Article
Pediatrics
Ludmila N. Bakhireva, Aydan Sparks, Michael Herman, Lauren Hund, Malia Ashley, Amy Salisbury
Summary: This study suggests that the use of SRIs among pregnant women undergoing treatment for opioid use disorder may lead to more severe neonatal opioid withdrawal syndrome.
PEDIATRIC RESEARCH
(2022)
Review
Neurosciences
Silvano Gallus, Alessandra Lugo, Elisa Borroni, Teo Vignoli, Lisa Lungaro, Giacomo Caio, Roberto De Giorgio, Giorgio Zoli, Fabio Caputo
Summary: This systematic review summarizes literature on major symptoms of protracted alcohol withdrawal in patients with alcohol use disorder. The pharmacological approach to manage protracted alcohol withdrawal ensures a more rapid reduction of symptoms (craving in particular), achieving in three weeks similar results obtained only after almost 6 months without treatment.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Daphne Nakhid, Carly A. McMorris, Hongfu Sun, Ben Gibbard, Christina Tortorelli, Catherine Lebel
Summary: Prenatal alcohol exposure has negative effects on brain development and increases the risk of poor mental health. This study found that susceptibility in the nucleus accumbens was negatively associated with internalizing problems, while amygdala susceptibility was positively associated with internalizing problems. Prenatal alcohol exposure moderated the relationships between thalamus and putamen susceptibility and internalizing and externalizing symptoms. Brain volume was not related to internalizing or externalizing symptoms.
Article
Multidisciplinary Sciences
Corinde E. Wiers, Leandro F. Vendruscolo, Jan-Willem Van der Veen, Peter Manza, Ehsan Shokri-Kojori, Danielle S. Kroll, Dana E. Feldman, Katherine L. McPherson, Catherine L. Biesecker, Rui Zhang, Kimberly Herman, Sophie K. Elvig, Janaina C. M. Vendruscolo, Sara A. Turner, Shanna Yang, Melanie Schwandt, Dardo Tomasi, Mackenzie C. Cervenka, Anders Fink-Jensen, Helene Benveniste, Nancy Diazgranados, Gene-Jack Wang, George F. Koob, Nora D. Volkow
Summary: This study suggests that a ketogenic diet may help in managing alcohol withdrawal and reducing alcohol consumption by decreasing the need for benzodiazepines during withdrawal, lowering cravings for alcohol, and improving brain bioenergetics.
Review
Neurosciences
Eileen M. Moore, Yingjing Xia
Summary: Prenatal alcohol exposure can interfere with neurodevelopment and have detrimental effects on brain structure, function, cognition, behavior, and mental health. Studies have shown that individuals with PAE have atypical developmental trajectories in brain cortical and white matter microstructure during childhood and adolescence. More research is needed to investigate the role of factors such as sex and postnatal experiences, as well as the long-term developmental trajectories beyond young adulthood.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Medicine, Research & Experimental
Doaa Fathi, Ahmed I. Abulsoud, Muhammed A. Saad, Noha N. Nassar, Mina M. Maksimos, Sherine M. Rizk, Mahmoud A. Senousy
Summary: Agomelatine treatment in a rat model of alcoholism led to a significant decrease in alcohol consumption and positive effects on behavior and biochemical markers. Agomelatine reversed alcohol cravings and withdrawal symptoms associated with alcohol dependence by modulating the Notch1 signaling pathway.
Article
Cell Biology
Riley T. Bottom, Olga O. Kozanian, David J. Rohac, Michael A. Erickson, Kelly J. Huffman
Summary: This study used a transgenerational mouse model to investigate the effects of prenatal ethanol exposure on offspring behavior. The results suggest that behavioral abnormalities can be passed down to multiple generations. However, the specific brain mechanisms underlying these behavioral changes remain unclear.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biology
Monika Ostap-Chec, Monika Opalek, Daniel Stec, Krzysztof Miler
Summary: Honeybee workers exhibit withdrawal symptoms, with increased ethanol consumption and mortality rates, after prolonged exposure to ethanol spiked food, but do not display an increased appetite for ethanol diluted in water. These findings suggest that workers can develop alcohol dependence and may be a valuable model for studying alcohol addiction in a natural setting.
Review
Neurosciences
Ahmad Alhowail
Summary: Alcohol is commonly used by pregnant women as an illicit substance, but it can have long-lasting effects on cognitive functions of the offspring by affecting fetal brain development. The mechanisms altered following prenatal alcohol exposure include long-term potentiation, mitochondrial function, and protein kinase activation, and these changes are potentially associated with behavioral changes in affected offspring.
Article
Biochemistry & Molecular Biology
Constance Marie, Gregory Fouquet, Anoisia Courtois, Rabbind Singh Amrathlal, Nicolas Jankovsky, Hakim Ouled-Haddou, Riad Tebbakha, Hicham Bouhlal, Eric Nguyen-Khac, Mickael Naassila, Ingrid Marcq
Summary: Alcohol-related liver disease is the most prevalent chronic liver disease, accounting for 30% of hepatocellular carcinoma cases and HCC-specific deaths. However, the mechanisms by which alcohol consumption leads to cancer progression and aggressiveness are not well understood. Better understanding of the clinical features and mechanisms of alcohol-induced HCC is crucial for prevention and development of novel treatments.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Environmental Sciences
Nia McRae, Chris Gennings, Nadya Rivera Rivera, Marcela Tamayo-Ortiz, Ivan Pantic, Chitra Amarasiriwardena, Lourdes Schnaas, Rosalind Wright, Martha M. Tellez-Rojo, Robert O. Wright, Maria Jose Rosa
Summary: The study found that prenatal exposure to lead was associated with higher odds of wheezing in children, while exposure to manganese was negatively associated with current wheezing. This highlights the need to further consider the impact of prenatal metal exposure on respiratory outcomes in children.
ENVIRONMENTAL RESEARCH
(2022)
Article
Neurosciences
Preeti Kar, Jess E. Reynolds, William Ben Gibbard, Carly McMorris, Christina Tortorelli, Catherine Lebel
Summary: Prenatal alcohol exposure is associated with alterations in brain white matter microstructure. Children with prenatal alcohol exposure show slower white matter development in certain brain regions, which may have implications for cognitive and behavioral learning.
HUMAN BRAIN MAPPING
(2022)
Article
Psychiatry
Guanghui Shen, Shizhuo Yang, Liujun Wu, Yingjie Chen, Yueling Hu, Fan Zhou, Wei Wang, Peining Liu, Fenzan Wu, Yanlong Liu, Fan Wang, Li Chen
Summary: This study aims to explore the modulatory role of the polymorphism OXTR rs2254298 on mood disorders during alcohol withdrawal and to help researchers better understand and develop effective relapse prevention and interventions for alcohol use disorders.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Biochemistry & Molecular Biology
Dae D. Chung, Marisa R. Pinson, Lokeshwar S. Bhenderu, Michael S. Lai, Rhea A. Patel, Rajesh C. Miranda
Summary: Prenatal alcohol exposure can have toxic and teratogenic effects on fetal development and individual health, with potential lifelong consequences. Current research focuses on understanding the mechanisms behind the immediate and long-term impacts of alcohol on health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pediatrics
Katarzyna Anna Dylag, Florencia Anunziata, Gretchen Bandoli, Christina Chambers
Summary: Since the identification of fetal alcohol syndrome, alcohol has been acknowledged as a teratogen in humans. However, the connection between prenatal alcohol exposure and a wide range of major birth defects remains poorly understood. This review aimed to provide a summary of the evidence regarding the association between prenatal alcohol exposure and major congenital abnormalities. The strongest evidence to date suggests a link between alcohol exposure and herniation, oral clefts, and cardiac defects. The evidence for gastrointestinal anomalies, diaphragmatic hernia, genitourinary anomalies, and neural tube defects is less consistent. There is no substantial support for an association between prenatal alcohol exposure and choanal atresia, biliary atresia, or clubfoot.