Evidence for altered dendritic spine compartmentalization in Alzheimer’s disease and functional effects in a mouse model

Dendritic Spines Prevent Synaptic Voltage Clamp

(2018) Lou Beaulieu-Laroche et al.   NEURON

Three-dimensional analysis of synapses in the transentorhinal cortex of Alzheimer’s disease patients

(2018) M. Domínguez-Álvaro et al.   Acta Neuropathologica Communications

βIII Spectrin Is Necessary for Formation of the Constricted Neck of Dendritic Spines and Regulation of Synaptic Activity in Neurons

(2017) Nadia Efimova et al.   JOURNAL OF NEUROSCIENCE

Aβ mediates F-actin disassembly in dendritic spines leading to cognitive deficits in Alzheimer's disease

(2017) Reddy Peera Kommaddi et al.   JOURNAL OF NEUROSCIENCE

Biophysical model of the role of actin remodeling on dendritic spine morphology

(2017) C. A. Miermans et al.   PLoS One

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Early synaptic deficits in the APP/PS1 mouse model of Alzheimer’s disease involve neuronal adenosine A2A receptors

(2016) Silvia Viana da Silva et al.   Nature Communications

Dendritic Spines as Tunable Regulators of Synaptic Signals

(2016) Jan Tønnesen et al.   Frontiers in Psychiatry

Periodic F-actin structures shape the neck of dendritic spines

(2016) Julia Bär et al.   Scientific Reports

Intraneuronal APP and extracellular Aβ independently cause dendritic spine pathology in transgenic mouse models of Alzheimer’s disease

(2015) Chengyu Zou et al.   ACTA NEUROPATHOLOGICA

Biochemical Computation for Spine Structural Plasticity

(2015) Jun Nishiyama et al.   NEURON

Evidence for Alzheimer’s disease-linked synapse loss and compensation in mouse and human hippocampal CA1 pyramidal neurons

(2014) Krystina M. Neuman et al.   Brain Structure & Function

Early fear memory defects are associated with altered synaptic plasticity and molecular architecture in the TgCRND8 Alzheimer's disease mouse model

(2014) John W. Steele et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Spine neck plasticity regulates compartmentalization of synapses

(2014) Jan Tønnesen et al.   NATURE NEUROSCIENCE

Adaptive and non-adaptive changes in activity-deprived presynaptic terminals

(2013) Süzel Horellou et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Synaptic Changes in the Dentate Gyrus of APP/PS1 Transgenic Mice Revealed by Electron Microscopy

(2013) Lidia Alonso-Nanclares et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Disruption of Arp2/3 Results in Asymmetric Structural Plasticity of Dendritic Spines and Progressive Synaptic and Behavioral Abnormalities

(2013) I. H. Kim et al.   JOURNAL OF NEUROSCIENCE

AMPARs and Synaptic Plasticity: The Last 25 Years

(2013) Richard L. Huganir et al.   NEURON

Long-term depression triggers the selective elimination of weakly integrated synapses

(2013) J. S. Wiegert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase-2 is required for dendritic spine and behavioural alterations in J20 APP transgenic mice

(2013) Julio Pozueta et al.   Nature Communications

Synapses and Alzheimer's Disease

(2012) M. Sheng et al.   Cold Spring Harbor Perspectives in Biology

Reduction in glutamate uptake is associated with extrasynaptic NMDA and metabotropic glutamate receptor activation at the hippocampal CA1 synapse of aged rats

(2010) Brigitte Potier et al.   AGING CELL

Layer-specific alterations to CA1 dendritic spines in a mouse model of Alzheimer's disease

(2010) P. Merino-Serrais et al.   HIPPOCAMPUS

APP/PS1KI bigenic mice develop early synaptic deficits and hippocampus atrophy

(2009) Henning Breyhan et al.   ACTA NEUROPATHOLOGICA

Classification and basic pathology of Alzheimer disease

(2009) Charles Duyckaerts et al.   ACTA NEUROPATHOLOGICA

Divergent Pathways Mediate Spine Alterations and Cell Death Induced by Amyloid- , Wild-Type Tau, and R406W Tau

(2009) C. Tackenberg et al.   JOURNAL OF NEUROSCIENCE

Molecular Architecture of Synaptic Actin Cytoskeleton in Hippocampal Neurons Reveals a Mechanism of Dendritic Spine Morphogenesis

(2009) Farida Korobova et al.   MOLECULAR BIOLOGY OF THE CELL

Impaired neurogenesis, neuronal loss, and brain functional deficits in the APPxPS1-Ki mouse model of Alzheimer's disease

(2009) A. Faure et al.   NEUROBIOLOGY OF AGING

Deficits in working memory and motor performance in the APP/PS1ki mouse model for Alzheimer's disease

(2007) Oliver Wirths et al.   NEUROBIOLOGY OF AGING