Article
Environmental Sciences
Chenzhi Yan, Xuan Wu, Xue Cao, Meng Li, Lei Zhou, Guangli Xiu, Jiayi Zeng
Summary: It is widely acknowledged that diesel exhaust particles (DEPs) are closely associated with organ system dysfunction. This study evaluated the potential toxicity of DEP using in vitro human BEAS-2B cell line and in vivo animal model Caenorhabditis elegans, showing that DEP exposure can impair cell and organism stability. The study also found that DEP exposure led to membrane integrity damage, decreased cell viability, and increased levels of reactive oxygen species, damaged DNA fragments, and apoptosis in cell lines.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Immunology
Byeong-Gon Kim, Da Yeon Choi, Min-Gyoung Kim, An-Soo Jang, Myung-Whan Suh, Jun Ho Lee, Seung Ha Oh, Moo Kyun Park
Summary: This study investigated the effects of diesel exhaust particles (DEP) on inflammation and lymphangiogenesis in a mouse model of acute otitis media (AOM). The results showed that pre-exposure to DEP leads to increased levels of inflammation and lymphangiogenesis in the mouse model of AOM.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Luca Massimino, Alessandra Bulbarelli, Paola Antonia Corsetto, Chiara Milani, Laura Botto, Francesca Farina, Luigi Antonio Lamparelli, Elena Lonati, Federica Ungaro, Krishna Rao Maddipati, Paola Palestini, Angela Maria Rizzo
Summary: Airborne ultrafine particles (UFPs) pose a significant risk to health, as they have been linked to increased cardiovascular mortality, neurodegenerative diseases, and occupational and environmental morbidity. In this study, the researchers investigated the impact of acute and subacute exposure to diesel exhaust particles (DEPs) on polyunsaturated fatty acid-derived lipid mediators (LMs) in mouse lung and cortex. The findings suggest that lipids play a crucial role in DEP-induced tissue damage, as they are associated with inflammatory processes and oxidative stress.
Article
Energy & Fuels
Xiaochen Wang, Ying Wang, Yuanqi Bai, Funan Guo, Dongxing Wang
Summary: The study showed that particulates emitted from gasoline/diesel dual-fuel combustion were easier to oxidize and had higher volatile organic fraction compared to diesel particles. It was also found that particles at lower engine speed exhibited higher oxidation reactivity and volatile organic fraction. The nanostructure of dual-fuel soot contributed to its increased oxidative reactivity, with a more amorphous nature being a key factor.
Article
Allergy
Nahyun Kim, Dohyun Han, Injae Joseph Wang, Doo Hee Han, Myung-Whan Suh, Jun Ho Lee, Seung-Ha Oh, Moo Kyun Park
Summary: The study found that the action of diesel exhaust particles (DEP) combined with lipopolysaccharide can significantly affect the secretome of human nasal epithelium, and is associated with biomarkers related to upper airway inflammatory diseases.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Joong Won Lee, Hee Jae Lee, Young-Joo Lee, Yong-beom Lim, Woo Jong Sim, Ji-Hye Jang, Hye-Ryeon Heo, Hyun Joung Lim, Ji-Won Jung, Jin Sik Kim
Summary: Studies have found that exposure to diesel exhaust particles (DEP) can lead to chromosomal DNA damage in normal human lung cells, indicating a potential genotoxic effect of DEP.
Article
Biochemistry & Molecular Biology
Anton Murashko, Anastasia A. Frolova, Anastasiya A. Akovantseva, Svetlana L. Kotova, Peter S. Timashev, Yuri M. Efremov
Summary: Cytotoxicity assays are important tests for studying the safety and biocompatibility of substances and the effectiveness of anticancer drugs. Recent studies have shown that the internal biophysical parameters of cells can be linked to cellular damage. By using atomic force microscopy, researchers assessed the changes in the viscoelastic parameters of cells treated with different cytotoxic agents, revealing that cell softening is a common response to treatment. The mechanical parameters were found to be more sensitive than morphological parameters in detecting cell damage. These findings support the concept of cell mechanics-based cytotoxicity tests.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2023)
Article
Chemistry, Multidisciplinary
Alessandra Zerboni, Rossella Bengalli, Luisa Fiandra, Tiziano Catelani, Paride Mantecca
Summary: The study examined the effects of DEPs, metal oxide nanoparticles, and their mixtures on alveolar cells, finding that NPs can influence autophagy, cell motility, migration, and E-cadherin expression, as well as alter colony phenotypes.
Article
Environmental Sciences
Santon Thaver, Lisa Foa, Stephen M. Richards, A. Bruce Lyons, Graeme R. Zosky
Summary: In utero exposure to particulate matter from different sources affects post-natal immune development and function, with the response varying depending on the PM source. Diesel exhaust particles had different effects on male and female mice, while exposure to silica had no impact on the measured immune parameters.
Article
Thermodynamics
Yan Hua, Zhong Wang, Ruina Li, Shuai Liu, Yang Zhao, Lei Qu, Deqing Mei, Hui Lv
Summary: This study investigated the morphology, nanostructure, and oxidation reactivity of particles produced by the combustion of Fischer-Tropsch (F-T) diesel, biodiesel, and regular diesel through techniques such as HRTEM, RS, and TGA. The results showed that F-T diesel particles had smaller fractal dimension and fringe tortuosity, higher graphitization degree, and lower oxidation reactivity compared to regular diesel particles. Biodiesel particles exhibited the opposite characteristics and were more prone to oxidation. The application of exhaust gas recirculation (EGR) increased particle agglomeration, reduced graphitization degree and oxidation characteristic temperature, and enhanced particle oxidation reactivity.
Article
Energy & Fuels
Hongling Ju, Fanquan Bian, Mingrui Wei, Yi Zhang
Summary: In this study, insulating cotton was used to change the airflow temperature in the exhaust pipe of a diesel engine, and the morphologies and microstructures of soot particles collected at different positions were observed. The characteristic parameters, including primary particle diameter, aggregate radius of gyration, fractal dimension of soot particle, carbon layer spacing, and carbon layer torsion resistance, were analyzed. The results showed that after installing the cotton, the size of the soot particles increased and the fractal dimension increased. The increase in airflow temperature promoted the growth of primary soot particles and enhanced turbulence, resulting in a decrease in particle aggregation and an increase in fractal dimension.
Article
Environmental Sciences
Zhe Chen, Fagui Chen, Zhangfu Fang, Huasi Zhao, Chen Zhan, Chenhui Li, Yaowei He, Chuqin Huang, Li Long, Kefang Lai
Summary: Exposure to diesel exhaust particulate matter (DEP) can lead to inflammation and oxidative stress in the nucleus of solitary tract (NTS), especially in the high exposure group. Increased numbers of microglia and astrocytes, as well as elevated NGF expression, were observed in the NTS following DEP exposure. Ultrastructural changes in NTS neurons and an imbalance of oxidants and antioxidants were also detected.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Environmental Sciences
Vahid Jalali Farahani, Milad Pirhadi, Constantinos Sioutas
Summary: The study compared the chemical characteristics of standardized diesel exhaust particles (DEP) with real-world particulate matter (PM) collected in different urban settings to evaluate their representativeness for toxicological studies. Results showed that standardized DEPs are not suitable representatives of traffic emissions or typical ambient PM due to inconsistencies in their chemical composition.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Chemistry, Analytical
Lina Zheng, M. Eileen Birch, Belinda Johnson, Michael Breitenstein, John Snawder, Pramod Kulkarni
Summary: The suitability of graphitic carbon (GC) content of diesel particulate matter (DPM) as a surrogate measure of elemental carbon (EC) was investigated using Raman spectroscopy. Comparison of Raman spectra for different samples showed that GC quantification based on peak height and peak area had an uncertainty of around 6.0-6.9%. A calibration curve was constructed to relate GC measured by a portable Raman spectrometer to EC concentration. The study demonstrated that GC measurement by a handheld Raman spectrometer can provide a useful indicator of EC in workplace aerosols.
ANALYTICAL CHEMISTRY
(2023)
Editorial Material
Neurosciences
Michelle L. Block, Urmila P. Kodavanti
Summary: The mechanisms by which urban air pollution exposure conveys Alzheimer's disease risk and affects plaque pathology are largely unknown. Due to the variability of particulate matter across different locations, pollution sources, and times, it is not feasible to use a single model to represent all ambient particulate matter in research on the role of air pollution in central nervous system diseases. Investigating multiple models of particulate matter with specific components from different sources is essential to fully understand the characteristics of particulate matter that affect Alzheimer's disease.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Otorhinolaryngology
Jonatas Bussador do Amaral, Antonio Carlos Bloise, Carolina Nunes Franca, Claudina Perez-Novo, Glaucia Maria Machado-Santelli, Adriano Mesquita Alencar, Rogerio Pezato
AURIS NASUS LARYNX
(2020)
Article
Physiology
Renata Alves, Camila Liyoko Suehiro, Flavia Garcia de Oliveira, Eliete Dalla Corte Frantz, Renata Frauches de Medeiros, Rodolfo de Paula Vieira, Milton de Arruda Martins, Chin Jia Lin, Antonio Claudio Lucas da Nobrega, Alessandra Choqueta de Toledo-Arruda
JOURNAL OF APPLIED PHYSIOLOGY
(2020)
Article
Multidisciplinary Sciences
Daniela Perroni Frias, Raquel Labiapari Nunes Gomes, Kelly Yoshizaki, Regiani Carvalho-Oliveira, Monique Matsuda, Mara de Souza Junqueira, Walcy Rosolia Teodoro, Perola de Castro Vasconcellos, Daniela Cristina de Almeida Pereira, Paulo Roberto da Conceicao, Paulo Hilario Nascimento Saldiva, Thais Mauad, Mariangela Macchione
SCIENTIFIC REPORTS
(2020)
Article
Respiratory System
Fernando Conrado Abrao, Igor Renato Louro B. de Abreu, Mariana Campello de Oliveira, Geisa Garcia Viana, Jose Franklin Soares Pompa Filho, Riad Naim Younes, Elnara Marcia Negri
JOURNAL OF THORACIC DISEASE
(2020)
Article
Physiology
Elnara Marcia Negri, Bruna Mamprim Piloto, Luciana Kato Morinaga, Carlos Viana Poyares Jardim, Shari Anne El-Dash Lamy, Marcelo Alves Ferreira, Elbio Antonio D'Amico, Daniel Deheinzelin
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Oncology
Ximena Camacho, Carolina Perroni, Camila L. Machado, Camila de Godoi Carneiro, Mara de Souza Junqueira, Daniele Faria, Maria F. Garcia, Marcelo Fernandez, Natalia Oddone, Juan Benech, Carlos A. Buchpiguel, Hugo Cerecetto, Roger Chammas, Eloisa Riva, Pablo Cabral, Juan P. Gambini
Summary: This study aimed to label and evaluate Fab(Tocilizumab) as potential imaging agents for multiple myeloma, targeting IL-6R. Analysis of IL-6R distribution in MM cell lines was conducted through Laser Confocal Microscopy. Radiolabeling and biodistribution studies were performed to assess the potential of Fab(Tocilizumab) for MM imaging.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Physical
Alexandre B. Almeida, Sergey Buldyrev, Adriano M. Alencar, Nicolas Giovambattista
Summary: Molecular dynamics simulations were used to study nanoscale water capillary bridges between parallel walls, showing that the capillarity theory is valid up to a certain wall separation distance but breaks down at smaller distances.
JOURNAL OF PHYSICAL CHEMISTRY C
(2021)
Article
Pathology
Robson Seriani, Carla Peres de Paula, Anderson Ferreira da Cunha, Marcos Antonio de Oliveira, Paloma Gava Krempel, Daniela Perroni Frias, Elnara Marcia Negri, Thais Mauad, Mariangela Macchione
Summary: Exposure to diesel exhaust particles may decrease the gene expression patterns of the PRDX family in bronchial epithelial airway cells, leading to an increase in oxidative stress levels.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2021)
Article
Cell Biology
Juliana D. Lourenco, Walcy R. Teodoro, Denise F. Barbeiro, Ana Paula P. Velosa, Larissa E. F. Silva, Julia B. Kohler, Alyne R. Moreira, Marcelo Aun, Isadora C. da Silva, Frederico L. A. Fernandes, Elnara M. Negri, Jefferson L. Gross, Iolanda F. L. C. Tiberio, Juliana T. Ito, Fernanda D. T. Q. S. Lopes
Summary: Th17/Treg imbalance is found in COPD patients, with increased intracellular signaling in the lungs at different stages. Increased gene expression of IL-6 and related genes was observed in COPD I and II, while systemic responses showed elevated IL-6 levels in COPD I and II, and elevated gene expression in COPD III and IV.
Article
Biochemistry & Molecular Biology
Fernando A. Oliveira, Mariana P. Nucci, Javier B. Mamani, Arielly H. Alves, Gabriel N. A. Rego, Andrea T. Kondo, Nelson Hamerschlak, Mara S. Junqueira, Lucas E. B. de Souza, Lionel E. Gamarra
Summary: This study proposed an innovative method to evaluate the tracking and homing of hematopoietic stem cells from young and old mice, showing that SPIONNIRF-Rh had high internalization efficiency and played a good role in homing. The comprehensive evaluation of multimodal nanoparticles highlighted the importance of combined techniques.
Article
Physics, Condensed Matter
Yan B. Barreto, Adriano M. Alencar
Summary: A random-walk model was used to describe the dynamics of glucose uptake by SGLT2, and two new states were added to the canonical model to better explain the experimental results.
JOURNAL OF PHYSICS-CONDENSED MATTER
(2022)
Article
Chemistry, Physical
Cristofher Victor Vivas Palomares, Yan Borges Barreto, Natalia Marchesan Bexiga, Sergio Hiroshi Toma, Jonnatan Julival dos Santos, Koiti Araki, Adriano Mesquita Alencar, Antonio Carlos Bloise
Summary: This study investigates the metabolic changes in cells exposed to nanoparticles and their response to cytotoxicity manipulation. The findings suggest that improving wound healing treatments can be achieved by modulating cellular activity through fine-tuning exposure parameters.
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
(2023)
Article
Multidisciplinary Sciences
Silvia Y. Bando, Fernanda B. Bertonha, Pedro H. N. Menezes, Andre K. Takahara, Nathalia A. Khaled, Paula Santos, Mara S. Junqueira, Roberto M. Cesar, Carlos A. Moreira-Filho
Summary: Febrile seizures in early childhood pose a risk for developing epilepsy of the mesial temporal lobe, however, the underlying molecular mechanisms remain poorly understood. Therefore, rat models of hyperthermia-induced seizures have been used to investigate these mechanisms.
SCIENTIFIC REPORTS
(2023)
Article
Materials Science, Biomaterials
Cristofher Victor Vivas, Jennifer Adriane dos Santos, Yan Borges Barreto, Sergio Hiroshi Toma, Jonnatan Julival dos Santos, Marco Antonio Stephano, Cristiano Luis Pinto de Oliveira, Koiti Araki, Adriano Mesquita Alencar, Antonio Carlos Bloise
Summary: The bactericidal and antimicrobial properties of silver nanoparticles (AgNPs) have been studied to improve wound healing. In this study, the cytotoxicity and metabolic changes induced by AgNPs on human fibroblast and endothelial cell lines were investigated. The results showed decreased cell proliferation, viability, and metabolic activity in the treated cells compared to the control. Metabolomic analysis revealed changes in glycolytic, amino acid, tricarboxylic acid cycle, and phospholipid metabolism pathways.