Journal
ACTA DERMATO-VENEREOLOGICA
Volume 98, Issue 4, Pages 390-395Publisher
ACTA DERMATO-VENEREOLOGICA
DOI: 10.2340/00015555-2873
Keywords
positron emission tomography computed tomography; inflammation; spleen; psoriasis; vascular inflammation; atherosclerosis
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Funding
- Pfizer [WS2640077]
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The spleen is thought to play a role in atherosclerosisassociated immunity and cardiovascular research has indicated the existence of a cardio-splenic axis. The aim of this study was to assess splenic 18F-fluorodeoxyglucose uptake as a measure of systemic inflammation in patients with untreated psoriasis compared with historical controls assessed by positron emission tomography- computed tomography. Patients with moderate-tosevere psoriasis (n = 12, age 61.4 +/- 4.1 years, 83% men, mean Psoriasis Area Severity Index score of 14.5) and controls (n = 23, age 60.4 +/- 4.5 years, 87% men) were included in the study. Splenic inflammation was measured using the background-corrected spleen-liver-ratio (SLR) based on mean standardized uptake values. Mean +/- SD SLR was increased in patients with psoriasis compared with controls (0.94 +/- 0.11 vs. 0.82 +/- 0.08; p = 0.001). SLR was significantly associated with aortic inflammation. These results support the existence of systemic inflammation in patients with psoriasis, and provide the rationale for a mechanistic link between psoriasis-driven inflammation and cardiovascular comorbidity through a spleen-atherosclerotic axis.
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