Journal
ACTA PHYSIOLOGICA
Volume 224, Issue 1, Pages -Publisher
WILEY
DOI: 10.1111/apha.13080
Keywords
antihypertensive; blood pressure; cardiovascular disease; hypertension; inorganic nitrate; nitric oxide
Categories
Funding
- Vetenskapsradet [2016-01381]
- Karolinska Institutet [2-560/2015]
- Swedish Heart and Lung Foundation [20140448, 20170124]
- Swedish Research Council [2016-01381] Funding Source: Swedish Research Council
Ask authors/readers for more resources
Nitric oxide (NO) importantly contributes to cardiovascular homeostasis by regulating blood flow and maintaining endothelial integrity. Conversely, reduced NO bioavailability is a central feature during natural ageing and in many cardiovascular disorders, including hypertension. The inorganic anions nitrate and nitrite are endogenously formed after oxidation of NO synthase (NOS)-derived NO and are also present in our daily diet. Knowledge accumulated over the past two decades has demonstrated that these anions can be recycled back to NO and other bioactive nitrogen oxides via serial reductions that involve oral commensal bacteria and various enzymatic systems. Intake of inorganic nitrate, which is predominantly found in green leafy vegetables and beets, has a variety of favourable cardiovascular effects. As hypertension is a major risk factor of morbidity and mortality worldwide, much attention has been paid to the blood pressure reducing effect of inorganic nitrate. Here, we describe how dietary nitrate, via stimulation of the nitrate-nitrite-NO pathway, affects various organ systems and discuss underlying mechanisms that may contribute to the observed blood pressure-lowering effect.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available