Regulation of cell signaling and apoptosis by tumor suppressor WWOX

Wwox suppresses breast cancer cell growth through modulation of the hedgehog–GLI1 signaling pathway

(2014) Anwen Xiong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tumor suppressor WWOX regulates glucose metabolism via HIF1α modulation

(2014) M Abu-Remaileh et al.   CELL DEATH AND DIFFERENTIATION

Characterizing WW Domain Interactions of Tumor Suppressor WWOX Reveals Its Association with Multiprotein Networks

(2014) Mohammad Abu-Odeh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Origin of the Binding of WWOX Tumor Suppressor to ErbB4 Receptor Tyrosine Kinase

(2013) Brett J. Schuchardt et al.   BIOCHEMISTRY

WW domain containing oxidoreductase induces apoptosis in gallbladder-derived malignant cell by upregulating expression of P73 and PUMA

(2013) Dong Wei et al.   TUMOR BIOLOGY

WWOX suppresses autophagy for inducing apoptosis in methotrexate-treated human squamous cell carcinoma

(2013) C-W Tsai et al.   Cell Death & Disease

Tumor suppressor WWOX binds to ΔNp63α and sensitizes cancer cells to chemotherapy

(2013) Z Salah et al.   Cell Death & Disease

Genetic alterations of WWOX in Wilms’ tumor are involved in its carcinogenesis

(2012) ELŻBIETA PŁUCIENNIK et al.   ONCOLOGY REPORTS

WW domain-containing oxidoreductase promotes neuronal differentiation via negative regulation of glycogen synthase kinase 3β

(2011) H-Y Wang et al.   CELL DEATH AND DIFFERENTIATION

Wwox inactivation enhances mammary tumorigenesis

(2011) S K Abdeen et al.   ONCOGENE

The tumor suppressor gene WWOX links the canonical and noncanonical NF- B pathways in HTLV-I Tax-mediated tumorigenesis

(2010) J. Fu et al.   BLOOD

Frequent Attenuation of the WWOX Tumor Suppressor in Osteosarcoma Is Associated with Increased Tumorigenicity and Aberrant RUNX2 Expression

(2010) K. C. Kurek et al.   CANCER RESEARCH

WWOX gene may contribute to progression of non-small-cell lung cancer (NSCLC)

(2010) Onur Baykara et al.   TUMOR BIOLOGY

Fragile histidine triad protein, WW domain-containing oxidoreductase protein Wwox, and activator protein 2γ expression levels correlate with basal phenotype in breast cancer

(2009) Gulnur Guler et al.   CANCER

Transforming Growth Factor β1 Signaling via Interaction with Cell Surface Hyal-2 and Recruitment of WWOX/WOX1

(2009) Li-Jin Hsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of the Wnt/β-catenin pathway by the WWOX tumor suppressor protein

(2009) N Bouteille et al.   ONCOGENE

Complement C1q Activates Tumor Suppressor WWOX to Induce Apoptosis in Prostate Cancer Cells

(2009) Qunying Hong et al.   PLoS One

Dramatic Co-Activation of WWOX/WOX1 with CREB and NF-κB in Delayed Loss of Small Dorsal Root Ganglion Neurons upon Sciatic Nerve Transection in Rats

(2009) Meng-Yen Li et al.   PLoS One

Role of the WWOX gene, encompassing fragile region FRA16D, in suppression of pancreatic carcinoma cells

(2008) Shunji Nakayama et al.   CANCER SCIENCE

Zfra is an inhibitor of Bcl-2 expression and cytochrome c release from the mitochondria

(2008) Li-Jin Hsu et al.   CELLULAR SIGNALLING

MPP+-induced neuronal death in rats involves tyrosine 33 phosphorylation of WW domain-containing oxidoreductase WOX1

(2008) Chen-Peng Lo et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Low levels of WWOX protein immunoexpression correlate with tumour grade and a less favourable outcome in patients with urinary bladder tumours

(2008) D Ramos et al.   HISTOPATHOLOGY

The WWOX Tumor Suppressor Is Essential for Postnatal Survival and Normal Bone Metabolism

(2008) Rami I. Aqeilan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The JNK inhibitor SP600129 enhances apoptosis of HCC cells induced by the tumor suppressor WWOX

(2008) Ileana Aderca et al.   JOURNAL OF HEPATOLOGY