Article
Polymer Science
Yapincak Goncu
Summary: This study presents an injectable hybrid hydrogel composed of hyaluronic acid and hexagonal boron nitride particles, mimicking the rheological properties of joint fluid. The research shows that this hydrogel exhibits good lubricating properties and has the potential to alleviate the symptoms of osteoarthritis, improving the quality of life for patients.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Polymer Science
Michelangelo Palco, Paolo Rizzo, Giorgio Carmelo Basile, Angelo Alito, Daniele Bruschetta, Maria Accorinti, Roberto Restuccia, Danilo Leonetti
Summary: This study compared the effectiveness of L-PRP and PRP+HA in patients with mild to moderate HOA, finding that both treatments were effective in reducing pain, with L-PRP showing better results in reducing VAS over time, making it a potentially preferred treatment option. Further research is needed to better describe the clinical outcome of these formulations.
Article
Multidisciplinary Sciences
Jean-Michel Vandeweerd, Bernado Innocenti, Guillem Rocasalbas, Sandrine Emilia Gautier, Pierre Douette, Laurence Hermitte, Fanny Hontoir, Mickael Chausson
Summary: The study characterized the performance of KiOmedine((R)) CM-Chitosan in terms of lubrication and free radical scavenging, showing that it demonstrated a higher capacity to scavenge free radicals and had better lubrication effect compared to crosslinked hyaluronan formulations.
Article
Chemistry, Applied
Soyeon Kim, Hyun Jung Lee, Byeongmoon Jeong
Summary: HA-g-PPG was prepared to improve the stability of F127 gel, and the hybrid thermogel showed longer drug release time and good tissue compatibility.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Multidisciplinary
Dalila Scaturro, Fabio Vitagliani, Pietro Terrana, Daniele Cuntrera, Vincenzo Falco, Sofia Tomasello, Giulia Letizia Mauro
Summary: This study found that intra-articular injections of hybrid hyaluronic acid (HA) complexes can significantly improve pain, disease severity, cardiopulmonary function, and quality of life in overweight patients with knee osteoarthritis (KOA). Additionally, it can help control pain by reducing analgesic intake.
APPLIED SCIENCES-BASEL
(2021)
Article
Biochemistry & Molecular Biology
Hesuyuan Huang, Xuyang Ding, Dan Xing, Jianjing Lin, Zhongtang Li, Jianhao Lin
Summary: In this study, a series of glycosides of oligosaccharides of hyaluronic acid (o-HAs) were synthesized and their effects on osteoarthritis (OA) progression were examined. The results showed that o-HA derivatives had similar therapeutic mechanisms to high molecular weight hyaluronic acid in alleviating OA. This study supports the potential of oligosaccharide-mediated therapy for OA.
Article
Orthopedics
B. J. Heard, K. Barton, S. Abubacker, M. Chung, C. R. Martin, T. A. Schmidt, N. G. Shrive, D. A. Hart
Summary: The study aimed to investigate the effectiveness of a single intra-articular injection of hyaluronic acid (HA) alone and in combination with Dexamethasone (DEX) as a treatment option for preventing posttraumatic osteoarthritis (PTOA). The results showed a significant protective effect of DEX + HA combination treatment on synovial tissue, while HA alone may interfere with the effectiveness of DEX. Therefore, co-treatment with HA following an intra-articular injury is not recommended for inhibiting PTOA progression in this model.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Medicine, General & Internal
Chun-Ping Wang, Wen-Chung Lee, Ru-Lan Hsieh
Summary: Repeated co-injections of corticosteroids plus hyaluronic acid were more effective than hyaluronic acid injections alone in reducing pain and improving physical function and performance from 1 week to 6 months posttreatment.
AMERICAN JOURNAL OF MEDICINE
(2022)
Article
Polymer Science
Jennifer Rodon Fores, Alexis Bigo-Simon, Deborah Wagner, Mathilde Payrastre, Camille Damestoy, Lucille Blandin, Fouzia Boulmedais, Julien Kelber, Marc Schmutz, Morgane Rabineau, Miryam Criado-Gonzalez, Pierre Schaaf, Loic Jierry
Summary: Hydrogel coatings are ideal for biomaterial design due to their biocompatibility and ability to carry biologically active compounds. Using localized enzyme-assisted self-assembly, supramolecular hydrogels can be guided effectively, with hyaluronic acid impacting internal structure and cell adhesion.
Article
Biochemistry & Molecular Biology
Chien-Hsing Lee, Chi-Fu Chiang, Feng-Chih Kuo, Sheng-Chiang Su, Chia-Luen Huang, Jhih-Syuan Liu, Chieh-Hua Lu, Chang-Hsun Hsieh, Chih-Chien Wang, Chian-Her Lee, Pei-Hung Shen
Summary: The study indicated HMW-HA can protect synovium from inflammation and macrophage polarization by reducing IL-6 and PGE2 levels. The involvement of the GRP78-NF-kappa B signaling pathway was highlighted in this protective mechanism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Physical
Suhas Gotla, Silvina Matysiak
Summary: Neurodegeneration in Alzheimer's disease is caused by abnormal accumulation of amyloid-beta (Aβ) peptides. Chitosan (CHT), a macromolecule, has been found to inhibit the aggregation of Aβ and reduce neurotoxicity. Molecular dynamics simulations showed that CHT binds and sequesters Aβ peptides, limiting their aggregation. CHT also reshapes the conformational landscapes of Aβ peptides, depending on its concentration and cationicity, which could guide the development of CHT-based materials for Alzheimer's treatment.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Cell & Tissue Engineering
Lauren J. Pruett, Hannah L. Kenny, William M. Swift, Katarina J. Catallo, Zoe R. Apsel, Lisa S. Salopek, Philip O. Scumpia, Patrick S. Cottler, Donald R. Griffin, James J. Daniero
Summary: Biomaterial-enabled de novo formation of non-fibrotic tissue in situ is important for physicians. In the case of glottic insufficiency, a debilitating laryngeal disorder, a novel microporous annealed particle (MAP) scaffold successfully provided persistent vocal fold augmentation in rabbits, resulting in tissue de novo formation that matched the mixture of fibrotic and non-fibrotic collagens of the contralateral vocal tissue. This study demonstrates improved outcomes compared to the current clinical standard.
NPJ REGENERATIVE MEDICINE
(2023)
Review
Medicine, Research & Experimental
Anil Ranawat, Kaiwen Guo, Mark Phillips, Amy Guo, Faizan Niazi, Mohit Bhandari, Brian Waterman
Summary: Hyaluronic acid (HA) use for knee osteoarthritis (OA) has been extensively studied, and there is a need to further understand the empirical data and health economic implications. This systematic review aims to identify and summarize the available evidence comparing commercially available HA products in the USA, as well as the health economic evidence and socioeconomic outcomes associated with HA use for knee OA.
ADVANCES IN THERAPY
(2023)
Article
Materials Science, Biomaterials
Monica Helena Monteiro do Nascimento, Felipe Nogueira Ambrosio, Debora Carajiliascov Ferraraz, Hermann Windisch-Neto, Samyr Machado Querobino, Michelle Nascimento-Sales, Carlos Alberto-Silva, Marcelo Augusto Christoffolete, Margareth K. K. D. Franco, Ben Kent, Fabiano Yokaichiya, Christiane Bertachini Lombello, Daniele Ribeiro de Araujo
Summary: The study developed PL-HA hybrid hydrogels as a delivery system for SFN intra-articular release and demonstrated potential therapeutic effects for osteoarthritis.
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Surgery
Hyun-Jin Shin, Shin-Hyo Lee, Jung-Ah Park, Ki-Seok Koh, Wu-Chul Song
Summary: This study dissected cadaver orbits to determine the arterial distribution, revealing a relatively safe zone for filler injections to avoid major vessel injury. The detailed topographic information provided may help reduce the risk of retrobulbar hemorrhage and vision-threatening complications.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2021)
Article
Biochemistry & Molecular Biology
Gulcihan Gulseren, Gulistan Tansik, Ruslan Garifullin, Ayse B. Tekinay, Mustafa O. Guler
MACROMOLECULAR BIOSCIENCE
(2019)
Article
Biochemical Research Methods
Cagla Eren Cimenci, Gozde Uzunalli Kurtulus, Ozum S. Caliskan, Mustafa O. Guler, Ayse B. Tekinay
BIOCONJUGATE CHEMISTRY
(2019)
Article
Materials Science, Multidisciplinary
Fuat Topuz, Ashif Y. Shaikh, Mustafa O. Guler, Tamer Uyar
JOURNAL OF MATERIALS SCIENCE
(2020)
Article
Biochemical Research Methods
Muhammed Burak Demircan, Sehmus Tohumeken, Nuray Gunduz, Mohammad Aref Khalily, Turgay Tekinay, Mustafa O. Guler, Ayse B. Tekinay
BIOTECHNOLOGY JOURNAL
(2020)
Article
Biochemistry & Molecular Biology
Melike Sever-Bahcekapili, Canelif Yilmaz, Altan Demirel, Mustafa Cemil Kilinc, Ihsan Dogan, Yusuf Sukru Caglar, Mustafa O. Guler, Ayse B. Tekinay
Summary: The study demonstrates the use of peptide nanofibers as a promising approach for stimulating cellular regeneration in spinal cord injuries. These neuroactive nanofibers provide bioactive cues to enable neural regeneration and enhance tissue integrity in both in vitro and in vivo models. Treatment with these peptide nanofiber scaffolds also leads to significant behavioral improvement, suggesting their potential for facilitating regeneration in the white matter of the spinal cord.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Chemistry, Analytical
Kenana Dayob, Aygul Zengin, Ruslan Garifullin, Mustafa O. Guler, Timur I. Abdullin, Abdulla Yergeshov, Diana V. Salakhieva, Hong Hanh Cong, Mohamed Zoughaib
Summary: This study demonstrates the design of self-assembling nanofiber scaffolds based on peptide amphiphile molecules containing multi-functional histidine residues. The study explores the self-assembly of peptide amphiphiles and the characteristics of nanofiber scaffolds, as well as their interaction with essential microelements such as zinc, copper, and manganese. The effects of metal-activated peptide amphiphile scaffolds on mammalian cell behavior and reactive oxygen species levels were investigated. The results reveal the ability of these scaffolds to modulate cell adhesion, proliferation, and morphological differentiation, particularly through the role of manganese in cell-matrix interaction and neuritogenesis. This study provides proof-of-concept for the development of histidine-functionalized peptide nanofiber scaffolds activated with reactive oxygen species-modulating metals to induce regenerative responses.
Article
Pharmacology & Pharmacy
Seher Yaylaci, Erdem Dinc, Bahri Aydin, Ayse B. Tekinay, Mustafa O. Guler
Summary: In this study, self-assembled hydrogels composed of peptide amphiphile molecules were developed for sustained release of ranibizumab in the treatment of wet age-related macular degeneration. The hydrogel system showed extended release patterns of ranibizumab without dose dumping, and the released drug was biologically functional and effective in blocking angiogenesis. In vivo experiments demonstrated that the drug released from the hydrogel nanofiber system had longer retention time in the posterior chamber of the rabbit eye compared to a control group. The peptide-based hydrogel nanofiber delivery system holds promise for intravitreal anti-VEGF drug delivery in clinics.
Article
Chemistry, Multidisciplinary
Jovana Mitrovic, Gabriella Richey, Sarah Kim, Mustafa O. O. Guler
Summary: Peptides serve as versatile building blocks for the fabrication of various nanostructures, such as hydrogels and nanoparticles. Precise chemical functionalization allows for controlled bioactivity and physical properties, enabling the development of functional materials. The intermolecular interactions and intrinsic peptide characteristics are determined by the conjugation of small molecules on amino acid side chains. This Perspective discusses peptide building blocks, nanostructure formation mechanisms, and the properties of these peptide materials, providing insights from recent publications. Bioinstructive and stimuli-responsive peptide materials have significant impacts in the field of nanomedicine, including drug delivery, cellular engineering, regenerative medicine, and biomedicine.
Article
Materials Science, Biomaterials
Maria Lopes, Marilia Torrado, Daryl Barth, Sofia D. Santos, Melike Sever-Bahcekapili, Ayse B. Tekinay, Mustafa O. Guler, Franck Cleymand, Ana P. Pego, Joao Borges, Joao F. Mano
Summary: Peptide amphiphiles (PAs) are effective molecular building blocks for self-assembling nanobiomaterials. This study developed a simple approach to recreate the native neural extracellular matrix (ECM) using electrostatic-driven supramolecular presentation of a laminin-derived IKVAV-containing self-assembling PA (IKVAV-PA). The bioactive ECM-mimetic supramolecular nanofilms promote primary neuronal cells' adhesion, viability, morphology, and neurite outgrowth, making them promising for neural tissue regeneration.
BIOMATERIALS SCIENCE
(2023)
Article
Nanoscience & Nanotechnology
Thai Duong Luong, Mohamed Zoughaib, Ruslan Garifullin, Svetlana Kuznetsova, Mustafa O. Guler, Timur Abdullin
ACS APPLIED BIO MATERIALS
(2020)
Article
Nanoscience & Nanotechnology
Ozge Uysal, Elif Arslan, Gulcihan Gulseren, Mustafa Cemil Kilinc, Ihsan Dogan, Hakan Ozalp, Yusuf Sukru Caglar, Mustafa O. Guler, Ayse B. Tekinay
ACS APPLIED BIO MATERIALS
(2019)
Review
Pharmacology & Pharmacy
Gozde Uzunalli, Mustafa O. Guler
THERAPEUTIC DELIVERY
(2020)