Article
Clinical Neurology
Shiro Horisawa, Atsushi Fukui, Kotaro Kohara, Takakazu Kawamata, Takaomi Taira
Summary: The study suggests that unilateral pallidotomy is an acceptable treatment option for patients with asymmetrical cervical dystonia, with over half of the patients showing significant improvement in TWSTRS scores at 6 months postoperatively. Preoperative severity of the condition was identified as a prognostic factor for treatment outcomes. Further research with larger sample sizes and longer follow-up periods are needed to confirm these findings.
JOURNAL OF NEUROSURGERY
(2021)
Article
Neurosciences
Suzhen Lin, Lingbing Wang, Yimei Shu, Shunyu Guo, Tao Wang, Hongxia Li, Chencheng Zhang, Bomin Sun, Dianyou Li, Yiwen Wu
Summary: Bilateral STN-DBS plus unilateral PVP may be an effective rescue procedure for patients with isolated dystonia who experienced suboptimal movement improvement following GPi-DBS.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Wentao Zheng, Gaoquan Lv, Yunwei Lu, Jiayu Liu, Qingpei Hao, Hu Ding, Yezu Liu, Ruen Liu
Summary: Bilateral globus pallidus internus deep brain stimulation (GPi-DBS) is a safe and effective treatment approach for Meige syndrome, improving motor function and quality of life without cognitive and mood side effects.
Article
Clinical Neurology
Vincenzo Levi, Giovanna Zorzi, Giuseppe Messina, Luigi Romito, Irene Tramacere, Ivano Dones, Nardo Nardocci, Angelo Franzini
Summary: Both deep brain stimulation (DBS) and pallidotomy are safe and effective treatments for drug-resistant status dystonicus, with high success rates. The choice between the two techniques should be individualized based on patient-specific factors.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Suzhen Lin, Yimei Shu, Chencheng Zhang, Lingbing Wang, Peng Huang, Yixin Pan, Jianqing Ding, Bomin Sun, Dianyou Li, Yiwen Wu
Summary: This study compared the effectiveness of targeting the globus pallidus internus (GPi) and the subthalamic nucleus (STN) in patients with isolated dystonia. The results showed that STN-DBS had superior effects at 1 month, 1 year, and 3 years, while GPi-DBS was better for axis symptoms, particularly for trunk involvement. STN-DBS was also more effective for symptoms involving the eyes and generalized dystonia, and required less electrical energy.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Takashi Tsuboi, Marc Charbel, David T. Peterside, Mohit Rana, Ahmad Elkouzi, Wissam Deeb, Adolfo Ramirez-Zamora, Janine Lemos Melo Lobo Jofili Lopes, Leonardo Almeida, Pamela R. Zeilman, Robert S. Eisinger, Kelly D. Foote, Lela Okromelidze, Sanjeet S. Grewal, Michael S. Okun, Erik H. Middlebrooks
Summary: This study aimed to identify anatomical regions related to stimulation-induced dyskinesia (SID) in PD patients after pallidal DBS and analyze the connectivity associated with SID. The results showed that SID VTAs were primarily located in the dorsal GPi/GPe and had higher structural connectivity to certain cortical regions compared to non-SID VTAs. Differences in connectivity between motor-related cortices and subcortical regions may explain the presence or absence of SID.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Nicholas Dietz, Ahmad Alhourani, Scott A. Wylie, Jessica L. McDonnell, Fenna T. Phibbs, Benoit M. Dawant, William J. Rodriguez, Elise B. Bradley, Joseph S. Neimat, Nelleke C. van Wouwe
Summary: Deep brain stimulation (DBS) of the Subthalamic Nucleus (STN) and Globus Pallidus (GPi) in Parkinson's disease (PD) patients have similar effects on inhibitory control processes.
CLINICAL NEUROPHYSIOLOGY
(2022)
Review
Medicine, General & Internal
Marwan Hariz, Patric Blomstedtl
Summary: Parkinson's disease is a progressive neurodegenerative illness with motor and nonmotor symptoms. Deep brain stimulation is an effective symptomatic treatment that can be tailored to individual patients. DBS has significant effects on tremors, rigidity, and dyskinesias, but less responsive for axial symptoms. Specialized multidisciplinary teams are required for DBS in PD.
JOURNAL OF INTERNAL MEDICINE
(2022)
Review
Clinical Neurology
Stephen Tisch, Kishore Raj Kumar
Summary: GPi DBS is an effective intervention for refractory dystonia, with factors such as disease duration and subtype influencing outcomes. Other factors affecting variability in results include body distribution, pattern of dystonia, and DBS-related factors. Different monogenic forms of dystonia may respond differently to DBS.
FRONTIERS IN NEUROLOGY
(2021)
Article
Surgery
Marek Balaz, Jiri Buril, Tereza Jurkova, Eva Koritakova, Dusan Hrabovsky, Jonas Kunst, Petra Bartova, Jan Chrastina
Summary: This study aims to compare the preplanned trajectories for deep brain stimulation (DBS) with the final trajectories selected after electrophysiological monitoring, and to discuss the factors responsible for the differences. The results showed significant differences between the preplanned and final trajectories, but no predictors for these differences were identified. There was also no association between the anatomical-electrophysiological differences and clinical outcome.
FRONTIERS IN SURGERY
(2023)
Article
Clinical Neurology
Hong Tian, Bo Zhang, Yanbing Yu, Xueke Zhen, Li Zhang, Yue Yuan, Liang Wang
Summary: DBS of the posterior GPi may lead to better clinical outcomes in treating primary Meige syndrome, and higher GPi neuronal activity, particularly in the ventral part, can be utilized as a biomarker to guide DBS electrode implantation during surgery.
Article
Clinical Neurology
Chun-Hwei Tai, Sheng-Che Chou, Chin-Hsien Lin, Wang-Tso Lee, Ruey-Meei Wu, Sheng-Hong Tseng
Summary: Patients with isolated dystonia, either monogenic or idiopathic, tend to respond better to GPi DBS compared to those with acquired dystonia. Selection of patients based on dystonia etiology, accurate placement of DBS leads in GPi targets, and proper stimulation programming are crucial for achieving better long-term outcomes.
WORLD NEUROSURGERY
(2022)
Article
Neurosciences
Kantharuby Tambirajoo, Luciano Furlanetti, Michael Samuel, Keyoumars Ashkan
Summary: Adult-onset dystonic syndromes presenting with dystonic opisthotonus are rare, and often refractory to medical management. In this study, three patients showed rapid and sustained clinical improvement of symptoms following GPi-DBS, with the ability to resume daily activities and reintegrate into society. Thorough investigation and tailored management are necessary for this highly disabling condition with varying etiologies.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Neurosciences
Shiro Horisawa, Kotaro Kohara, Masato Murakami, Atsushi Fukui, Takakazu Kawamata, Takaomi Taira
Summary: The Forel field has potential for the treatment of cervical dystonia, Parkinson's disease, and dystonia. Recent studies have shown promising results for the efficacy of FF-DBS in treating dystonia.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Review
Clinical Neurology
Roopa Rajan, Kanwaljeet Garg, Achal. K. Srivastava, Manmohan Singh
Summary: In advanced Parkinson's disease (PD), subthalamic nucleus deep brain stimulation (STN-DBS) provides greater improvement in patient and clinician relevant outcomes compared to globus pallidus interna (GPi) DBS and intrajejunal levodopa infusion (IJLI). Unilateral pallidotomy may be beneficial for motor symptoms and activities of daily living in resource limited settings, although overall quality of life may not be improved.
MOVEMENT DISORDERS
(2022)
Review
Clinical Neurology
Andrea Franzini, Edvin Zekaj, Alberto Bona, Andrea Ciuffi, Mauro Porta, Domenico Servello
Summary: We report a case of resection of a cerebellar primary central nervous system lymphoma with intraoperative fluorescein to improve visualization and guide surgery. Low-dose fluorescein was administered to distinguish lymphomatous tissue from the surrounding brain parenchyma. The fluorescein-guided technique allowed for safe tumor resection and sampling of pathological tissue without neurological damage, but there is limited literature on this approach.
BRITISH JOURNAL OF NEUROSURGERY
(2023)
Article
Clinical Neurology
Francesco Prada, Andrea Franzini, Shayan Moosa, Frederic Padilla, David Moore, Luigi Solbiati, Francesco DiMeco, Wynn Legon
Summary: The authors evaluated the acoustic properties of a novel cranial prosthesis for transmitting ultrasound energy with minimal distortion. The results showed the prosthesis was suitable for ultrasound transmission with minimal distortion, indicating potential applications in diagnostic and therapeutic ultrasound procedures for the brain.
JOURNAL OF NEUROSURGERY
(2021)
Review
Clinical Neurology
Andrea Franzini, Zefferino Rossini, Shayan Moosa, Maria Pia Tropeano, Davide Milani, Luca Attuati, Elena Clerici, Pierina Navarria, Federico Pessina, Piero Picozzi
Summary: Medial thalamotomy using stereotactic radiosurgery (SRS) is effective for select patients with treatment-resistant pain and remarkably safe when modern radiation delivery platforms are used. More studies are warranted to shed light on differences in patient responses.
NEUROSURGICAL REVIEW
(2022)
Article
Clinical Neurology
Nico Golfre Andreasi, Luigi Michele Romito, Roberta Telese, Roberto Cilia, Antonio Emanuele Elia, Alessio Novelli, Giovanni Tringali, Giuseppe Messina, Vincenzo Levi, Grazia Devigili, Sara Rinaldo, Angelo Amato Franzini, Roberto Eleopra
Summary: STN-DBS has a long-lasting effect on motor complications in both male and female PD patients, but there may be slight differences in certain aspects that require further investigation.
NEUROLOGICAL SCIENCES
(2022)
Article
Medicine, General & Internal
Federico Pessina, Pierina Navarria, Elena Clerici, Luisa Bellu, Andrea Franzini, Davide Milani, Matteo Simonelli, Pasquale Persico, Letterio S. Politi, Alessandra Casarotti, Bethania Fernandes, Simone Olei, Martina Sollini, Arturo Chiti, Marta Scorsetti
Summary: The study found that [11C]-methionine PET can detect areas at higher risk of recurrence located in FLAIR abnormalities in GBM patients, influencing the extent of surgical resection. However, integrating morphological and functional imaging to better define the extent of surgical resection remains a challenging issue.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Luca Raspagliesi, Antonio D'Ammando, Matteo Gionso, Natasha D. Sheybani, Maria-Beatriz Lopes, David Moore, Steven Allen, Jeremy Gatesman, Edoardo Porto, Kelsie Timbie, Andrea Franzini, Francesco Di Meco, Jason Sheehan, Zhiyuan Xu, Francesco Prada
Summary: This study demonstrated the safety of low-intensity ultrasound irradiation of healthy brain tissue using FDA-approved sonosensitizers in a large animal model. The results support the clinical translation of sonodynamic therapy for intracranial gliomas and other brain tumors.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Eric J. Lehrer, Jason Gurewitz, Kenneth Bernstein, Dev Patel, Douglas Kondziolka, Ajay Niranjan, Zhishuo Wei, L. Dade Lunsford, Timothy D. Malouff, Henry Ruiz-Garcia, Samir Patel, Phillip A. Bonney, Lindsay Hwang, Cheng Yu, Gabriel Zada, David Mathieu, Claire Trudel, Rahul N. Prasad, Joshua D. Palmer, Brianna M. Jones, Sonam Sharma, Kareem R. Fakhoury, Chad G. Rusthoven, Christopher P. Deibert, Piero Picozzi, Andrea Franzini, Luca Attuati, Cheng-Chia Lee, Huai-Che Yang, Manmeet S. Ahluwalia, Jason P. Sheehan, Daniel M. Trifiletti
Summary: The occurrence of symptomatic radiation necrosis (RN) in patients with renal cell carcinoma (RCC) brain metastases treated with immune checkpoint inhibitors (ICIs) and stereotactic radiosurgery (SRS) is relatively low, with most events being grade 1 to 3 and managed by medical means. Concurrent therapy with ICI/SRS does not appear to increase the risk of RN. Efforts to improve dose conformality may be the most successful strategy for mitigating RN in single-fraction SRS.
Review
Clinical Neurology
Andrea Franzini, Elena Clerici, Pierina Navarria, Piero Picozzi
Summary: Gamma Knife radiosurgery (GKRS) can be used to treat drug-resistant cluster headache (CH). The outcomes of studies on GKRS for CH are inconsistent, and the ideal target and treatment parameters are unclear. This systematic review evaluates the safety and efficacy of GKRS for drug-resistant CH, showing high short-term pain reduction rates but controversial long-term results.
NEUROSURGICAL REVIEW
(2022)
Article
Oncology
Pierina Navarria, Federico Pessina, Elena Clerici, Luisa Bellu, Ciro Franzese, Andrea Franzini, Matteo Simonelli, Lorenzo Bello, Armando Santoro, Letterio Salvatore Politi, Giuseppe Roberto D'agostino, Alessandra Casarotti, Bethania Fernandes, Valter Torri, Marta Scorsetti
Summary: This is a single arm prospective phase II study evaluating the efficacy and toxicity of re-irradiation in recurrent high grade glioma. The results showed that re-irradiation is a safe and feasible treatment option, with better outcomes in younger patients and those with grade 3 IDH mutated gliomas.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Clinical Neurology
Eric J. Lehrer, Jason Gurewitz, Kenneth Bernstein, Douglas Kondziolka, Kareem R. Fakhoury, Chad G. Rusthoven, Ajay Niranjan, Zhishuo Wei, L. Dade Lunsford, Timothy D. Malouff, Henry Ruiz-Garcia, Jennifer L. Peterson, Phillip Bonney, Lindsay Hwang, Cheng Yu, Gabriel Zada, Christopher P. Deibert, Rahul N. Prasad, Raju R. Raval, Joshua D. Palmer, Samir Patel, Piero Picozzi, Andrea Franzini, Luca Attuati, David Mathieu, Claire Trudel, Cheng-Chia Lee, Huai-Che Yang, Brianna M. Jones, Sheryl Green, Manmeet S. Ahluwalia, Jason P. Sheehan, Daniel M. Trifiletti
Summary: This study evaluated the risk of radiation necrosis (RN) with concurrent and nonconcurrent stereotactic radiosurgery (SRS) and immune checkpoint inhibitors (ICIs). The results showed that the concurrent administration of ICIs and SRS was not associated with an increased risk of RN. However, tumors harboring BRAF mutation may increase this risk.
Article
Clinical Neurology
Andrea Franzini, Zefferino Rossini, Maria Pia Tropeano, Piero Picozzi, Franco Servadei, Federico Pessina
Summary: This article analyzes the management of war-related head injuries by an Italian field hospital during the Greco-Italian War. The results show that the surgical technique and treatment measures were similar to those of the Allied forces during the same period, and the operative mortality rate was comparable. Although surgical techniques have evolved, many aspects of the approach are still part of the standard of care today.
NEUROSURGICAL FOCUS
(2022)
Article
Clinical Neurology
Andrea DI Rita, Vincenzo Levi, Giulia L. Gribaudi, Giuseppe Casaceli, Giovanni DI Leo, Luigi Berra, Marcello Egidi
Summary: The study compared the safety and outcomes of the interlaminar contralateral approach (ICA) with conventional surgical treatments for far-lateral lumbar disc herniations (FLLDH). The results suggest that ICA is a safe and effective alternative to conventional approaches.
JOURNAL OF NEUROSURGICAL SCIENCES
(2023)
Meeting Abstract
Oncology
Eric Lehrer, Manmeet Ahluwalia, Jason Gurewitz, Kenneth Bernstein, Douglas Kondziolka, Zhishuo Wei, Ajay Niranjan, L. Dade Lunsford, Kareem Fakhoury, Chad Rusthoven, David Mathieu, Claire Trudel, Timothy Malouff, Henry Ruiz-Garcia, Phillip Bonney, Lindsay Hwang, Cheng Yu, Gabriel Zada, Samir Patel, Christopher Deibert, Piero Picozzi, Andrea Franzini, Luca Attuati, Rahul Prasad, Raju Raval, Joshua Palmer, Cheng-Chia Lee, Huai-che Yang, Brianna Jones, Sheryl Green, Jason Sheehan, Daniel Trifiletti
Article
Clinical Neurology
David T. Asuzu, Adomas Bunevicius, Rithika Kormath Anand, Mohanad Suleiman, Ahmed M. Nabeel, Wael A. Reda, Sameh R. Tawadros, Khaled Abdel Karim, Amr M. N. El-Shehaby, Reem M. Emad Eldin, Tomas Chytka, Roman Liscak, Kimball Sheehan, Darrah Sheehan, Marco Perez Caceres, David Mathieu, Cheng-Chia Lee, Huai-Che Yang, Piero Picozzi, Andrea Franzini, Luca Attuati, Herwin Speckter, Jeremy Olivo, Samir Patel, Christopher P. Cifarelli, Daniel T. Cifarelli, Joshua D. Hack, Ben A. Strickland, Gabriel Zada, Eric L. Chang, Kareem R. Fakhoury, Chad G. Rusthoven, Ronald E. Warnick, Jason P. Sheehan
Summary: This international multicenter study found that the majority of patients with meningiomas in direct contact with the anterior optic pathways achieved tumor control and preservation of visual function when treated with SRS.
JOURNAL OF NEUROSURGERY
(2022)
Article
Surgery
Edvin Zekaj, Christian Saleh, Andrea Franzini, Andrea Ciuffi, Domenico Servello
Summary: This study presents a surgical technique for treating CSM with OPLL by performing double level discectomy and selective wedge corpectomy, along with using two cages for arthrodesis and segmental stability. Postoperative CT scan and MRI confirmed spinal canal decompression and fusion.
SPINE SURGERY AND RELATED RESEARCH
(2021)
