy Terlikowski
Summary: To improve the quality of care, it is important to understand patients' needs and expectations. This study found that socioeconomic status, marital status, and age were associated with patients' expectations of family nurses. Younger patients were more likely to expect health counseling from family nurses, while those who expected home visits had lower self-evaluated health. These findings suggest that family nurses should tailor their services to individual patients' situations and needs.
HEALTH & SOCIAL CARE IN THE COMMUNITY
(2022)
Article
Multidisciplinary Sciences
Malgorzata Chlabicz, Marlena Dubatowka, Jacek Jamiolkowski, Pawel Sowa, Magda Lapinska, Andrzej Raczkowski, Wojciech Laguna, Anna M. Moniuszko-Malinowska, Napoleon Waszkiewicz, Irina Kowalska, Karol A. Kaminski
Summary: This study found that well-being among non-obese adults is influenced by body composition, with women's well-being mainly associated with the distribution of adipose tissue and men's well-being more dependent on muscle mass.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Siamala Sinnadurai, Pawel Sowa, Piotr Jankowski, Zbigniew Gasior, Dariusz A. Kosior, Maciej Haberka, Danuta Czarnecka, Andrzej Pajak, Malgorzata Setny, Jacek Jamiolkowski, Magda Lapinska, Karol A. Kaminski
Summary: Cardiac rehabilitation has a positive impact on controlling risk factors for patients with ischemic heart disease in the long term, with participants being more likely to quit smoking, achieve good glucose control, and have a better quality of life.
POLISH ARCHIVES OF INTERNAL MEDICINE-POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ
(2021)
Article
Cardiac & Cardiovascular Systems
Remigiusz Kazimierczyk, Lukasz A. Malek, Piotr Szumowski, Stephan G. Nekolla, Piotr Blaszczak, Dorota Jurgilewicz, Marcin Hladunski, Bozena Sobkowicz, Janusz Mysliwiec, Ryszard Grzywna, Wlodzimierz J. Musial, Karol A. Kaminski
Summary: This study proposed a multimodal approach to estimate the prognostic value of RV coupling parameters in PAH patients, revealing that coupling parameters are related to RV hemodynamics and glucose metabolism and suggesting that RV GLS/PASP may be an important predictor of clinical endpoints.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2021)
