Article
Oncology
Rui-huan Gan, Li-song Lin, Dan-ping Zheng, Yong Zhao, Lin-can Ding, Da-li Zheng, You-guang Lu
Summary: Abnormal expression of Notch2 is associated with proliferation, invasion, and migration of tongue squamous cell carcinoma. Inhibition of Notch2 can suppress the malignant behavior of TSCC cells, while overexpression of Notch2 has a promoting effect on tongue cancer cells.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Chemistry, Medicinal
Zhenzhen Li, Siyue Ma, Xingye Yang, Ling Zhang, Dong Liang, Gaopan Dong, Lupei Du, Zhenghua Lv, Minyong Li
Summary: The catalytic properties of small-molecule proteolysis targeting chimeras (PROTACs) may lead to uncontrolled degradation. The main disadvantages of PROTACs are non-cancer specificity and relatively high toxicity, which limit their clinical application. Photocontrolled PROTACs (photoPROTACs) can be triggered by ultraviolet A (UVA) or visible light to induce the degradation of the target protein. A study successfully designed photoPROTACs to degrade bromodomain-containing protein 4 (BRD4) using 365 nm light, with compound N2 proving effective in inducing BRD4 degradation and inhibiting tumor growth in a zebrafish xenograft model of skin cancer tongue squamous cell carcinoma (TSCC) in a photocontrol manner.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Cell Biology
Xiaodong Yan, Meng Cao, Zhigang Wang, Shenglin Wang, Qinchao Chen
Summary: Recent studies have shown that C-reactive protein (CRP) plays a role in promoting chemoresistance in tongue squamous cell carcinoma (TSCC) by inhibiting the activation of caspase-3/9.
Article
Oncology
Yaoting Zhang, Dongsheng Gu
Summary: This study found that pretreatment serum CRP level is associated with prognosis in patients with head and neck squamous cell carcinoma. Patients with high CRP level had worse survival outcomes, and CRP level is correlated with N1-3 stage and prognosis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Peng Ye, Ye Liu, Ye-Jun Cai, Hong Yang, Hong-Tao Xu, Zhi-Yue Lu
Summary: Tongue squamous cell carcinoma patients showed a significant increase in oral microbiotic diversity, with differences in bacterial community structure and decreased levels of specific taxa in cancer samples. The bacterial community in cancer samples appeared more conserved than in normal tissue, suggesting potential carcinogenic mechanisms.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Yuan Xu, Yuhuan Jia, Liang Chen, Jing Gao, DeQin Yang
Summary: The study demonstrated that Streptococcus anginosus supernatant had a significant inhibitory effect on oral cancer cells SCC15 by enhancing autophagy activity and promoting apoptosis, leading to reduced proliferation, migration, and invasion abilities.
Article
Biotechnology & Applied Microbiology
Liang Yi, Ying Liu, Anji Xu, Sha Li, Hailin Zhang, Mingjing Peng, Zan Li, Huayi Ren, Jie Dai, Chenhui Luo, Yazhou Xiao, Xiao Zhou, Ying Long
Summary: miR-26b-5p is decreased in TSCC tissues and induces cell cycle arrest by targeting PRR11, suggesting it as a promising therapeutic strategy for TSCC treatment.
Article
Pharmacology & Pharmacy
Danfeng Xue, Xiongming Zhou, Jiaxuan Qiu
Summary: The study found that plumbagin has a greater inhibitory effect on drug-resistant cells compared to sensitive cells, inducing apoptosis and protective autophagy in TSCC cells. Mechanistically, plumbagin induces apoptosis and autophagy by generating reactive oxygen species to mediate JNK and AKT/mTOR pathways, and its growth inhibitory effect against drug-resistant TSCC was confirmed in vivo.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2021)
Article
Oncology
Thomas Parzefall, Julia Schnoell, Laura Monschein, Elisabeth Foki, David Tianxiang Liu, Alexandra Frohne, Stefan Grasl, Johannes Pammer, Trevor Lucas, Lorenz Kadletz, Markus Brunner
Summary: The study revealed that high expression of PRKCA protein is frequent among young tongue cancer patients without alcohol and smoking history, indicating a potential novel risk factor. This overexpression is associated with poor prognosis and may serve as a molecular marker for a high-risk subgroup. Further analysis of PRKCA interactome is needed to elucidate the underlying mechanisms.
Article
Medical Laboratory Technology
Jian Zhang, Linlin Wang, Xiao Xie
Summary: Several studies have shown that RFC4 is up-regulated in various cancers and associated with progression. In oral tongue squamous cell carcinoma, RFC4 is up-regulated and closely related to TNM stage, but not to age, gender, or differentiation. Knockdown of RFC4 can significantly inhibit the proliferation and carcinogenesis of oral tongue squamous cell carcinoma in vitro and in vivo.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Biochemistry & Molecular Biology
Chung-Chih Tseng, Chung-Ching Hung, Chih-Wen Shu, Cheng-Hsin Lee, Chun-Feng Chen, Mei-Shu Kuo, Yu-Ying Kao, Chun-Lin Chen, Luo-Ping Ger, Pei-Feng Liu
Summary: Currently, there is a lack of effective biomarkers for the diagnosis and treatment of tongue squamous cell carcinoma (TSCC). However, the expression of REEP6, a transmembrane endoplasmic reticulum resident protein, was found to be higher in TSCC tissues compared to normal tissues. Knockdown of REEP6 resulted in reduced malignancy of TSCC cells, including decreased colony/tumorsphere formation, G1 arrest, migration, drug resistance, and cancer stemness. Furthermore, high co-expression of REEP6 with epithelial-mesenchymal transition or cancer stemness markers was associated with poor prognosis in oral cancer patients.
Article
Oncology
Yusuke Yano, Takaya Ohno, Kazumasa Komura, Wataru Fukuokaya, Taizo Uchimoto, Takahiro Adachi, Yosuke Hirasawa, Takeshi Hashimoto, Atsuhiko Yoshizawa, Shogo Yamazaki, Satoshi Tokushige, Kazuki Nishimura, Takuya Tsujino, Keita Nakamori, Shutaro Yamamoto, Kosuke Iwatani, Fumihiko Urabe, Keiichiro Mori, Takafumi Yanagisawa, Shunsuke Tsuduki, Kiyoshi Takahara, Teruo Inamoto, Jun Miki, Takahiro Kimura, Yoshio Ohno, Ryoichi Shiroki, Haruhito Azuma
Summary: This study evaluated the predictive value of serum CRP level for metastatic renal cell carcinoma treated with first-line ipilimumab and nivolumab. The results indicated that patients with CRP >1 mg/dL had significantly shorter survival than those with CRP <1 mg/dL, regardless of ccRCC or nccRCC.
Article
Dentistry, Oral Surgery & Medicine
Oscar Rapado-Gonzalez, Nicolas Costa-Fraga, Aida Bao-Caamano, Jose Luis Lopez-Cedrun, Roberto Alvarez-Rodriguez, Ana Belen Crujeiras, Laura Muinelo-Romay, Rafael Lopez-Lopez, Angel Diaz-Lagares, Maria Mercedes Suarez-Cunqueiro
Summary: This is the first large-scale genome-wide DNA methylation study on OTSCC, identifying a group of novel tumor-specific DNA methylation markers with diagnostic potential in saliva.
Article
Pharmacology & Pharmacy
Tiina Koivikko, Priscila Campioni Rodrigues, Mari Vehvilaeinen, Petra Hyvonen, Elias Sundquist, Riikka K. Arffman, Ahmed Al-Samadi, Hanna Valimaa, Tuula Salo, Maija Risteli
Summary: This study investigates the predominance of HSV-1 in oral HSV infections and its effect on oral tongue squamous cell carcinoma (OTSCC). The results show that HSV-1 is the predominant type in oral HSV infections and is also detected in OTSCC samples without clinical significance. Furthermore, low doses of HSV-1 do not affect cell survival or invasion in OTSCC.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Dapeng Li, Changyu Yao, Zhao Ding, Ping Liu, Xue Chen, Weiwei Liu, Fangzheng Yi, Chuanya Jiang, Hongwu Li, Yehai Liu, Jing Wu
Summary: The study reveals that PES1 expression is associated with prognosis and tumour growth in head and neck squamous cell carcinoma. It also plays a role in drug resistance and may serve as a potential cancer marker and therapeutic target for HNSCC.