Journal
ACS CHEMICAL BIOLOGY
Volume 13, Issue 4, Pages 951-957Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acschembio.7b01024
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Funding
- National Institutes of Health [R37 GM 058822, S10 RR027109]
- Human Frontiers Science Program [RGP0015/2017]
- National Science Foundation [MCB-1716766]
- National Science Foundation Graduate Research Fellowship
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Lantibiotics are ribosomally synthesized and post-translationally modified peptide natural products that contain thioether cross-links formed by lanthionine and methyllanthionine residues. They exert potent antimicrobial activity against Gram-positive bacteria. We herein report production of analogues of two lantibiotics, lacticin 481 and nisin, that contain nonproteinogenic amino acids using two different strategies involving amber stop codon suppression technology. These methods complement recent alternative approaches to incorporate nonproteinogenic amino acids into lantibiotics.
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