Direct Measurements of kT-Scale Capsule-Substrate Interactions and Deposition Versus Surfactants and Polymer Additives

We report a novel approach to directly measure the interactions and deposition behavior of functional capsule delivery systems on glass substrates versus the concentration of an anionic surfactant sodium lauryl ether sulfate (SLES) and a cationic acrylamide-acrylamidopropyltrimonium copolymer (AAC). Analyses of three-dimensional optical microscopy trajectories were used to quantify lateral diffusive dynamics, deposition lifetimes, and potentials of mean force for different solution conditions. In the absence of additives, negatively charged capsule surfaces yield electrostatic repulsion with the negatively charged substrate, which inhibits deposition. With an increasing SLES concentration below the critical micelle concentration (CMC), capsule-substrate electrostatic repulsion is mediated by the charged surfactant solution that decreases the Debye length. Above the SLES CMC, depletion attraction causes enhanced deposition until eventually depletion repulsion inhibits deposition at concentrations similar to 10 wt %. Addition of an ACC causes deposition via capsule-substrate bridging at all concentrations; the weakest deposition occurs at intermediate AAC concentrations from a competition of steric repulsion and attraction via a few extended bridges. The novel measurements and models of capsule interactions and deposition on substrates in this work provide a basis to fundamentally understand and rationally design complex rinse-off cleansing formulations with optimal characteristics.