Article
Oncology
Anjin Wang, Qiying Xu, Rengaowa Sha, Tonghui Bao, Xiaoli Xi, Guilan Guo
Summary: The study revealed that miR-29a was downregulated in cervical cancer tissues and cells, and inhibited cell proliferation and induced cell cycle arrest by regulating the methylation level of the p16 gene.
Article
Medicine, Research & Experimental
Zhihui Gao, Qianqing Wang, Mei Ji, Xiangcui Guo, Li Li, Xiaoke Su
Summary: The study revealed that UCA1 regulates SOX2 expression by sponging miR-122-5p, affecting the functions of CC stem cells, while CaSki-Exo promotes the invasion and migration of CC stem cells. Silencing UCA1 or up-regulating miR-122-5p reduced the invasion and migration abilities of CC stem cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
RongXin Xiao, Hong Wang, Biao Yang
Summary: The study showed that overexpression of miR-98-5p can inhibit the growth and spread of cervical cancer cells, and promote cell apoptosis, making it a potential target for future research in treating cervical cancer.
Article
Oncology
Lili Zhang, Huixiao Chen, Fengxi He, Shiqian Zhang, Aihua Li, Aifeng Zhang, Anqi Zhang
Summary: miR-320a plays an important role in ovarian cancer progression and infiltration, promoting the proliferation, migration, and invasion of EOC cells by targeting RASSF8.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Maria Magdalena Barreca, Chiara Zichittella, Riccardo Alessandro, Alice Conigliaro
Summary: Hypoxia, a key characteristic of the tumor microenvironment, is crucial for cancer progression and therapeutic response. The hypoxia-inducible factors (HIFs) play a master regulatory role in modulating hypoxic gene expression and signaling pathways, ultimately changing the cell phenotype to be more aggressive. Non-coding RNAs (ncRNAs) have been identified as important molecular mediators in hypoxic responses, regulating gene expression at various levels and contributing to tumor growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Rhafaela Lima Causin, Andre Van Helvoort Lengert, Izabela Natalia Faria Gomes, Ana Julia Aguiar De Freitas, Marcela Nunes Rosa, Ricardo Dos Reis, Rui Manuel Reis, Marcia Maria Chiquitelli Marques
Summary: miR-130a-3p is overexpressed in cervical cancer cells and plays a significant role in the development of cervical cancer. Inhibiting miR-130a-3p can significantly reduce the proliferation, migration, and invasion of cervical cancer cells. miR-130a-3p may regulate the biological functions of cervical cancer cells by directly targeting the DLL1 gene. Therefore, miR-130a-3p may serve as a biomarker for determining cervical cancer progression.
Review
Gastroenterology & Hepatology
Matias Estaras, Antonio Gonzalez
Summary: In solid tumors, slower vasculature development compared to rapid cell proliferation leads to localized hypoxia, where cells adapt and survive through intracellular pathways and cell-to-cell communication mechanisms.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Multidisciplinary Sciences
Xiangke Cao, Qinghua Ma, Bin Wang, Qingqiang Qian, Yinan Xi
Summary: Circ-E2F3 is upregulated in cervical cancer tissues and cell lines, correlating with clinicopathological features and poor prognosis of patients. It promotes proliferation, invasion, migration of cancer cells, and tumor growth in vivo, by inhibiting miR-296-5p to facilitate nuclear translocation of STAT3 and affect cyclin D1 expression.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Aleksandra Majewska, Klaudia Brodaczewska, Aleksandra Filipiak-Duliban, Arkadiusz Kajdasz, Claudine Kieda
Summary: MicroRNAs are important regulators of gene expression and play a role in various pathological states, including cancer. This study focuses on the miRNA pattern in renal cancer and its association with hypoxia and PTEN dysregulation. The findings show that hypoxia induces changes in miRNA expression, and the loss of PTEN affects the response to hypoxia. It is important to consider the specificity of the tumor microenvironment and key suppressor mutations when identifying miRNA patterns in cancer.
Article
Oncology
Zhi Wei, Jianfeng Gan, Xuan Feng, Mo Zhang, Zhixian Chen, Hongbo Zhao, Yan Du
Summary: This study found that A3B is overexpressed in cervical cancer and progressively activated during its development. The results also suggest that A3B promotes cell proliferation, migration, and cell cycle, and inhibits apoptosis in cervical cancer cells through the p53 pathway. Additionally, A3B may contribute to chemoresistance in cervical cancer cells.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Ming An, Xuefeng Xing, Tonghua Chen
Summary: The long non-coding RNA UCA1 is upregulated in cervical cancer tissues and cell lines and promotes cell proliferation and invasion by negatively regulating miR-299-3p expression. Overexpression of miR-299-3p can reverse the effects of UCA1 overexpression on cervical cancer cell proliferation and invasion.
Article
Medicine, Research & Experimental
Qingling Zheng, Jin Zhang, Ting Zhang, Yanxiang Liu, Xiuluan Du, Xin Dai, Donghua Gu
Summary: The study found that hsa_circ_0000520 and CDK2 were highly expressed in cervical cancer tissues, and hsa_circ_0000520 could competitively bind to miR-1296 to affect CDK2 expression, thereby inhibiting cell proliferation and promoting apoptosis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Xiuhui Shi, Jingxuan Yang, Mingyang Liu, Yuqing Zhang, Zhijun Zhou, Wenyi Luo, Kar -Ming Fung, Chao Xu, Michael S. Bronze, Courtney W. Houchen, Min Li
Summary: This study identified circANAPC7 as a novel tumor suppressor that functions through the CREB-miR-373-PHLPP2 axis, leading to AKT dephosphorylation, down-regulation of cyclin D1 and transforming growth factor-b, and ultimately suppressing tumor growth and muscle wasting in pancreatic cancer.
Article
Medicine, Research & Experimental
Xiaowei Wu, Minjie Li, Ying Li, Yu Deng, Shun Ke, Fan Li, Yujin Wang, Shuchang Zhou
Summary: The study demonstrated that FGF11 acts as an oncogene in non-small cell lung cancer, while miR-525-5p may negatively regulate FGF11. Targeting FGF11 and HIF-1 alpha could serve as novel strategies for the treatment of NSCLC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Masashi Ishikawa, Masae Iwasaki, Hailin Zhao, Junichi Saito, Cong Hu, Qizhe Sun, Atsuhiro Sakamoto, Daqing Ma
Summary: The study showed that sevoflurane and desflurane enhanced ovarian cancer cell malignancy by deactivating miRNAs and increasing HIF-1 alpha expression. Further research is needed to determine the translational value of these findings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)